10.07.2020 | Original Research | Ausgabe 9/2020
Mental Health Status in Patients Undergoing Intracoronary Acetylcholine Provocation Test
- Zeitschrift:
- Advances in Therapy > Ausgabe 9/2020
Wichtige Hinweise
Electronic supplementary material
The online version of this article (https://doi.org/10.1007/s12325-020-01424-9) contains supplementary material, which is available to authorized users.
Yuichi Saito and Toshihiro Shoji contributed equally.
Digital Features
To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12535028.
Abstract
Background
Previous studies showed the relation of mental distress such as anxiety and depression to coronary vasoconstriction and myocardial ischemia. However, the mental health status of patients suspected to have vasospastic angina is unclear.
Methods
A total of 99 patients underwent intracoronary acetylcholine (ACh) provocation tests for the diagnosis of vasospastic angina and mental health assessment using the 12-item General Health Questionnaire (GHQ-12) and State-Trait Anxiety Inventory Form Y (STAI Y-2). Patients with binary GHQ-12 ≥ 4 were defined as having poor mental health.
Results
Median GHQ-12 and STAI Y-2 were 3 [1, 6] and 44 [36, 50]. Forty-one (41%) patients had binary GHQ-12 ≥ 4, and 48 (48%) had positive ACh provocation tests. The number of provoked vasospasms and rate of electrocardiographic change and chest pain during ACh tests were not significantly different between patients with and without GHQ-12 ≥ 4. The incidence of positive ACh provocation test was similar between the two groups (49% vs. 48%, p = 1.00). The multivariable analysis indicated that younger age, no history of percutaneous coronary intervention and no diabetes mellitus were factors associated with higher GHQ-12 and/or STAI Y-2 scores.
Conclusions
More than 40% of patients who underwent ACh provocation tests had poor mental condition. No impact of mental distress on positive ACh tests was found in this study.
