Skip to main content
main-content
Erschienen in: Der Deutsche Dermatologe 11/2018

01.11.2018 | Merkel-Zell-Karzinom | Fortbildung

Merkelzellkarzinom

Die Checkpointinhibition hält Einzug

verfasst von: Anne-Charlotte Niesert, Markus Heppt, Thomas Ruzicka, Prof. Dr. med. Carola Berking

Erschienen in: Deutsche Dermatologie | Ausgabe 11/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das Merkelzellkarzinom ist ein aggressiver, neuroendokriner Tumor der Haut mit steigender Inzidenz. Im Oktober 2017 wurde der erste Immuncheckpointinhibitor zur Therapie des metastasierten Merkelzellkarzinoms in Deutschland zugelassen. Wie schon beim Melanom und anderen Malignomen scheinen auch Patienten mit Merkelzellkarzinom von der Reaktivierung des Immunsystems zu profitieren.
Literatur
1.
Zurück zum Zitat Eisemann N et al. Non-melanoma skin cancer incidence and impact of skin cancer screening on incidence. J Invest Dermatol 2014; 134 (1): 43–50 CrossRef Eisemann N et al. Non-melanoma skin cancer incidence and impact of skin cancer screening on incidence. J Invest Dermatol 2014; 134 (1): 43–50 CrossRef
2.
Zurück zum Zitat Hussain SK et al. Incidence trends of squamous cell and rare skin cancers in the Swedish national cancer registry point to calendar year and age-dependent increases. J Invest Dermatol 2010; 130 (5): 1323–8 CrossRef Hussain SK et al. Incidence trends of squamous cell and rare skin cancers in the Swedish national cancer registry point to calendar year and age-dependent increases. J Invest Dermatol 2010; 130 (5): 1323–8 CrossRef
3.
Zurück zum Zitat Albores-Saavedra J et al. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol 2010; 37 (1): 20–7 CrossRef Albores-Saavedra J et al. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol 2010; 37 (1): 20–7 CrossRef
4.
Zurück zum Zitat Agelli M et al. The etiology and epidemiology of merkel cell carcinoma. Curr Probl Cancer 2010; 34 (1): 14–37 CrossRef Agelli M et al. The etiology and epidemiology of merkel cell carcinoma. Curr Probl Cancer 2010; 34 (1): 14–37 CrossRef
5.
Zurück zum Zitat Schadendorf D et al. Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs. Eur J Cancer 2017; 71: 53–69 CrossRef Schadendorf D et al. Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs. Eur J Cancer 2017; 71: 53–69 CrossRef
6.
Zurück zum Zitat Sastre-Garau X et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol 2009; 218 (1): 48–56 CrossRef Sastre-Garau X et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol 2009; 218 (1): 48–56 CrossRef
7.
Zurück zum Zitat Lunder EJ, Stern RS. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N Engl J Med 1998; 339 (17): 1247–8 CrossRef Lunder EJ, Stern RS. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. N Engl J Med 1998; 339 (17): 1247–8 CrossRef
8.
Zurück zum Zitat Kaae J et al. Merkel cell carcinoma: incidence, mortality, and risk of other cancers. J Natl Cancer Inst 2010; 102 (11): 793–801 CrossRef Kaae J et al. Merkel cell carcinoma: incidence, mortality, and risk of other cancers. J Natl Cancer Inst 2010; 102 (11): 793–801 CrossRef
9.
Zurück zum Zitat Clarke CA et al. Risk of merkel cell carcinoma after solid organ transplantation. J Natl Cancer Inst 2015; 107 (2). pii: dju382 CrossRef Clarke CA et al. Risk of merkel cell carcinoma after solid organ transplantation. J Natl Cancer Inst 2015; 107 (2). pii: dju382 CrossRef
10.
Zurück zum Zitat Tadmor T et al. Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral ties. Ann Oncol 2011; 22 (2): 250–6 CrossRef Tadmor T et al. Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral ties. Ann Oncol 2011; 22 (2): 250–6 CrossRef
11.
Zurück zum Zitat Yom SS et al. Merkel cell carcinoma of the tongue and head and neck oral mucosal sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101 (6): 761–8 CrossRef Yom SS et al. Merkel cell carcinoma of the tongue and head and neck oral mucosal sites. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101 (6): 761–8 CrossRef
12.
Zurück zum Zitat Harms KL et al. Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System. Ann Surg Oncol 2016; 23 (11): 3564–71 CrossRef Harms KL et al. Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System. Ann Surg Oncol 2016; 23 (11): 3564–71 CrossRef
13.
Zurück zum Zitat Wong HH, Wang J. Merkel cell carcinoma. Arch Pathol Lab Med 2010; 134 (11): 1711–6 PubMed Wong HH, Wang J. Merkel cell carcinoma. Arch Pathol Lab Med 2010; 134 (11): 1711–6 PubMed
14.
Zurück zum Zitat Chan JK et al. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 1997; 21 (2): 226–34 CrossRef Chan JK et al. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 1997; 21 (2): 226–34 CrossRef
15.
Zurück zum Zitat Sur M et al. TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20 (11): 1113–20 CrossRef Sur M et al. TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. Mod Pathol 2007; 20 (11): 1113–20 CrossRef
16.
Zurück zum Zitat Jour G et al. Intraepidermal Merkel cell carcinoma: A case series of a rare entity with clinical follow up. J Cutan Pathol 2017; 44 (8): 684–91 CrossRef Jour G et al. Intraepidermal Merkel cell carcinoma: A case series of a rare entity with clinical follow up. J Cutan Pathol 2017; 44 (8): 684–91 CrossRef
17.
Zurück zum Zitat Amin MB et al. (Eds). AJCC Cancer Staging Manual. 8th ed. Springer International Publishing, New York 2017 CrossRef Amin MB et al. (Eds). AJCC Cancer Staging Manual. 8th ed. Springer International Publishing, New York 2017 CrossRef
18.
Zurück zum Zitat Lemos BD et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63 (5): 751–61 CrossRef Lemos BD et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63 (5): 751–61 CrossRef
19.
Zurück zum Zitat Kachar SD et al. Sentinel lymph node biopsy is associated with improved survival in Merkel cell carcinoma. Ann Surg Oncol 2014; 21 (5): 1624–30 CrossRef Kachar SD et al. Sentinel lymph node biopsy is associated with improved survival in Merkel cell carcinoma. Ann Surg Oncol 2014; 21 (5): 1624–30 CrossRef
20.
Zurück zum Zitat Allen PJ et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 2005; 23 (10): 2300–9 CrossRef Allen PJ et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 2005; 23 (10): 2300–9 CrossRef
21.
Zurück zum Zitat Mehrany K et al. A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma. Dermatol Surg 2002; 28 (2): 113–7; discussion 117 PubMed Mehrany K et al. A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma. Dermatol Surg 2002; 28 (2): 113–7; discussion 117 PubMed
22.
Zurück zum Zitat Sattler E et al. Sentinel lymph node in Merkel cell carcinoma: to biopsy or not to biopsy? J Dermatol 2013; 40 (5): 374–9 CrossRef Sattler E et al. Sentinel lymph node in Merkel cell carcinoma: to biopsy or not to biopsy? J Dermatol 2013; 40 (5): 374–9 CrossRef
23.
Zurück zum Zitat Geimer T et al. The impact of sentinel node dissection on disease-free and overall tumour-specific survival in melanoma patients: a single centre group-matched analysis of 1192 patients. J Eur Acad Dermatol Venereol 2017; 31 (4): 629–35 CrossRef Geimer T et al. The impact of sentinel node dissection on disease-free and overall tumour-specific survival in melanoma patients: a single centre group-matched analysis of 1192 patients. J Eur Acad Dermatol Venereol 2017; 31 (4): 629–35 CrossRef
24.
Zurück zum Zitat Bichakjian CK et al. Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2016; 14 (5): 574–97 CrossRef Bichakjian CK et al. Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2016; 14 (5): 574–97 CrossRef
25.
Zurück zum Zitat Lebbe C et al. Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer 2015; 51 (16): 2396–403 CrossRef Lebbe C et al. Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer 2015; 51 (16): 2396–403 CrossRef
26.
Zurück zum Zitat Gollard R et al. Merkel cell carcinoma: review of 22 cases with surgical, pathologic, and therapeutic considerations. Cancer 2000; 88 (8): 1842–51 CrossRef Gollard R et al. Merkel cell carcinoma: review of 22 cases with surgical, pathologic, and therapeutic considerations. Cancer 2000; 88 (8): 1842–51 CrossRef
27.
Zurück zum Zitat Harrington C, Kwan W. Outcomes of Merkel cell carcinoma treated with radiotherapy without radical surgical excision. Ann Surg Oncol 2014; 21 (11): 3401–5 CrossRef Harrington C, Kwan W. Outcomes of Merkel cell carcinoma treated with radiotherapy without radical surgical excision. Ann Surg Oncol 2014; 21 (11): 3401–5 CrossRef
28.
Zurück zum Zitat Fang LC et al. Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer 2010; 116 (7): 71783–90 CrossRef Fang LC et al. Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer 2010; 116 (7): 71783–90 CrossRef
29.
Zurück zum Zitat Poulsen M et al. Weekly carboplatin reduces toxicity during synchronous chemoradiotherapy for Merkel cell carcinoma of skin. Int J Radiat Oncol Biol Phys. 2008; 72 (4): 1070–4 CrossRef Poulsen M et al. Weekly carboplatin reduces toxicity during synchronous chemoradiotherapy for Merkel cell carcinoma of skin. Int J Radiat Oncol Biol Phys. 2008; 72 (4): 1070–4 CrossRef
30.
Zurück zum Zitat Tai PT et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J Clin Oncol 2000; 18 (12): 2493–9 CrossRef Tai PT et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. J Clin Oncol 2000; 18 (12): 2493–9 CrossRef
31.
Zurück zum Zitat Kaufman HL et al. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol 2016; 17 (10): 1374–85 CrossRef Kaufman HL et al. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol 2016; 17 (10): 1374–85 CrossRef
32.
Zurück zum Zitat D’Angelo SP et al. Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic Merkel Cell Carcinoma: A preplanned interim analysis of a clinical trial. JAMA Oncol 2018; 4 (9): e180077 CrossRef D’Angelo SP et al. Efficacy and safety of first-line avelumab treatment in patients with stage IV metastatic Merkel Cell Carcinoma: A preplanned interim analysis of a clinical trial. JAMA Oncol 2018; 4 (9): e180077 CrossRef
33.
Zurück zum Zitat Nghiem PT et al. PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. N Engl J Med 2016; 374 (26): 2542–52 CrossRef Nghiem PT et al. PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. N Engl J Med 2016; 374 (26): 2542–52 CrossRef
Metadaten
Titel
Merkelzellkarzinom
Die Checkpointinhibition hält Einzug
verfasst von
Anne-Charlotte Niesert
Markus Heppt
Thomas Ruzicka
Prof. Dr. med. Carola Berking
Publikationsdatum
01.11.2018
Verlag
Springer Medizin
Erschienen in
Deutsche Dermatologie / Ausgabe 11/2018
Print ISSN: 2731-7692
Elektronische ISSN: 2731-7706
DOI
https://doi.org/10.1007/s15011-018-2186-6

Weitere Artikel der Ausgabe 11/2018

Der Deutsche Dermatologe 11/2018 Zur Ausgabe

Neu im Fachgebiet Dermatologie

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Dermatologie und bleiben Sie gut informiert – ganz bequem per eMail.