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Zeitschrift für Rheumatologie

Erschienen in:

22.04.2020 | Systemische Sklerodermie | Leitthema

Mesenchymale Stammzelltherapie bei Autoimmunerkrankungen

verfasst von: apl. Prof. Dr. med. habil. Gernot Keyßer

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 5/2020

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Zusammenfassung

Mesenchymale Stroma- oder Stammzellen (MSC) besitzen starke immunmodulierende Eigenschaften. Durch ihr großes Potenzial zur Differenzierung in verschiedene Zellformen sind sie zudem in der Lage, die Reparatur von Gewebeschäden in Gang zu setzen. Bei einer Reihe von rheumatischen Erkrankungen haben sich in vitro Einschränkungen der MSC-Funktion darstellen lassen, auch wenn die Bedeutung dieser Phänomene für die Pathogenese jener Krankheiten nicht abschließend geklärt ist. Dennoch könnte v. a. die allogene, möglicherweise auch die autologe MSC-Transplantation (MSCT) ein interessantes Instrument für die Therapie schwerer rheumatologischer Autoimmunerkrankungen darstellen. Erste klinische Studien haben positive Effekte bei systemischem Lupus erythematodes, der systemischen Sklerodermie, dem Sjögren-Syndrom und anderen Erkrankungen des rheumatischen Formenkreises berichtet. Allerdings sind die Fragen nach der langfristigen Wirkung und Sicherheit ebenso unbeantwortet wie die Frage nach der besten Quelle von MSC, der optimalen Kultivierungstechnik und der effektivsten Applikationsart.

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Titel: Mesenchymale Stammzelltherapie bei Autoimmunerkrankungen
verfasst von: apl. Prof. Dr. med. habil. Gernot Keyßer
Publikationsdatum: 22.04.2020
Verlag: Springer Medizin
Schlagwörter: Systemische Sklerodermie
Systemischer Lupus erythematodes
Rheumatoide Arthritis
Sklerodermie
Erschienen in: Zeitschrift für Rheumatologie / Ausgabe 5/2020
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI: https://doi.org/10.1007/s00393-020-00790-7

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Mesenchymale Stammzelltherapie bei Autoimmunerkrankungen

Zusammenfassung

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Zusammenfassung

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin