Background
Methods
Search strategy
Study selection criteria
Data extraction
Choice of genetic model
Heterogeneity test
Meta-analysis and subgroup analysis
Results
Literature search
Study characteristics
T2DM | Control | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Study | Year | Population | Ethnicity | CC | CT | TT | CC | CT | TT | HWE |
Ezzidi et al. | 2009 | Arabic Tunisian | Arab | 250 | 396 | 217 | 181 | 235 | 95 | 0.227155 |
Saadi et al. | 2008 | Arab | Arab | 30 | 54 | 11 | 71 | 94 | 23 | 0.388992 |
Humphries et al. | 2006 | Afro-Caribbean | Black African | 141 | 136 | 30 | 161 | 124 | 26 | 0.75859 |
Yu et al. | 2009 | African American | Black African | 255 | 212 | 48 | 1156 | 921 | 165 | 0.31807 |
Danquah et al. | 2013 | Ghanaian | Black African | 273 | 323 | 78 | 182 | 165 | 28 | 0.257132 |
Yu et al. | 2009 | USA Caucasian | Caucasian | 430 | 392 | 101 | 4295 | 3391 | 693 | 0.515248 |
Groves et al. | 2006 | English | Caucasian | 771 | 960 | 270 | 1175 | 1084 | 217 | 0.944175 |
Humphries et al. | 2006 | European | Caucasian | 601 | 665 | 193 | 1295 | 1001 | 197 | 0.854011 |
Cauchi et al. | 2006 | Austrian | Caucasian | 200 | 208 | 78 | 555 | 432 | 88 | 0.759981 |
Dahlgren et al. | 2007 | Swedish | Caucasian | 67 | 83 | 18 | 496 | 327 | 62 | 0.421344 |
Mayans et al. | 2007 | Swedish | Caucasian | 452 | 318 | 54 | 532 | 253 | 35 | 0.480907 |
Van et al. | 2007 | Dutch | Caucasian | 203 | 221 | 72 | 459 | 365 | 83 | 0.396927 |
Kimber et al. | 2007 | English | Caucasian | 1405 | 1459 | 361 | 1714 | 1329 | 248 | 0.662991 |
De Silva et al. | 2007 | English | Caucasian | 420 | 507 | 161 | 1032 | 887 | 180 | 0.58617 |
Vcelak et al. | 2012 | Czech | Caucasian | 148 | 156 | 43 | 205 | 147 | 24 | 0.730572 |
Hayashi et al. | 2007 | Japanese | East Asian | 1450 | 165 | 4 | 980 | 85 | 2 | 0.91209 |
Horikoshi et al. | 2007 | Japanese | East Asian | 165 | 22 | 2 | 251 | 21 | 0 | 0.507848 |
Kazuaki et al. | 2008 | Japanese | East Asian | 1921 | 228 | 5 | 1696 | 137 | 1 | 0.29539 |
Yasuharu et al. | 2009 | Japanese | East Asian | 434 | 45 | 2 | 372 | 26 | 0 | 0.50056 |
Zheng et al. | 2011 | Chinese | East Asian | 202 | 24 | 1 | 139 | 13 | 0 | 0.581813 |
Marquezine et al. | 2007 | Brazilian | Brazilian | 45 | 54 | 13 | 564 | 603 | 128 | 0.070107 |
Barra et al. | 2013 | Brazilian | Brazilian | 55 | 49 | 6 | 58 | 40 | 11 | 0.304112 |
Assmann et al. | 2014 | Brazilian | Brazilian | 382 | 415 | 156 | 261 | 215 | 59 | 0.147418 |
Bodhini et al. | 2007 | Asian Indian | South Asian | 462 | 455 | 114 | 555 | 391 | 92 | 0.531352 |
Chandak et al. | 2007 | Indian | South Asian | 391 | 423 | 141 | 205 | 160 | 34 | 0.726021 |
Rees et al. | 2008 | UK South Asian | South Asian | 352 | 360 | 116 | 222 | 166 | 44 | 0.12238 |
Gupta et al. | 2010 | Indian | South Asian | 55 | 96 | 44 | 62 | 78 | 21 | 0.64658 |
Hussain et al. | 2014 | Indian | South Asian | 25 | 36 | 7 | 43 | 35 | 4 | 0.349985 |
Heterogeneity test
Subgroup | Dominant | Recessive | Additive(CT vs CC) | Allele | Additive(TT vs CC) | |||||
---|---|---|---|---|---|---|---|---|---|---|
I2 | P | I2 | P | I2 | P | I2 | P | I2 | P | |
Caucasian | 28.00% | 0.18 | 0.00% | 0.51 | 9.00% | 0.36 | 38.00% | 0.1 | 20.00% | 0.26 |
East Asian | 0.00% | 0.9 | 0.00% | 0.85 | 0.00% | 0.96 | 0.00% | 0.82 | 0.00% | 0.84 |
South Asian | 0.00% | 0.9 | 0.00% | 0.47 | 0.00% | 0.97 | 0.00% | 0.7 | 0.00% | 0.44 |
Others | 0.00% | 0.62 | 0.00% | 0.19 | 0.00% | 0.81 | 17.00% | 0.29 | 29.00% | 0.19 |
Total | 5.00% | 0.39 | 9.00% | 0.33 | 0.00% | 0.76 | 29.00% | 0.08 | 22.00% | 0.15 |
Publication bias analysis and sensitivity analysis
Association between rs7903146 and type 2 diabetes mellitus
Subgroup | Dominant | Recessive | Additive(CT vs CC) | Allele | Additive(TT vs CC) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Z | P | Z | P | Z | P | Z | P | Z | P | |
Caucasian | 14.86 | <0.0001 | 12.35 | <0.0001 | 11.67 | <0.0001 | 16.98 | <0.0001 | 15.15 | <0.0001 |
South Asian | 4.69 | <0.0001 | 1.95 | 0.0509 | 4.42 | <0.0001 | 4.86 | <0.0001 | 2.01 | 0.0446 |
East Asian | 6.61 | <0.0001 | 4.47 | <0.0001 | 5.45 | <0.0001 | 7.12 | <0.0001 | 5.83 | <0.0001 |
Others | 4.17 | <0.0001 | 3.75 | 0.0002 | 3.11 | 0.0019 | 4.89 | <0.0001 | 4.65 | <0.0001 |
Total | 17.2 | <0.0001 | 13.53 | <0.0001 | 13.73 | <0.0001 | 19.38 | <0.0001 | 13.73 | <0.0001 |