Skip to main content

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Public Health 1/2015

Meta-analysis of studies on chemical, physical and biological agents in the control of Aedes aegypti

BMC Public Health > Ausgabe 1/2015
Estelita Pereira Lima, Marília Oliveira Fonseca Goulart, Modesto Leite Rolim Neto
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

EPL designed the study, collected field data, carried out the statistical analyses and drafted the manuscript. MLRN coordinated the study and helped in the preparation of the manuscript. MFOG helped in the preparation of the manuscript. All authors gave final approval for publication.

Author’s information

EPL is an assistant professor in the Faculty of Medicine at the Federal University of Cariri, Brazil. MOFG is an assistant professor in the Federal University of Alagoas, Brazil. MLRN is an assistant professor in the Faculty of Medicine at the Federal University of Cariri, Brazil.



Aedes aegypti is a vector of international concern because it can transmit to humans three important arboviral diseases: yellow fever, dengue and chikungunya. Epidemics that are repeated year after year in a variety of urban centers indicate that there are control failures, allowing the vector to continue expanding.


To identify the most effective vector control strategies and the factors that contributed to the success or failure of each strategy, we carried out a systematic review with meta-analysis of articles published in 12 databases, from 1974 to the month of December 2013. We evaluated the association between the use of whatever chemical substance, mechanical agent, biological or integrated actions against A. aegypti and the control of the vector, as measured by 10 indicators.


We found 2,791 articles, but after careful selection, only 26 studies remained for analysis related to control interventions implemented in 15 countries, with 5 biological, 5 chemical, 3 mechanical and 13 integrated strategies. The comparison among all of them, indicated that the control of A. aegypti is significantly associated with the type of strategy used, and that integrated interventions consist of the most effective method for controlling A. aegypti.


The most effective control method was the integrated approach, considering the influence of eco-bio-social determinants in the virus-vector-man epidemiological chain, and community involvement, starting with community empowerment as active agents of vector control.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2015

BMC Public Health 1/2015 Zur Ausgabe