10.07.2020 | Original Article | Ausgabe 2/2021
Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis
- Zeitschrift:
- Neurological Sciences > Ausgabe 2/2021
Wichtige Hinweise
Baiyuan Yang, Chenghui Yang and Junwei Ren contributed equally to this work.
Heading
1. This manuscript provides what we believe to be the first report of the association between CHCHD10 Pro34Ser variant and risk of amyotrophic lateral sclerosis.
2. This manuscript demonstrated that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants.
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Abstract
Background
Amyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS.
Methods
PubMed, Web of Science, and Embase databases were systematically searched for genome-wide association studies or case–control studies published up to March 28, 2020, on the association between Pro34Ser variant and risk of ALS. Data from eligible studies were extracted and analyzed.
Results
Twelve case–control studies involving 7442 patients with sporadic ALS and 75,371 controls were analyzed. The Pro34Ser variant was not associated with increased risk of ALS disease based on fixed-effects meta-analysis (Pro34Ser-positive vs Pro34Ser-negative: OR 1.23, 95% CI 0.90 to 1.69, P = 0.201).
Conclusion
Existing evidence suggests that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants. However, our results ought to be validated using large, well-designed studies, especially in Asian and African populations.