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Clinical & Experimental Metastasis
Erschienen in: Clinical & Experimental Metastasis 6-7/2017

23.10.2017 | Research Paper

Metabolic advantages and vulnerabilities in brain metastases

verfasst von: Alexandra K. Ciminera, Rahul Jandial, John Termini

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 6-7/2017

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Abstract

Metabolic adaptations permit tumor cells to metastasize to and thrive in the brain. Brain metastases continue to present clinical challenges due to rising incidence and resistance to current treatments. Therefore, elucidating altered metabolic pathways in brain metastases may provide new therapeutic targets for the treatment of aggressive disease. Due to the high demand for glucose in the brain, increased glycolytic activity is favored for energy production. Primary tumors that undergo Warburg-like metabolic reprogramming become suited to growth in the brain microenvironment. Indeed, elevated metabolism is a predictor of metastasis in many cancer subtypes. Specifically, metabolic alterations are seen in primary tumors that are associated with the formation of brain metastases, namely breast cancer, lung cancer, and melanoma. Because of this selective pressure, inhibitors of key metabolic factors may reduce tumor cell viability, thus exploiting metabolic pathways for cancer therapeutics. This review summarizes the metabolic advantages and vulnerabilities of brain metastases.
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Metadaten
Titel
Metabolic advantages and vulnerabilities in brain metastases
verfasst von
Alexandra K. Ciminera
Rahul Jandial
John Termini
Publikationsdatum
23.10.2017
Verlag
Springer Netherlands
Erschienen in
Clinical & Experimental Metastasis / Ausgabe 6-7/2017
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-017-9864-8

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