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The journal of nutrition, health & aging

Erschienen in:

26.06.2018

Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men

verfasst von: W. Liu, Y. Liu, Y. Yang, W. Ou, X. Chen, B. Huang, H. Wang, Meilin Liu

Erschienen in: The journal of nutrition, health & aging | Ausgabe 10/2018

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Abstract

Background

Aging is an acknowledged risk factor for most chronic diseases and functional impairments. The practicability of potential biomarkers of aging remains unsure. Moreover, biomarkers related to certain geriatric diseases, such as carotid atherosclerosis and multiple co-morbidities are less understood. The purpose of this study was to investigate the definite relationship between metabolic biomarkers and aging-related diseases.

Methods

Eighty-five male adults aged fifty years or older from the general population were enrolled. Plasma metabolic biomarkers, including fourteen amino acids and thirty-six acylcarnitines, were measured by liquid chromatography mass spectrometry. Bivariate correlation analysis was employed to estimate the correlations between variables and age, and also to evaluate the relationship between metabolic biomarkers and aging-related diseases. Receiver operating characteristic (ROC) curve was conducted to judge the diagnostic efficiency of potential metabolic biomarkers for co-morbidities.

Results

Certain metabolic biomarkers were strongly positively correlated with age, such as tetradecenoylcarnitine (C14:1), microalbumin-urine creatinine ratio (UACR), dodecenoylcarnitine (C12:1) and citrulline (p < 0.001). Carotid atherosclerosis and co-morbidities were positively correlated with aging (p < 0.001). After adjustment for age, hydroxytetradecanoylcarnitine (C14OH) remained positively correlated with carotid plague area. Besides, citrulline had diagnostic power for co-morbidities.

Conclusions

Citrulline may be a promising metabolic biomarker in the middle-aged and elderly men. Larger-scale and long-term studies are needed to confirm our findings.

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Titel: Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men
verfasst von: W. Liu
Y. Liu
Y. Yang
W. Ou
X. Chen
B. Huang
H. Wang
Meilin Liu
Publikationsdatum: 26.06.2018
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 10/2018
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-018-1062-0

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Metabolic Biomarkers of Aging and Aging-related Diseases in Chinese Middle-Aged and Elderly Men

Abstract

Background

Methods

Results

Conclusions

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