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Current Osteoporosis Reports

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28.02.2018 | Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis

verfasst von: Russell T. Turner, Stephen A. Martin, Urszula T. Iwaniec

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

Mesenchymal stem cells (MSCs) located in the bone marrow have the capacity to differentiate into multiple cell lineages, including osteoblast and adipocyte. Adipocyte density within marrow is inversely associated with bone mass during aging and in some pathological conditions, contributing to the prevailing view that marrow adipocytes play a largely negative role in bone metabolism. However, a negative association between marrow adipocytes and bone balance is not universal. Although MAT levels appear tightly regulated, establishing the precise physiological significance of MAT has proven elusive. Here, we review recent literature aimed at delineating the function of MAT.

Recent Findings

An important physiological function of MAT may be to provide an expandable/contractible fat depot, which is critical for minimization of energy requirements for sustaining optimal hematopoiesis. Because the energy requirements for storing fat are negligible compared to those required to maintain hematopoiesis, even small reductions in hematopoietic tissue volume to match a reduced requirement for hematopoiesis could represent an important reduction in energy cost. Such a physiological function would require tight coupling between hematopoietic stem cells and MSCs to regulate the balance between MAT and hematopoiesis. Kit-ligand, an important regulator of proliferation, differentiation, and survival of hematopoietic cells, may function as a prototypic factor coupling MAT and hematopoiesis.

Summary

Crosstalk between hematopoietic and mesenchymal cells in the bone marrow may contribute to establishing the balance between MAT levels and hematopoiesis.

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Titel: Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis
verfasst von: Russell T. Turner
Stephen A. Martin
Urszula T. Iwaniec
Publikationsdatum: 28.02.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 2/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0422-3

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Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis

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Recent Findings

Summary

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