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International Journal of Hematology

Erschienen in:

24.05.2017 | Progress in Hematology

Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions

verfasst von: Daiki Karigane, Keiyo Takubo

Erschienen in: International Journal of Hematology | Ausgabe 1/2017

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Abstract

Hematopoietic stem cells (HSCs) exhibit multilineage differentiation and self-renewal activities that maintain the entire hematopoietic system during an organism’s lifetime. These abilities are sustained by intrinsic transcriptional programs and extrinsic cues from the microenvironment or niche. Recent studies using metabolomics technologies reveal that metabolic regulation plays an essential role in HSC maintenance. Metabolic pathways provide energy and building blocks for other factors functioning at steady state and in stress. Here we review recent advances in our understanding of metabolic regulation in HSCs relevant to cell cycle quiescence, symmetric/asymmetric division, and proliferation following stress and lineage commitment, and discuss the therapeutic potential of targeting metabolic factors or pathways to treat hematological malignancies.

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Titel: Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions
verfasst von: Daiki Karigane
Keiyo Takubo
Publikationsdatum: 24.05.2017
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 1/2017
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-017-2261-x

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