The burden of non-communicable disease in the developing countries is increasing, and leading to high mortality rates [1]. Nowadays T2DM is pandemic and there are no signs of reduction in the incidence rates [2]. Forexamle, according to international diabetes federation report indicates that more than 415 million of people worldwide adults have diabetes. By 2040 this will rise to 642 million. In Africa, 441 million people live with diabetes which is likely to increase by 926 million in 2040 [3]. Diabetic population are at increased risk of mortality and morbidity primarily due to cardiovascular diseases [4]. The relative risks are 1 to 3 in men and from 2 to 5 in women [5]. Metabolic syndrome would have its own contribution in these outcomes of DM. Metabolic syndromeis highly prevalent in T2DM patients [6‐8]. However, several studies have reported lower prevalence of MetS [9, 10] and this is largely due to differences in characteristics of the studied population such as residence, type of disease and comorbidities, etc.

Metabolic syndrome can be defined as a cluster of interconnected cardio-metabolic dysfunctions which is characterized by the increase in fasting blood sugar (FBS), abdominal circumference (AC), arterial pressure (AP), triglycerides (TG), and reduction in high-density lipoprotein cholesterol (HDL) [11]. This syndrome has different set of criterias to measure it. Those are National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) [12], WHO criteria’s [13] and IDF [14]. The NCEP-ATP III definition uses the presence of 3 or more parameters as a cutoff to define MetS and the WHO as well as IDF definitions require the presence of at least two parameters.

The syndrome can directly contributes to the development of CVD and the appearance of T2DM in non-diabetic patients. Additionally, it increases the risk of premature death, renal disease, mental disorders and cancer. Thus MetS represents a serious public health problem [15‐17].

Metabolic syndrome is not also with out cost implications. For instance, Boudreau et al. found that costs for subjects with diabetes plus weight risk, dyslipidemia, and hypertension were almost double the costs for subjects with prediabetes plus similar risk factors ($8067 vs. $4638) [18].

Globally, 20–25% of the adult population has MetS and they are twice as likely to die from it; and they are three times more likely to have a heart attack or stroke compared with people without the syndrome [14, 19]. However, the prevalence of MetS in type 2 diabetes in sub-Saharan Africans according to two sets of diagnostic criteria was 71.7% according to the IDF criteria and 60.4% using NCEP-ATP III criteria [20]. In Ethiopia the prevalence of MetS was range from (26–70%) using NCEP-ATP III criteria [21‐23].

Nowadays, MetS has become a significant public health problem. Therefore, there is a need for investigation in this area [24]. Taking into consideration, diabetic patients who had MetS also they have cardiovascular risk factors, therefore the diagnosis of MetS in those patients is very important for detection, prevention, and treatment of the underlying risk factors and for the reduction of the cardiovascular disease burden in the general population [25, 26].

While limited studies of MetS among diabetic patients in Ethiopia acknowledge its burden, they followed a single criteria(NCEP-ATP III) to define MetS and using a signle criteria may either under or over estimate the problem. Thus denying or providing interventions to minimize the risks of MetS complications would be irrational since a given patient may be categorized as having MetS in one set of definition but not in the others. In this regard, the present study employed three commonly used criteria to define MetS so that it would be easy to acknowledge the importance of having a unified MetS criterion to make appropriate clinical decision in the context of Ethiopia.Therefore, this study was aimed at inevestigating the prevalence of MetS and its determinant factors among T2DM patients attending a comphrensivespecialized hospital.

This study was aimed at describing the prevalence and predictors of Metabolic syndrome among type 2 diabetic patients attending a comprehensive specialized hospital in Northwest Ethiopia. The main finding of the present study demonstrates that MetS is a major health concern for diabetic patients in Ethiopia and the predictors like female gender, age between 51 and 64 years old, urban area residence, and being single, are modifiable.

The prevalence of MetS in this study was 70.3, 57 & 45.3% using NCEP-ATP III, IDF& WHO criteria respectively. These different prevalence rates arise due to the different cutoff points and sets of criteria used by those three definitions. In previous studies among DM patients, a lower 45.9% and comparable 70.1% results were reported from Ethiopia using NCEP-ATP III criteria [22, 23]. However, a higher rate of prevalence, 73.9, 69.9 and 66.8%, was reported from Nepal using NCEP-ATP III, WHO and IDF criteria respectively [30] and 73.4 & 64.9% using NCEP-ATP III and IDF criteria respectively was reported from Iran [31]. On the other hand, a lower prevalence of MetS was reported from India 45.8, 57.7 and 28% using NCEP-ATP III, WHO and IDF criteria respectively [8] and 58% was from Ghana using NCEP-ATP III criteria [7]. The prevalence of MetS in the present study some what different from others and this could be due to differences in sample size, socio-economic status, ethnicity difference [32], sampling method and difference in life style of study participants.

The present study demonstrated that prevalence of MetS was found to be higher in female (83.3, 66.1 & 70.7%) study participants than men (17, 31.9 & 29.3%) using IDF, NCEP-ATPIII & WHO criteria’s respectively. This result is in agreement with other studies [7, 30, 31]. As shown in Table 2, a significantly higher proportion of females than males have abnormal components in four (66.7%) of the six components used to define MetS in the three criterias. This might explain the observed higher prevalence of MetS in the female geneder. Such discrepancy is attributed to the several physiological differences: Pregnancy induced increase in weight as well as gestational DM; the use of hormonal oral contraceptives that can decrease insulin sensitivity, glucose tolerance, increase blood pressure and increase in weight gain; menopause promotes a change in body fat distribution to increase central adiposity [33]. However, as the majority of females in the present study (81.8%) were above 46 years old, the increased prevalence of MetS among females unlike that of males may be due to menopause. The presence of hormonal replacement therapy (HRT) was, however, not assessed but might have some effect on the higher prevalence of MetS. Inaddition, less proportion of females were involved in regular physical exercise than males in this study which might have its own contribution to the observed higher MetS prevalence among female. Females in Ethiopia are socio-economically and culturally influenced to stay at home so that they are typically involved in daily living activities rather than regular physical exercise to maintain body fitness. The role of exercise in minimizing risks of developing MetS is reported in Greec study of 1128 men and 1154 women [34].

According to the NCEP- ATPIII criteria, where the highest prevalence of MetS was observed, TG and HDL were the most frequent abnormal MetS components. Abnormal levels of TG and HDL has been implicated with adverse health effects. Fore example, Callaghan et al. reported that hypertriglyceridemia is a significant risk factor for lower-extremity amputation in a 10-year cohort study (from 1995 to 2006) of 28,701 diabetic patients [35]. A 2 years of multi-ethnic study of atherosclerosis on a total of 6814 participants showed that low level of HDL in the body is associated with an increased risk of CVD, coronary heart diseases and death [36]. Thus, interventions focusing on abnormal TG and HDL need to be prioritized.

Regarding to residency, the association of MetS and urbanization could be as a result of a sedentary life style, increased intake of calorie rich foods and central obesity.This result is supported by other studies world wide [37, 38]. In addition, people who were self employed had significant association with MetS and the reason could be also sedentary life style related with the type of job they are involved .

On the other hand, patients who were secondary school and above had significantly associated with MetS.This might be due to significantly higher economic status (greater than 1500 ETB) of those who are highly educated in our study population (Secondary school and above:59 (77.6%); primary school:15 (19.7%). This finding is consistent with that of Chakraborty et al. and Khanam et al. [39, 40]. Therefore, higher levl of education may indirectly lead to risky life style adoption interms of dietary pattern and physical activity.

When compared to those patients aged 30 years and less, the ones in the age intervals 31–40, 41–50, and 51–64 were at inceased risk of MetS. The reasons for a direct relations of age and MetS is that age related processes such as gradual decrease in the basal metabolic rate, stress induced hypercortisolism, hypogonadism, decreased growth hormone secretion, concomitant insulin resistance and abdominal fat deposition [41, 42]. However, those patients who are 65 years old and above were found to have no significantly increased risk of MetS. This might be because of reduced survival of patients who developed MetS in this age group. In this regard, further prospective studies need to be carried out. The finding reiterates that of Devers et al. According to this study which was conducted among 1429 adults aged ≥25 years from randomly selected house holds in Australia, MetS components cluster most markedly in those aged < 65 years [43]. Therefore, serious preventive and control measures should be taken as age increases. Individuals should be advised to make life style changes. Doing reguar exercise, eating foods containing little amount of saturated fats and cholesterol as well as taking more fiber-rich foods should be encouraged. Chandalia et al. have shown that taking high fiber diets have the potential to lower fasting plasma glucose, total cholesterol, triglyceride, and helps to have good glycemic index through a decrease in gastrointestinal absorption of cholesterol and carbohydrates [44].

Regarding to duration of period since DM was diagnosed, those patients diagnosed within a year had significantly higher risk of developing MetS according to NCEP-ATPIII criteria. Since lifestyle modifications on diet and physical activity are the main initial interventions in T2DM patients, those respondents treated for short period of time may not effectively adopt the needed life style changes and hence are at increaed risk of MetS. It is also worth to note that some of the patients in our study might be in the very ealy stages of treatment so that reduction of MetS components might be unlikely. Incontrast to our finding, a previous study in Ethiopia reported the absence of impact of duration of treatment on MetS development [22]. Since in this study patients were classified based on higher cut off treatment duration i.e. below or above 10 years, it might fail to signify the impact of duration on MetS. On the otherhand, patients who stayed on treatment for short duration were not specifically isolated and compared with others who stayed longer on therapy. In this study using WHO criteria it indicate that patients who were single had association with MetS,the possible reason may be small sample size of this segment of respondants (N = 18,7%).

In general, the findings of the present stydy taken together showed that MetS is a mjor burden among T2DM patients in Ethiopia. Early identification of MetS among T2DM patients is of great importance since MetS imply increased risk of morbidities such as CVD,decreased quality of life, increased health care cost, as well as mortality. Therefore, UGCSH has to strengthen appropriate and targeted prevention strategies such as encouraging people to adopt dietary modification and physical activity which are reported to reduce occurrence and progression of MetS [45]. Inaddition, there should be a more frequent screening of patients for MetS components prior to full blow development of MetS.

This study for the first time in Ethiopia, employed three defining criteria for MetS and was able to highlight the importance of having unified definition to diagnose and make clinical decisions in the context of low income settings. Data were also collected prospectively and this strengthens the conclusions made. Yet, there are limitations and one should consider these in interpreting the findings. The study may not be generalized to the nation as a whole due to small sample size and thus further studies would be important. It is also important to show the health related outcome and economic consequences of MetS among T2DM patients in Ethiopia.

In conclusion, this study demonstrates that MetS is a major health concern for diabetic patients in Ethiopia. They are at increased risk of developing complications such as cardiovascular diseases and premature mortality.The predictors, female gender, age between 51 and 64 years old, urban area residence, and being single, are modifiable. Thus, health authorities shall provide targeted interventions to this most at risk sub populations of diabetic patients such as promotion of life style modifications.