The online version of this article (doi:10.1186/1471-2261-14-176) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
CS made conception and study design, acquisition, analysis and interpretation of data and wrote and reviewed the manuscript. SK performed the statistical analysis and reviewed the manuscript. VK has reviewed the manuscript critically. RM participated in study design and coordination, and has been involved in revising critically the manuscript and has given final approval of the version to be published. All authors read and approved the final manuscript version.
The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease.
In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up.
Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p < 0.001). In cox regression analysis, only MS was independently associated with study endpoint (HR = 9.655 , 95% CI 3.000-31.0.68 , p < 0.001).
MS is associated with a higher recurrence rate of outflow tract PVCs after CA in patients without structural heart disease.
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- Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation
Maria Caterina Pace
Maria Beatrice Passavanti
Giovanni Francesco Nicoletti
- BioMed Central
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