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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Cardiovascular Disorders 1/2014

Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation

Zeitschrift:
BMC Cardiovascular Disorders > Ausgabe 1/2014
Autoren:
Celestino Sardu, Giovanni Carreras, Spyridon Katsanos, Vasileios Kamperidis, Maria Caterina Pace, Maria Beatrice Passavanti, Ilaria Fava, Pasquale Paolisso, Gorizio Pieretti, Giovanni Francesco Nicoletti, Gaetano Santulli, Giuseppe Paolisso, Raffaele Marfella
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Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2261-14-176) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

CS made conception and study design, acquisition, analysis and interpretation of data and wrote and reviewed the manuscript. SK performed the statistical analysis and reviewed the manuscript. VK has reviewed the manuscript critically. RM participated in study design and coordination, and has been involved in revising critically the manuscript and has given final approval of the version to be published. All authors read and approved the final manuscript version.

Abstract

Background

The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease.

Methods

In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up.

Results

Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p < 0.001). In cox regression analysis, only MS was independently associated with study endpoint (HR = 9.655 , 95% CI 3.000-31.0.68 , p < 0.001).

Conclusions

MS is associated with a higher recurrence rate of outflow tract PVCs after CA in patients without structural heart disease.
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