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Erschienen in: Metabolic Brain Disease 4/2020

09.03.2020 | Original Article

Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats

verfasst von: Yong He, Yue Wang, Zhonghao Wu, Tianlan Lan, Yu Tian, Xi Chen, Yan Li, Ruozhi Dang, Mengge Bai, Ke Cheng, Peng Xie

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2020

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Abstract

Major depressive disorder (MDD) is a serious mood disorder and leads to a high suicide rate as well as financial burden. The volume and function (the sensitivity and neurogenesis) of the olfactory bulb (OB) were reported to be altered among the MDD patients and rodent models of depression. In addition, the olfactory epithelium was newly reported to decrease its volume and function under chronic unpredictable mild stress (CUMS) treatment. However, the underlying molecular mechanism still remains unclear. Herein, we conducted the non-targeted metabolomics method based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate statistical analysis to characterize the differential metabolites in OB of CUMS rats. Our results showed that 19 metabolites were categorized into two perturbed pathways: purine metabolism and lipid metabolism, which were regarded as the vital pathways concerned with dysfunction of OB. These findings indicated that the turbulence of metabolic pathways may be partly responsible for the dysfunction of OB in MDD.
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Metadaten
Titel
Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats
verfasst von
Yong He
Yue Wang
Zhonghao Wu
Tianlan Lan
Yu Tian
Xi Chen
Yan Li
Ruozhi Dang
Mengge Bai
Ke Cheng
Peng Xie
Publikationsdatum
09.03.2020
Verlag
Springer US
Erschienen in
Metabolic Brain Disease / Ausgabe 4/2020
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-020-00557-8

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