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Journal of Diabetes & Metabolic Disorders
Erschienen in:

26.11.2021 | Review article

Metabolomics prospect of obesity and metabolic syndrome; a systematic review

verfasst von: Moloud Payab, Akram Tayanloo-Beik, Khadijeh Falahzadeh, Maryamossadat Mousavi, Saeede Salehi, Shirin Djalalinia, Mahbube Ebrahimpur, Nafiseh Rezaei, Mostafa Rezaei-Tavirani, Bagher Larijani, Babak Arjmand, Kambiz Gilany

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2022

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Abstract

Purpose

Due to growing concerns about the obesity pandemic as a worldwide phenomenon, a global effort has been made for managing it and associated disorders. Accordingly, metabolomics as a promising field of “OMICS” is presented for investigating different molecular pathways in obesity and related disorders through the evaluation of specific metabolites in both animal and human subjects. Herein, the aim of the present study as the first systematic review is to evaluate all available studies about different mechanisms and their biomarkers discovery using metabolomics approaches.

Method

The study was designed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a comprehensive search strategy we searched in databases including; Web of Science, PubMed, and Scopus using specific keywords. Based on predefined inclusion/exclusion criteria study selection has been conducted considering the type of studies, participant, and outcome measures. Quality assessment was done using CASP (Critical Appraisal Skills Programme) checklist followed by data extraction according to a predefined data extraction sheet.

Results

Among the articles that resulted from electronic search, a total of 74 articles met our inclusion criteria. The most prevalent studied metabolites were amino acids and lipid derivatives and both targeted and non-targeted approaches were applied for metabolomics studies.

Conclusion

This systematic review summarized a wide range of studies regardless of the age, history, language, and type of the study. Further studies are needed to compare the application of emerging methods in the treatment of obesity and related disorders.

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Metadaten
Titel
Metabolomics prospect of obesity and metabolic syndrome; a systematic review
verfasst von
Moloud Payab
Akram Tayanloo-Beik
Khadijeh Falahzadeh
Maryamossadat Mousavi
Saeede Salehi
Shirin Djalalinia
Mahbube Ebrahimpur
Nafiseh Rezaei
Mostafa Rezaei-Tavirani
Bagher Larijani
Babak Arjmand
Kambiz Gilany
Publikationsdatum
26.11.2021
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2022
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-021-00917-w

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