The online version of this article (doi:10.1186/1757-2215-7-33) contains supplementary material, which is available to authorized users.
An erratum to this article can be found online at http://dx.doi.org/10.1186/s13048-016-0286-z .
The co-Editors-in-Chief and Publisher have retracted this article because the scientific integrity of the content cannot be guaranteed. An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship. This article showed evidence of plagiarism and peer review and authorship manipulation.
The authors declare that they have no competing interests.
FKH and MJGH participated in the histopathological evaluation, performed the literature review, acquired photomicrographs and drafted the manuscript and gave the final histopathological diagnosis. JJ, SSH, FKH, SHH, SRT, JYYM, ARG, FSA and AA designed and carried out all the experiments and the principal investigators of the laboratory in which the research were performed and contributed to the interpretation of the data and writing of the manuscript. All authors read and approved the final manuscript.
Ovarian cystadenocarcinoma is characterized by marked heterogeneity and may be composed of an admixture of histologic growth patterns, including acinar, papillary and solid. In the present study, a case of isolated small intestine metastasis of ovarian papillary cystadenocarcinoma was reported. A 7-year-old female mixed-breed dog presented with a mass in the left upper quadrant with progressive enlargement of the abdomen, periodic bloody discharge from the vulva and incontinence. The tumor was histologically characterized by the presence of cysts and proliferation of papillae, both lined by single- or multi-layered pleomorphic epithelial cells. Furthermore, the mass was composed by intense cellular and nuclear pleomorphism and numerous mitotic figures. These findings indicate a tumor of high-grade malignancy with infiterative tumor cells resembling the papillary ovarian tumor in the serosal surface of the small intestine along with an intact serosa. Immunohistochemically, tumor was positive for CK7 and negative immunoreactivity for CK20. The histopathologic features coupled with the CK7 immunoreactivity led to a diagnosis of high grade ovarian papillary cystadenocarcinoma. To the best of our knowledge, this is the first case of small intestine serousal surface metastasis from ovarian papillary cystadenocarcinoma.
Schlaffer DH, Miller RB: Female genital system. In Jubb, Kennedy and Palmer’s pathology of domestic animals. Volume 3. 5th edition. Edited by: Maxie MG. San Diego, CA: Academic Press; 2007:431–563.
Nelson LW, Todd GC, Migaki G: Ovarian neoplasms in swine. J Am Vet Med Assoc 1967, 151: 1331–1333. PubMed
Sundberg JP, Williams ES, Hill D: Detection of papillomaviruses in cutaneous fibromas of white-tailed and mule deer. Am J Vet Res 1985, 46: 1145–1149. PubMed
Patnaik AK, Greenlee PG: Canine ovarian neoplasms: a clinicopathologic study of 71 cases, including history of 12 granulosa cell tumors. Vet Pathol 1987, 24: 509–514. PubMed
Held JP, Burgelt C, Colahan P: Serous cystadenoma in a mare. J Am Vet Med Assoc 1982, 181: 496–498. PubMed
Yoon B-I, Kweon O-K, Kwon S-W: Concurrent multicentric hemangiosarcoma and ovarian teratoma in an aged Père Davids’s deer (Elaphurus davidianus). J Zoo Wildl Med 1999, 30: 456–458. PubMed
Bossart GD, Hubbel G: Ovarian papillary cystadenocarcinoma in a jaguar (Pathera onca). J Zoo Anim Med 1983, 14: 73–76. 10.2307/20094643 CrossRef
MacLachlan NJ, Kennedy PC: Tumors of the genital systems. In Tumors in domestic animals. 4th edition. Edited by: Meuten DJ. Ames, IA: Iowa State Press; 2002:547–573.
Auersperg N, Wong AS, Choi KC: Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 2001, 22: 255–288. PubMed
Kennedy PC, Cullen JM, Edwards JF: Histological classification of tumors of the genital system of domestic animals. In World Health Organization international histological classification of tumors of domestic animals. Volume IV. Washington, DC: Armed Force Institute of Pathology; 1998.
Seifert G, Sobin LH: Histological classification salivary gland tumors. 2nd edition. Berlin: Springer-Verlag; 1991:1–38. CrossRef
Ellis GL, Auclair PL: Malignant epithelial tumours. Tumors of the salivary glands: atlas of tumor pathology. 3rd edition. Washington, DC: Armed Forces Institute of Pathology; 1996:155–373.
Mittal K, Soslow R, McCluggage WG: Application of immunohistochemistry to gynecologic pathology. Arch Pathol Lab Med 2008, 132: 402–423. PubMed
Czernobilsky B, Moll R, Levy R, Franke WW: Co-expression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of the human ovary. Eur J Cell Biol 1985, 37: 175–190. PubMed
Dragan E, Aljoa M, Marina P, Katarina K, Milana P: Metastatic spread of mucinous cystadenocarcinoma of the ovaries into abdominal wall. Arch Oncol 2005, 13(2):86–88. 10.2298/AOO0502086Z CrossRef
Haughney RV, Slade RJ, Brain AN: An isolated abdominal wall metastasis of ovarian carcinoma ten years after primary surgery. Eur J Gynaecol Oncol 2001, 22(2):102–103. PubMed
Baron MA, Ladonne JM, Resch B: Abdominal wall metastasis from ovarian cancer after laparo-tomy. A case report. Eur J Gynaecol Oncol 2002, 23(6):561–562. PubMed
Kennedy PC, Miller RB: The Female Genital System. In Jubb, Kennedy, Palmer, editors. Pathology of Domestic Animals. New-York: Academic Press; 1993:349–470.
Seidman JD, Russell P, Kurman RJ: Surface epithelial tumors of the ovary. In Blaustein’s Pathology of Ovarian Cancer. 5th edition. Edited by: Kurman RJ. New York: Springer Publishers; 2002.
Berezowski K, Stastny JF, Kornstein MJ: Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma. Mod Pathol 1996, 9: 426–429. [PubMed] PubMed
Khaki F, Javanbakht J, Sasani F, Gharagozlou MJ, Bahrami A, Moslemzadeh H, Sheikhzadeh R: Cervical type AB thymoma (Mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study. Diagn Pathol 2013, 8(1):98. 10.1186/1746-1596-8-98 CrossRefPubMedPubMedCentral
Tavasoly A, Javanbakht J, Khaki F, Hosseini E, Bahrami A, Hassan MA, Mirabad M: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study. Diagn Pathol 2013, 8(1):86. 10.1186/1746-1596-8-86 CrossRefPubMedPubMedCentral
Shafiee R, Javanbakht J, Atyabi N, Kheradmand P, Kheradmand D, Bahrami A, Daraei H, Khadivar F: Diagnosis, classification and grading of canine mammary tumours as a model to study human breast cancer: an Clinico-Cytohistopathological study with environmental factors influencing public health and medicine. Cancer Cell Int 2013, 13(1):79. 10.1186/1475-2867-13-79 CrossRefPubMedPubMedCentral
Shafiee R, Javanbakht J, Atyabi N, Bahrami A, Kheradmand D, Safaei R, Khadivar F, Hosseini E: Comparative value of clinical, cytological, and histopathological features in feline mammary gland tumors; an experimental model for the study of human breast cancer. Diagn Pathol 2013, 8: 136. 10.1186/1746-1596-8-136 CrossRefPubMedPubMedCentral
- RETRACTED ARTICLE: Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy
Mohammad Javad Gharagozlou
Javad Yaghoobi Yeganeh Manesh
Seyed Hojjat Hosseini
Seyed Rashid Touni
Fatemeh Soghra Abdi
- BioMed Central
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