Skip to main content
Erschienen in: International Journal of Clinical Pharmacy 1/2011

01.02.2011 | Case Report

Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia

verfasst von: T. Bauters, V. Mondelaers, H. Robays, H. De Wilde, Y. Benoit, B. De Moerloose

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 1/2011

Einloggen, um Zugang zu erhalten

Abstract

Case We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy. Conclusion Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.
Literatur
1.
Zurück zum Zitat Ueng S. Rasburicase (Elitek): a novel agent for tumor lysis syndrome. Proc (Bayl Univ Med Cent). 2005;18(3):275–9. Ueng S. Rasburicase (Elitek): a novel agent for tumor lysis syndrome. Proc (Bayl Univ Med Cent). 2005;18(3):275–9.
2.
Zurück zum Zitat Pui CH, Mahmoud HH, Wiley JM, Woods GM, Leverger G, Camitta B, et al. Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma. J Clin Oncol. 2001;19(3):697–704.PubMed Pui CH, Mahmoud HH, Wiley JM, Woods GM, Leverger G, Camitta B, et al. Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma. J Clin Oncol. 2001;19(3):697–704.PubMed
3.
Zurück zum Zitat Cairo MS. Prevention and treatment of hyperuricemia in hematological malignancies. Clin Lymphoma. 2002; Suppl 1:S26–31. Cairo MS. Prevention and treatment of hyperuricemia in hematological malignancies. Clin Lymphoma. 2002; Suppl 1:S26–31.
4.
Zurück zum Zitat de Bont JM, Pieters R. Management of hyperuricemia with rasburicase review. Nucleosides Nucleotides Nucleic Acids. 2004;23(8–9):1431–40.PubMedCrossRef de Bont JM, Pieters R. Management of hyperuricemia with rasburicase review. Nucleosides Nucleotides Nucleic Acids. 2004;23(8–9):1431–40.PubMedCrossRef
5.
Zurück zum Zitat Browning LA, Kruse J. Hemolysis and methemoglobinemia secondary to rasburicase administration. Ann Pharmacother. 2005;39(11):1932–5.PubMedCrossRef Browning LA, Kruse J. Hemolysis and methemoglobinemia secondary to rasburicase administration. Ann Pharmacother. 2005;39(11):1932–5.PubMedCrossRef
6.
Zurück zum Zitat Maher JF, Rath CE, Schreiner GE. Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis. Arch Intern Med. 1969;123(2):198–200.PubMedCrossRef Maher JF, Rath CE, Schreiner GE. Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis. Arch Intern Med. 1969;123(2):198–200.PubMedCrossRef
8.
Zurück zum Zitat Goldman SC, Holcenberg JS, Finklestein JZ, Hutchinson R, Kreissman S, Johnson FL, et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97(10):2998–3003.PubMedCrossRef Goldman SC, Holcenberg JS, Finklestein JZ, Hutchinson R, Kreissman S, Johnson FL, et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97(10):2998–3003.PubMedCrossRef
9.
Zurück zum Zitat Kizer N, Martinez E, Powell M. Report of two cases of rasburicase-induced methemoglobinemia. Leuk Lymphoma. 2006;47(12):2648–50.PubMedCrossRef Kizer N, Martinez E, Powell M. Report of two cases of rasburicase-induced methemoglobinemia. Leuk Lymphoma. 2006;47(12):2648–50.PubMedCrossRef
11.
Zurück zum Zitat Borinstein SC, Xu M, Hawkins DS. Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. Pediatr Blood Cancer. 2008;50(1):189.PubMedCrossRef Borinstein SC, Xu M, Hawkins DS. Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia. Pediatr Blood Cancer. 2008;50(1):189.PubMedCrossRef
12.
Zurück zum Zitat Bhat P, Sisler I, Collier AB 3rd. Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient. Pediatr Blood Cancer. 2008;51(4):568.PubMedCrossRef Bhat P, Sisler I, Collier AB 3rd. Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient. Pediatr Blood Cancer. 2008;51(4):568.PubMedCrossRef
13.
Zurück zum Zitat Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356(9237):1255–9.PubMedCrossRef Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356(9237):1255–9.PubMedCrossRef
Metadaten
Titel
Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia
verfasst von
T. Bauters
V. Mondelaers
H. Robays
H. De Wilde
Y. Benoit
B. De Moerloose
Publikationsdatum
01.02.2011
Verlag
Springer Netherlands
Erschienen in
International Journal of Clinical Pharmacy / Ausgabe 1/2011
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-011-9484-3

Weitere Artikel der Ausgabe 1/2011

International Journal of Clinical Pharmacy 1/2011 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.