The purpose of this study was to report the first case of acute bacterial keratitis produced by methicillin-resistant Staphylococcus aureus after the implantation of two intracorneal ring segments during an uneventful procedure for treating keratoconus in a 13-year-old child.
Case Report
A patient with grade III keratoconus underwent an implantation of intracorneal ring segments with no complications during the procedure. Three days later, a whitish corneal infiltrate appeared in between the union of both corneal rings. Sample cultures were positive for methicillin-resistant S. aureus (MRSA). Corneal infiltrate did not improve despite intensive topical and systemic antibiotics. Melting appeared even after the explantation of both corneal rings. Keratoplasty à chaud had to be performed to preserve the eye integrity.
Conclusions
MRSA keratitis following intracorneal ring segment implantation is a rare but severe complication that can lead to a therapeutic penetrating keratoplasty to definitely cure the process.
In the past century, penetrating keratoplasty (PK) was the one and only procedure to treat patients with keratoconus. Fortunately, nowadays the treatment of keratoconus has multiple options. Different techniques have improved in the last decade, thereby reducing the need for a corneal graft. In early stages of keratoconus, we may use gas-permeable contact lens, corneal cross-linking, or even intracorneal segment rings (ICSR). The use of ICSR has been increasing since Colin [1] first reported its efficacy.
ICSR were first approved to correct low myopia. Years later the refractive procedure switched to an orthopedic one. The use of ICSR for keratoconus, pellucid marginal degeneration, or post-LASIK ectasia is widely accepted. Reversibility, adjustability, and the fact that the center of the cornea is left untouched are the main advantages of this procedure [2].
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Although rare, complications like extrusion of the ring, neovascularization, corneal haze, corneal melting, and infectious keratitis have been described after ICSR implantation [3]. We report the first case of methicillin-resistant Staphylococcus aureus (MRSA) acute keratitis after ICSR implantation aided by femtosecond laser in a child.
Case Report
A 13-year-old boy presented with bilateral and asymmetrical keratoconus relating to a 3-year history of blurred vision. The best-spectacle corrected visual acuity (BSCVA) of the right eye (RE) was 20/25 (+0.25–1.50 × 95°), the maximum keratometry (Kmax) was 43.8 diopter (D), and the thinnest pachymetry was 573 μm. The BSCVA of the left eye (LE) was 20/400 (−3.0 to 3.0 × 160°), Kmax was 59.8 D, and the thinnest pachymetry was 504 μm. The patient did not tolerate the test with gas-permeable contact lens.
The implantation of intracorneal ring segments (ICRS) was performed, after informed consent was obtained from the patient and his parents, on the LE in order to regularize the shape of the cornea and decreasing corneal aberrations. Femtosecond laser (Visumax® Zeiss) was used to create the intrastromal channel. Two Ferrara rings of 160° (AJL Ophthalmic S.A., Spain) were implanted at 400-μm corneal depth by using an incision at 65°.
One day after the implantation, the BSCVA was 20/200 and the Kmax was 52.5 D. No other findings on the slit-lamp examination were reported (Fig. 1).
Fig. 1
Day 1 slit-lamp examination after the implantation of ICRS
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Seventy-two hours after the procedure, the patient presented with hyperemia and ocular pain. A whitish infiltrate appeared in the inferior union of both rings. Anterior chamber reaction was mild but no hypopyon was present at that time. Corneal curettage samples were collected for stain and culture. Topical treatment with hourly fortified antibiotics was started (vancomycin 50 mg/mL and ceftazidime 50 mg/mL). On day 4, the infiltrate grew and a 5-mm hypopyon appeared. The patient was hospitalized to explant the ICRS and irrigate the ring channels with vancomycin and moxifloxacin. Intravenous vancomycin 350 mg every 8 h was started.
Cultures came back positive for methicillin-resistant S. aureus.
One day after the explantation, the hypopyon level was higher and an intense corneal melting was present (Fig. 2). An 8.5-mm keratoplasty à chaud had to be performed to save the integrity of the globe. Ten days after the surgery the corneal graft was clear with no signs of infection. Tobramycin (3 mg/mL) and dexamethasone (1 mg/mL) eye drops (Tobradex; Alcon Cusí S.A., Barcelona, Spain) five times daily were started. The patient was allowed to return to his country of origin but presented 4 months later with a marked corneal edema and all the stitches were loose (Fig. 3a). One month later a new penetrating keratoplasty was performed and the patient now has a transparent graft (Fig. 3b).
Fig. 2
Evolution of the case. a Day 3 after ICSR implantation. A whitish corneal infiltrate appeared in the inferior union of both rings. b Day 4 after ICSR implantation. A 5-mm hypopyon is present. c Explanted ISCR. d Day 1 after the explantation. Corneal melting and 6-mm hypopyon
Fig. 3
a Four months after therapeutic penetrating keratoplasty. Corneal edema and loose stitches. b Second penetrating keratoplasty
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Discussion
Infectious keratitis is a rare complication after the implantation of ICRS. Despite its low frequency it can be a serious and sight-threatening event when it occurs. Coskunseven et al. [4] reported the largest series of complications after the implantation of ICRS aided with femtosecond laser. Only one patient of those 850 presented with an infectious keratitis (0.1%). Other authors like Shabayek and Alió [5] reported an incidence of 4.8%. Most of the reported cases are adults. Cases in children are extremely rare. Mulet et al. [2] indicates that ring implantation using a femtosecond laser is safer than using a manual technique. Other publications suggest that there is no significant difference between both techniques [6].
Multiple microorganisms have been reported in the context of this complication. Both bacteria and fungi can produce an infectious keratitis. However, S. aureus is the most common microorganism reported [6]. Different risk factors have been reported such as contact lens misuse, diabetes, loose sutures, trauma, and atopic blepharoconjunctivitis. In this case, the patient was constantly rubbing his eye, which is another well-described risk factor. The use of a Ferrara ring seems to increase the incidence of infectious keratitis as a result of its triangular shape and higher risk of extrusion [6]. It is important to try to prevent those risk factors, treating any kind of pathology before implanting the ring and also educating the patient by explaining the risk behaviors.
Topical antibiotic therapy is the most extensive way of treating infectious keratitis after ICRS implantation. Bourcier et al. [7] reported that the use of topical antibiotics alone was enough to treat the infection. On the other hand, ring removal is considered in some publications as the first therapeutic option to treat this complication. Hofling-Lima et al. [8] reported, as in this case, the need to perform penetrating keratoplasty à chaud to control the infection in two patients out of eight.
Therapeutic keratoplasty (TKP) is indicated in cases with progressive ulceration despite maximum antibacterial medication, extensive corneal involvement, descemetocele, or high risk of perforation. TKP has an incidence of 3–6% in bacterial corneal ulceration [9]. This procedure has a definitive role in the management of progressive microbial keratitis refractory to medical therapy and offers a cure rate up to 100% in bacterial and fungal keratitis [10]. Methicillin-resistant S. aureus is a rare microorganism that can cause an infectious keratitis after ICRS implantation for keratoconus, an acute and serious complication that can lead to therapeutic keratoplasty to save the eye integrity.
In conclusion, we recommend a strict follow-up of patients with risk factors and ICRS implantation for keratoconus to try to prevent such a severe keratitis. Educating the patients about avoidable risk factors and alarm symptoms may help to prevent and detect this severe complication early.
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Acknowledgements
No funding or sponsorship was received for this study or publication of this article. The article processing charges were funded by the authors. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.
Disclosures
Gonzalo García de Oteyza, Andrea Laiseca, Paola Sauvageot, and Juan Álvarez de Toledo have nothing to disclose.
Compliance with Ethics Guideslines
Informed consent was obtained from the patient and his parents.
Data Availability
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
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Open Access
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
