Skip to main content
Erschienen in: MMW - Fortschritte der Medizin 1/2018

15.01.2018 | Methotrexat | FORTBILDUNG . ÜBERSICHT

Immer besser im Griff

Die Rheumatoide Arthritis

verfasst von: Prof. Dr. med. habil. Gernot Keyßer, Dr. med. Christoph Schäfer

Erschienen in: MMW - Fortschritte der Medizin | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Bei der Rheumatoiden Arthritis handelt es sich um eine chronische Gelenkentzündung mit destruierendem Charakter. Sie kann bereits im Jugendalter beginnen, aber auch im Senium sind Neuerkrankungen möglich. Es handelt sich um eine Autoimmunerkrankung, die nicht nur Gelenke, sondern auch innere Organe betreffen kann. Eine frühe Diagnose und eine rechtzeitige Therapie können die Prognose deutlich verbessern.
Literatur
1.
Zurück zum Zitat Westhoff G, Schneider M, Raspe H et al. Advance and unmet need of health care for patients with rheumatoid arthritis in the German population—results from the German Rheumatoid Arthritis Population Survey (GRAPS). Rheumatology. 2009;48:650–7; https://​doi.​org/​10.​1093/​rheumatology/​kep045 CrossRefPubMed Westhoff G, Schneider M, Raspe H et al. Advance and unmet need of health care for patients with rheumatoid arthritis in the German population—results from the German Rheumatoid Arthritis Population Survey (GRAPS). Rheumatology. 2009;48:650–7; https://​doi.​org/​10.​1093/​rheumatology/​kep045 CrossRefPubMed
2.
Zurück zum Zitat Guthrie KA, Dugowson CE, Voigt LF et al. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum. 2010;62:1842–8; https://​doi.​org/​10.​1002/​art.​27459 PubMedPubMedCentral Guthrie KA, Dugowson CE, Voigt LF et al. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum. 2010;62:1842–8; https://​doi.​org/​10.​1002/​art.​27459 PubMedPubMedCentral
3.
Zurück zum Zitat Kallberg H, Ding B, Padyukov L et al. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis. 2011;70:508–11; https://​doi/​10.​1136/​ard.​2009.​120899 CrossRefPubMed Kallberg H, Ding B, Padyukov L et al. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis. 2011;70:508–11; https://​doi/​10.​1136/​ard.​2009.​120899 CrossRefPubMed
4.
Zurück zum Zitat Svendsen AJ, Junker P, Houen G et al. Incidence of Chronic Persistent Rheumatoid Arthritis and the Impact of Smoking: A Historical Twin Cohort Study. Arthritis Care Res. 2017;69:616–24; https://​doi/​10.​1002/​acr.​22987 CrossRef Svendsen AJ, Junker P, Houen G et al. Incidence of Chronic Persistent Rheumatoid Arthritis and the Impact of Smoking: A Historical Twin Cohort Study. Arthritis Care Res. 2017;69:616–24; https://​doi/​10.​1002/​acr.​22987 CrossRef
5.
Zurück zum Zitat Sundstrom B, Johansson I, Rantapaa-Dahlqvist S. Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study. Rheumatology. 2015;54: 487–93; https://​doi/​10.​1093/​rheumatology/​keu330 CrossRefPubMed Sundstrom B, Johansson I, Rantapaa-Dahlqvist S. Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study. Rheumatology. 2015;54: 487–93; https://​doi/​10.​1093/​rheumatology/​keu330 CrossRefPubMed
6.
Zurück zum Zitat de Hair MJ, Landewe RB, van de Sande MG et al. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis. 2013;72:1654–8; https://​doi/​10.​1136/​annrheumdis-2012-202254 CrossRefPubMed de Hair MJ, Landewe RB, van de Sande MG et al. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis. 2013;72:1654–8; https://​doi/​10.​1136/​annrheumdis-2012-202254 CrossRefPubMed
7.
Zurück zum Zitat Stolt P, Yahya A, Bengtsson C et al. Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis. 2010;69:1072–6; https://​doi/​10.​1136/​ard.​2009.​114694 CrossRefPubMed Stolt P, Yahya A, Bengtsson C et al. Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis. 2010;69:1072–6; https://​doi/​10.​1136/​ard.​2009.​114694 CrossRefPubMed
8.
Zurück zum Zitat Di Giuseppe D, Wallin A, Bottai M et al. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Ann Rheum Dis. 2014;73:1949–53; https://​doi/​10.​1136/​annrheumdis-2013-203338 CrossRefPubMed Di Giuseppe D, Wallin A, Bottai M et al. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Ann Rheum Dis. 2014;73:1949–53; https://​doi/​10.​1136/​annrheumdis-2013-203338 CrossRefPubMed
9.
Zurück zum Zitat Jin Z, Xiang C, Cai Q et al. Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis. 2014;73:1962–7; https://​doi/​10.​1136/​annrheumdis-2013-203323 CrossRefPubMed Jin Z, Xiang C, Cai Q et al. Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis. 2014;73:1962–7; https://​doi/​10.​1136/​annrheumdis-2013-203323 CrossRefPubMed
10.
Zurück zum Zitat McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365:2205–19; https://​doi.​org/​10.​1056/​NEJMra1004965 CrossRefPubMed McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365:2205–19; https://​doi.​org/​10.​1056/​NEJMra1004965 CrossRefPubMed
11.
Zurück zum Zitat England BR, Thiele GM, Mikuls TR. Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol. 2017;29:57–64; https://​doi.​org/​10.​1097/​BOR.​0000000000000356​ CrossRefPubMed England BR, Thiele GM, Mikuls TR. Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol. 2017;29:57–64; https://​doi.​org/​10.​1097/​BOR.​0000000000000356​ CrossRefPubMed
12.
Zurück zum Zitat Mikuls TR, Payne JB, Yu F et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol 2014;66:1090–100; https://​doi.​org/​10.​1002/​art.​38348 CrossRefPubMedPubMedCentral Mikuls TR, Payne JB, Yu F et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol 2014;66:1090–100; https://​doi.​org/​10.​1002/​art.​38348 CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Maradit-Kremers H, Nicola PJ, Crowson CS et al. Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2005;52:722–32; https://​doi.​org/​10.​1002/​art.​20878 CrossRefPubMed Maradit-Kremers H, Nicola PJ, Crowson CS et al. Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2005;52:722–32; https://​doi.​org/​10.​1002/​art.​20878 CrossRefPubMed
14.
Zurück zum Zitat Ranganath VK, Elashoff DA, Khanna D et al. Age adjustment corrects for apparent differences in erythrocyte sedimentation rate and C-reactive protein values at the onset of seropositive rheumatoid arthritis in younger and older patients. J Rheumatol. 2005;32:1040–2 PubMed Ranganath VK, Elashoff DA, Khanna D et al. Age adjustment corrects for apparent differences in erythrocyte sedimentation rate and C-reactive protein values at the onset of seropositive rheumatoid arthritis in younger and older patients. J Rheumatol. 2005;32:1040–2 PubMed
15.
Zurück zum Zitat Nell VP, Machold KP, Stamm TA et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1731–6; https://​doi.​org/​10.​1136/​ard.​2005.​035691 CrossRefPubMedPubMedCentral Nell VP, Machold KP, Stamm TA et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1731–6; https://​doi.​org/​10.​1136/​ard.​2005.​035691 CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Schellekens GA, Visser H, de Jong BA et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000; 43:155–63; https://​doi.​org/​10.​1002/​1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3 CrossRefPubMed Schellekens GA, Visser H, de Jong BA et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000; 43:155–63; https://​doi.​org/​10.​1002/​1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3 CrossRefPubMed
17.
Zurück zum Zitat Rantapaa-Dahlqvist S, de Jong BA, Berglin E et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741–9; https://​doi.​org/​10.​1002/​art.​11223 CrossRefPubMed Rantapaa-Dahlqvist S, de Jong BA, Berglin E et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741–9; https://​doi.​org/​10.​1002/​art.​11223 CrossRefPubMed
18.
Zurück zum Zitat De Rycke L, Peene I, Hoffman IE et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis. 2004;63:1587–93; https://​doi.​org/​10.​1136/​ard.​2003.​017574 CrossRefPubMedPubMedCentral De Rycke L, Peene I, Hoffman IE et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis. 2004;63:1587–93; https://​doi.​org/​10.​1136/​ard.​2003.​017574 CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Kellner H, Schmidt W, Rau R. Imaging procedures in rheumatology. Differential diagnosis using various imaging procedures in rheumatoid arthritis (RA). Z Rheumatol. 2005;64:553–6; https://​doi.​org/​10.​1007/​s00393-005-0720-x CrossRefPubMed Kellner H, Schmidt W, Rau R. Imaging procedures in rheumatology. Differential diagnosis using various imaging procedures in rheumatoid arthritis (RA). Z Rheumatol. 2005;64:553–6; https://​doi.​org/​10.​1007/​s00393-005-0720-x CrossRefPubMed
20.
Zurück zum Zitat Aletaha D, Neogi T, Silman AJ et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–81; https://​doi.​org/​10.​1002/​art.​27584 CrossRefPubMed Aletaha D, Neogi T, Silman AJ et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–81; https://​doi.​org/​10.​1002/​art.​27584 CrossRefPubMed
21.
Zurück zum Zitat Smolen JS, Landewe R, Bijlsma J et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960–77; https://​doi.​org/​10.​1136/​annrheumdis-2016-210715 CrossRefPubMed Smolen JS, Landewe R, Bijlsma J et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960–77; https://​doi.​org/​10.​1136/​annrheumdis-2016-210715 CrossRefPubMed
22.
Zurück zum Zitat Combe B, Landewe R, Daien CI et al. 2016 update of the EULAR recommendations for the management of early arthritis. Ann Rheum Dis. 2017;76: 948–59,; https://​doi.​org/​10.​1136/​annrheumdis-2016-210602 CrossRefPubMed Combe B, Landewe R, Daien CI et al. 2016 update of the EULAR recommendations for the management of early arthritis. Ann Rheum Dis. 2017;76: 948–59,; https://​doi.​org/​10.​1136/​annrheumdis-2016-210602 CrossRefPubMed
23.
Zurück zum Zitat Kruger K, Wollenhaupt J, Albrecht K et al. [German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm]. Z Rheumatol. 2012;71:592-603; https://​doi.​org/​10.​1007/​s00393-012-1038-0 CrossRefPubMed Kruger K, Wollenhaupt J, Albrecht K et al. [German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm]. Z Rheumatol. 2012;71:592-603; https://​doi.​org/​10.​1007/​s00393-012-1038-0 CrossRefPubMed
24.
Zurück zum Zitat Braun J, Kay J. The safety of emerging biosimilar drugs for the treatment of rheumatoid arthritis. Expert Opin Drug Saf. 2017;16:289–302; https://​doi.​org/​10.​1080/​14740338.​2017.​1273899 CrossRefPubMed Braun J, Kay J. The safety of emerging biosimilar drugs for the treatment of rheumatoid arthritis. Expert Opin Drug Saf. 2017;16:289–302; https://​doi.​org/​10.​1080/​14740338.​2017.​1273899 CrossRefPubMed
25.
Zurück zum Zitat Taylor PC, Keystone EC, van der Heijde D et al. Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis. New Eng J Med. 2017; 376: 652–62; https://​doi.​org/​10.​1056/​NEJMoa1608345 CrossRefPubMed Taylor PC, Keystone EC, van der Heijde D et al. Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis. New Eng J Med. 2017; 376: 652–62; https://​doi.​org/​10.​1056/​NEJMoa1608345 CrossRefPubMed
26.
Zurück zum Zitat Singh JA, Hossain A, Mudano AS et al. Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2017;5: CD012657; https://​doi.​org/​10.​1002/​14651858.​CD012657 PubMed Singh JA, Hossain A, Mudano AS et al. Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2017;5: CD012657; https://​doi.​org/​10.​1002/​14651858.​CD012657 PubMed
Metadaten
Titel
Immer besser im Griff
Die Rheumatoide Arthritis
verfasst von
Prof. Dr. med. habil. Gernot Keyßer
Dr. med. Christoph Schäfer
Publikationsdatum
15.01.2018
Verlag
Springer Medizin
Erschienen in
MMW - Fortschritte der Medizin / Ausgabe 1/2018
Print ISSN: 1438-3276
Elektronische ISSN: 1613-3560
DOI
https://doi.org/10.1007/s15006-018-0001-7

Weitere Artikel der Ausgabe 1/2018

MMW - Fortschritte der Medizin 1/2018 Zur Ausgabe

FORTBILDUNG . KRITISCH GELESEN

PPI: Niereninsuffizienz auch ohne Vorstufe

AKTUELLE MEDIZIN . REPORT

Delir im Alter meist vermeidbar

AKTUELLE MEDIZIN . REPORT

Auch die Seele braucht den Hausarzt

AKTUELLE MEDIZIN . SPRECHSTUNDE NATURHEILKUNDE

Mehr Mut zu natürlichen Mitteln!

Facharzt-Training Allgemeinmedizin

Die ideale Vorbereitung zur anstehenden Prüfung mit den ersten 24 von 100 klinischen Fallbeispielen verschiedener Themenfelder

Mehr erfahren

Update Allgemeinmedizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.