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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.10.2003 | Laboratory Investigation

Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs

verfasst von: José Melena, Neville N. Osborne

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2003

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Abstract.

Background

Free radical production seems to be involved in the pathogenesis of a number of ocular diseases. Certain β-adrenoceptor antagonists display antioxidant properties, but these have not been ascribed to any of the presently used ophthalmic β-adrenoceptor antagonists. Therefore, we examined the influence of ophthalmic β-adrenoceptor antagonists and other antiglaucoma drugs on stimulated lipid peroxidation in rat brain homogenates.

Methods

Lipid peroxidation in rat brain homogenates was stimulated by iron/ascorbate or sodium nitroprusside. Lipid peroxidation was assessed by the formation of thiobarbituric acid reactive species (TBARS).

Results

Of the antiglaucoma drugs tested (brimonidine, carteolol, dorzolamide, latanoprost, levobetaxolol, levobunolol, metipranolol, pilocarpine, timolol, travoprost and unoprostone), only metipranolol and its active metabolite, desacetylmetipranolol, were found to significantly reduce iron/ascorbate-induced lipid peroxidation in rat brain homogenates with IC₅₀ values of 6.9 and 1.1 μM, respectively. Metipranolol and desacetylmetipranolol also concentration-dependently inhibited sodium nitroprusside-stimulated lipid peroxidation in rat brain homogenates, displaying IC₅₀ values of 25.1 and 2.6 μM, respectively.

Conclusion

These data indicate that metipranolol and desacetylmetipranolol exhibit remarkable antioxidant properties, with an effect not dissimilar from the reference antioxidant trolox.

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Titel: Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs
verfasst von: José Melena
Neville N. Osborne
Publikationsdatum: 01.10.2003
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2003
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-003-0726-5

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Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs

Abstract.

Background

Methods

Results

Conclusion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

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Update Augenheilkunde

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract.

Background

Methods

Results

Conclusion

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