Metoprolol has a similar therapeutic effect as amlodipine on BP lowering in hypertensive patients with obstructive sleep apnea

Zurück zum Zitat Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5(2):136–143CrossRefPubMedPubMedCentral Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5(2):136–143CrossRefPubMedPubMedCentral

Zurück zum Zitat Sova M, Sovova E, Hobzova M, Zapletalova J, Kamasova M, Kolek V (2015) The effect of continuous positive airway pressure therapy on the prevalence of masked hypertension in obstructive sleep apnea patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159(2):277–282CrossRefPubMed Sova M, Sovova E, Hobzova M, Zapletalova J, Kamasova M, Kolek V (2015) The effect of continuous positive airway pressure therapy on the prevalence of masked hypertension in obstructive sleep apnea patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159(2):277–282CrossRefPubMed

Zurück zum Zitat Marcus JA, Pothineni A, Marcus CZ, Bisognano JD (2014) The role of obesity and obstructive sleep apnea in the pathogenesis and treatment of resistant hypertension. Curr Hypertens Rep 16:411CrossRefPubMed Marcus JA, Pothineni A, Marcus CZ, Bisognano JD (2014) The role of obesity and obstructive sleep apnea in the pathogenesis and treatment of resistant hypertension. Curr Hypertens Rep 16:411CrossRefPubMed

Zurück zum Zitat Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Poulter NR, Sever PS, ASCOT-BPLA and MRC Trial Investigators (2010) Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 9(5):469–480CrossRefPubMed Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Poulter NR, Sever PS, ASCOT-BPLA and MRC Trial Investigators (2010) Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol 9(5):469–480CrossRefPubMed

Zurück zum Zitat Levi-Marpillat N, Macquin-Mavier I, Tropeano AI, Parati G, Maison P (2014) Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension. Hypertens Res 37(6):585–590CrossRefPubMed Levi-Marpillat N, Macquin-Mavier I, Tropeano AI, Parati G, Maison P (2014) Antihypertensive drug classes have different effects on short-term blood pressure variability in essential hypertension. Hypertens Res 37(6):585–590CrossRefPubMed

Zurück zum Zitat Webb AJ, Fischer U, Mehta Z, Rothwell PM (2010) Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 375(9718):906–915CrossRefPubMed Webb AJ, Fischer U, Mehta Z, Rothwell PM (2010) Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 375(9718):906–915CrossRefPubMed

Zurück zum Zitat Zhao J, Xu W, Yun F, Zhao H, Li W, Gong Y, Yuan Y, Yan S, Zhang S, Ding X, Wang D, Zhang C, Dong D, Xiu C, Yang N, Liu L, Xue J, Li Y (2014) Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. Basic Res Cardiol 109(5):427CrossRefPubMed Zhao J, Xu W, Yun F, Zhao H, Li W, Gong Y, Yuan Y, Yan S, Zhang S, Ding X, Wang D, Zhang C, Dong D, Xiu C, Yang N, Liu L, Xue J, Li Y (2014) Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. Basic Res Cardiol 109(5):427CrossRefPubMed

Zurück zum Zitat Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y (2016) Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model. Oncotarget 7(36):57545–57555CrossRefPubMedPubMedCentral Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y (2016) Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model. Oncotarget 7(36):57545–57555CrossRefPubMedPubMedCentral

Zurück zum Zitat Yu C, Liu Y, Sun L, Wang D, Wang Y, Zhao S, Dai H, Zhao J, Zhang S, Li M, Han Y, Lu S, Dong X, Liu G, Yu S, Li Y (2017) Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway. Oncotarget 8(23):37705–37716CrossRefPubMedPubMedCentral Yu C, Liu Y, Sun L, Wang D, Wang Y, Zhao S, Dai H, Zhao J, Zhang S, Li M, Han Y, Lu S, Dong X, Liu G, Yu S, Li Y (2017) Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway. Oncotarget 8(23):37705–37716CrossRefPubMedPubMedCentral

Zurück zum Zitat Li W, Yan S, Zhao J, Ding X, Zhang S, Wang D, Liu L, Peng W, Li H, Wang D, Liu Z, Li Y (2015) Metoprolol inhibits cardiac apoptosis and fibrosis in a canine model of chronic obstructive sleep apnea. Cell Physiol Biochem 36(3):1131–1141CrossRefPubMed Li W, Yan S, Zhao J, Ding X, Zhang S, Wang D, Liu L, Peng W, Li H, Wang D, Liu Z, Li Y (2015) Metoprolol inhibits cardiac apoptosis and fibrosis in a canine model of chronic obstructive sleep apnea. Cell Physiol Biochem 36(3):1131–1141CrossRefPubMed

Zurück zum Zitat Zakopoulos NA, Tsivgoulis G, Barlas G, Papamichael C, Spengos K, Manios E, Ikonomidis I, Kotsis V, Spiliopoulou I, Vemmos K, Mavrikakis M, Moulopoulos SD (2005) Time rate of blood pressure variation is associated with increased common carotid artery intima-media thickness. Hypertension 45:505–512CrossRefPubMed Zakopoulos NA, Tsivgoulis G, Barlas G, Papamichael C, Spengos K, Manios E, Ikonomidis I, Kotsis V, Spiliopoulou I, Vemmos K, Mavrikakis M, Moulopoulos SD (2005) Time rate of blood pressure variation is associated with increased common carotid artery intima-media thickness. Hypertension 45:505–512CrossRefPubMed

Zurück zum Zitat Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, de Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, de Buyzere M, de Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D, Mahrholdt H, Olsen MH, Ostergren J, Parati G, Perk J, Polonia J, Popescu BA, Reiner Z, Rydén L, Sirenko Y, Stanton A, Struijker-Boudier H, Tsioufis C, van de Borne P, Vlachopoulos C, Volpe M, Wood DA (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34:2159–2219CrossRefPubMed Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, de Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, de Buyzere M, de Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D, Mahrholdt H, Olsen MH, Ostergren J, Parati G, Perk J, Polonia J, Popescu BA, Reiner Z, Rydén L, Sirenko Y, Stanton A, Struijker-Boudier H, Tsioufis C, van de Borne P, Vlachopoulos C, Volpe M, Wood DA (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34:2159–2219CrossRefPubMed

Zurück zum Zitat Xiong H, Wu D, Tian X, Lin WH, Li C, Zhang H, Cai Y, Zhang YT. The relationship between the 24 h blood pressure variability and carotid intima-media thickness: a compared study. Comput Math Methods Med 2014;2014:303159, 1, 9 Xiong H, Wu D, Tian X, Lin WH, Li C, Zhang H, Cai Y, Zhang YT. The relationship between the 24 h blood pressure variability and carotid intima-media thickness: a compared study. Comput Math Methods Med 2014;2014:303159, 1, 9

Zurück zum Zitat Shi J, Piao J, Liu B, Pan Y, Gong Y, Deng X, Sun W, Lu S, Li Y (2017) Obstructive sleep apnea increases systolic and diastolic blood pressure variability in hypertensive patients. Blood Press Monit 22(4):208–212CrossRefPubMed Shi J, Piao J, Liu B, Pan Y, Gong Y, Deng X, Sun W, Lu S, Li Y (2017) Obstructive sleep apnea increases systolic and diastolic blood pressure variability in hypertensive patients. Blood Press Monit 22(4):208–212CrossRefPubMed

Zurück zum Zitat Muntner P, Shimbo D, Tonelli M, Reynolds K, Arnett DK, Oparil S (2011) The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994. Hypertension 57(2):160–166CrossRefPubMed Muntner P, Shimbo D, Tonelli M, Reynolds K, Arnett DK, Oparil S (2011) The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994. Hypertension 57(2):160–166CrossRefPubMed

Zurück zum Zitat Camargo S, Riedl M, Anteneodo C, Kurths J, Penzel T, Wessel N (2014) Sleep apnea-hypopnea quantification by cardiovascular data analysis. PLoS One 9:e107581CrossRefPubMedPubMedCentral Camargo S, Riedl M, Anteneodo C, Kurths J, Penzel T, Wessel N (2014) Sleep apnea-hypopnea quantification by cardiovascular data analysis. PLoS One 9:e107581CrossRefPubMedPubMedCentral

Zurück zum Zitat Abuzaid AS, Al Ashry HS, Elbadawi A, Ld H, Saad M, Elgendy IY et al (2017) Meta-analysis of cardiovascular outcomes with continuous positive airway pressure therapy in patients with obstructive sleep apnea. Am J Cardiol 120(4):693–699CrossRefPubMed Abuzaid AS, Al Ashry HS, Elbadawi A, Ld H, Saad M, Elgendy IY et al (2017) Meta-analysis of cardiovascular outcomes with continuous positive airway pressure therapy in patients with obstructive sleep apnea. Am J Cardiol 120(4):693–699CrossRefPubMed

Zurück zum Zitat Shiina K, Tomiyama H, Takata Y, Matsumoto C, Odaira M, Kato K, Yamaguchi T, Usui Y, Yamashina A (2016) Obstructive sleep apnea as possible causal factor for visit-to-visit blood pressure variability. Circ J 80(8):1787–1794CrossRefPubMed Shiina K, Tomiyama H, Takata Y, Matsumoto C, Odaira M, Kato K, Yamaguchi T, Usui Y, Yamashina A (2016) Obstructive sleep apnea as possible causal factor for visit-to-visit blood pressure variability. Circ J 80(8):1787–1794CrossRefPubMed

Zurück zum Zitat Pengo MF, Ratneswaran C, Berry M, Kent BD, Kohler M, Rossi GP, Steier J (2016) Effect of continuous positive airway pressure on blood pressure variability in patients with obstructive sleep apnea. J Clin Hypertens (Greenwich) 18(11):1180–1184CrossRef Pengo MF, Ratneswaran C, Berry M, Kent BD, Kohler M, Rossi GP, Steier J (2016) Effect of continuous positive airway pressure on blood pressure variability in patients with obstructive sleep apnea. J Clin Hypertens (Greenwich) 18(11):1180–1184CrossRef

Zurück zum Zitat Abe H, Takahashi M, Yaegashi H, Eda S, Tsunemoto H, Kamikozawa M, Koyama J, Yamazaki K, Ikeda U (2010) Efficacy of continuous positive airway pressure on arrhythmias in obstructive sleep apnea patients. Heart Vessel 25(1):63–69CrossRef Abe H, Takahashi M, Yaegashi H, Eda S, Tsunemoto H, Kamikozawa M, Koyama J, Yamazaki K, Ikeda U (2010) Efficacy of continuous positive airway pressure on arrhythmias in obstructive sleep apnea patients. Heart Vessel 25(1):63–69CrossRef

Zurück zum Zitat Schein AS, Kerkhoff AC, Coronel CC, Plentz RD, Sbruzzi G (2014) Continuous positive airway pressure reduces blood pressure in patients with obstructive sleep apnea; a systematic review and meta-analysis with 1000 patients. J Hypertens 32(9):1762–1773CrossRefPubMed Schein AS, Kerkhoff AC, Coronel CC, Plentz RD, Sbruzzi G (2014) Continuous positive airway pressure reduces blood pressure in patients with obstructive sleep apnea; a systematic review and meta-analysis with 1000 patients. J Hypertens 32(9):1762–1773CrossRefPubMed

Zurück zum Zitat Muxfeldt ES, Margallo V, Costa LM, Guimarães G, Cavalcante AH, Azevedo JC, de Souza F, Cardoso CR, Salles GF (2015) Effects of continuous positive airway pressure treatment on clinic and ambulatory blood pressures in patients with obstructive sleep apnea and resistant hypertension: a randomized controlled trial. Hypertension 65(4):736–742CrossRefPubMed Muxfeldt ES, Margallo V, Costa LM, Guimarães G, Cavalcante AH, Azevedo JC, de Souza F, Cardoso CR, Salles GF (2015) Effects of continuous positive airway pressure treatment on clinic and ambulatory blood pressures in patients with obstructive sleep apnea and resistant hypertension: a randomized controlled trial. Hypertension 65(4):736–742CrossRefPubMed

Zurück zum Zitat Weaver TE, Grunstein RR (2008) Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 5(2):173–178CrossRefPubMedPubMedCentral Weaver TE, Grunstein RR (2008) Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 5(2):173–178CrossRefPubMedPubMedCentral

Zurück zum Zitat Miller WP (1982) Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 73(3):317–321CrossRefPubMed Miller WP (1982) Cardiac arrhythmias and conduction disturbances in the sleep apnea syndrome. Prevalence and significance. Am J Med 73(3):317–321CrossRefPubMed

Zurück zum Zitat Guilleminault C, Connolly SJ, Winkle RA (1983) Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52(5):490–494CrossRefPubMed Guilleminault C, Connolly SJ, Winkle RA (1983) Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 52(5):490–494CrossRefPubMed

Zurück zum Zitat Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, Sahadevan J, Redline S, Sleep Heart Health Study (2006) Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 173(8):910–916CrossRefPubMedPubMedCentral Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, Sahadevan J, Redline S, Sleep Heart Health Study (2006) Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 173(8):910–916CrossRefPubMedPubMedCentral

Zurück zum Zitat Grau N, Bazan V, Kallouchi M, Rodriguez D, Estirado C, Corral MI, Valls MT, Ramos P, Sanjuas C, Felez M, Valles E, Benito B, Gea J, Bruguera-Cortada J, Martí-Almor J (2016) Long-term impact of continuous positive airway pressure therapy on arrhythmia and heart rate variability in patients with sleep apnea. Arch Bronconeumol 52(1):17–23CrossRefPubMed Grau N, Bazan V, Kallouchi M, Rodriguez D, Estirado C, Corral MI, Valls MT, Ramos P, Sanjuas C, Felez M, Valles E, Benito B, Gea J, Bruguera-Cortada J, Martí-Almor J (2016) Long-term impact of continuous positive airway pressure therapy on arrhythmia and heart rate variability in patients with sleep apnea. Arch Bronconeumol 52(1):17–23CrossRefPubMed

Zurück zum Zitat Wolf J, Drozdowski J, Czechowicz K, Winklewski PJ, Jassem E, Kara T, Somers VK, Narkiewicz K (2016) Effect of beta-blocker therapy on heart rate response in patients with hypertension and newly diagnosed untreated obstructive sleep apnea syndrome. Int J Cardiol 202:67–72CrossRefPubMed Wolf J, Drozdowski J, Czechowicz K, Winklewski PJ, Jassem E, Kara T, Somers VK, Narkiewicz K (2016) Effect of beta-blocker therapy on heart rate response in patients with hypertension and newly diagnosed untreated obstructive sleep apnea syndrome. Int J Cardiol 202:67–72CrossRefPubMed

Zurück zum Zitat Fogari R, Zoppi A, Tettamanti F, Poletti L, Rizzardi G, Fiocchi G (1990) Comparative effects of celiprolol, propranolol, oxprenolol, and atenolol on respiratory function in hypertensive patients with chronic obstructive lung disease. Cardiovasc Drugs Ther 4(4):1145–1149CrossRefPubMed Fogari R, Zoppi A, Tettamanti F, Poletti L, Rizzardi G, Fiocchi G (1990) Comparative effects of celiprolol, propranolol, oxprenolol, and atenolol on respiratory function in hypertensive patients with chronic obstructive lung disease. Cardiovasc Drugs Ther 4(4):1145–1149CrossRefPubMed

Zurück zum Zitat Tivenius L (1976) Effects of multiple doses of metoprolol and propranolol on ventilatory function in patients with chronic obstructive lung disease. Scand J Respir Dis 57(4):190–196PubMed Tivenius L (1976) Effects of multiple doses of metoprolol and propranolol on ventilatory function in patients with chronic obstructive lung disease. Scand J Respir Dis 57(4):190–196PubMed