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Erschienen in: Breast Cancer Research 1/2010

01.05.2010 | Poster presentation

Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency

verfasst von: E Lamers, FA McDyer, JM Mulligan, F Couch, KI Savage, NE O'Brien, PB Mullan, RD Kennedy, DP Harkin, JE Quinn

Erschienen in: Breast Cancer Research | Sonderheft 1/2010

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Excerpt

The BRCA1 tumour suppressor gene is mutated in a significant proportion of hereditary breast cancer cases. Downregulation of BRCA1 mRNA and protein expression has also been reported in approximately 30% of sporadic breast cancer cases. BRCA1 is strongly implicated in the maintenance of genomic stability by its involvement in multiple cellular pathways including DNA damage signalling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Both pathological and gene expression profiling studies provide evidence that breast cancers with germline mutations in BRCA1 are different from non-BRCA1-related breast cancers. …
Metadaten
Titel
Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency
verfasst von
E Lamers
FA McDyer
JM Mulligan
F Couch
KI Savage
NE O'Brien
PB Mullan
RD Kennedy
DP Harkin
JE Quinn
Publikationsdatum
01.05.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 1/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2541

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