Background
Results
Patients characteristics
CD-associated microbiota
Phylogenetic level | Abundance CD (%) | Abundance control (%) | Ratio | FDR corrected p-value |
---|---|---|---|---|
Order | ||||
Spirochaetales | 0.003 | 0.02 | 0.11 | 0.0002 |
Lactobacillales | 0.32 | 2.42 | 0.13 | 0.008 |
Fusobacteriales | 0.32 | 0.01 | 23.4 | 0.01 |
Erysipelotrichales | 0.04 | 0.23 | 0.19 | 0.01 |
Pseudomonadales | 0.33 | 0.01 | 22.5 | 0.01 |
Rhizobiales | 0.02 | 0.04 | 0.51 | 0.02 |
Actinomycetales | 0.01 | 0.05 | 0.25 | 0.03 |
Family | ||||
Spirochaetaceae | 0.003 | 0.02 | 0.11 | 0.00037 |
Comamonadaceae | 0.005 | 0.02 | 0.24 | 0.01 |
Moraxellaceae | 0.23 | 0.004 | 58.8 | 0.01 |
Fusobacteriaceae | 0.32 | 0.01 | 23.4 | 0.01 |
Erysipelotrichaceae | 0.04 | 0.23 | 0.19 | 0.01 |
Streptococcaceae | 0.14 | 1.23 | 0.11 | 0.01 |
Lactobacillaceae | 0.05 | 0.22 | 0.22 | 0.01 |
Clostridiaceae | 1.71 | 6.7 | 0.25 | 0.02 |
Genus | ||||
Mitsuokella | 0.002 | 0.07 | 0.03 | 0.0001 |
Turicibacter | 0.01 | 0.19 | 0.06 | 0.0018 |
Peptostreptococcus | 0.06 | 0.002 | 40.7 | 0.002 |
Intestinibacter | 0.04 | 0.25 | 0.16 | 0.002 |
Psychrobacter | 0.12 | 0.001 | 81.0 | 0.004 |
Ruminiclostridium | 0.03 | 0.27 | 0.12 | 0.011 |
Paludibacter | 0.008 | 0.06 | 0.13 | 0.011 |
Fusobacterium | 0.32 | 0.01 | 23.4 | 0.011 |
Streptococcus | 0.13 | 1.22 | 0.11 | 0.013 |
Lactobacillus | 0.05 | 0.22 | 0.21 | 0.013 |
Acinetobacter | 0.09 | 0.003 | 27.8 | 0.013 |
Megasphaera | 0.01 | 0.07 | 0.18 | 0.013 |
Clostridium | 1.67 | 6.62 | 0.25 | 0.02 |
Ruminococcus | 0.57 | 3.72 | 0.15 | 0.02 |
Roseburia | 0.24 | 1.04 | 0.23 | 0.04 |
Species | ||||
Roseburia inulinivorans | 0.02 | 0.59 | 0.03 | 0.00019 |
Bacteroides clarus | 0.33 | 0.01 | 25.9 | 0.0002 |
Clostridium disporicum | 0.008 | 0.30 | 0.03 | 0.0007 |
Turicibacter spp. | 0.01 | 0.18 | 0.06 | 0.0019 |
Ruminiclostridium eubacterium siraeum | 0.006 | 0.14 | 0.04 | 0.0019 |
Intestinibacter clostridium bartlettii | 0.04 | 0.25 | 0.16 | 0.0019 |
Bacteroides xylanolyticus | 0.01 | 0.35 | 0.04 | 0.0019 |
Psychrobacter pulmonis | 0.12 | 0.001 | 80.9 | 0.0035 |
Ruminococcus spp. | 0.18 | 1.47 | 0.12 | 0.0037 |
Streptococcus salivarius | 0.07 | 1.02 | 0.07 | 0.0070 |
Ruminococcus flavefaciens | 0.04 | 0.98 | 0.04 | 0.010 |
Fusobacterium nucleatum | 0.25 | 0.01 | 21.6 | 0.01 |
Eubacterium spp. | 0.07 | 0.68 | 0.11 | 0.02 |
Eubacterium hallii | 0.05 | 0.34 | 0.15 | 0.04 |
Phylogenetic level | Abundance CD (%) | Abundance control (%) | Ratio | aFDR corrected p-value |
---|---|---|---|---|
A. Colonic mucosa | ||||
Family | ||||
Erysipelotrichaceae | 0.07 | 0.26 | 0.25 | 0.007 |
Genus | ||||
Mitsuokella
| 0.009 | 0.03 | 0.25 | 0.001 |
Holdemanella
| 0.007 | 0.06 | 0.13 | 0.009 |
Ruminiclostridium
| 0.02 | 0.12 | 0.20 | 0.01 |
Turicibacter
| 0.02 | 0.08 | 0.25 | 0.02 |
Species | ||||
Streptococcus salivarius
| 0.1 | 0.4 | 0.25 | 0.05 |
Clostridium disporicum
| 0.04 | 0.25 | 0.15 | 0.05 |
B. Ileal mucosa | ||||
Family | ||||
Erysipelotrichaceae | 0.03 | 0.42 | 0.08 | 0.02 |
Lactobacillaceae | 0.03 | 0.56 | 0.06 | 0.03 |
Acidaminococcaceae | 0.03 | 0.26 | 0.11 | 0.03 |
Genus | ||||
Roseburia
| 0.09 | 1.01 | 0.09 | 0.05 |
Lactobacillus
| 0.03 | 0.55 | 0.06 | 0.05 |
Species | ||||
Phascolarctobacterium
| 0.03 | 0.26 | 0.11 | 0.05 |
Bifidobacterium catenulatum
| 0.008 | 0.17 | 0.05 | 0.01 |
Clostridium perfringens
| 0.02 | 0.35 | 0.05 | 0.03 |
Roseburia inulinivorans
| 0.04 | 0.51 | 0.07 | 0.03 |
Blautia ruminococcus gnavus
| 0.08 | 0.67 | 0.12 | 0.04 |