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Erschienen in: Osteoporosis International 5/2003

01.09.2003 | Original Article

Microdamage and bone strength

verfasst von: David Burr

Erschienen in: Osteoporosis International | Sonderheft 5/2003

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Excerpt

There has been much discussion about the role that microdamage plays in reducing bone's mechanical properties and increasing the risk of fracture [1]. Data showing a clear relationship between microdamage and biomechanical properties are sparse; the role of damage in fracture/fracture risk is completely unclear. …
Literatur
1.
Zurück zum Zitat Burr DB, Forwood MR, Fyhrie DP, et al (1997) Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12:6–15PubMed Burr DB, Forwood MR, Fyhrie DP, et al (1997) Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12:6–15PubMed
2.
Zurück zum Zitat Mashiba T, Hirano T, Turner CH, et al (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613–620PubMed Mashiba T, Hirano T, Turner CH, et al (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613–620PubMed
3.
Zurück zum Zitat Mashiba T, Turner CH, Hirano T, et al (2001) Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone 28:524–531CrossRefPubMed Mashiba T, Turner CH, Hirano T, et al (2001) Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone 28:524–531CrossRefPubMed
4.
Zurück zum Zitat Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB (2000) Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation? Bone 27:13–20 Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB (2000) Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation? Bone 27:13–20
5.
Zurück zum Zitat Brown C, Norman T, Wang Z (1996) Microdamage influences fracture toughness of human cortical bone. Trans Orthop Res Soc 21:58 Brown C, Norman T, Wang Z (1996) Microdamage influences fracture toughness of human cortical bone. Trans Orthop Res Soc 21:58
6.
Zurück zum Zitat Norman TL, Yeni YN, Brown CU, Wang Z (1998) Influence of microdamage on fracture toughness of the human femur and tibia. Bone 23:303–306CrossRefPubMed Norman TL, Yeni YN, Brown CU, Wang Z (1998) Influence of microdamage on fracture toughness of the human femur and tibia. Bone 23:303–306CrossRefPubMed
7.
Zurück zum Zitat Burr DB, Turner CH, Naick P, et al (1998) Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31:337–345 Burr DB, Turner CH, Naick P, et al (1998) Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31:337–345
8.
Zurück zum Zitat Schaffler M, Radin EL, Burr DB (1989) Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone 10:207–214PubMed Schaffler M, Radin EL, Burr DB (1989) Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone 10:207–214PubMed
9.
Zurück zum Zitat Keaveny TM, Wachtel E, Guo X, Hayes W (1994) Mechanical behavior of damaged trabecular bone. J Biomech 27:1309–1318PubMed Keaveny TM, Wachtel E, Guo X, Hayes W (1994) Mechanical behavior of damaged trabecular bone. J Biomech 27:1309–1318PubMed
10.
Zurück zum Zitat Jepsen K, Davy D (1997) Comparison of damage accumulation measures in human cortical bone. J Biomech 30:891–894CrossRefPubMed Jepsen K, Davy D (1997) Comparison of damage accumulation measures in human cortical bone. J Biomech 30:891–894CrossRefPubMed
11.
Zurück zum Zitat Pidaparti R, Akyuz U, Naick P, Burr D (2000) Fatigue data analysis of canine femurs under four-point bending. Biomed Mater Eng 10:43–50PubMed Pidaparti R, Akyuz U, Naick P, Burr D (2000) Fatigue data analysis of canine femurs under four-point bending. Biomed Mater Eng 10:43–50PubMed
12.
Zurück zum Zitat Pattin C, Caler W, Carter D (1996) Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech 29:69–79CrossRefPubMed Pattin C, Caler W, Carter D (1996) Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech 29:69–79CrossRefPubMed
13.
Zurück zum Zitat Schaffler M, Boyce T, Fyhrie D (1996) Tissue and matrix failure modes in human compact bone during tensile fatigue. Trans Orthop Res Soc 21:57 Schaffler M, Boyce T, Fyhrie D (1996) Tissue and matrix failure modes in human compact bone during tensile fatigue. Trans Orthop Res Soc 21:57
14.
Zurück zum Zitat Currey J, Brear K, Zioupos P (1996) The effects of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech 29:257CrossRefPubMed Currey J, Brear K, Zioupos P (1996) The effects of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech 29:257CrossRefPubMed
15.
Zurück zum Zitat Martin R, Burr DB (1989) Structure, function and adaptation of compact bone. Raven Press, New York Martin R, Burr DB (1989) Structure, function and adaptation of compact bone. Raven Press, New York
16.
Zurück zum Zitat Martin R, Burr DB, Sharkey N (1998) Skeletal tissue mechanics. Springer, New York Heidelberg Martin R, Burr DB, Sharkey N (1998) Skeletal tissue mechanics. Springer, New York Heidelberg
17.
Zurück zum Zitat Frost N (1965) The growth of fatigue cracks. Proc of the First International Conference on Fracture 3:1433–1459 Frost N (1965) The growth of fatigue cracks. Proc of the First International Conference on Fracture 3:1433–1459
18.
Zurück zum Zitat Martin R, Mashiba T, Hirano T, Burr DB (2000) Computer simulation of the effects of bone remodeling suppression on microdamage. Trans Orthop Res Soc 25:35 Martin R, Mashiba T, Hirano T, Burr DB (2000) Computer simulation of the effects of bone remodeling suppression on microdamage. Trans Orthop Res Soc 25:35
19.
Zurück zum Zitat Schaffler MB, Choi K, Milgrom C (1995) Aging and matrix microdamage accumulation in human compact bone. Bone 17:521–525CrossRefPubMed Schaffler MB, Choi K, Milgrom C (1995) Aging and matrix microdamage accumulation in human compact bone. Bone 17:521–525CrossRefPubMed
20.
Zurück zum Zitat Norman TL, Wang Z (1997) Microdamage of human cortical bone: incidence and morphology in long bones. Bone 20:375–379PubMed Norman TL, Wang Z (1997) Microdamage of human cortical bone: incidence and morphology in long bones. Bone 20:375–379PubMed
21.
Zurück zum Zitat Mori S, Harruff R, Ambrosius W, Burr DB (1997) Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 21:521–526CrossRefPubMed Mori S, Harruff R, Ambrosius W, Burr DB (1997) Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 21:521–526CrossRefPubMed
22.
Zurück zum Zitat Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P (1998) Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 22:381–388CrossRefPubMed Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P (1998) Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 22:381–388CrossRefPubMed
23.
Zurück zum Zitat Podenphant J, Engel U (1987) Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman. Calcif Tissue Int 40:184–188PubMed Podenphant J, Engel U (1987) Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman. Calcif Tissue Int 40:184–188PubMed
24.
Zurück zum Zitat Rosso R, Minisola S, Scarda A, et al. (1995) Temporal relationship between bone loss and increased bone turnover: A longitudinal study following natural menopause. J Endocrinol Invest 18:723–728PubMed Rosso R, Minisola S, Scarda A, et al. (1995) Temporal relationship between bone loss and increased bone turnover: A longitudinal study following natural menopause. J Endocrinol Invest 18:723–728PubMed
25.
Zurück zum Zitat Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD (1996) Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 11:337–349PubMed Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD (1996) Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 11:337–349PubMed
26.
Zurück zum Zitat Parfitt A (1996) Skeletal heterogeneity and the purpose of bone remodeling. Implications for the understanding of osteoporosis. In: Kelsey J (ed.) Osteoporosis. Academic Press, San Diego, pp 315–329 Parfitt A (1996) Skeletal heterogeneity and the purpose of bone remodeling. Implications for the understanding of osteoporosis. In: Kelsey J (ed.) Osteoporosis. Academic Press, San Diego, pp 315–329
27.
Zurück zum Zitat Melton LJ, 3rd, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. (1997) Relationship of bone turnover to bone density and fractures. J Bone Miner Res 12:1083–1091PubMed Melton LJ, 3rd, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. (1997) Relationship of bone turnover to bone density and fractures. J Bone Miner Res 12:1083–1091PubMed
28.
Zurück zum Zitat Frost H (1960) Presence of microscopic cracks in vivo in bone. Henry Ford Med Bull 8:27–35 Frost H (1960) Presence of microscopic cracks in vivo in bone. Henry Ford Med Bull 8:27–35
29.
Zurück zum Zitat Hasegawa K, Turner CH, Chen J, Burr DB (1995) Effect of disc lesion on microdamage accumulation in lumbar vertebrae under cyclic compression loading. Clin Orthop 311:190–198PubMed Hasegawa K, Turner CH, Chen J, Burr DB (1995) Effect of disc lesion on microdamage accumulation in lumbar vertebrae under cyclic compression loading. Clin Orthop 311:190–198PubMed
30.
Zurück zum Zitat Wenzel T, Schaffler MB, Fyhrie D (1996) In vivo trabecular microcracks in human vertebral bone. Bone 19:89–95CrossRefPubMed Wenzel T, Schaffler MB, Fyhrie D (1996) In vivo trabecular microcracks in human vertebral bone. Bone 19:89–95CrossRefPubMed
31.
Zurück zum Zitat Courtney A, Hayes W, Gibson L (1996) Age-related differences in post-yield damage in human cortical bone. Experiment and model. J Biomech 29:1463–1471CrossRefPubMed Courtney A, Hayes W, Gibson L (1996) Age-related differences in post-yield damage in human cortical bone. Experiment and model. J Biomech 29:1463–1471CrossRefPubMed
32.
Zurück zum Zitat Burr D (2002) The contribution of the organic matrix to the bone's material properties. Bone 31:8–11CrossRefPubMed Burr D (2002) The contribution of the organic matrix to the bone's material properties. Bone 31:8–11CrossRefPubMed
33.
Zurück zum Zitat Norman T, Nivargikar S, Burr DB (1996) Resistance to crack growth in human cortical bone is greater in shear than in tension. J Biomech 29:1023–1031CrossRefPubMed Norman T, Nivargikar S, Burr DB (1996) Resistance to crack growth in human cortical bone is greater in shear than in tension. J Biomech 29:1023–1031CrossRefPubMed
34.
Zurück zum Zitat Zioupos P (2001) Accumulation of in-vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone. J Microsc 201(Pt2):270–278CrossRef Zioupos P (2001) Accumulation of in-vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone. J Microsc 201(Pt2):270–278CrossRef
35.
Zurück zum Zitat Zioupos P, Currey JD (1998) Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 22:57–66CrossRefPubMed Zioupos P, Currey JD (1998) Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 22:57–66CrossRefPubMed
36.
Zurück zum Zitat Yates AJ, Rodan G (1998) Alendronate and osteoporosis. Drug Discovery Today 3:69–78CrossRef Yates AJ, Rodan G (1998) Alendronate and osteoporosis. Drug Discovery Today 3:69–78CrossRef
37.
Zurück zum Zitat Raisz L, Smith JA, Trahiotis M, et al. (2000) Short-term risedronate treatment in postmenopausal women: Effects on biochemical markers of bone turnover. Osteoporos Int 11:615–620CrossRefPubMed Raisz L, Smith JA, Trahiotis M, et al. (2000) Short-term risedronate treatment in postmenopausal women: Effects on biochemical markers of bone turnover. Osteoporos Int 11:615–620CrossRefPubMed
38.
Zurück zum Zitat Mongiorgi R, Romagnoli R, Olmi R, Moroni A (1983) Mineral alternations in senile osteoporosis. Biomaterials 4:192–196CrossRefPubMed Mongiorgi R, Romagnoli R, Olmi R, Moroni A (1983) Mineral alternations in senile osteoporosis. Biomaterials 4:192–196CrossRefPubMed
39.
Zurück zum Zitat Paschallis E, Phipps R (2002) Three-years treatment with risedronate does not alter bone mineral crystallinity in post-menopausal osteoporotic subjects. J Bone Min Res 17 (Suppl 1):S368 Paschallis E, Phipps R (2002) Three-years treatment with risedronate does not alter bone mineral crystallinity in post-menopausal osteoporotic subjects. J Bone Min Res 17 (Suppl 1):S368
40.
Zurück zum Zitat Roschger P, Rinnerthaler S, Yates J, et al. (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29:185–191CrossRefPubMed Roschger P, Rinnerthaler S, Yates J, et al. (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29:185–191CrossRefPubMed
41.
Zurück zum Zitat Boivin G, Meunier P(2002) The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tissue Int 70:503–511CrossRefPubMed Boivin G, Meunier P(2002) The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tissue Int 70:503–511CrossRefPubMed
42.
Zurück zum Zitat Kendall K (1975) Control of cracks by interfaces in composites. Proc Royal Soc London 341:409–428 Kendall K (1975) Control of cracks by interfaces in composites. Proc Royal Soc London 341:409–428
43.
Zurück zum Zitat Paschallis E, Burr DB, Mendelsohn R, Hock J, Boskey A (2003) Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH (1–34) for 18 months. J Bone Min Res 18:769–775 Paschallis E, Burr DB, Mendelsohn R, Hock J, Boskey A (2003) Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH (1–34) for 18 months. J Bone Min Res 18:769–775
Metadaten
Titel
Microdamage and bone strength
verfasst von
David Burr
Publikationsdatum
01.09.2003
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe Sonderheft 5/2003
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1476-2

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