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Neuroscience Bulletin
Erschienen in:

01.06.2019 | Original Article

MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells

verfasst von: Meng Jia, Xuewei Wang, Haolin Zhang, Can Ye, Hui Ma, Mingda Yang, Yijing Li, Cailian Cui

Erschienen in: Neuroscience Bulletin | Ausgabe 3/2019

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Abstract

MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, specific overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus (DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These findings indicate that miR-132 is involved in opioid addiction, probably by promoting the differentiation of NSCs in the adult DG.
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Metadaten
Titel
MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells
verfasst von
Meng Jia
Xuewei Wang
Haolin Zhang
Can Ye
Hui Ma
Mingda Yang
Yijing Li
Cailian Cui
Publikationsdatum
01.06.2019
Verlag
Springer Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 3/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-019-00338-z

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