MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells
- 01.06.2019
- Original Article
Erschienen in:
- Verfasst von
- Meng Jia
- Xuewei Wang
- Haolin Zhang
- Can Ye
- Hui Ma
- Mingda Yang
- Yijing Li
- Cailian Cui
- Erschienen in
- Neuroscience Bulletin | Ausgabe 3/2019
Abstract
MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, specific overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus (DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These findings indicate that miR-132 is involved in opioid addiction, probably by promoting the differentiation of NSCs in the adult DG.
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- Titel
- MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells
- Verfasst von
-
Meng Jia
Xuewei Wang
Haolin Zhang
Can Ye
Hui Ma
Mingda Yang
Yijing Li
Cailian Cui
- Publikationsdatum
- 01.06.2019
- Verlag
- Springer Singapore
- Erschienen in
-
Neuroscience Bulletin / Ausgabe 3/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218 - DOI
- https://doi.org/10.1007/s12264-019-00338-z
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