Erschienen in:
01.05.2010 | Poster presentation
MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer
verfasst von:
HH Alnakhle, PA Burns, M Cummings, AM Hanby, TA Hughes, S Satheesha, AM Shaaban, L Smith, V Speirs
Erschienen in:
Breast Cancer Research
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Sonderheft 1/2010
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Excerpt
ERβ1 is often downregulated in cancer compared with normal cells, suggesting that it may function as a tumour suppressor and could play an important role in carcinogenesis. The expression of ERβ1 is regulated by multiple mechanisms such as methylation. Five splice variants of ERβ mRNA have been identified, ERβ1 to ERβ5. However, it is unclear whether and how the full-length version, ERβ1, is regulated post-transcriptionally. …