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Erschienen in: Breast Cancer Research 1/2010

01.05.2010 | Poster presentation

MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer

verfasst von: HH Alnakhle, PA Burns, M Cummings, AM Hanby, TA Hughes, S Satheesha, AM Shaaban, L Smith, V Speirs

Erschienen in: Breast Cancer Research | Sonderheft 1/2010

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Excerpt

ERβ1 is often downregulated in cancer compared with normal cells, suggesting that it may function as a tumour suppressor and could play an important role in carcinogenesis. The expression of ERβ1 is regulated by multiple mechanisms such as methylation. Five splice variants of ERβ mRNA have been identified, ERβ1 to ERβ5. However, it is unclear whether and how the full-length version, ERβ1, is regulated post-transcriptionally. …
Metadaten
Titel
MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer
verfasst von
HH Alnakhle
PA Burns
M Cummings
AM Hanby
TA Hughes
S Satheesha
AM Shaaban
L Smith
V Speirs
Publikationsdatum
01.05.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 1/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2508

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