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Acta Neurologica Belgica
Erschienen in:

21.02.2019 | Review article

MicroRNAs in contusion spinal cord injury: pathophysiology and clinical utility

verfasst von: Fang Li, Mou-Wang Zhou

Erschienen in: Acta Neurologica Belgica | Ausgabe 1/2019

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Abstract

Spinal cord injury (SCI) in humans is a common central nervous system trauma. Pathophysiologically, SCI involves both primary and secondary damages. Therapeutically, targeting secondary damage including inflammation, neuropathic pain, apoptosis, demyelination, and glial reaction to promote functional benefits for SCI patients has long been considered a potential treatment strategy by neuroscientists and clinicians. As a type of small non-coding RNA, microRNAs (miRNAs) have been shown to play essential roles in the regulation of pathophysiologic processes of SCI and are considered to be an effective treatment method for SCI. Dysregulated expression of miRNAs is observed in SCI patients and animal models of SCI. Furthermore, miRNAs might also be used as biomarkers for diagnostic and prognostic purposes in SCI. Given contusion injury is the most clinically relevant type of SCI, this review mainly focuses on the role of miRNAs in the pathophysiology of contusion SCI and the putative utilization of miRNAs as diagnostic biomarkers and therapeutic targets for contusion SCI.
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Metadaten
Titel
MicroRNAs in contusion spinal cord injury: pathophysiology and clinical utility
verfasst von
Fang Li
Mou-Wang Zhou
Publikationsdatum
21.02.2019
Verlag
Springer International Publishing
Erschienen in
Acta Neurologica Belgica / Ausgabe 1/2019
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-019-01076-9

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