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01.06.2019 | Research Article

Microstimulation-induced inhibition of thalamic reticular nucleus in non-human primates

verfasst von: Jennifer Lymer, Ian A. Prescott, Ron Levy

Erschienen in: Experimental Brain Research | Ausgabe 6/2019

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Abstract

The thalamic reticular nucleus (TRN) modulates activity in the thalamus and controls excitatory input from corticothalamic and thalamocortical glutamatergic projections. It is made up of GABAergic neurons which project topographically to the thalamus. The TRN also receives inhibitory projections from the globus pallidus and the substantia nigra pars reticulata. Photostimulation of the TRN results in local inhibition in rat slice preparations but the effects of local stimulation in vivo are not known. This study aimed to characterize stimulation-evoked responses in the TRN of non-human primates (NHPs). Microelectrodes were inserted into the TRN and neurons were stimulated at 5, 10, 15, and 20 µA using 0.5 s trains at 100 Hz and the subsequent response was recorded from the same electrode. Stimulation in surrounding nuclei and the internal capsule was used for mapping the anatomical borders of the TRN. Stimulation as low as 10 µA resulted in predominantly inhibition, recorded in both single units and background unit activity (BUA). The duration of inhibition (~ 1–3 s) increased with increasing stimulation amplitude and was significantly increased in BUA when single units were present. At 20 µA of current, 93% of the single units (41/44) and 92% of BUA sites (67/73) were inhibited. Therefore, microstimulation of the NHP TRN with low currents results in current-dependent inhibition of single units and BUA. This finding may be useful to further aid in localization of deep thalamic and subthalamic nuclei during brain surgery.

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Titel: Microstimulation-induced inhibition of thalamic reticular nucleus in non-human primates
verfasst von: Jennifer Lymer
Ian A. Prescott
Ron Levy
Publikationsdatum: 01.06.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Experimental Brain Research / Ausgabe 6/2019
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-019-05526-x

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Microstimulation-induced inhibition of thalamic reticular nucleus in non-human primates

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