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Erschienen in: Der Schmerz 1/2022

17.01.2022 | Migräne | CME

CGRP-Antikörper in der Migräneprophylaxe

Der neue Standard in der Migränetherapie?

verfasst von: Till Hamann, Florian Rimmele, Tim Patrick Jürgens

Erschienen in: Der Schmerz | Ausgabe 1/2022

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Zusammenfassung

Die Migräne geht mit einem starken individuellen Leidensdruck einher, weshalb einer effektiven prophylaktischen Behandlung hohe Bedeutung zukommt. Das Spektrum klassischer Prophylaktika wird nun durch monoklonale Antikörper gegen das „calcitonin gene-related peptide“ (CGRP) und dessen Rezeptor erweitert. Die Antikörper wiesen in den Zulassungsstudien eine zuverlässige Wirksamkeit gegenüber Placebo und einen raschen Wirkeintritt bei niedriger Nebenwirkungsrate und vernachlässigbaren Interaktionen auf. Zudem wurde in zahlreichen Studien unter anderem eine Wirkung der Antikörper auch bei therapierefraktärer Migräne nachgewiesen. Umfassende direkte Vergleiche der Antikörper untereinander und mit den bisher etablierten Medikamenten gibt es noch nicht. Erste Studien legen aber eine bessere Verträglichkeit und Wirksamkeit gegenüber etablierten Medikamenten oder anderen Antikörpern nahe. Die Rolle der Antikörper in den etablierten Therapiekaskaden bleibt zu klären.
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Metadaten
Titel
CGRP-Antikörper in der Migräneprophylaxe
Der neue Standard in der Migränetherapie?
verfasst von
Till Hamann
Florian Rimmele
Tim Patrick Jürgens
Publikationsdatum
17.01.2022
Verlag
Springer Medizin
Erschienen in
Der Schmerz / Ausgabe 1/2022
Print ISSN: 0932-433X
Elektronische ISSN: 1432-2129
DOI
https://doi.org/10.1007/s00482-021-00613-x