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25.10.2020 | KEY LECTURE

Migraine neuroscience: from experimental models to target therapy

verfasst von: Rosaria Greco, Chiara Demartini, Roberto De Icco, Daniele Martinelli, Alessia Putortì, Cristina Tassorelli

Erschienen in: Neurological Sciences | Sonderheft 2/2020

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Abstract

Migraine sciences have witnessed tremendous advances in recent years. Pre-clinical and clinical experimental models have contributed significantly to provide useful insights into the brain structures that mediate migraine attacks. These models have contributed to elucidate the role of neurotransmission pathways and to identify the role of important molecules within the complex network involved in migraine pathogenesis. The contribution and efforts of several research groups from all over the world has ultimately lead to the generation of novel therapeutic approaches, specifically targeted for the prevention of migraine attacks, the monoclonal antibodies directed against calcitonin gene-related peptide or its receptor. These drugs have been validated in randomized placebo-controlled trials and are now ready to improve the lives of a large multitude of migraine sufferers. Others are in the pipeline and will soon be available.

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Titel: Migraine neuroscience: from experimental models to target therapy
verfasst von: Rosaria Greco
Chiara Demartini
Roberto De Icco
Daniele Martinelli
Alessia Putortì
Cristina Tassorelli
Publikationsdatum: 25.10.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe Sonderheft 2/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04808-5

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