Skip to main content
Erschienen in:

10.08.2023 | Original Article

Milk intake and hip fracture incidence in community-dwelling old Icelandic adults

verfasst von: Sigrun S. Skuladottir, Ingibjorg Hjaltadottir, Lenore Launer, Mary-Frances Cotch, Kristin Siggeirsdottir, Vilmundur Gudnason, Gunnar Sigurdsson, Laufey Steingrimsdottir, Thorhallur Halldorsson, Alfons Ramel

Erschienen in: Osteoporosis International | Ausgabe 11/2023

Einloggen, um Zugang zu erhalten

Abstract

Summary

Milk and milk products have been known as important for bone health. Can ingestion of milk and milk products lower hip fracture risk for older adults? In this study, older Icelandic adults who were ingesting higher milk had a lower risk of hip fractures.

Introduction

This study describes associations between milk intake and hip fracture risk in older Icelanders. The data indicate that no/low milk consumption is related to greater hip fracture risk. Hip fracture can have a severe effect on the life of older adults. Health authorities recommend milk intake for better bone health. However, previous studies addressing this association have been divergent.

Methods

This prospective study included 4614 subjects (mean age 76 years) recruited between 2002 and 2006 into the Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik) study. Information on hip fractures occurring between recruitment and end of follow-up in 2012 was extracted from hospital records.

Results

A total of 14% of participants reported milk intake < 0.5 times/day (the lowest category) and 22% of the participants consumed at least milk two times/day (highest category). Milk consumption was positively related to the volumetric bone mineral density at baseline with a sex- and age-adjusted difference of 8.95 ± 2.5 mg/cm3 between the highest compared to lowest milk intake categories (P < 0.001). During the follow-up, 7.4% of participants had a hip fracture, and we observed a decreased risk of incident hip fractures in the highest compared to the lowest milk intake category with a hazard ratio of 0.69 (95% CI: 0.47–0.99) in adjusted model. Further analysis indicated a linear relationship between milk intake and fracture risk (P-value for linear trend < 0.001).

Conclusion

Milk intake is associated with a lower risk of incident hip fracture in a linear way in Icelandic community-dwelling older adults.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
2.
Zurück zum Zitat Rapp K et al (2019) Epidemiology of hip fractures : systematic literature review of German data and an overview of the international literature. Z Gerontol Geriatr 52(1):10–16PubMedCrossRef Rapp K et al (2019) Epidemiology of hip fractures : systematic literature review of German data and an overview of the international literature. Z Gerontol Geriatr 52(1):10–16PubMedCrossRef
4.
Zurück zum Zitat Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767PubMedCrossRef Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767PubMedCrossRef
5.
Zurück zum Zitat Cheng SY et al (2011) Geographic trends in incidence of hip fractures: a comprehensive literature review. Osteoporos Int 22(10):2575–2586PubMedCrossRef Cheng SY et al (2011) Geographic trends in incidence of hip fractures: a comprehensive literature review. Osteoporos Int 22(10):2575–2586PubMedCrossRef
6.
7.
8.
Zurück zum Zitat Mattisson L, Bojan A, Enocson A (2018) Epidemiology, treatment and mortality of trochanteric and subtrochanteric hip fractures: data from the Swedish fracture register. BMC Musculoskelet Disord 19(1):369PubMedPubMedCentralCrossRef Mattisson L, Bojan A, Enocson A (2018) Epidemiology, treatment and mortality of trochanteric and subtrochanteric hip fractures: data from the Swedish fracture register. BMC Musculoskelet Disord 19(1):369PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Skuladottir SS et al (2019) Hip fractures among older people in Iceland between 2008 and 2012. Int J Orthop Trauma Nurs 32:27–31PubMedCrossRef Skuladottir SS et al (2019) Hip fractures among older people in Iceland between 2008 and 2012. Int J Orthop Trauma Nurs 32:27–31PubMedCrossRef
10.
Zurück zum Zitat Marks R (2010) Hip fracture epidemiological trends, outcomes, and risk factors, 1970–2009. Int J Gen Med 3:1–17PubMedPubMedCentral Marks R (2010) Hip fracture epidemiological trends, outcomes, and risk factors, 1970–2009. Int J Gen Med 3:1–17PubMedPubMedCentral
11.
12.
Zurück zum Zitat Cusack S, Cashman KD (2003) Impact of genetic variation on metabolic response of bone to diet. Proc Nutr Soc 62(4):901–912PubMedCrossRef Cusack S, Cashman KD (2003) Impact of genetic variation on metabolic response of bone to diet. Proc Nutr Soc 62(4):901–912PubMedCrossRef
14.
Zurück zum Zitat Eysteinsdottir T et al (2014) Milk consumption throughout life and bone mineral content and density in elderly men and women. Osteoporos Int 25(2):663–672PubMedCrossRef Eysteinsdottir T et al (2014) Milk consumption throughout life and bone mineral content and density in elderly men and women. Osteoporos Int 25(2):663–672PubMedCrossRef
15.
Zurück zum Zitat Rizzoli R (2014) Dairy products, yogurts, and bone health. Am J Clin Nutr 99(5 Suppl):1256s-s1262PubMedCrossRef Rizzoli R (2014) Dairy products, yogurts, and bone health. Am J Clin Nutr 99(5 Suppl):1256s-s1262PubMedCrossRef
16.
Zurück zum Zitat Rozenberg S et al (2016) Effects of dairy products consumption on health: benefits and beliefs–a commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Calcif Tissue Int 98(1):1–17PubMedCrossRef Rozenberg S et al (2016) Effects of dairy products consumption on health: benefits and beliefs–a commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Calcif Tissue Int 98(1):1–17PubMedCrossRef
18.
Zurück zum Zitat Malmir H, Larijani B, Esmaillzadeh A (2020) Consumption of milk and dairy products and risk of osteoporosis and hip fracture: a systematic review and Meta-analysis. Crit Rev Food Sci Nutr 60(10):1722–1737PubMedCrossRef Malmir H, Larijani B, Esmaillzadeh A (2020) Consumption of milk and dairy products and risk of osteoporosis and hip fracture: a systematic review and Meta-analysis. Crit Rev Food Sci Nutr 60(10):1722–1737PubMedCrossRef
19.
Zurück zum Zitat Hidayat K et al (2020) Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence. Osteoporos Int 31(8):1411–1425PubMedCrossRef Hidayat K et al (2020) Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence. Osteoporos Int 31(8):1411–1425PubMedCrossRef
20.
Zurück zum Zitat Knapik JJ, Hoedebecke SS (2021) Vitamin A and bone fractures. J Spec Oper Med 21(1):115–119PubMedCrossRef Knapik JJ, Hoedebecke SS (2021) Vitamin A and bone fractures. J Spec Oper Med 21(1):115–119PubMedCrossRef
22.
23.
Zurück zum Zitat Kanis JA et al (2005) A meta-analysis of milk intake and fracture risk: low utility for case finding. Osteoporos Int 16(7):799–804PubMedCrossRef Kanis JA et al (2005) A meta-analysis of milk intake and fracture risk: low utility for case finding. Osteoporos Int 16(7):799–804PubMedCrossRef
24.
Zurück zum Zitat Ólafsdóttir, L.S.H.Þ.A.S. (2003) Hvað borða Íslendingar. Reykjavik, Manneldisráð Íslands p 103 Ólafsdóttir, L.S.H.Þ.A.S. (2003) Hvað borða Íslendingar. Reykjavik, Manneldisráð Íslands p 103
25.
Zurück zum Zitat Thorgeirsdottir H, Valgeirsdottir H, Gunnarsdottir I et al (2011) Hvað borða Íslendingar? Könnun á mataræði Íslendinga 2010–2011. Helstu niðurstöður: Embætti Landlæknis, Matvælastofnun and Rannsóknastofa í næringarfræði Thorgeirsdottir H, Valgeirsdottir H, Gunnarsdottir I et al (2011) Hvað borða Íslendingar? Könnun á mataræði Íslendinga 2010–2011. Helstu niðurstöður: Embætti Landlæknis, Matvælastofnun and Rannsóknastofa í næringarfræði
26.
Zurück zum Zitat Harris TB et al (2007) Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol 165(9):1076–1087PubMedCrossRef Harris TB et al (2007) Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol 165(9):1076–1087PubMedCrossRef
27.
Zurück zum Zitat Steingrimsdottir L et al (2014) Hip fractures and bone mineral density in the elderly–importance of serum 25-hydroxyvitamin D. PLoS ONE 9(3):e91122PubMedPubMedCentralCrossRef Steingrimsdottir L et al (2014) Hip fractures and bone mineral density in the elderly–importance of serum 25-hydroxyvitamin D. PLoS ONE 9(3):e91122PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Era P et al (1994) Maximal isometric muscle strength and anthropometry in 75-year-old men and women in three Nordic localities. Scand J Med Sci Sports 4(1):26–31CrossRef Era P et al (1994) Maximal isometric muscle strength and anthropometry in 75-year-old men and women in three Nordic localities. Scand J Med Sci Sports 4(1):26–31CrossRef
30.
Zurück zum Zitat Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148PubMedCrossRef Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39(2):142–148PubMedCrossRef
31.
Zurück zum Zitat Siggeirsdóttir K et al (2002) The timed ‘Up & G’ is dependent on chair type. Clin Rehabil 16(6):609–616PubMedCrossRef Siggeirsdóttir K et al (2002) The timed ‘Up & G’ is dependent on chair type. Clin Rehabil 16(6):609–616PubMedCrossRef
32.
33.
Zurück zum Zitat Sigurdsson G et al (2006) Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone 39(3):644–651PubMedCrossRef Sigurdsson G et al (2006) Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK). Bone 39(3):644–651PubMedCrossRef
34.
Zurück zum Zitat Johannesdottir F et al (2012) Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). Calcif Tissue Int 90(5):354–364PubMedPubMedCentralCrossRef Johannesdottir F et al (2012) Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study). Calcif Tissue Int 90(5):354–364PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Skuladottir SS, Ramel A, Eymundsdottir H, Hjaltadottir I, Launer LJ, Cotch MF, Siggeirsdottir K, Gudnason V, Sigurdsson G, Steingrimsdottir L, Halldorsson TI (2021) Serum 25-hydroxy-vitamin D status and incident hip fractures in elderly adults: looking beyond bone mineral density. J Bone Miner Res 36(12):2351–2360. https://doi.org/10.1002/jbmr.4450CrossRefPubMed Skuladottir SS, Ramel A, Eymundsdottir H, Hjaltadottir I, Launer LJ, Cotch MF, Siggeirsdottir K, Gudnason V, Sigurdsson G, Steingrimsdottir L, Halldorsson TI (2021) Serum 25-hydroxy-vitamin D status and incident hip fractures in elderly adults: looking beyond bone mineral density. J Bone Miner Res 36(12):2351–2360. https://​doi.​org/​10.​1002/​jbmr.​4450CrossRefPubMed
37.
Zurück zum Zitat Siggeirsdottir K et al (2007) Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry. Eur J Epidemiol 22(9):631–639PubMedCrossRef Siggeirsdottir K et al (2007) Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry. Eur J Epidemiol 22(9):631–639PubMedCrossRef
38.
Zurück zum Zitat Cumming RG et al (1997) Calcium intake and fracture risk: results from the study of osteoporotic fractures. Am J Epidemiol 145(10):926–934PubMedCrossRef Cumming RG et al (1997) Calcium intake and fracture risk: results from the study of osteoporotic fractures. Am J Epidemiol 145(10):926–934PubMedCrossRef
39.
Zurück zum Zitat Sahni S et al (2013) Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Arch Osteoporos 8:119PubMedPubMedCentralCrossRef Sahni S et al (2013) Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Arch Osteoporos 8:119PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Sahni S et al (2014) Protective association of milk intake on the risk of hip fracture: results from the Framingham Original Cohort. J Bone Miner Res 29(8):1756–1762PubMedCrossRef Sahni S et al (2014) Protective association of milk intake on the risk of hip fracture: results from the Framingham Original Cohort. J Bone Miner Res 29(8):1756–1762PubMedCrossRef
41.
Zurück zum Zitat Feskanich D et al (2018) Milk and other dairy foods and risk of hip fracture in men and women. Osteoporos Int 29(2):385–396PubMedCrossRef Feskanich D et al (2018) Milk and other dairy foods and risk of hip fracture in men and women. Osteoporos Int 29(2):385–396PubMedCrossRef
42.
Zurück zum Zitat Meyer HE et al (1997) Dietary factors and the incidence of hip fracture in middle-aged Norwegians. A prospective study. Am J Epidemiol 145(2):117–123PubMedCrossRef Meyer HE et al (1997) Dietary factors and the incidence of hip fracture in middle-aged Norwegians. A prospective study. Am J Epidemiol 145(2):117–123PubMedCrossRef
43.
Zurück zum Zitat Bergholdt HKM et al (2018) Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta-analysis. J Intern Med 284(3):254–269PubMedCrossRef Bergholdt HKM et al (2018) Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta-analysis. J Intern Med 284(3):254–269PubMedCrossRef
44.
Zurück zum Zitat Holvik K et al (2019) Milk drinking and risk of hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). Br J Nutr 121(6):709–718PubMedCrossRef Holvik K et al (2019) Milk drinking and risk of hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS). Br J Nutr 121(6):709–718PubMedCrossRef
45.
Zurück zum Zitat Itkonen ST, Erkkola M, Lamberg-Allardt CJE (2018) Vitamin D fortification of fluid milk products and their contribution to vitamin D intake and vitamin D status in observational studies—a review. Nutrients 10(8):1054PubMedPubMedCentralCrossRef Itkonen ST, Erkkola M, Lamberg-Allardt CJE (2018) Vitamin D fortification of fluid milk products and their contribution to vitamin D intake and vitamin D status in observational studies—a review. Nutrients 10(8):1054PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Grønborg IM et al (2019) Modelling of adequate and safe vitamin D intake in Danish women using different fortification and supplementation scenarios to inform fortification policies. Eur J Nutr 58(1):227–232PubMedCrossRef Grønborg IM et al (2019) Modelling of adequate and safe vitamin D intake in Danish women using different fortification and supplementation scenarios to inform fortification policies. Eur J Nutr 58(1):227–232PubMedCrossRef
47.
Zurück zum Zitat Eleni A, Panagiotis P (2020) A systematic review and meta-analysis of vitamin D and calcium in preventing osteoporotic fractures. Clin Rheumatol 39(12):3571–3579PubMedCrossRef Eleni A, Panagiotis P (2020) A systematic review and meta-analysis of vitamin D and calcium in preventing osteoporotic fractures. Clin Rheumatol 39(12):3571–3579PubMedCrossRef
48.
Zurück zum Zitat Matía-Martín P et al (2019) Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Adv Nutr 10(suppl_2):S120-s143PubMedPubMedCentralCrossRef Matía-Martín P et al (2019) Effects of milk and dairy products on the prevention of osteoporosis and osteoporotic fractures in Europeans and non-Hispanic Whites from North America: a systematic review and updated meta-analysis. Adv Nutr 10(suppl_2):S120-s143PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Curry SJ et al (2018) Screening for osteoporosis to prevent fractures: US preventive services task force recommendation statement. JAMA 319(24):2521–2531PubMedCrossRef Curry SJ et al (2018) Screening for osteoporosis to prevent fractures: US preventive services task force recommendation statement. JAMA 319(24):2521–2531PubMedCrossRef
50.
Zurück zum Zitat Shi Y et al (2020) Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos 15(1):48PubMedCrossRef Shi Y et al (2020) Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Arch Osteoporos 15(1):48PubMedCrossRef
52.
Zurück zum Zitat Knapik JJ, Hoedebecke SS (2021) Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 21(2):100–107PubMedCrossRef Knapik JJ, Hoedebecke SS (2021) Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 21(2):100–107PubMedCrossRef
53.
Zurück zum Zitat Moerman S et al (2018) Less than one-third of hip fracture patients return to their prefracture level of instrumental activities of daily living in a prospective cohort study of 480 patients. Geriatr Gerontol Int 18(8):1244–1248PubMedCrossRef Moerman S et al (2018) Less than one-third of hip fracture patients return to their prefracture level of instrumental activities of daily living in a prospective cohort study of 480 patients. Geriatr Gerontol Int 18(8):1244–1248PubMedCrossRef
54.
Zurück zum Zitat Katsoulis M et al (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281(3):300–310PubMedCrossRef Katsoulis M et al (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281(3):300–310PubMedCrossRef
Metadaten
Titel
Milk intake and hip fracture incidence in community-dwelling old Icelandic adults
verfasst von
Sigrun S. Skuladottir
Ingibjorg Hjaltadottir
Lenore Launer
Mary-Frances Cotch
Kristin Siggeirsdottir
Vilmundur Gudnason
Gunnar Sigurdsson
Laufey Steingrimsdottir
Thorhallur Halldorsson
Alfons Ramel
Publikationsdatum
10.08.2023
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 11/2023
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-023-06883-8

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie erweitert durch Fallbeispiele, Videos und Abbildungen. Zur Fortbildung und Wissenserweiterung, verfasst und geprüft von Expertinnen und Experten der Gesellschaft für Arthroskopie und Gelenkchirurgie (AGA).


Jetzt entdecken!

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Ab sofort gelten die neuen Verordnungsausnahmen für Lipidsenker

Freie Fahrt für Lipidsenker? Das nicht, doch mit niedrigerem Schwellenwert fürs Infarktrisiko und neuen Indikationen hat der G-BA die Verordnungs-Handbremse ein gutes Stück weit gelockert.

Aerobes Training hilft bei Fibromyalgie

Sport im aeroben Bereich ist ein veritables Mittel, um die Schmerzen von Menschen mit Fibromyalgie zu reduzieren, wie eine Metaanalyse zeigt. Frequenz, Dauer und Intensität der Übungen geben den Ausschlag.

MedTalk Leitlinie KOMPAKT: S3-Leitline zu peripheren Nervenverletzungen

  • Webinar | 10.02.2025 | 13:00

Über den Weg zur finalen Fassung der S3-Leitlinie "Versorgung peripherer Nervenverletzungen" sprechen Prof. Dr. Leila Harhaus-Wähner und Ressortleiter Dr. Gunter Freese im WebTalk Leitlinie KOMPAKT, einer neuen Webcast-Serie von SpringerMedizin passend zu Ihrem Fachmagazin Orthopädie und Unfallchirurgie Mitteilungen und Nachrichten. In dem kurzen Video geht es darum, was sich im Vergleich zur vorigen Fassung der Leitlinie geändert hat, welche Aspekte für die tägliche Praxis besonders wichtig sind und was jeder gemäß Leitlinie nun anders oder besser machen sollte.

Zi veröffentlicht Ranking zur Fehleranfälligkeit gängiger Praxis-EDV

Welches Praxisverwaltungssystem macht am wenigsten Probleme? Das Zi dokumentiert jetzt detaillierte Produktbewertungen zu 17 konkreten Anwendungssituationen.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.