Erschienen in:
16.11.2018 | Original Paper
Mindfulness-based cognitive therapy (MBCT) in patients with obsessive–compulsive disorder (OCD) and residual symptoms after cognitive behavioral therapy (CBT): a randomized controlled trial
verfasst von:
Anne Katrin Külz, Sarah Landmann, Barbara Cludius, Nina Rose, Thomas Heidenreich, Lena Jelinek, Heike Alsleben, Karina Wahl, Alexandra Philipsen, Ulrich Voderholzer, Jonathan G. Maier, Steffen Moritz
Erschienen in:
European Archives of Psychiatry and Clinical Neuroscience
|
Ausgabe 2/2019
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Abstract
Up to one-third of individuals with obsessive–compulsive disorder (OCD) do not benefit from evidence-based psychotherapy. We examined the efficacy of mindfulness-based cognitive therapy (MBCT) as a complementary treatment option. In a prospective, bicentric, assessor-blinded, randomized, and actively controlled clinical trial, 125 patients with OCD and residual symptoms after cognitive behavioral therapy (CBT) were randomized to either an MBCT group (n = 61) or to a psychoeducational group (OCD-EP; n = 64) as an active control condition. At post-treatment, there was no significant benefit of MBCT over OCD-EP with the Yale-Brown-Obsessive–Compulsive Scale (Y-BOCS) as the primary outcome measure, but with the Obsessive–Compulsive Inventory [OCI-R; F(1, 101) = 5.679, p = .036, effect size η2partial = 0.053]. Moreover, the response rate and the improvement on secondary outcomes such as obsessive beliefs and quality of life was significantly larger in the MBCT group. Non-completion rates were below 10%. At the 6-month follow-up, OC symptoms were further improved in both groups; group differences were no longer significant. Our findings suggest that MBCT, compared to a psychoeducational program, leads to accelerated improvement of self-reported OC symptoms and secondary outcomes, but not of clinician-rated OC symptoms. In the midterm, both interventions yield similar and stable, but small improvements, suggesting that additional treatment options may be necessary.