The online version of this article (doi:10.1186/s12883-017-0832-3) contains supplementary material, which is available to authorized users.
Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities that have a detrimental effect on quality of life (QOL), but it is not clear whether MBIs can help. We systematically reviewed the literature to determine the effectiveness of MBIs in people with epilepsy.
Medline, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, Allied and Complimentary Medicine Database, and PsychInfo were searched in March 2016. These databases were searched using a combination of subject headings where available and keywords in the title and abstracts. We also searched the reference lists of related reviews. Study quality was assessed using the Cochrane Collaboration risk of bias tool.
Three randomised controlled trials (RCTs) with a total of 231 participants were included. The interventions were tested in the USA (n = 171) and China (Hong Kong) (n = 60). Significant improvements were reported in depression symptoms, quality of life, anxiety, and depression knowledge and skills. Two of the included studies were assessed as being at unclear/high risk of bias - with randomisation and allocation procedures, as well as adverse events and reasons for drop-outs poorly reported. There was no reporting on intervention costs/benefits or how they affected health service utilisation.
This systematic review found limited evidence for the effectiveness of MBIs in epilepsy, however preliminary evidence suggests it may lead to some improvement in anxiety, depression and quality of life. Further trials with larger sample sizes, active control groups and longer follow-ups are needed before the evidence for MBIs in epilepsy can be conclusively determined.
Additional file 1: MEDLINE with Full Text (OVID) search strategy. (DOCX 13 kb)12883_2017_832_MOESM1_ESM.docx
Kabat-Zinn J. Full catastrophe living: the program of the stress reduction clinic at the university of Massachusetts medical centre. New York: Delta; 1990.
Segal ZV, Williams JMG, Teasdale JD. Mindfulness- Based Cognitive Therapy for Depression. Second edn. New York: Guilford Press; 2012.
Lustyk M, Chawla N, Nolan R, Marlatt G. Mindfulness meditation research: issues of participant screening, safety procedures, and researcher training. Adv Mind Body Med. 2009;24(1):20–30. PubMed
Wood K, Lawrence M, Jani B, Simpson R, Mercer SW: Mindfulness based interventions in epilepsy. 2016. http://www.gla.ac.uk/researchinstitutes/healthwellbeing/research/generalpractice/research/mbsr-epilepsy/. Accessed 9 Dec 2016
Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. 2011. [updated March 2011] http://www.handbook.cochrane.org. Accessed 15 Mar 2016.
Thompson NJ, Walker ER, Obolensky N, Winning A, Barmon C, DiIorio C, Compton MT. Distance delivery of mindfulness-based cognitive therapy for depression: project UPLIFT. Epilepsy Behav. 2010;19(3):247–54. http://dx.doi.org/10.1016/j.yebeh.2010.07.031. CrossRefPubMed
Kabat-Zinn J. Mindfulness-based interventions in context: past, present, and future. Clin Psychol. 2003;10(2):144–56. doi: 10.1093/clipsy.bpg016.
Dahl JLT. Analysis and treatment of epilepsy using mindfulness, acceptance, values, and countermeasures. In: McCracken LM, editor. Mindfulness and acceptance in behavioral medicine. Oakland: New Harbinger Publications; 2011.
Kabat-Zinn J. Coming to our senses: healing ourselves and the world through mindfulness. New York: Hyperion; 2006.
Ramaratnam S, Baker GA, Goldstein LH. Psychological treatments for epilepsy. Cochrane Database Syst Rev. 2008(3):Cd002029. 10.1002/14651858.CD002029.pub3
Lundgren T, Dahl J, Yardi N, Melin L. Acceptance and commitment therapy and yoga for drug-refractory epilepsy: a randomized controlled trial. Epilepsy Behav. 2008;13(1):102–8. http://dx.doi.org/10.1016/j.yebeh.2008.02.009. CrossRefPubMed
Panjwani U, Gupta H, Singh S, Selvamurthy W, Rai U. Effect of Sahaja yoga practice on stress management in patients of epilepsy. Indian J Physiol Pharmacol. 1995;39:111. PubMed
- Mindfulness-based interventions in epilepsy: a systematic review
Stewart W. Mercer
- BioMed Central