Background
Acute Achilles tendon ruptures are frequent traumatic injuries with considerable morbidity [
1,
2]. It mainly occurs in male individuals during sports activities, such as tennis, badminton, soccer, and basketball [
1,
3]. The prevalence of Achilles tendon rupture is 18 per 100,000 per year and is still increasing because of a rise in the number of populations participating in sport activities [
2]. Achilles tendon rupture can be treated by nonsurgical or surgical [
4]. The majority of surgeons choose surgical repair for Achilles tendon rupture, because nonsurgical treatment is associated with a high risk of rerupture. In general, surgical treatments for Achilles tendon rupture include minimally invasive surgery (MIS) and open surgery (OS). Although surgical strategies have a rapid progress in recent years, the optimal surgical intervention for acute Achilles tendon ruptures is debatable [
5‐
7].
Several randomized clinical trials (RCTs) comparing MIS with OS for Achilles tendon ruptures have been performed. However, their findings are conflicting [
8‐
13]. In addition, although many meta-analyses of RCTs, representing the best evidence, have been published to compare these two procedures for treating acute Achilles tendon rupture, these overlapping meta-analyses also showed discordant findings [
14‐
17]. These inconsistent findings have resulted in uncertainty for decision-makers with respect to the surgical interventions of Achilles tendon rupture.
In recent years, systematic reviews of overlapping meta-analyses have been reported in many medical fields [
18‐
21]. These studies help to select the best evidence for decision-making by evaluating the overlapping meta-analyses on certain topic [
22]. However, to our knowledge, there is no systematic review of overlapping meta-analyses investigating the relative effects between MIS and OS for Achilles tendon rupture. Therefore, the present study aimed to carry out a systematic review of overlapping meta-analyses regarding MIS versus OS for acute Achilles tendon rupture, to assist decision-makers in selecting among conflicting meta-analyses, and to offer intervention recommendations according to the best evidence.
Methods
This study was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement [
23]. The design of this study was based on previous similar publications [
18‐
21].
Literature search
On August 10, 2015, the databases of PubMed, Embase, and Cochrane Library were systematically retrieved. The keywords were used, including Achilles, systematic review, and meta-analysis. The search strategy was independently conducted by two authors, with the restriction of English language. The references of the included studies were also checked to find possible meta-analyses. The titles and abstracts were first reviewed, and the full texts were acquired if the information was not enough. Disagreements were settled by discussion.
Eligibility criteria
The inclusion criteria were as follows: (1) comparing MIS with OS for acute Achilles tendon rupture, (2) a meta-analysis only comprising RCTs, and (3) at least one outcome, such as rerupture rate and functional outcome. The narrative review, meetings abstract, correspondence, meta-analysis comprising non-RCTs, and systematic review without meta-analysis conducted were excluded.
The following data was independently extracted by two authors: first author, year of publications, databases for search, primary study design, the number of RCTs, I
2 statistic value, and outcomes. Disagreements between the two authors were resolved by discussion.
Quality evaluation
The quality of meta-analysis was evaluated by the Oxford Levels of Evidence [
24] and the Assessment of Multiple Systematic Reviews (AMSTAR) instrument [
25]. AMSTAR is a methodological assessment with good reliability, validity, and responsibility [
26,
27]. It is widely used to evaluate the quality of meta-analysis [
20,
21]. The meta-analysis quality was individually evaluated by two authors. Disagreements between authors were settled by discussion.
Application of the Jadad decision algorithm
The Jadad decision algorithm was used to investigate the origin of inconsistence among systematic reviews, comprising medical question, eligibility criteria, data extraction, quality evaluation, data synthesis, and statistical analysis [
22]. It has been widely conducted to offer treatment recommendations among meta-analyses with discordant conclusions [
18‐
21]. This algorithm was independently applied by three authors, who reached a consensus regarding which meta-analysis offered the best evidence.
Discussion
Achilles tendon ruptures can be treated surgically using either MIS or OS [
3,
28‐
30]. In recent years, multiple meta-analyses have been conducted to assess the difference regarding MIS versus OS. However, discordant results were observed among these meta-analyses [
14‐
17], which complicated decision-makers. To solve this problem, systematic reviews of overlapping meta-analyses are increasingly published in medical fields [
18‐
21]. To our knowledge, this is the first systematic review of overlapping meta-analyses on the topic of MIS versus OS for acute Achilles tendon ruptures. In this study, four meta-analyses were included using a systematic literature review. Based on the Jadad decision algorithm, a high-quality meta-analysis with more RCTs was selected as the current best available evidence [
14].
We found that most of the meta-analyses comprehensively conducted the literature search within a similar period, but they did not include the same primary trials, and did not provide the same conclusion on the surgical intervention for acute Achilles tendon rupture [
14‐
17]. This phenomenon can be attributed to multiple factors, including the clinical question, study selection and inclusion, data extraction, quality evaluation, assessment of the ability to combine studies, and statistical methods for data pooling [
22]. A decision algorithm, which was adopted in this study, was designed to choose the high-quality level of evidence from currently discordant systematic reviews [
22]. This tool was widely used to find the best available evidence among overlapping systematic reviews [
18‐
21].
In this study, the meta-analysis by McMahon et al. [
14] was selected according to the Jadad decision algorithm. Their study demonstrated that there were no differences between MIS and OS with respect to rerupture, deep infection, deep vein thrombosis, adhesions, sural nerve injury, and subjective outcomes (fair). However, MIS was superior to OS in superficial infection and subjective outcomes (good to excellent). In other words, when comparing with OS, MIS could decrease the incidence of superficial infection and could improve subjective patient satisfaction, while not raising the risk of rerupture. Therefore, the best available evidence suggests that MIS may be superior to OS for the treatment of acute Achilles tendon rupture. This conclusion should be cautiously interpreted and confirmed by further well-designed RCTs due to the small sample size of the selected meta-analysis.
There are several limitations in this study. First, the literature search was limited to English papers. Non-English literature could not be included in this systematic review, despite that multiple databases were searched. Second, in order to get the best available evidence, only meta-analyses of RCTs were comprised. Nevertheless, all the included studies were Level-II evidence. Therefore, this systematic review could not offer treatment recommendations based on Level-I evidence.
Conclusions
Based on the systematic review of overlapping meta-analyses regarding MIS versus OS for acute Achilles tendon rupture, MIS may be superior to OS for treating acute Achilles tendon rupture. However, large and high-quality RCTs are still needed to confirm this finding due to the limitations of the current evidence.
Abbreviations
AMSTAR Assessment Of Multiple Systematic Reviews, MIS minimally invasive surgery, OS open surgery, PRISMA, Preferred Reporting Items For Systematic Reviews And Meta-Analysis, RCTs randomized controlled trials
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