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Lasers in Medical Science

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05.09.2019 | Original Article

miR-548b-3p functions as a tumor suppressor in lung cancer

verfasst von: Zhenlin Wang, Xingfu Wu, Xiangwei Hou, Wenqiu Zhao, Cheng Yang, Wei Wan, Lixia Chen

Erschienen in: Lasers in Medical Science | Ausgabe 4/2020

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Abstract

miR-548-3p is one of the members of miR-548 family, a large primate-specific miRNA gene family. The role of miR-548-3p in lung cancer was less studied. In this study, we found the expression of miR-548-3p was lower both in clinical tumor specimens and lung cancer cells compared with normal controls. In vitro, miR-548-3p inhibited lung cancer cell growth and promoted cell apoptosis at the S stage of cell cycle. The underlying mechanism of miR-548b-3p-induced cell proliferation inhibition and apoptosis may be associated with the inhibition of PI3K/AKT signaling pathway. In vivo, miR-548b-3p also suppressed tumor growth in xenografts model of lung cancer cells. Our results indicated that miR-548b-3p might be an anti-tumor target of lung cancer in the future.

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Titel: miR-548b-3p functions as a tumor suppressor in lung cancer
verfasst von: Zhenlin Wang
Xingfu Wu
Xiangwei Hou
Wenqiu Zhao
Cheng Yang
Wei Wan
Lixia Chen
Publikationsdatum: 05.09.2019
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 4/2020
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-019-02865-7

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

miR-548b-3p functions as a tumor suppressor in lung cancer

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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