Background
Methods
Data collection
Statistics
Results
Description N (%) or Median [IQR] | Pre-PrEP area infections N = 741 | PrEP area infections N = 225 | Total N = 966 |
p
|
---|---|---|---|---|
Socio-demographic characteristics | ||||
Age (years) | 37 [29–47] | 33 [26–44] | 36 [29–46] | 0.001 |
Sex | ||||
Male | 507 (68.42) | 202 (89.78) | 709 (73.40) |
<.0001
|
Female | 234 (31.58) | 23 (10.22) | 257 (26.60) | |
Birth area | ||||
West or central Africa | 213 (34.98) | 20 (11.30) | 233 (29.64) |
<.0001
|
France | 238 (39.08) | 128 (72.32) | 366 (46.56) | |
Other | 158 (25.94) | 29 (13.37) | 187 (23.79) | |
HIV transmission route | ||||
MSM | 281 (37.97) | 168 (76.02) | 449 (46.72) |
<.0001
|
Heterosexual | 365 (49.32) | 45 (20.36) | 410 (42.66) | |
Other | 94 (12.70) | 8 (3.62) | 102 (10.61) | |
CDC Stage | ||||
A | 490 (78.03) | 194 (96.04) | 684 (82.41) |
<.0001
|
B | 37 (5.89) | 7 (3.47) | 44 (5.30) | |
C | 101 (16.08) | 1 (0.50) | 102 (12.29) | |
Biological data at HIV-diagnosis | ||||
HIV viral load (log cp/ml) | 4.92 [4.05–5.60] | 5.50 [4.45–6.40] | 5.20 [4.30–6.00] | <.0001 |
CD4 (cell count/mm3) | 347 [155–520] | 480 [334–635] | 378 [202–555] |
<.0001
|
CD4 (cell count /mm3) | ||||
≤200 | 205 (30.73) | 14 (6.60) | 219 (24.91) |
<.0001
|
200–350 | 135 (20.24) | 46 (21.70) | 181 (20.59) | |
350–500 | 145 (21.74) | 59 (27.83) | 204 (23.21) | |
>500 | 182 (27.29) | 93 (43.87) | 275 (31.29) | |
HCV antibodies | ||||
Negative | 565 (96.42) | 189 (97.93) | 754 (96.79) |
0.30
|
Positive | 21 (3.58) | 4 (2.07) | 25 (3.21) | |
HBV AgHbs | ||||
Negative | 570 (95.80) | 195 (98.98) | 765 (96.59) |
0.03
|
Positive | 25 (4.20) | 2 (1.02) | 27 (3.41) | |
HVA antibodies | ||||
Negative | 179 (37.45) | 105 (63.25) | 284 (44.10) |
<.0001
|
Positive | 299 (62.55) | 61 (36.75) | 360 (55.90) | |
Syphilis serology | ||||
Negative | 340 (79.63) | 98 (65.33) | 438 (75.91) | 0.0004 |
Positive | 87 (20.37) | 52 (34.67) | 139 (24.09) | |
History of other sexuality transmitted disease (STI): N = 348 | ||||
Syphilis | ||||
No | 177 (91.24) | 110 (71.43) | 287 (82.47) | <.0001 |
Yes | 17 (8.76) | 44 (28.57) | 61 (17.53) | |
Gonorrhea | ||||
No | 187 (96.39) | 134 (87.01) | 321 (92.24) | 0.001 |
Yes | 7 (3.61) | 20 (12.99) | 27 (7.76) | |
Chlamydia | ||||
No | 191 (98.45) | 141 (91.56) | 332 (95.40) | 0.002 |
Yes | 3 (1.55) | 13 (8.44) | 16 (4.60) | |
Number of STIs | ||||
0 | 160 (82.47) | 92 (59.74) | 252 (72.41) |
<.0001
|
1 | 29 (14.95) | 40 (25.97) | 69 (19.83) | |
≥2 | 5 (2.58) | 22 (14.29) | 27 (7.76) |
PrEP area vs pre-PrEP area infected patients
Eligible for PrEP vs non-eligible among patients infected in the PrEP area
N (%) or Median [IQR] | Not eligible for PrEP (n = 11) | Eligible for PrEP. (n = 110) | PrEP area infection (n = 121) |
p
|
---|---|---|---|---|
Socio-demographic characteristics | ||||
Age (years) | 31 [29; 38] | 31 [25; 44] | 31 [25; 41] | 0.74 |
<25 years | 1 (9.09) | 25 (22.73) | 26 (21.49) | 0.61 |
[25–35] | 6 (54.55) | 41 (37.27) | 47 (38.84) | |
[35–45[ | 3 (27.27) | 18 (16.36) | 21 (17.36) | |
[45–55[ | 1 (9.09) | 18 (16.36) | 19 (15.70) | |
≥55 years | 0 (00) | 8 (7.27) | 8 (6.61) | |
Sex | ||||
Male | 6 (54.55) | 104 (94.55) | 110 (90.91) | 0.001a |
Female | 5 (45.45) | 6 (5.45) | 11 (9.09) | |
Birth area | ||||
West or central Africa | 1 (11.11) | 9 (11.11) | 10 (11.11) | 0.85 |
France | 6 (66.67) | 62 (76.54) | 68 (75.56) | |
Other | 2 (22.22) | 10 (12.35) | 12 (13.33) | |
HIV transmission route | ||||
MSM | 4 (36.36) | 91 (85.85) | 95 (81.20) | 0.001a |
Heterosexual | 6 (54.55) | 13 (12.26) | 19 (16.24) | |
Other | 1 (9.09) | 2 (1.89) | 3 (2.56) | |
Primary HIV infection | ||||
No | 6 (54.55) | 53 (48.18) | 59 (48.76) |
0.76
|
Yes | 5 (45.45) | 57 (51.82) | 62 (51.24) | |
Biological data at HIV diagnosis | ||||
HIV viral load (log/ml) | 5.6 [4.7; 5.9] | 5.4 [4.4; 6.4] | 5.4 [4.3; 6.3] | 0.64 |
CD4 (cell count /mm3) | 470 [340; 650] | 478 [328; 635] | 480 [340; 641] | 0.46 |
CD4 (%) | 19 [14–25] | 26 [20–34] | 25 [19–33] | 0.05 |
HCV antibodies | ||||
Negative | 9 (100.00) | 93 (97.89) | 102 (98.08) |
1
a
|
Positive | 0 (0.00) | 2 (2.11) | 2 (1.92) | |
HBV AgHbs | ||||
Negative | 9 (100.00) | 93 (97.89) | 102 (98.08 |
1
a
|
Positive | 0 (0.00) | 2 (2.11) | 2 (1.92) | |
HAV antibodies | ||||
Negative | 6 (100.00) | 51 (66.23) | 57 (68.67) |
0.17
a
|
Positive | 0 (0.00) | 26 (33.77) | 26 (31.33) | |
Syphilis serology | ||||
Negative | 7 (100.00) | 40 (60.61) | 47 (64.38) |
0.05
|
Positive | 0 (0.00) | 26 (39.39) | 26 (35.62) | |
History of other sexuality transmitted diseases (STI) | ||||
Syphilis | ||||
No | 10 (90.91) | 77 (70.00) | 87 (71.90) |
0.18
|
Yes | 1 (9.09) | 33 (30.00) | 34 (28.10) | |
Gonorrhea | ||||
No | 10 (90.91) | 96 (87.27) | 106 (87.60) |
1
a
|
Yes | 1 (9.09) | 14 (12.73) | 15 (12.40) | |
Chlamydia | ||||
No | 11 (100.00) | 99 (90.00) | 110 (90.91) |
0.60
a
|
Yes | 0 (0.00) | 11 (10.00) | 11 (9.09) | |
Number of STIs | ||||
0 | 10 (90.91) | 62 (56.36) | 72 (59.50) | 0.06a |
1 | 0 (0.00) | 30 (27.27) | 30 (24.79) | |
≥2 | 1 (9.09) | 18 (16.36) | 19 (15.70) |
Distribution of PrEP eligibility criteria among patients eligible for PrEP
Men who have sex with men or transgender and at least one of these criteria | 91 (82.7) |
- Unprotected anal intercourse with at least two different partners in the last 6 months | 67 (60.9) |
- Incident of sexually transmitted infection (STI) in the last 12 months | 33 (30.0) |
- Several uses of Post-Exposure Prophylaxis in the last 12 months | 1 (0.9) |
- Use of psychoactive drugs during sexual intercourse | 16 (14.5) |
Other persons who are at substantial risk of HIV acquisition among whom PrEP can be considered case by case | 25 (22.7) |
- Person in situation of prostitution submitted to non-protected sexual intercourse | 4 (3.6) |
- Person in a situation of vulnerability exposed to non-protected sexual intercourse with a person belonging to a group with a high HIV prevalence: ✓ native of a high HIV prevalence area ✓ who has multiple sexual partners ✓ who injects drug | 13 (11.8) 8 (7.3) 4 (3.6) 1 (0.9) |
- Person who has non-protected sexual intercourse with persons with physical factors increasing HIV risk transmission to the exposed person (anal or genital ulceration, associated STI, bleeding) | 3 (2.7) |
- Other situations judged at high risk of HIV acquisition by sexual way: ✓ Migrant in precarious situation, probably exposed to non-consensual sex ✓ HIV seropositive partner not previously detected ✓ HIV seropositive regular partner (treated with no HIV viral load data) ✓ Untreated HIV seropositive partner ✓ MSM reports with excessive alcohol use during non-protected sexual intercourse | 5 (4.5) 1 (0.9) 1 (0.9) 1 (0.9) 1 (0.9) 1 (0.9) |