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Inflammation

Erschienen in:

30.06.2018 | REVIEW

Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases

verfasst von: Yan Zhao, Shaohui Huang, Jie Liu, Ximing Wu, Shuai Zhou, Ke Dai, Yurong Kou

Erschienen in: Inflammation | Ausgabe 5/2018

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Abstract

Mitophagy is a metabolic process to remove excessive or damaged mitochondria in eukaryotic cells. It is well-known that mitochondria are one of the major sources of reactive oxygen species (ROS). Mitochondrial ROS and damage-associated molecular patterns (DAMPs) can activate inflammasomes to induce inflammatory responses. Once the activation is regulated improperly, excessive inflammation will bring about various tissue injuries, resulting in a series of diseases. However, the selective mitochondrial autophagy can specifically eliminate dysfunctional mitochondria to maintain mitochondrial homeostasis and protect against the hyperinflammation induced by ROS and DAMPs. Recent studies demonstrated that a variety of internal and external factors regulate several inflammatory diseases via altering the level of mitophagy. In this review, we summarize the latest research progress of mitophagy and focus on the inflammatory responses regulated by mitophagy, aiming to illuminate the role of mitophagy in inflammation and provide clues to the diagnosis and therapy of inflammatory diseases.

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Titel: Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases
verfasst von: Yan Zhao
Shaohui Huang
Jie Liu
Ximing Wu
Shuai Zhou
Ke Dai
Yurong Kou
Publikationsdatum: 30.06.2018
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 5/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-018-0835-2

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Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases

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