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Erschienen in: Neurological Sciences 9/2016

01.09.2016 | Brief Communication

Mobitz type I and II atrioventricular blocks during fingolimod therapy

verfasst von: Francesco Saccà, Giorgia Puorro, Angela Marsili, Chiara Pane, Cinzia Valeria Russo, Roberta Lanzillo, Anna de Rosa, Antonio Cittadini, Giuseppe De Angelis, Vincenzo Brescia Morra

Erschienen in: Neurological Sciences | Ausgabe 9/2016

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Abstract

We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Three patients showed persistence of the S-AVB, with resolution on the second or third day. One patient had a persistent S-AVB up to the fourth day when fingolimod was discontinued. We conclude that Mobitz type II S-AVB is possible during fingolimod therapy. Patients with S-AVB could be monitored until resolution of the S-AVBs, as these may persist several days after the first fingolimod administration.
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Literatur
1.
Zurück zum Zitat Kappos L, Radue EW, O’Connor P et al (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362:387–401CrossRefPubMed Kappos L, Radue EW, O’Connor P et al (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362:387–401CrossRefPubMed
3.
Zurück zum Zitat Schmoulder R, Serra D, Wang Y et al (2006) FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects. J Clin Pharmacol 46:895–904CrossRef Schmoulder R, Serra D, Wang Y et al (2006) FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects. J Clin Pharmacol 46:895–904CrossRef
4.
Zurück zum Zitat Laroni A, Brogi D, Morra VB et al (2014) Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. BMC Neurol 14:65CrossRefPubMedPubMedCentral Laroni A, Brogi D, Morra VB et al (2014) Safety of the first dose of fingolimod for multiple sclerosis: results of an open-label clinical trial. BMC Neurol 14:65CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Gold R, Comi G, Palace J et al (2014) Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study. J Neurol 261:267–276CrossRefPubMed Gold R, Comi G, Palace J et al (2014) Assessment of cardiac safety during fingolimod treatment initiation in a real-world relapsing multiple sclerosis population: a phase 3b, open-label study. J Neurol 261:267–276CrossRefPubMed
6.
Zurück zum Zitat Silverman ME, Upshaw CB Jr, Lange HW (2004) Woldemar Mobitz and His 1924 classification of second-degree atrioventricular block. Circulation 110:1162–1167CrossRefPubMed Silverman ME, Upshaw CB Jr, Lange HW (2004) Woldemar Mobitz and His 1924 classification of second-degree atrioventricular block. Circulation 110:1162–1167CrossRefPubMed
Metadaten
Titel
Mobitz type I and II atrioventricular blocks during fingolimod therapy
verfasst von
Francesco Saccà
Giorgia Puorro
Angela Marsili
Chiara Pane
Cinzia Valeria Russo
Roberta Lanzillo
Anna de Rosa
Antonio Cittadini
Giuseppe De Angelis
Vincenzo Brescia Morra
Publikationsdatum
01.09.2016
Verlag
Springer Milan
Erschienen in
Neurological Sciences / Ausgabe 9/2016
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-016-2621-y

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