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Erschienen in: Breast Cancer Research 1/2010

01.05.2010 | Poster presentation

Modelling breast cancer in a three-dimensional heterotypic culture system

verfasst von: DL Holliday, S Maltby, MA Moss, AM Hanby, JL Jones, V Speirs

Erschienen in: Breast Cancer Research | Sonderheft 1/2010

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Excerpt

Microenvironmental factors are fundamental in the regulation of normal and tumour breast tissue. Two cell types have been implicated in having opposing effects on breast tumour cell behaviour: myoepithelial cells exhibit broad tumour-suppressor activity, whilst fibroblasts frequently promote tumour growth and invasion. Previous work has described the development of a physiologically relevant three-dimensional heterotypic culture system containing tumour, myoepithelial and fibroblast cells. The data showed organisation of the cells into co-unit structures recapitulating ductal carcinoma in situ breast, with homing of myoepithelial cells around luminal cells, and highlighted a central role for tumour-associated fibroblasts in disrupting ductal carcinoma in situ structures. This study describes further manipulation of the model to include tumour cells that represent the heterogeneity of breast cancer. …
Metadaten
Titel
Modelling breast cancer in a three-dimensional heterotypic culture system
verfasst von
DL Holliday
S Maltby
MA Moss
AM Hanby
JL Jones
V Speirs
Publikationsdatum
01.05.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 1/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2556

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