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Erschienen in: European Journal of Nutrition 3/2016

24.05.2015 | Original Contribution

Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice

verfasst von: Giridhar Kanuri, Marianne Landmann, Josephine Priebs, Astrid Spruss, Marina Löscher, Doreen Ziegenhardt, Carolin Röhl, Christian Degen, Ina Bergheim

Erschienen in: European Journal of Nutrition | Ausgabe 3/2016

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Abstract

Purpose

Using ob/ob mice as a model of non-alcoholic fatty liver disease (NAFLD), we investigated the effect of moderate alcohol intake on the development of NAFLD and molecular mechanisms involved.

Methods

Ob/ob mice were fed water or ethanol solution (2.5 g/kg body weight/day) for 6 weeks, and markers of liver injury, insulin signalling and adiponectin in visceral adipose tissue were determined.

Results

Whereas bodyweight and the degree of liver steatosis did not differ among ob/ob mouse groups, those consuming ethanol had markedly less macrovesicular hepatic fat accumulation, inflammatory alterations and significantly lower transaminase levels. Despite similarly elevated protein levels of tumour necrosis factor α, protein concentrations of plasminogen activator inhibitor 1 were significantly lower in livers of ob/ob mice consuming ethanol in comparison with controls. The hepato-protective property of moderate alcohol ingestion in ob/ob mice was associated with an induction of the sirtuin-1/adiponectin-signalling cascade in visceral fat tissue and an activation of Akt in the liver. Similar effects of moderate alcohol exposure were also found in vitro in 3T3-L1 and AML-12 cells.

Conclusion

These data suggest that moderate alcohol intake may diminish the development of NAFLD through sirtuin-1/-adiponectin-dependent signalling cascades.
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Metadaten
Titel
Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice
verfasst von
Giridhar Kanuri
Marianne Landmann
Josephine Priebs
Astrid Spruss
Marina Löscher
Doreen Ziegenhardt
Carolin Röhl
Christian Degen
Ina Bergheim
Publikationsdatum
24.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 3/2016
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-015-0929-7

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