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03.01.2021 | Original Article

Modification of erythrogram, testosterone and prolactin profiles in jacks following experimental infection with Trypanosoma congolense

verfasst von: Samuel Uchenna Felix, Kolo Ndabatsado Hyacinth, Mathew Shinkut, Echekwu Ochife Wilson, Idris Yusuf Sheriff, Kolawole Bamidele J, Chiezey Ngozi Paulin, Rekwot Ibrahim Peter

Erschienen in: Comparative Clinical Pathology | Ausgabe 1/2021

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Abstract

Equine trypanosomosis, a haemoparasitic disease leads to anaemia, low testosterone and prolactin levels. The aim of this study was to examine the effect of experimental Trypanosoma congolense (T. congolense) infection in jacks on erythrogram, testosterone and prolactin profiles. Four apparently healthy jacks aged 6–7 years, housed in fly-proof stables, were used for this study. To establish infection, they were, each, intravenously inoculated with 2 ml of blood from infected donor jack containing 2.0 × 10⁶ trypanosomes. Daily rectal temperatures were measured, for 2 weeks pre-infection and 4 weeks post-infection. Parasitaemia was measured daily and scored. Blood of 3 ml was collected from jugular venipuncture, twice in a week at 09:00 h for 2 weeks pre-infection and 4 weeks post-infection and 1 ml is used for erythrogram analysis, while 2 ml was used for testosterone and prolactin assay using competitive enzyme-linked immunosorbent assay kits (ELISA). T. congolense infection, caused by variation of rectal temperatures, from day 4 post-infection, were significantly higher (P < 0.05) than those of pre-infection. Parasitaemia was detected on day 3 post-infection reaching peak on day 9 post-infection. There was a significant decrease in packed cell volume (PCV), haemoglobin concentration (Hgb) and red blood cell count (RBC) (P < 0.05) from pre-infection to post-infection. The average mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) decreased non-significantly (P > 0.05) from day 5 post-infection compared to pre-infection period. The mean average testosterone decreased significantly (P < 0.05) from day 5 post-infection, throughout the experimental period compared to pre-infection values; also the mean average prolactin increased significantly (P < 0.05) from day 5 post-infection compared to pre-infection values. It was concluded that experimental T .congolense infection in jacks altered testosterone, prolactin and erythrogram.

Abdelmoneim A, Bakr A, Naif A, Mohamed A, Mohamed G, Ahmed NFN (2020) Pathological and molecular detection of a rare case of cutaneous cryptococcosis in a 9-year-old horse. Comp Clin Pathol 29:883–886

Abebe GR, Eley RM, Kole-Moiyoi O (1993) Reduced responsiveness of the hypothalamic-pituitary-gonadal axis in Boran cattle infected with T. congolense. Acta Endocrinol 129:74–80

Adamu S, Abiodun AI, Jatau ID, Neils JS, Useh NM, Bisalla M, Ibrahim NDG, Nok AJ, Esievo KAN (2008) Changes in the serum profiles of lipids and cholesterol in sheep experimental model of acute African trypanosomosis. Afr J Biotechnol 7:2090–2098

Adamu S, Barde N, Abenga JN, Useh NM, Ibrahim NDG, Esievo KAN (2009) Experimental Trypanosoma brucei infection-induced changes in the serum profiles of lipids and cholesterol and the clinical implications in pigs. J Cell Anim Biol 3:015–020

Adenowo TK, Njoku CO, Oyedipe EO, Sanusi A (2005) Lesions of the hypothalamus, hypophysis and the ovaries in Trypanosoma vivax-infected Yankas ewes. Niger Vet J 26:56–62

Ahmed SK, Rahman AH, Hassan MA, Salih SEM, Paone M, Cecchi G (2016) An atlas of tsetse and bovine trypanosomosis in Sudan. Parasit Vectors 9:194PubMedPubMedCentral

Ahmed NFN, Abdelmoneim AA, Essam AM (2020) Jeopardy of Lyssavirus infection in relation to hemato-biochemical parameters and diagnostic markers of cerebrospinal fluid in rabid calves. Comp Clin Pathol 29:553–560

Akanji MA, Adeyemi OS, Oguntoye SO, Sulyman F (2009) Psidium guajava extract reduces trypanosomosis associated lipid peroxidation and raises glutathione concentrations in infected animals. EXCLI J 8:148–154

Amany AMA, Nasr AMN, Ahmed NFN, Heba IA (2019) Evaluation of the hematoprotective and hepato-renal protective effects of Thymus vulgaris aqueous extract on thermally oxidized oil-induced hematotoxicity and hepato-renal toxicity. Comp Clin Pathol 29:451–461

Amany AMA, Nasr AMN, Heba IA, Ahmed NFN (2020) Effect of the aqueous root extract of Curcuma longa L. (turmeric) against thermally oxidized oil-induced hematological, biochemical and histopathological alterations. Comp Clin Pathol 29:837–845

Anosa VO, Isoun TT (1980) Haematological studies on Trypanosoma vivax infection of goats and splenectomized sheep. J Comp Pathol 90:153–168

Batista JS, Riet-Correa F, Teixeira MM, Madruga CR, Simões SD, Maia TF (2007) Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: description of an outbreak and lesions in the nervous system. Vet Parasitol 31:174–181

Bernard V, Young J, Binart N (2019) Prolactin- a pleiotropic factor in health and disease. Nat Rev Endocrinol 15(6):356–365PubMed

Blench R, de Jode A, Gherzi E (2004) Donkeys in Nigeria: history, distribution and productivity. Donkeys, People and Development: A Resource Book of Animal Traction Network for Eastern and Southern Africa (ATNESA). ACP-EU Technical Centre for Agricultural and Rural Cooperation (CTA), Wageningen, p 244

Blench R, De Jode A, Gherzi E (2013) Donkeys in Nigeria: history, distribution and productivity. A Resource Book of the Animal Traction Network for Eastern and Southern Africa (ATNESA). ACP-EU Technical Centre for Agricultural and Rural Cooperation (CTA), Wageningen, The Netherlands, 244 pp

Blood DC, Radostits OM (2007, 2004) Veterinary medicine: a textbook of diseases of cattle, sheep, pigs, goats and horses, 10th edition. Bailliere Tindall

Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 19:225–268PubMed

Boly H, Humblot P, Tillet Y, Thibier M (1994) Effects of Trypanosoma congolense infection on the pituitary gland of Baoule bulls: immunohistochemistry of LH- and FSH-secreting cells and response of plasma LH and testosterone to combined dexamethasone and GnRH treatment. J Reprod Fertil 100:157–162PubMed

Büscher P, Gonzatti MI, Hébert L, Inoue N, Pascucci I, Schnaufer A (2019) Equine trypanosomosis: enigmas and diagnostic challenges. Parasit Vectors 12:234–240PubMedPubMedCentral

Clark BJ, Prough RA, Klinge CM (2018) Mechanism of action of dehydroepiandrosterone. Vitam Horm 108:29–73PubMed

Coetzer JAW, Tustin RC (2005) Infectious diseases of livestock. 2nd ed. Oxford University Press, Oxford

Cole EH (1974) Veterinary clinical pathology. (2nd Edition). W.B. sanders Co, Philadelphia, pp 110–116

Croos GAM (2003) Antigenic variation in African trypanosomes and malaria. In: Marr JJ, Nilsen TW, Komuniecky RW (eds) Molecular medical parasitology. Academic Press, San Diego, pp 82–110

Déthié F, José S, Yaghouba K, Jean-Francois B, Stephen L, Yalace K, Noelita Melo de S, Bertrand L, Stanny G (2001) Effects of an experimental Trypanosoma congolense infection on the reproductive performance of West African Dwarf goats. Vet Parasitol 101:101–114

Dimpho MM, Ruishan C (2020) Telecoupling of the trade of donkey-hides between Botswana and China: challenges and opportunities. Sustainability 12:1–10

Dombrowicz D, Sente B, Closset J, Hennen G (1992) Dose-dependent effects of human prolactin on the immature hypophysectomized rat testis. Endocrinol 130:695–700

Emery DL, Moloo SK (1981) The dynamic of the cellular reactions elicited in the skin of goats by Glossina morsitans morsitans infected with Trypanosoma (Nannomonas) congolense or Trypanosoma (Duttonella) vivax. Acta Trop 38:15–28PubMed

Essam AM, Walaa ME, Ahmed NFN (2020) Influence of uterine torsion in water buffaloes (Bubalus bubalis) with insights into the hematological and biochemical prognostic values regarding to manual correction Trop. Anim Health Prod 52:3165–3171

Food and Agriculture Organization (2016) Available online: ttp://www.fao.org/faostat/en/#home (accessed on 12 Nov 2019)

Food and Agriculture Organization Corporate Statistical Database (2013) FAO statistical database. Food and Agricultural Organisation of the United Nations, Retrieved from http://faostat.fao.org/

Grattan DR, Jasoni CL, Liu X, Anderson GM, Herbison AE (2007) Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocr 148:4344–4351

Grubb P (2005) Order Perissodactyla. In: Wilson DE, Reeder DM (eds) Manual species of the world: a taxonomic and geographic reference (3rd ed). John’s Hopkins University Press, pp 625–630

Guegan F, Plazolles N, Baltz T, Coustou V (2013) Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during Trypanosoma vivax infection. Cell Microbiol 15:1285–1303PubMed

Hassan MR, Steenstra FA, Udo HMJ (2013) Benefits of donkeys in rural and urban areas in northwest Nigeria. Afr J Agric Res 8:6202–6212

Healy VM, Boyd GW, Gutierrez PH, Mortimer RG, Piotrowski JR (1993) Investigating optimal bull:heifer ratios required for estrous-synchronized heifers. J Anim Sci 71:291–297PubMed

Hoehn K, Marieb EN (2007) Human anatomy and physiology. Pearson Benjamin Cummings, San Francisco, p 605

Holmes PH (1976) The use of radioisotopic tracers techniques in the study of the pathogenesis of trypanosomiasis. In: Nuclear techniques in animal production and health. IAEA, Vienna, pp 463–474

Horn D (2014) Antigenic variation in African trypanosomes. Mol Biochem Parasitol 195:123–129PubMedPubMedCentral

Igbokwe IO (1994) Mechanisms of cellular injury in African trypanosomiasis. Vet Bull 64:611–620

Imam SM, Seri HI, Hassan T, Tijani TA, Zolain HB, Abakar AD (2010) Therapeutic efficacy evaluation of anthelmintics activity of albendazole and ivermectin drench formulations in donkeys in Darfur, Sudan. Vet Arhiv 80:585–595

International Commission on Zoological Nomenclature (2003) Usage of 17 specific names based on wild species which are pre-dated by or contemporary with those based on domestic animals (Lepidoptera, Osteichthytes, Mammalia): conserved. Opinion 2027 (Case 3010). Bull Zool Nomencl 60:81–84

Irungu P, Nyamwaro SO, Masiga DK (2002) Financial implications of rearing sheep and goat under natural trypanosomosis challenge at Galana ranch, Kenya. Trop Anim Health Prod 34:503–513

Itard J (1989) African Animal Trypanonosomoses. In: Manual of Tropical Veterinary Parasitology, Translated by M. Shah-Fischer and R. Ralph Say.Vol. 1. CAB International, Wallingford. p177–264

Jill de G, Giuliano C, Massimo PPD, Weining Z (2020) The continental atlas of tsetse and African animal trypanosomosis in Nigeria. Acta Trop 204:105328. https://doi.org/10.1016/j.actatropica.2020.105328CrossRef

Johnson BH, Welsh TH, Juniewicz PE (1982) Suppression of luteinizing hormone and testosterone secretion in bulls following adrenocorticotropin hormone treatment. Biol Reprod 26:305–310PubMed

Katunguka-Rwakishaya E, Murray M, Holmes PH (1992) The pathophysiology of ovine trypanosomiasis: ferrokinetics and erythrocyte survival studies. Res Vet Sci 53:80–86PubMed

Khisk WH (2008) Interrelationship between ram plasma testosterone level and some semen characteristics. Slov J Anim Sci 41:67–71

Koike K, Hirota K, Ohmichi M, Kadowaki K, Ikegami H, Yomaguchi M, Miyake A, Tanizawa O (1991) Tumour necrosis factor and increase release of arachidonate and prolactin from rat anterior pituitary cells. Endocrinology 128:2791–2798PubMed

Litrap RM, Raeside JI (1975) Increase in plasma testosterone concentration after injection of adrenocorticotrophin into the boar. J Endocrinol 66:123–131

Logan-Henfrey LL, Gardiner PR, Mahmoud MM (1992) Animal trypanosomiasis in sub-Saharan Africa. In: Kreier JP, Baker J (eds) Parasitic protozoa, vol 2. Academic Press, San Diego, pp 157–276

Mamo E, Holmes PH (1975) The erythrokinetics of Zebu cattle infected with Trypanosoma congolense. Res Vet Sci 18:105–106PubMed

Mamoudou A, Payne VK, Sevidzem SL (2015) Haematocrit alterations and its effects in naturally infected indigenous cattle breeds due to Trypanosoma spp. on the Adamawa Plateau – Cameroon. Vet Wrld 8:813–818

Masake RA, Nantulya VM, Akol GWO, Musoke AJ (1984) Cerebral trypanosomiasis in cattle infected with mixed Trypanosoma congolense and T. brucei infections. Acta Trop 41:237–246PubMed

Maudlin I (2006) Centennial review: African trypanosomiasis. Ann Trop Med Parasitol 100:679–701PubMed

Mbaya AW, Ibrahim UI, Apagu ST (2010) Trypanosomosis of the dromedary camel (Camelus dromedarius) and its vectors in the tsetse-free arid zone of northeastern, Nigeria. Niger Vet J 31(3):195–200

Mohamed AH, Ahmed NFN, Mohamed AG (2018) A study on bovine babesiosis and treatment with reference to hematobiochemical and molecular diagnosis. Slov Vet Res 55(20):165–173

Murray M (1989) Factors affecting duration and intensity of trypanosomes infection of domestic animals. Ann Soc Med Trop 69:189–196

Mutayoba BM, Eckersall PD, Jeffcoate IA, Cestnik V, Holmes PH (1994) Effect of Trypanosoma congolense infection in ram on the pulsative secretion of LH and testosterone and responses to injection of GnRH. J Reprod Fertil 102:425–431PubMed

Naylor AM, Porter DWF, Lincoln DW (1990) Central administration of corticotrophin-releasing factor in the sheep: effects on secretion of gonadotrophins, prolactin and cortisol. J Endocrinol 124:117–125PubMed

Noakes DE, Parkinson TJ, England GC (2009) Veterinary reproduction and obstetrics. 9^th edn 868 pp. China: Elsevier

Paiva F, Lemos RAA, Nakazato L, Mori AE, Brum B, Bernardo KC (2000) Trypanosoma vivax em bovinos no pantanal do estado do Mato Grosso do Sul, Brasil: I: acompanhamento clínico, laboratorial e anatomopatológico de rebanhos infectados. Rev Bras Parasitol Vet 9:135–141

Paris J, Murray M, Mcodimba F (1982) A comparative evaluation of the parasitological techniques currently available for the diagnosis of African trypanosomiasis in cattle. Acta Trop 39:307–317PubMed

Prasanna R, Ashraf EA, Essam MA (2017) Chamomile and oregano extracts synergistically exhibit antihyperglycemic, antihyperlipidemic, and renal protective effects in alloxan-induced diabetic rats. Can J Physiol Pharmacol 95:84–92PubMed

Preston JM, Wellde BT, Kovatchi RM (1975) Trypanosoma congolense: calf erythrocyte survival. Exp Parasitol 48:118–125

Pritchard JC, Burn CC, Barr AR, Whay HR (2009) Haematological and serum biochemical reference values for apparently healthy working horses in Pakistan. Res Vet Sci 87:389–395PubMed

Raftery AG, Jallow S, Rodgers J, Sutton DGM (2019) Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. PLoS Negl Trop Dis 13:71–75

Ramnath V, Rekha PS, Sujatha KS (2008) Amelioration of heat stress induced disturbances of antioxidant defence system in chicken by Brahma Rasayana. Evid Based Complement Alternat Med 5:77–84PubMed

Reincke M, Arlt W, Heppner C, Petzke F, Chrousos GP, Allolio B (1998) Neuroendocrine dysfunction in African trypanosomiasis - the role of cytokines. Ann NY Acad Sci 840:809–821PubMed

Rivier CL, Rivier J, Vale W (1986) Stress-induced inhibition of reproductive function: role of endogenous corticotropin-releasing factor. Sci. 231:607–609

Samdi SM, Abenga JN, Attahir A, Haruna MK, Wayo BM, Fajinmi AO, Sumayin HM, Usman AO, Hussaina JZ, Muhammad H, Yarnap JE, Ovbagbedia RP, Abdullahi RA (2010) Impact of trypanosomosis on food security in Nigeria: a review. Int J Anim Vet Adv 2:47–50

Samuel FU, Adamu S, Bisalla M, Chiezey NP, Mohammed AK, Bello TK, Ibrahim AM, Ereke SO, Magaji HJ, Maikaji FS (2016) Effect of T. congolense on haematological parameters in experimentally infected donkeys. J Anim Prod Res 28:14–24

Samuel FU, Adamu S, Bisalla M, Chiezey PN, Mohammed AK, Ereke SO, Ibrahim MA (2018) Effect Of experimental Trypanosoma congolense infection on serum profiles of lipid and cholesterol in pack donkeys. Niger Vet J 39:57–65

Sekoni VO, Rekwot PI, Bawa EK (2004) Effect of Trypanosoma vivax and Trypanosoma congolense infection on the reaction time and semen characteristic of Zebu (Bunaji) Friesian cross breed bull. Therio 61:55–62

Shaw AP, Cecchi G, Wint GR, Mattioli RC, Robinson TP (2014) Mapping the economic benefits to livestock keepers from intervening against bovine trypanosomosis in eastern Africa. Prev Vet Med 113:197–210PubMed

Snedecor GW, Cochran WG (1994) Statistical methods. 8th edn. Affiliated East. West Press, New Delhi, pp 1467–1473

Swallow BM (2000) Impact of trypanosomiasis on agriculture. PAAT Tech Sci Ser 2:35–38

Taylor K, Authié EML (2004) Pathogenesis of animal trypanosomiasis. In: Maudlin I, Holmes PH, Miles MA (eds) The trypanosomiases. CABI Publishing, Wallingford, pp 331–353

The Donkey Sanctuary (2017) Under the skin: the emerging trade in donkey skins and its implications for donkey welfare and livelihoods. Available online: https://www.thedonkeysanctuary.org.uk/sites/uk/files/2017-11/under_the_skin_report.pdf.

Vourchakbé J, Arnol ZT, Auvaker M, Mpoame M, Gustave S (2020) Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad. Parasit Vectors 13:323PubMedPubMedCentral

Waindi EN, Gombe S, Oduor-Okelo D (1986) Plasma testosterone in Trypanosoma congolense infected Togara goats. Archiv Andro 17:9–17

Whicher JT, Westacott CI (1992) Acute phase response. In: Whicher JT, Evans SW (eds) Biochemistry of inflammation, immunology and medicine series. Vol. 18, ed. Kluwer Academic Publisher, London, pp 234–269

Woo PTK (1970) The haematocrit centrifugation technique for the diagnosis of African trypanosomiasis. Acta Trop 27:384–386PubMed

Woodruff AW, Topley E, Knight R, Downie CGB (1973) The anaemias of Kalaazar. Br J Haematol 22:319–329

Titel: Modification of erythrogram, testosterone and prolactin profiles in jacks following experimental infection with Trypanosoma congolense
verfasst von: Samuel Uchenna Felix
Kolo Ndabatsado Hyacinth
Mathew Shinkut
Echekwu Ochife Wilson
Idris Yusuf Sheriff
Kolawole Bamidele J
Chiezey Ngozi Paulin
Rekwot Ibrahim Peter
Publikationsdatum: 03.01.2021
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 1/2021
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-020-03191-z

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01.04.2024 | Forensische Traumatologie | CME

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Modification of erythrogram, testosterone and prolactin profiles in jacks following experimental infection with Trypanosoma congolense

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