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European Archives of Paediatric Dentistry
Erschienen in:

15.08.2021 | Short Communication

Molar-incisor hypomineralisation: an updated view for aetiology 20 years later

verfasst von: D. G. Bussaneli, A. R. Vieira, L. Santos-Pinto, M. Restrepo

Erschienen in: European Archives of Paediatric Dentistry | Ausgabe 1/2022

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Abstract

Background

The term Molar–Incisor Hypomineralisation (MIH) was introduced in 2001 by Weerheijm, Jälevik and Alaluusua, and describes a defect of systemic origin that affects one to four first permanent molars, often associated with permanent incisors. In the past 20 years, this definition dictated the work regarding MIH prevalence, associated risk factors, association with dental caries, impact on quality of life, and therapeutic options.

Purpose

In this report, we offer an updated and comprehensive view of MIH centred on the patient and the tooth.

Conclusion

MIH today is globally recognized as a potential public health problem and it is not a defect of purely systemic origin but rather a condition with complex aetiology that in some instances may be the result of gene-environmental interactions.
Literatur
Americano GC, Jacobsen PE, Soviero VM, Haubek D. A systematic review on the association between molar incisor hypomineralization and dental caries. Int J Paediatr Dent. 2016;27(1):11–21.CrossRef
Arslanagic A, Markovic N, Bajric E, Burnazovic RL. Demarcated opacities as predictors of progression of the molar incisor hypomineralisation: a pilot study. Acta Stomatol Croat. 2020;54(4):420–30.CrossRef
Bezamat M, Souza JF, Silva FMF, Correa EG, Fatturi AL, Brancher JA, et al. Gene-environment interaction in molar-incisor hypomineralization. PLoS One. 2021;16(1):e0241898.
Bhaskar SA, Hegde S. Molar-incisor hypomineralization: prevalence, severity and clinical characteristics in 8- to 13-year-old children of Udaipur, India. J Indian Soc Pedod Prev Dent. 2014;32(4):322–9.CrossRef
Bronckers AL. Ion Transport by Ameloblasts during Amelogenesis. J Dent Res. 2017;96(3):243–53.CrossRef
Bronckers AL, Lyaruu D, Jalali R, Medina JF, Zandieh-Doulabi B, DenBesten PK. Ameloblast Modulation and Transport of Cl(-), Na(+), and K(+) during Amelogenesis. J Dent Res. 2015;94(12):1740–7.CrossRef
Bussaneli DG, Restrepo M, Fragelli CMB, Santos-Pinto L, Jeremias F, Cordeiro RCL, et al. Genes regulating immune response and amelogenesis interact in increasing the susceptibility to molar-incisor hypomineralization. Caries Res. 2018;53(2):217–27.CrossRef
Crombie F, Manton D, Kilpatrick N. Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent. 2009;19(2):73–83.CrossRef
Da Costa-Silva CM, Ambrosano GM, Jeremias F, De Souza JF, Mialhe FL. Increase in severity of molar-incisor hypomineralization and its relationship with the colour of enamel opacity: a prospective cohort study. Int J Paediatr Dent. 2011;21(5):333–41.CrossRef
Dantas-Neta NB, Moura LF, Cruz PF, Moura MS, Paiva SM, Martins CC, et al. Impact of molar-incisor hypomineralization on oral health-related quality of life in schoolchildren. Braz Oral Res. 2016;30(1):e117.
de Farias AL, Rojas-Gualdron DF, Bussaneli DG, Santos-Pinto L, Mejia JD, Restrepo M. Does Molar-Incisor Hypomineralization (MIH) affect only permanent first molars and incisors? New observations on permanent second molars. Int J Paediatr Dent. 2021. https://​doi.​org/​10.​1111/​ipd.​12780.CrossRef
Elhennawy K, Manton DJ, Crombie F, Zaslansky P, Radlanski RJ, Jost-Brinkmann PG, et al. Structural, mechanical and chemical evaluation of molar-incisor hypomineralization-affected enamel: a systematic review. Arch Oral Biol. 2017;83:272–81.CrossRef
Fatturi AL, Menoncin BL, Reyes MT, Meger M, Scariot R, Brancher JA, et al. The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study. Clin Oral Investig. 2020;24(11):3971–80.CrossRef
Fragelli CM, Souza JF, Jeremias F, Cordeiro Rde C, Santos-Pinto L. Molar incisor hypomineralization (MIH): conservative treatment management to restore affected teeth. Braz Oral Res. 2015;29(29):S1806-83242015000100270.
Garot E, Denis A, Delbos Y, Manton D, Silva M, Rouas P. Are hypomineralised lesions on second primary molars (HSPM) a predictive sign of molar incisor hypomineralisation (MIH)? A systematic review and a meta-analysis. J Dent. 2018;72:8–13.CrossRef
Hocevar L, Kovac J, Podkrajsek KT, Battelino S, Pavlic A. The possible influence of genetic aetiological factors on molar-incisor hypomineralisation. Arch Oral Biol. 2020;118:104848.
Jalevik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12(1):24–32.
Jeremias F, Koruyucu M, Kuchler EC, Bayram M, Tuna EB, Deeley K, et al. Genes expressed in dental enamel development are associated with molar-incisor hypomineralization. Arch Oral Biol. 2013;58(10):1434–42.CrossRef
Jeremias F, Pierri RA, Souza JF, Fragelli CM, Restrepo M, Finoti LS, et al. Family-based genetic association for molar-incisor hypomineralization. Caries Res. 2016;50(3):310–8.CrossRef
Jeremias F, Bussaneli DG, Restrepo M, Pierri RAG, Souza JF, Fragelli CMB, et al. Inheritance pattern of molar-incisor hypomineralization. Braz Oral Res. 2021;35:e035.
Josephsen K, Takano Y, Frische S, Praetorius J, Nielsen S, Aoba T, et al. Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation. Am J Physiol Cell Physiol. 2010;299(6):C1299–307.CrossRef
Kevrekidou A, Kosma I, Kotsanos I, Arapostathis KN, Kotsanos N. Enamel opacities in all other than Molar Incisor Hypomineralisation index teeth of adolescents. Int J Paediatr Dent. 2021;31(2):270–7.CrossRef
Koch G, Hallonsten AL, Ludvigsson N, Hansson BO, Holst A, Ullbro C. Epidemiologic study of idiopathic enamel hypomineralization in permanent teeth of Swedish children. Community Dent Oral Epidemiol. 1987;15(5):279–85.CrossRef
Kuhnisch J, Thiering E, Heitmuller D, Tiesler CM, Grallert H, Heinrich-Weltzien R, et al. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). Clin Oral Investig. 2014;18(2):677–82.CrossRef
Kwak SY, Yamakoshi Y, Simmer JP, Margolis HC. MMP20 proteolysis of native amelogenin regulates mineralization in vitro. J Dent Res. 2016;95(13):1511–7.CrossRef
Lygidakis NA, Wong F, Jälevik B, Vierrou AM, Alaluusua S, Espelid I. Best Clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an EAPD policy document. Eur Arch Paediatr Dent. 2010;11(2):75–81.CrossRef
Machiulskiene V, Campus G, Carvalho JC, Dige I, Ekstrand KR, Jablonski-Momeni A, et al. Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and cariology research group of IADR. Caries Res. 2020;54(1):7–14.CrossRef
Mangum JE, Crombie FA, Kilpatrick N, Manton DJ, Hubbard MJ. Surface integrity governs the proteome of hypomineralized enamel. J Dent Res. 2010;89(10):1160–5.CrossRef
Neves AB, Americano GCA, Soares DV, Soviero VM. Breakdown of demarcated opacities related to molar-incisor hypomineralization: a longitudinal study. Clin Oral Investig. 2019;23(2):611–5.CrossRef
Paine ML, Zhu DH, Luo W, Bringas P Jr, Goldberg M, White SN, et al. Enamel biomineralization defects result from alterations to amelogenin self-assembly. J Struct Biol. 2000;132(3):191–200.CrossRef
Pang L, Li X, Wang K, Tao Y, Cui T, Xu Q, et al. Interactions with the aquaporin 5 gene increase the susceptibility to molar-incisor hypomineralization. Arch Oral Biol. 2020;111:104637.
Perez VA, Mangum JE, Hubbard MJ. Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel. Front Physiol. 2020;11:579015.
Raposo F, de Carvalho Rodrigues AC, Lia EN, Leal SC. Prevalence of hypersensitivity in teeth affected by molar-incisor hypomineralization (MIH). Caries Res. 2019;53(4):424–30.CrossRef
Restrepo M, Cárdenas J, de Farias AL. Orientação do comportamento Hipomineralização de Molares e Incisivos. Nova Odessa, SP: Napoleão—Quintessence Publishing Brazil; 2020. p. 144–51.
Scheffel DLS, Jeremias F, Fragelli CMB, Dos Santos-Pinto LAM, Hebling J, de Oliveira OB, Jr. Esthetic dental anomalies as motive for bullying in schoolchildren. Eur J Dent. 2014;8(1):124-28
Schmalfuss A, Stenhagen KR, Tveit AB, Crossner CG, Espelid I. Canines are affected in 16-year-olds with molar-incisor hypomineralisation (MIH): an epidemiological study based on the Tromso study: “Fit Futures.” Eur Arch Paediatr Dent. 2016;17(2):107–13.CrossRef
Simmer JP, Hu JC. Expression, structure, and function of enamel proteinases. Connect Tissue Res. 2002;43(2–3):441–9.CrossRef
Smith CE. Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med. 1998;9(2):128–61.CrossRef
Smith CE, Hu Y, Richardson AS, Bartlett JD, Hu JC, Simmer JP. Relationships between protein and mineral during enamel development in normal and genetically altered mice. Eur J Oral Sci. 2011;119(Suppl 1):125–35.CrossRef
Vieira AR, Kup E. On the Etiology of Molar-Incisor Hypomineralization. Caries Res. 2016;50(2):166–9.CrossRef
Vieira AR, Manton DJ. On the variable clinical presentation of molar-incisor hypomineralization. Caries Res. 2019;53(4):482–8.CrossRef
Weerheijm KL, Jalevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res. 2001;35(5):390–1.CrossRef
Weerheijm KL, Duggal M, Mejare I, Papagiannoulis L, Koch G, Martens LC, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4(3):110–3.
Williams R, Perez VA, Mangum JE, Hubbard MJ. Pathogenesis of molar hypomineralisation: hypomineralised 6-year molars contain traces of fetal serum albumin. Front Physiol. 2020;11:619.CrossRef
Metadaten
Titel
Molar-incisor hypomineralisation: an updated view for aetiology 20 years later
verfasst von
D. G. Bussaneli
A. R. Vieira
L. Santos-Pinto
M. Restrepo
Publikationsdatum
15.08.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Paediatric Dentistry / Ausgabe 1/2022
Print ISSN: 1818-6300
Elektronische ISSN: 1996-9805
DOI
https://doi.org/10.1007/s40368-021-00659-6

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