Molar incisor hypomineralization (MIH) is a significant public health issue with far-reaching implications for children‘s oral health-related quality of life (OHRQoL). Public health aspects include the impact on oral health, burden on healthcare systems, long-term financial impact for the patient, and need for preventive measures. Strategies against these issues include early diagnosis and intervention, education and awareness, knowledge dissemination, training for healthcare providers, research and data collection (including funding by policymakers), integrated health services, and decreased barriers to care. The impact of MIH on OHRQoL is profound with children often experiencing pain, embarrassment, and social stigma due to the appearance and sensitivity of their teeth, which can lead to anxiety, low self-esteem, and avoidance of social interactions. Addressing MIH requires a multifaceted approach that includes early detection, education/awareness, access to care, and ongoing research.