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01.01.2005 | Original Investigation | Ausgabe 1-2/2005

Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children

Zeitschrift:: Medical Microbiology and Immunology > Ausgabe 1-2/2005

Autoren:: R. Mentel, U. Ilgert, U. Wegner, K. Zimmermann, R. Bruns, L. Gürtler

Abstract

The objective of this study was to determine the importance of respiratory syncytial virus (RSV) for hospitalization in the north east of Germany and to obtain molecular epidemiological data of the circulating strains. Using a rapid and sensitive reverse transcriptase-PCR, it was found that a quarter of pediatric respiratory disease admissions were due to RSV. Infections caused by RSV in hospitalized patients were determined over the whole year. Both RSV groups A and B were identified with a predominance of RSV A (86%) over the entire period. The analysis of the deduced amino acid sequences by direct sequencing showed that very similar RSV strains are circulating in the community.

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Abels S, Nadal D, Stroehle A, Bossart W (2001) Reliable detection of respiratory syncytial virus infection in children for adequate hospital infection control management. J Clin Microbiol 39:3135–3139 CrossRefPubMed

Behrendt CE, Decker MD, Burch DJ, Watson PH (1998) International variation in the management of infants hospitalized with respiratory syncytial virus. Eur J Pediatr 157:215–220 PubMed

Cane P, Matthews D, Pringle C (1992) Analysis of relatedness of subgroup A respiratory syncytial viruses isolated worldwide. Virus Res 25:15–22 CrossRefPubMed

Cane PA (2001) Molecular epidemiology of respiratory syncytial virus. Rev Med Virol 11:103–116 CrossRefPubMed

Falsey AR, Walsh EE (2000) Respiratory syncytial virus infection in adults. Clin Microbiol Rev 13:371–384 PubMed

Hall CB, Walsh EE, Schnabel KC, et al (1990) Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiological and clinical characteristics in hospitalized and ambulatory children. J Infect Dis 162:1283–1290 PubMed

Hornsleth A, Klug B, Nir M, Johansen J, Hansen KS, Christensen LS, Larsen LB (1998) Severity of respiratory syncytial virus disease related to type and genotype of virus and to cytokine values in nasopharyngeal secretions. Pediatr Infect Dis J 17:1114–1121 CrossRefPubMed

Hu A, Colella M, Tam JS, Rappaport R, Cheng SM (2003) Simultaneous detection, subgrouping, and quantitation of respiratory syncytial virus A and B by real-time PCR. J Clin Microbiol 41:149–154 CrossRefPubMed

Lukic-Grlic A, Cane PC, Bace A, Pringel CR, Mlinaric-Galinovic G, Popow-Kraupp T (1998) Antigenic and genomic diversity of central European respiratory syncytial virus strains. Arch Virol 143:1441–1447 CrossRefPubMed

10.

Mentel R, Wegner U, Bruns R, Gürtler L (2003) Real-time PCR improve the diagnostics of respiratory syncytial virus infection. J Med Microbiol 52:893–896 CrossRefPubMed

11.

Mlinaric-Galinovic G, Varda-Brkic D (2000) Nosocomial respiratory syncytial virus infections in children’s wards. Diagn Microbiol Infect Dis 37:237–246 CrossRefPubMed

12.

Paes BA (2003) Current strategies in the prevention of respiratory syncytial virus disease. Paediatr Respir Rev 4:21–27 CrossRefPubMed

13.

Peret TCT, Hall CB, Hammond GW, Piedra PA, Storch GA, Sullender WM, Tsou C, Anderson LJ (2000) Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America. J Infect Dis 181:1891–1896 CrossRefPubMed

14.

Resch B, Gusenleitner W, Müller W (2002) The impact of respiratory syncytial virus infection: a propective study in hospitalized infants younger than 2 years. Infection 30:193–197 CrossRefPubMed

15.

Rohwedder A, Keminer O, Forster J, Schneider K, Schneider E, Werchau H (1998) Detection of respiratory syncytial virus RNA in blood of neonates by polymerase chain reaction. J Med Virol 54:320–327 CrossRefPubMed

16.

Seki K, Tsutsumi H, Ohsaki M, Kamasaki H, Chiba S (2001) Genetic variability of respiratory syncytial virus subgroup A strain in 15 successive epidemics in one city. J Med Virol 64:374–380 CrossRefPubMed

17.

Shigeta S (2000) Recent progress in antiviral chemotherapy for respiratory syncytial virus infections. Expert Opin Investig Drugs 9:221–235 PubMed

18.

Stockton J, Ellis JS, Saville M, Clewley JP, Zambon C (1998) Multiplex PCR for typing and subtyping influenza and respiratory syncytial viruses. J Clin Microbiol 36:2990–2995 PubMed

19.

Taylor GS, Vipond IB, Caul EO (2001) Molecular epidemiologiy of outbreak of respiratory syncytial virus within bone marrow transplantation unit. J Clin Microbiol 39:801–803 CrossRefPubMed

20.

Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Ande Fukuda K (2003) Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289:227–229 PubMed

21.

Venter M, Madhi SA, Tiemessen CT, Schoub BD (2001) Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes. J Gen Virol 82:2117–2124 PubMed

22.

Walsh EE, McConnochie KM, Long CE, Hall CB (1997) Severity of respiratory syncytial virus infection is related to virus strain. J Infect Dis 175:814–820 PubMed

23.

Weigl JAI, Puppe W, Schmitt HJ (2002) Seasonality of respiratory syncytial virus-positive hospitalizations in children in Kiel, Germany, over a 7-year period. Infection 30:186–192 CrossRefPubMed

Titel: Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children
Autoren:: R. Mentel
U. Ilgert
U. Wegner
K. Zimmermann
R. Bruns
L. Gürtler
Publikationsdatum: 01.01.2005
DOI: https://doi.org/10.1007/s00430-003-0215-9
Verlag: Springer-Verlag
Zeitschrift: Medical Microbiology and Immunology
Ausgabe 1-2/2005
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831

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Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children

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