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Molecular Autism

Ausgabe 1/2021

Inhalt (74 Artikel)

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models

  • Open Access
  • Research

Sandra Martin Lorenzo, Valérie Nalesso, Claire Chevalier, Marie-Christine Birling, Yann Herault

Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model

  • Open Access
  • Research

Emmanuel Matas, Alexandre Maisterrena, Mathieu Thabault, Eric Balado, Maureen Francheteau, Anais Balbous, Laurie Galvan, Mohamed Jaber

Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids

  • Open Access
  • Methodology

Dwaipayan Adhya, George Chennell, James A. Crowe, Eva P. Valencia-Alarcón, James Seyforth, Neveen A. Hosny, Marina V. Yasvoina, Robert Forster, Simon Baron-Cohen, Anthony C. Vernon, Deepak P. Srivastava

Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism

  • Open Access
  • Research

Thomas W. Frazier, Ritika Jaini, Robyn M. Busch, Matthew Wolf, Tammy Sadler, Patricia Klaas, Antonio Y. Hardan, Julian A. Martinez-Agosto, Mustafa Sahin, Charis Eng, Simon K. Warfield, Benoit Scherrer, Kira Dies, Rajna Filip-Dhima, Amanda Gulsrud, Ellen Hanson, Jennifer M. Phillips

Cannabinoid treatment for autism: a proof-of-concept randomized trial

  • Open Access
  • Research

Adi Aran, Moria Harel, Hanoch Cassuto, Lola Polyansky, Aviad Schnapp, Nadia Wattad, Dorit Shmueli, Daphna Golan, F. Xavier Castellanos

Touch and olfaction/taste differentiate children carrying a 16p11.2 deletion from children with ASD

  • Open Access
  • Research

Joana Maria Almeida Osório, Borja Rodríguez-Herreros, David Romascano, Vincent Junod, Aline Habegger, Aurélie Pain, Sonia Richetin, Paola Yu, Bertrand Isidor, Lionel Van Maldergem, Linda Pons, Sabine Manificat, Nadia Chabane, Marine Jequier Gygax, Anne Manuela Maillard

Modified CBT for social anxiety and social functioning in young adults with autism spectrum disorder

  • Open Access
  • Research

Emily R. Bemmer, Kelsie A. Boulton, Emma E. Thomas, Ben Larke, Suncica Lah, Ian B. Hickie, Adam J. Guastella

Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank

  • Open Access
  • Research

Chloe X. Yap, Gail A. Alvares, Anjali K. Henders, Tian Lin, Leanne Wallace, Alaina Farrelly, Tiana McLaren, Jolene Berry, Anna A. E. Vinkhuyzen, Maciej Trzaskowski, Jian Zeng, Yuanhao Yang, Dominique Cleary, Rachel Grove, Claire Hafekost, Alexis Harun, Helen Holdsworth, Rachel Jellett, Feroza Khan, Lauren Lawson, Jodie Leslie, Mira Levis Frenk, Anne Masi, Nisha E. Mathew, Melanie Muniandy, Michaela Nothard, Peter M. Visscher, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Helen S. Heussler, Andrew J. O. Whitehouse, Naomi R. Wray, Jacob Gratten

Is social camouflaging associated with anxiety and depression in autistic adults?

  • Open Access
  • Research

Laura Hull, Lily Levy, Meng-Chuan Lai, K. V. Petrides, Simon Baron-Cohen, Carrie Allison, Paula Smith, Will Mandy

Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine

  • Open Access
  • Research

Robert H. Wichers, James L. Findon, Auke Jelsma, Vincent Giampietro, Vladimira Stoencheva, Dene M. Robertson, Clodagh M. Murphy, Sarah Blainey, Grainne McAlonan, Christine Ecker, Katya Rubia, Declan G. M. Murphy, Eileen M. Daly

Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms

  • Open Access
  • Research

Yasuhiko Kato, Hitoshi Kuwabara, Takashi Okada, Toshio Munesue, Seico Benner, Miho Kuroda, Masaki Kojima, Walid Yassin, Yosuke Eriguchi, Yosuke Kameno, Chihiro Murayama, Tomoko Nishimura, Kenji Tsuchiya, Kiyoto Kasai, Norio Ozaki, Hirotaka Kosaka, Hidenori Yamasue

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

  • Open Access
  • Research

Shaun Hurley, Conor Mohan, Philipp Suetterlin, Robert Ellingford, Kimberley L. H. Riegman, Jacob Ellegood, Angela Caruso, Caterina Michetti, Olivier Brock, Romy Evans, Fabrizio Rudari, Alessio Delogu, Maria Luisa Scattoni, Jason P. Lerch, Cathy Fernandes, M. Albert Basson

Sleep disorders in rare genetic syndromes: a meta-analysis of prevalence and profile

  • Open Access
  • Research

Georgie Agar, Chloe Brown, Daniel Sutherland, Sean Coulborn, Chris Oliver, Caroline Richards

Towards robust and replicable sex differences in the intrinsic brain function of autism

  • Open Access
  • Research

Dorothea L. Floris, José O. A. Filho, Meng-Chuan Lai, Steve Giavasis, Marianne Oldehinkel, Maarten Mennes, Tony Charman, Julian Tillmann, Guillaume Dumas, Christine Ecker, Flavio Dell’Acqua, Tobias Banaschewski, Carolin Moessnang, Simon Baron-Cohen, Sarah Durston, Eva Loth, Declan G. M. Murphy, Jan K. Buitelaar, Christian F. Beckmann, Michael P. Milham, Adriana Di Martino

Evaluating the latent structure of the non-social domain of autism in autistic adults

  • Open Access
  • Research

Rachel Grove, Sander Begeer, Anke M. Scheeren, Ricarda F. Weiland, Rosa A. Hoekstra

Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders

  • Open Access
  • Research

Marianela Evelyn Traetta, Martín Gabriel Codagnone, Nonthué Alejandra Uccelli, Alberto Javier Ramos, Sandra Zárate, Analía Reinés

A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case–control study in California

  • Open Access
  • Review

Kristen Lyall, Jennifer L. Ames, Michelle Pearl, Michela Traglia, Lauren A. Weiss, Gayle C. Windham, Martin Kharrazi, Cathleen K. Yoshida, Robert Yolken, Heather E. Volk, Paul Ashwood, Judy Van de Water, Lisa A. Croen

Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

  • Open Access
  • Research

J. Ellegood, S. P. Petkova, A. Kinman, L. R. Qiu, A. Adhikari, A. A. Wade, D. Fernandes, Z. Lindenmaier, A. Creighton, L. M. J. Nutter, A. S. Nord, J. L. Silverman, J. P. Lerch

Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum

  • Open Access
  • Research

Svenja Espenhahn, Kate J. Godfrey, Sakshi Kaur, Maia Ross, Niloy Nath, Olesya Dmitrieva, Carly McMorris, Filomeno Cortese, Charlene Wright, Kara Murias, Deborah Dewey, Andrea B. Protzner, Adam McCrimmon, Signe Bray, Ashley D. Harris

Imitation and recognition of facial emotions in autism: a computer vision approach

  • Open Access
  • Research

Hanna Drimalla, Irina Baskow, Behnoush Behnia, Stefan Roepke, Isabel Dziobek

Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome

  • Open Access
  • Research

Michael. G. Mariscal, Elizabeth Berry-Kravis, Joseph D. Buxbaum, Lauren E. Ethridge, Rajna Filip-Dhima, Jennifer H. Foss-Feig, Alexander Kolevzon, Meera. E. Modi, Matthew W. Mosconi, Charles A. Nelson, Craig M. Powell, Paige M. Siper, Latha Soorya, Andrew Thaliath, Audrey Thurm, Bo Zhang, Mustafa Sahin, April R. Levin

Extremely preterm birth and autistic traits in young adulthood: the EPICure study

  • Open Access
  • Research

Helen O’Reilly, Yanyan Ni, Samantha Johnson, Dieter Wolke, Neil Marlow

An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults

  • Open Access
  • Research

Elizabeth Weir, Carrie Allison, Ken K. Ong, Simon Baron-Cohen

Examining a stepped-care telehealth program for parents of young children with autism: a proof-of-concept trial

  • Open Access
  • Research

Allison L. Wainer, Zachary E. Arnold, Caroline Leonczyk, Latha Valluripalli Soorya

Correction to: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

  • Open Access
  • Correction

Jessica A. Jiménez, Travis S. Ptacek, Alex H. Tuttle, Ralf S. Schmid, Sheryl S. Moy, Jeremy M. Simon, Mark J. Zylka

Bayonet-shaped language development in autism with regression: a retrospective study

  • Open Access
  • Research

David Gagnon, Abderrahim Zeribi, Élise Douard, Valérie Courchesne, Borja Rodríguez-Herreros, Guillaume Huguet, Sébastien Jacquemont, Mor Absa Loum, Laurent Mottron

Prospective and detailed behavioral phenotyping in DDX3X syndrome

  • Open Access
  • Research

Lara Tang, Tess Levy, Sylvia Guillory, Danielle Halpern, Jessica Zweifach, Ivy Giserman-Kiss, Jennifer H. Foss-Feig, Yitzchak Frank, Reymundo Lozano, Puneet Belani, Christina Layton, Bonnie Lerman, Emanuel Frowner, Michael S. Breen, Silvia De Rubeis, Ana Kostic, Alexander Kolevzon, Joseph D. Buxbaum, Paige M. Siper, Dorothy E. Grice

The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population

  • Open Access
  • Research

Michael C. W. English, Gilles E. Gignac, Troy A. W. Visser, Andrew J. O. Whitehouse, James T. Enns, Murray T. Maybery

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

  • Open Access
  • Research

Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey

Using the big data approach to clarify the structure of restricted and repetitive behaviors across the most commonly used autism spectrum disorder measures

  • Open Access
  • Research

Mirko Uljarević, Booil Jo, Thomas W. Frazier, Lawrence Scahill, Eric A. Youngstrom, Antonio Y. Hardan

Psychometric validation and refinement of the Interoception Sensory Questionnaire (ISQ) in adolescents and adults on the autism spectrum

  • Open Access
  • Research

Evan Suzman, Zachary J. Williams, Jacob I. Feldman, Michelle Failla, Carissa J. Cascio, Mark T. Wallace, Maria Niarchou, James S. Sutcliffe, Ericka Wodka, Tiffany G. Woynaroski

Genetic and morphological estimates of androgen exposure predict social deficits in multiple neurodevelopmental disorder cohorts

  • Open Access
  • Research

Brooke G. McKenna, Yongchao Huang, Kévin Vervier, Dabney Hofammann, Mary Cafferata, Seima Al-Momani, Florencia Lowenthal, Angela Zhang, Jin-Young Koh, Savantha Thenuwara, Leo Brueggeman, Ethan Bahl, Tanner Koomar, Natalie Pottschmidt, Taylor Kalmus, Lucas Casten, Taylor R. Thomas, Jacob J. Michaelson

Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

  • Open Access
  • Correction

Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li‑Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey

Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder

  • Open Access
  • Research

Jess Kerr-Gaffney, Hannah Hayward, Emily J. H. Jones, Daniel Halls, Declan Murphy, Kate Tchanturia

Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism

  • Open Access
  • Research

Christina Andica, Koji Kamagata, Eiji Kirino, Wataru Uchida, Ryusuke Irie, Syo Murata, Shigeki Aoki

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin

  • Open Access
  • Research

Charlotte M. Pretzsch, Dorothea L. Floris, Bogdan Voinescu, Malka Elsahib, Maria A. Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Elise Pretzsch, Steven Williams, Declan G. M. Murphy, Eileen Daly, Gráinne M. McAlonan

Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys

  • Open Access
  • Research

Ozge Oztan, Catherine F. Talbot, Emanuela Argilli, Alyssa C. Maness, Sierra M. Simmons, Noreen Mohsin, Laura A. Del Rosso, Joseph P. Garner, Elliott H. Sherr, John P. Capitanio, Karen J. Parker

Maternal steroid levels and the autistic traits of the mother and infant

  • Open Access
  • Research

A. Tsompanidis, E. Aydin, E. Padaigaitė, G. Richards, C. Allison, G. Hackett, T. Austin, R. Holt, S. Baron-Cohen

Initial action output and feedback-guided motor behaviors in autism spectrum disorder

  • Open Access
  • Research

Kathryn E. Unruh, Walker S. McKinney, Erin K. Bojanek, Kandace K. Fleming, John A. Sweeney, Matthew W. Mosconi

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

  • Open Access
  • Research

Sarah C. Borrie, Ellen Plasschaert, Zsuzsanna Callaerts-Vegh, Akihiko Yoshimura, Rudi D’Hooge, Ype Elgersma, Steven A. Kushner, Eric Legius, Hilde Brems

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

  • Open Access
  • Research

Vidya Saravanapandian, Divya Nadkarni, Sheng-Hsiou Hsu, Shaun A. Hussain, Kiran Maski, Peyman Golshani, Christopher S. Colwell, Saravanavel Balasubramanian, Amos Dixon, Daniel H. Geschwind, Shafali S. Jeste

The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology

  • Open Access
  • Methodology

Rachael Knott, Beth P. Johnson, Jeggan Tiego, Olivia Mellahn, Amy Finlay, Kathryn Kallady, Maria Kouspos, Vishnu Priya Mohanakumar Sindhu, Ziarih Hawi, Aurina Arnatkeviciute, Tracey Chau, Dalia Maron, Emily-Clare Mercieca, Kirsten Furley, Katrina Harris, Katrina Williams, Alexandra Ure, Alex Fornito, Kylie Gray, David Coghill, Ann Nicholson, Dinh Phung, Eva Loth, Luke Mason, Declan Murphy, Jan Buitelaar, Mark A. Bellgrove

Non-verbal IQ and change in restricted and repetitive behavior throughout childhood in autism: a longitudinal study using the Autism Diagnostic Interview-Revised

  • Open Access
  • Research

V. Courchesne, R. Bedford, A. Pickles, E. Duku, C. Kerns, P. Mirenda, T. Bennett, S. Georgiades, I. M. Smith, W. J. Ungar, T. Vaillancourt, A. Zaidman-Zait, L. Zwaigenbaum, P. Szatmari, M. Elsabbagh

Correction to: Biological motion perception in autism spectrum disorder: a meta-analysis

  • Open Access
  • Correction

Greta Krasimirova Todorova, Rosalind Elizabeth Mcbean Hatton, Frank Earl Pollick

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

  • Open Access
  • Research

Elizabeth L. Berg, Stela P. Petkova, Heather A. Born, Anna Adhikari, Anne E. Anderson, Jill L. Silverman

Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis

  • Open Access
  • Research

Stephanie Antoun, Pierre Ellul, Hugo Peyre, Michelle Rosenzwajg, Pierre Gressens, David Klatzmann, Richard Delorme

Individuals with FOXP1 syndrome present with a complex neurobehavioral profile with high rates of ADHD, anxiety, repetitive behaviors, and sensory symptoms

  • Open Access
  • Research

M. Pilar Trelles, Tess Levy, Bonnie Lerman, Paige Siper, Reymundo Lozano, Danielle Halpern, Hannah Walker, Jessica Zweifach, Yitzchak Frank, Jennifer Foss-Feig, Alexander Kolevzon, Joseph Buxbaum

A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome

  • Open Access
  • Research

J. Fastman, J. Foss-Feig, Y. Frank, D. Halpern, H. Harony-Nicolas, C. Layton, S. Sandin, P. Siper, L. Tang, P. Trelles, J. Zweifach, J. D. Buxbaum, A. Kolevzon

Affect and gaze responses during an Emotion-Evoking Task in infants at an increased likelihood for autism spectrum disorder

  • Open Access
  • Research

Lori-Ann R. Sacrey, Lonnie Zwaigenbaum, Jessica A. Brian, Isabel M. Smith, Vickie Armstrong, Sarah Raza, Tracy Vaillancourt, Louis A. Schmidt

Prediction learning in adults with autism and its molecular correlates

  • Open Access
  • Research

Laurie-Anne Sapey-Triomphe, Joke Temmerman, Nicolaas A. J. Puts, Johan Wagemans

Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder

  • Open Access
  • Research

Behrang Mahjani, Silvia De Rubeis, Christina Gustavsson Mahjani, Maureen Mulhern, Xinyi Xu, Lambertus Klei, F. Kyle Satterstrom, Jack Fu, Michael E. Talkowski, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Dorothy E. Grice, Kathryn Roeder, Bernie Devlin, Joseph D. Buxbaum

How rare and common risk variation jointly affect liability for autism spectrum disorder

  • Open Access
  • Research

Lambertus Klei, Lora Lee McClain, Behrang Mahjani, Klea Panayidou, Silvia De Rubeis, Anna-Carin Säll Grahnat, Gun Karlsson, Yangyi Lu, Nadine Melhem, Xinyi Xu, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Joseph D. Buxbaum, Kathryn Roeder, Bernie Devlin

Exploring sensory phenotypes in autism spectrum disorder

  • Open Access
  • Research

Nichole E. Scheerer, Kristina Curcin, Bobby Stojanoski, Evdokia Anagnostou, Rob Nicolson, Elizabeth Kelley, Stelios Georgiades, Xudong Liu, Ryan A. Stevenson

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis

  • Open Access
  • Research

Pierre Ellul, Michelle Rosenzwajg, Hugo Peyre, Gwladys Fourcade, Encarnita Mariotti-Ferrandiz, Vincent Trebossen, David Klatzmann, Richard Delorme

De novo variants in CACNA1E found in patients with intellectual disability, developmental regression and social cognition deficit but no seizures

  • Open Access
  • Research

Beryl Royer-Bertrand, Marine Jequier Gygax, Katarina Cisarova, Jill A. Rosenfeld, Jennifer A. Bassetti, Oana Moldovan, Emily O’Heir, Lindsay C. Burrage, Jake Allen, Lisa T. Emrick, Emma Eastman, Camille Kumps, Safdar Abbas, Geraldine Van Winckel, Nadia Chabane, Elaine H. Zackai, Sebastien Lebon, Beth Keena, Elizabeth J. Bhoj, Muhammad Umair, Dong Li, Kirsten A. Donald, Andrea Superti-Furga

Correction to: The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population

  • Open Access
  • Correction

Michael C. W. English, Gilles E. Gignac, Troy A. W. Visser, Andrew J. O. Whitehouse, James T. Enns, Murray T. Maybery

Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR)

  • Open Access
  • Research

Anouck Amestoy, Etienne Guillaud, Giulia Bucchioni, Tiziana Zalla, Daniel Umbricht, Christopher Chatham, Lorraine Murtagh, Josselin Houenou, Richard Delorme, Myriam Ly-Le Moal, Marion Leboyer, Manuel Bouvard, Jean-René Cazalets

Childhood diagnoses in individuals identified as autistics in adulthood

  • Open Access
  • Research

Eya-Mist Rødgaard, Kristian Jensen, Kamilla Woznica Miskowiak, Laurent Mottron

Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers

  • Open Access
  • Research

L. Mason, F. Shic, T. Falck-Ytter, B. Chakrabarti, T. Charman, E. Loth, J. Tillmann, T. Banaschewski, S. Baron-Cohen, S. Bölte, J. Buitelaar, S. Durston, B. Oranje, A. M. Persico, C. Beckmann, T. Bougeron, F. Dell’Acqua, C. Ecker, C. Moessnang, D. Murphy, M. H. Johnson, E. J. H. Jones, Jumana Ahmad, Sara Ambrosino, Sarah Baumeister, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Chris Chatham, Ineke Cornelissen, Daisy Crawley, Guillaume Dumas, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Joerg Hipp, Rosemary Holt, Meng-Chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, David J. Lythgoe, René Mandl, Andre Marquand, Maarten Mennes, Andreas Meyer-Lindenberg, Nico Bast, Bethany Oakley, Laurence O’Dwyer, Marianne Oldehinkel, Gahan Pandina, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge, Marcel P. Zwiers

Neu in den Fachgebieten Neurologie und Psychiatrie

Mephedron und „Monkey Dust“ erobern das Nachtleben

Seit der Pandemie machen sich zunehmend synthetische Cathinone in der Partyszene breit. Die Amphetamine werden geraucht oder geschnupft, beim Feiern oder zum Sex konsumiert und sorgen in Kliniken für immer mehr drogeninduzierte Psychosen.

GHB als Partydroge im Aufwind

Billig und stimulierend, solange man nicht zu viel davon nimmt: Gamma-Hydroxy-Buttersäure (GHB) hat sich einen schlechten Ruf als K.o.-Tropfen erworben. Verwendet wird die Substanz jedoch meist als Partydroge. In der Szene hat sie schon gut ein Drittel probiert.

Psilocybin hält therapieresistente Depressionen ein Jahr lang in Schach

Ein bis zwei Sitzungen mit einer Psilocybin-augmentierten Psychotherapie lindern therapieresistente Depressionen deutlich und langfristig: Der Therapieeffekt hält auch nach einem Jahr noch an. Männer profitieren jedoch stärker als Frauen.

Immer weniger Demenzdiagnosen in Deutschland

In Deutschland scheint die Zahl der Demenzkranken seit etwa zehn Jahren deutlich zu sinken: Bei Vertragsärzten, vor allem Hausärzten, werden immer weniger Demenzdiagnosen gestellt. Neben einem Rückgang von Risikofaktoren könnten Änderungen bei der Versorgung relevant sein.

Bildnachweise
Disco Party Club DJ (Generative KI)/© joernueding / stock.adobe.com (Symbolbild mit Fotomodell), Rauchende Teenies trinken Alkohol/© Joshua Resnick / Fotolia (Symbolbild mit Fotomodellen), Psilocybinhaltige Pilze/© kichigin19 / stock.adobe.com, Ärztliche Beratungssituation/© amnaj / stock.adobe.com (Symbolbild mit Fotomodellen)