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Molecular Autism

Ausgabe 1/2025

Inhalt (60 Artikel)

Molecular architecture of the altered cortical complexity in autism

  • Open Access
  • Research

Makliya Mamat, Yiyong Chen, Wenwen Shen, Lin Li

Suboptimal but intact integration of Bayesian components during perceptual decision-making in autism

  • Open Access
  • Research

Laurina Fazioli, Bat-Sheva Hadad, Rachel N. Denison, Amit Yashar

Autistic and transgender/gender diverse people’s experiences of health and healthcare

  • Open Access
  • Research

Kate Green, Elizabeth Weir, Lily Wright, Carrie Allison, Simon Baron-Cohen

Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes

  • Open Access
  • Research

Yukiko Kikuchi, Mohammed Uddin, Joris A. Veltman, Sara Wells, Christopher Morris, Marc Woodbury-Smith

Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism

  • Open Access
  • Research

Lauren Wagner, Megan Banchik, Tawny Tsang, Nana J. Okada, Rebecca Altshuler, Nicole McDonald, Susan Y. Bookheimer, Shafali S. Jeste, Shulamite Green, Mirella Dapretto

“What does ‘often’ even mean?” Revising and validating the Comprehensive Autistic Trait Inventory in partnership with autistic people

  • Open Access
  • Research

Friederike Charlotte Hechler, Outi Tuomainen, Nathan Weber, Frank Fahr, Bodie Karlek, Marie Maroske, Meike Misia, Nathan Caruana

Age-related changes in brain signal variability in autism spectrum disorder

  • Open Access
  • Research

Priyanka Sigar, Nicholas Kathrein, Elijah Gragas, Lauren Kupis, Lucina Q. Uddin, Jason S. Nomi

Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume

  • Open Access
  • Research

Yu Hao, Sarah Banker, Jadyn Trayvick, Sarah Barkley, Arabella W. Peters, Abigaël Thinakaran, Christopher McLaughlin, Xiaosi Gu, Daniela Schiller, Jennifer Foss-Feig

Deciphering the genetic basis of developmental language disorder in children without intellectual disability, autism or apraxia of speech

  • Open Access
  • Research

Clothilde Ormieres, Marion Lesieur-Sebellin, Karine Siquier-Pernet, Geoffroy Delplancq, Marlene Rio, Mélanie Parisot, Patrick Nitschké, Cristina Rodriguez-Fontenla, Alison Bodineau, Lucie Narcy, Emilie Schlumberger, Vincent Cantagrel, Valérie Malan

Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study

  • Open Access
  • Research

Daniel Tönsing, Bastian Schiller, Antonia Vehlen, Kathrin Nickel, Ludger Tebartz van Elst, Gregor Domes, Markus Heinrichs

Exploring EEG resting state differences in autism: sparse findings from a large cohort

  • Open Access
  • Research

Adam J.O. Dede, Wenyi Xiao, Nemanja Vaci, Michael X. Cohen, Elizabeth Milne

Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice

  • Open Access
  • Research

Andreea D. Pantiru, Stijn Van de Sompele, Clemence Ligneul, Camille Chatelain, Christophe Barrea, Jason P. Lerch, Beatrice M. Filippi, Serpil Alkan, Elfride De Baere, Jamie Johnston, Steven J. Clapcote

Transcallosal white matter and cortical gray matter variations in autistic adults aged 30–73 years

  • Open Access
  • Research

Young Seon Shin, Danielle Christensen, Jingying Wang, Desirae J. Shirley, Ann-Marie Orlando, Regilda A. Romero, David E. Vaillancourt, Bradley J. Wilkes, Stephen A. Coombes, Zheng Wang

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice

  • Open Access
  • Research

Mehdi Hooshmandi, David Ho-Tieng, Kevin C. Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G. Gkogkas, Arkady Khoutorsky

Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism

  • Open Access
  • Research

Xiaona Wang, Mengyuan Chen, Daoqi Mei, Shengli Shi, Jisheng Guo, Chao Gao, Qi Wang, Shuai Zhao, Xingxue Yan, Huichun Zhang, Yanli Wang, Bin Guo, Yaodong Zhang

White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study

  • Open Access
  • Research

Guannan Shen, Heather L. Green, Marybeth McNamee, Rose E. Franzen, Marissa DiPiero, Jeffrey I. Berman, Matthew Ku, Luke Bloy, Song Liu, Megan Airey, Sophia Goldin, Lisa Blaskey, Emily S. Kuschner, Mina Kim, Kimberly Konka, Gregory A. Miller, J. Christopher Edgar

Atypical maturation of the functional connectome hierarchy in autism

  • Open Access
  • Research

Jong-eun Lee, Sunghun Kim, Shinwon Park, Hyoungshin Choi, Bo-yong Park, Hyunjin Park

The “Tetris effect”: autistic and non-autistic people share an implicit drive for perceptual cohesion

  • Open Access
  • Research

Nazia Jassim, Brónagh McCoy, Esther Wing-Chi Yip, Carrie Allison, Simon Baron-Cohen, Rebecca P. Lawson

Flexible nonlinear modeling reveals age-related differences in resting-state functional brain connectivity in autistic males from childhood to mid-adulthood

  • Open Access
  • Research

Daniel Feldman, Molly Prigge, Andrew Alexander, Brandon Zielinski, Janet Lainhart, Jace King

Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder

  • Open Access
  • Research

Katherine Bonnycastle, Mohammed Sarfaraz Nawaz, Peter C. Kind, Michael A. Cousin

The intersection and developmental trajectory of morning cortisol and testosterone in autistic and neurotypical youth

  • Open Access
  • Research

Blythe A. Corbett, Trey McGonigle, Rachael A. Muscatello, Simon Vandekar, Rachel Calvosa

Publisher Correction: Flexible nonlinear modeling reveals age-related differences in resting-state functional brain connectivity in autistic males from childhood to mid-adulthood

  • Open Access
  • Publisher Correction

Daniel Feldman, Molly Prigge, Andrew Alexander, Brandon Zielinski, Janet Lainhart, Jace King

A cross-cultural examination of bi-directional mentalising in autistic and non-autistic adults

  • Open Access
  • Research

Bianca A. Schuster, Y. Okamoto, T. Takahashi, Y. Kurihara, C. T. Keating, J. L. Cook, H. Kosaka, M. Ide, H. Naruse, C. Kraaijkamp, R. Osu

Better statistical reporting does not lead to statistical rigour: lessons from two decades of pseudoreplication in mouse-model studies of neurological disorders

  • Open Access
  • Research

Constantinos Eleftheriou, Sarah Giachetti, Raven Hickson, Laura Kamnioti-Dumont, Robert Templaar, Alina Aaltonen, Eleni Tsoukala, Nawon Kim, Lysandra Fryer-Petridis, Chloe Henley, Ceren Erdem, Emma Wilson, Beatriz Maio, Jingjing Ye, Jessica C. Pierce, Kath Mazur, Lucia Landa-Navarro, Nina G. Petrović, Sarah Bendova, Hanan Woods, Manuela Rizzi, Vanesa Salazar-Sanchez, Natasha Anstey, Antonios Asiminas, Shinjini Basu, Sam A. Booker, Anjanette Harris, Sam Heyes, Adam Jackson, Alex Crocker-Buque, Aoife C. McMahon, Sally M. Till, Lasani S. Wijetunge, David JA Wyllie, Catherine M. Abbott, Timothy O’Leary, Peter C. Kind

Reduced relationship-specific social touching and atypical association with emotional bonding in autistic adults

  • Open Access
  • Research

Ayaka Fukuoka, Ryo Kitada, Kai Makita, Takuya Makino, Nodoka Sakakihara, Lauri Nummenmaa, Hirotaka Kosaka

Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1–12 years

  • Open Access
  • Research

Ammal M. Metwally, Ebtissam M. Salah El-Din, Samia M. Sami, Ehab R. Abdelraouf, Sara F. Sallam, Amal Elsaeid, Mostafa M. El-Saied, Engy A. Ashaat, Asmaa M. Fathy, Hazem M. El-Hariri, Ghada A. Elshaarawy, Maysa S. Nassar, Manal A. Shehata, Inas R. El-Alameey, Randa I. Bassiouni, Mohamed H. Abdou, Mona A. Helmy, Nahed A. Elghareeb, Mohamed AbdAllah, Thanaa M. Rabah, Somia I. Salama, Rehan M. Saleh, Lobna A. El Etreby, Dalia M. Elmosalami, Eman Eltahlawy, Dina Abu Zeid

Subgrouping autism and ADHD based on structural MRI population modelling centiles

  • Open Access
  • Research

Clara Pecci-Terroba, Meng-Chuan Lai, Michael V. Lombardo, Bhismadev Chakrabarti, Amber N. V. Ruigrok, John Suckling, Evdokia Anagnostou, Jason P. Lerch, Margot J. Taylor, Rob Nicolson, Stelios Georgiades, Jennifer Crosbie, Russell Schachar, Elizabeth Kelley, Jessica Jones, Paul D. Arnold, Jakob Seidlitz, Aaron F. Alexander-Bloch, Edward T. Bullmore, Simon Baron-Cohen, Saashi A. Bedford, Richard A. I. Bethlehem

The influence of interpersonal synchrony and autism on impressions of dyadic interactions: a preregistered study

  • Open Access
  • Research

Irene S. Plank, Ralf Tepest, Kai Vogeley, Christine M. Falter-Wagner

Access to services for autistic people across Europe

  • Open Access
  • Research

Siti Nurnadhirah Binte Mohd Ikhsan, Rosemary Holt, Joyce Man, Tracey Parsons, Rik Schalbroeck, Amber Ruigrok, Aurélie Baranger, Carrie Allison, Mary Doherty, Katrien Van den Bosch, Jerneja Terčon, Pierre Violland, Anjuli Ghosh, James Cusack, Simon Baron-Cohen

Accuracy of a 2-minute eye-tracking assessment to differentiate young children with and without autism

  • Open Access
  • Research

Kristelle Hudry, Lacey Chetcuti, Diana Weiting Tan, Alena Clark, Alexandra Aulich, Catherine A. Bent, Cherie C. Green, Jodie Smith, Kathryn Fordyce, Masaru Ninomiya, Atsushi Saito, Shuji Hakoshima, Andrew J. O. Whitehouse

A transdiagnostic study of theory of mind in children and youth with neurodevelopmental conditions

  • Open Access
  • Research

Kaela Amorim, Marlee M. Vandewouw, Nhu Huynh, Kathrina de Villa, Celine Safati, Aurora Almonte, Rob Nicolson, Elizabeth Kelley, Jennifer Crosbie, Jessica Brian, Evdokia Anagnostou, Margot J. Taylor, Julie Sato

Social orienting in prematurely born preschoolers: a case control study showing altered neural tuning towards voices, not faces

  • Open Access
  • Research

Rowena Van den Broeck, Lisa Gistelinck, Sofie Vettori, Ward Deferm, Silke Vos, Bieke Bollen, Gunnar Naulaers, Els Ortibus, Bart Boets

The neural bases of language processing during social and non-social contexts: a fNIRS study of autistic and neurotypical preschool-aged children

  • Open Access
  • Research

M. Pecukonis, J. Gerson, H. Gustafson-Alm, M. Wood, M. Yücel, D. A. Boas, H. Tager-Flusberg

Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study

  • Open Access
  • Research

Nico Bast, Jumana Ahmad, Luke Mason, Emily J. H. Jones, Magdalena Matyjek, Leonie Polzer, Christina Luckhardt, Anna Katharina Müller, Grainne M. McAlonan, Tobias Banaschewski, Sarah Baumeister, Eva Loth, Christine M. Freitag, Sara Ambrosino, Bonnie Auyeung, Simon Baron-Cohen, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Jan K. Buitelaar, Bhismadev Chakrabarti, Tony Charman, Ineke Cornelissen, Daisy Crawley, Flavio Dell’Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Mark Johnson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, Eva Loth, David J. Lythgoe, René Mandl, Andre Marquand, Maarten Mennes, Andreas Meyer-Lindenberg, Carolin Moessnang, Declan G. M. Murphy, Bethany Oakley, Laurence O’Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Julian Tillmann, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge, Marcel P. Zwiers

Social inference brain networks in autistic adults during movie-viewing: functional specialization and heterogeneity

  • Open Access
  • Research

Jasmin M. Turner, Lisa Byrge, Hilary Richardson, Paola Galdi, Daniel P. Kennedy, Dorit Kliemann

Correction to: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice

  • Open Access
  • Correction

Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig

Postural sway dynamics in adults across the autism spectrum: a multifactor approach

  • Open Access
  • Research

Bess F. Bloomer, Amanda R. Bolbecker, Emily L. Gildea, Daniel P. Kennedy, Krista M. Wisner, Brian F. O’Donnell, William P. Hetrick

UBE3A reinstatement restores behaviorand proteome in an Angelman syndrome mouse model of imprinting defects

  • Open Access
  • Research

Claudia Milazzo, Ramanathan Narayanan, Solveig Badillo, Silvia Wang, Rosaisela Almand, Roos Monshouwer, Manuel Tzouros, Sabrina Golling, Edwin Mientjes, Stormy Chamberlain, Thomas Kremer, Ype Elgersma

Subcortical brain volume variations in autistic individuals across the lifespan

  • Open Access
  • Research

Danielle Christensen, Young Seon Shin, Jingying Wang, Carolina R. Cuomo, Tyler Dentry, Hanna M. Gemmell, Stormi L. Pulver, Ann-Marie Orlando, Walker S. McKinney, Cassie J. Stevens, Kathryn E. Unruh, Bikram Karmakar, Stephen A. Coombes, Matthew W. Mosconi, Zheng Wang

Different exploration strategies along the autism spectrum: diverging effects of autism diagnosis and autism traits

  • Open Access
  • Research

Fien Goetmaeckers, Judith Goris, Jan R. Wiersema, Tom Verguts, Senne Braem

Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome

  • Open Access
  • Research

Rana Elmaghraby, Yanchen Liu, Priya Ramesh, Grace Westerkamp, Meredith A. Nelson, Travis Larsh, Elizabeth Smith, Donald L. Gilbert, Steve W. Wu, Craig A. Erickson, Ernest V. Pedapati

Comparing three algorithms of automated facial expression analysis in autistic children: different sensitivities but consistent proportions

  • Open Access
  • Research

Liora Manelis-Baram, Tal Barami, Michal Ilan, Gal Meiri, Idan Menashe, Elizabeth Soskin, Carmel Sofer, Ilan Dinstein

Genotype–phenotype correlations with autism spectrum disorder-related traits in noonan syndrome and noonan syndrome with multiple lentigines: a cross-sectional study

  • Open Access
  • Research

Chloe Alexa McGhee, Julia R. Plank, Luca Pannone, Odeya Russo, Naomi Fuhrmann, Aurora Ruggeri, Francesca Clementina Radio, Simone Martinelli, Marco Tartaglia, Tamar Green

The Developmental Assessment of Social Communication Ability (DASCA): initial creation and psychometric description

  • Open Access
  • Research

Aaron J. Kaat, Audrey Thurm, Cristan Farmer, Shuting Zheng, Sheila Ghods, Stelios Georgiades, Stephen Kanne, Shrikanth Narayanan, Somer L. Bishop

Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder

  • Open Access
  • Research

Kari L. Hanson, Thomas Avino, Sandra L. Taylor, Karl D. Murray, Cynthia M. Schumann

Exome sequencing in severe non-syndromic specific learning and language disorders in a French cohort

  • Open Access
  • Research

Eléonore Viora-Dupont, Julian Delanne, Aurore Garde, Sophie Nambot, Estelle Colin, Marie Bournez, Clémence Fauconnier-Fatus, Caroline Racine, Clément Simao De Souza, Céline Bernard, Agnès Maurer, Aurélie Espitalier, Christine Binquet, Marion Bouctot, Marie-Laure Humbert, Anne-Sophie Briffaut, Véronique Darmency, Patricia Plumet, Audrey Cotinaud-Ricou, Noémie Relin, Patrick Callier, Anne-Laure Mosca-Boidron, Nathalie Marle, Frederic Tran Mau-Them, Anne-Sophie Denommé-Pichon, Hana Safraou, Antonio Vitobello, Christophe Philippe, Yannis Duffourd, Ange-Line Bruel, Christel Thauvin-Robinet, Laurence Faivre

Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models

  • Open Access
  • Research

Evangelia Pollali, Daniel Frías Donaire, Miguel Del Ángel, Yunus Emre Demiray, Sara Enrile Lacalle, Jan-Oliver Hollnagel, Anil Annamneedi, Gürsel Çalışkan

Transdiagnostic similarities and distinctions in brain networks associated with autistic social impairments: a prospective cohort study

  • Open Access
  • Research

Jennifer L. Bruno, Julia R. Plank, Samantha Leder, Evelyn M.R. Lake, Emily S. Finn, Tamar Green

Effects of Metformin on children with Fragile X Syndrome: a randomized, double-blind, placebo-controlled trial

  • Open Access
  • Research

Yiting Zhu, Dongyun Li, Chunchun Hu, Yuxin Tian, Ping Lu, Randi J. Hagerman, Xiu Xu, Qiong Xu

Self-harm and suicidality experiences of autistic and non-autistic adults in midlife and old age

  • Open Access
  • Research

Sophie Roper, Rebecca Charlton, Francesca Happé, Gavin R. Stewart

The impact of camouflaging autistic traits on psychological and physiological stress: a co-twin control study

  • Open Access
  • Research

Sabela Conde-Pumpido Zubizarreta, Johan Isaksson, Åshild Faresjö, Tomas Faresjö, Angel Carracedo, Montse Fernández Prieto, Sven Bölte, Karl Lundin Remnélius

Neu in den Fachgebieten Neurologie und Psychiatrie

Psilocybin hält therapieresistente Depressionen ein Jahr lang in Schach

Ein bis zwei Sitzungen mit einer Psilocybin-augmentierten Psychotherapie lindern therapieresistente Depressionen deutlich und langfristig: Der Therapieeffekt hält auch nach einem Jahr noch an. Männer profitieren jedoch stärker als Frauen.

Wenn das Handy für die Psyche zum Problem wird

Bei problematischem Smartphone-Gebrauch leidet die Lebensqualität und Depressionen nehmen zu. Mit einer Feedback-App lässt sich das Problem etwas einschränken. Darauf deuten Resultate der deutschen SanePhone-Studien.

Glioblastom: Auf diese PPI sollten Sie verzichten

Eine Metaanalyse aus fünf Studien zeigt: Die Einnahme von Protonenpumpenhemmern (PPI) bei neu diagnostiziertem Glioblastom ist mit einem schlechteren Überleben assoziiert – allerdings nicht bei allen PPI.

Podcast

"Schlaf ist mehr als ein Leerlauf im Körper"

Wie viel Schlaf wir brauchen und wann wir besonders leistungsfähig sind, das hängt von verschiedenen Faktoren ab. Eines ist jedoch klar: Guter Schlaf ist wichtig für die Gesundheit. Schlafmangel kann sich zum Beispiel endokrinologisch auswirken und unser Essverhalten beeinflussen, so die Schlafexpertin Dr. Sarah Dietz-Terjung. Aber warum schlafen wir überhaupt? Und wie können wir gut schlafen?

Deutsche Gesellschaft für Innere Medizin
Bildnachweise
Psilocybinhaltige Pilze/© kichigin19 / stock.adobe.com, Frau mit Smartphone in der Hand/© kieferpix / Getty Images / iStock (Symbolbild mit Fotomodell), Mann hält Tablette und Wasserglas/© Syda Productions / stock.adobe.com (Symbolbild mit Fotomodell), DGIM Podcast-Reihe - Schlafmedizin/© (M) Andrey Popov / stock.adobe.com (Symbolbild mit Fotomodell) Logo: Springer Medizin Verlag GmbH