Ausgabe 1/2009
Inhalt (133 Artikel)
Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis
Lavinia Nardinocchi, Rosa Puca, Ada Sacchi, Gabriella D'Orazi
Evaluation of bioluminescent imaging for noninvasive monitoring of colorectal cancer progression in the liver and its response to immunogene therapy
Maider Zabala, Pilar Alzuguren, Carolina Benavides, Julien Crettaz, Gloria Gonzalez-Aseguinolaza, Carlos Ortiz de Solorzano, Manuela Gonzalez-Aparicio, Maria Gabriela Kramer, Jesus Prieto, Ruben Hernandez-Alcoceba
Senescence induction; a possible cancer therapy
Matilde E LLeonart, Ana Artero-Castro, Hiroshi Kondoh
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
Therese M Becker, Sebastian Haferkamp, Menno K Dijkstra, Lyndee L Scurr, Monika Frausto, Eve Diefenbach, Richard A Scolyer, David N Reisman, Graham J Mann, Richard F Kefford, Helen Rizos
A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
Rolf I Skotheim, Gard OS Thomassen, Marthe Eken, Guro E Lind, Francesca Micci, Franclim R Ribeiro, Nuno Cerveira, Manuel R Teixeira, Sverre Heim, Torbjørn Rognes, Ragnhild A Lothe
High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours
Martin Wilson, Nigel P Davies, Marie-Anne Brundler, Carmel McConville, Richard G Grundy, Andrew C Peet
Chmp 1A is a mediator of the anti-proliferative effects of All-trans Retinoic Acid in human pancreatic cancer cells
Jing Li, Brandon Orr, Kayla White, Natalia Belogortseva, Richard Niles, Goran Boskovic, Hanh Nguyen, Ava Dykes, Maiyon Park
Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy
Yingmei Wang, Ping Ji, Jinsong Liu, Russell R Broaddus, Fengxia Xue, Wei Zhang
Protein kinase Cε: an oncogene and emerging tumor biomarker
Michael A Gorin, Quintin Pan
The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest
Vanessa Tillement, Laurence Haren, Nicolas Roullet, Chantal Etievant, Andreas Merdes
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis
Keqiang Zhang, Shuya Hu, Jun Wu, Linling Chen, Jianming Lu, Xiaochen Wang, Xiyong Liu, Bingsen Zhou, Yun Yen
Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation
Samantha M Zunich, Taneka Douglas, Maria Valdovinos, Tiffany Chang, Wade Bushman, David Walterhouse, Philip Iannaccone, Marilyn LG Lamm
Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients
Samy L Habib
GSK3β N-terminus binding to p53 promotes its acetylation
Tae-Yeon Eom, Richard S Jope
Scaffold attachment factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis
Benny Abraham Kaipparettu, Klaudia M Dobrzycka, Ora Britton, Adrian V Lee, Alan J Herron, Yi Li, Michael T Lewis, Daniel Medina, Steffi Oesterreich
Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression
Joshua P Klopper, Vibha Sharma, Andrew Berenz, William R Hays, Michele Loi, Umarani Pugazhenthi, Sherif Said, Bryan R Haugen
Molecular assays for the detection of microRNAs in prostate cancer
Amara C Siva, Luke J Nelson, Chad L Fleischer, Mehrdad Majlessi, Michael M Becker, Robert L Vessella, Mark A Reynolds
Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds
Giulia Matusali, Giuseppe Arena, Alessandra De Leo, Livia Di Renzo, Elena Mattia
δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Yan Zeng, Agustin Abdallah, Jian-Ping Lu, Tao Wang, Yan-Hua Chen, David M Terrian, Kwonseop Kim, Qun Lu
From bench to bedside: current and future applications of molecular profiling in renal cell carcinoma
Androu Arsanious, Georg A Bjarnason, George M Yousef
A new dawn for the use of traditional Chinese medicine in cancer therapy
Harendra S Parekh, Gang Liu, Ming Q Wei
Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
Anna K Walduck, Matthias Weber, Christian Wunder, Stefan Juettner, Manfred Stolte, Michael Vieth, Bertram Wiedenmann, Thomas F Meyer, Michael Naumann, Michael Hoecker
PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein
György Stuber, Emilie Flaberg, Gabor Petranyi, Rita Ötvös, Nina Rökaeus, Elena Kashuba, Klas G Wiman, George Klein, Laszlo Szekely
CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
Clark C Chen, Richard D Kennedy, Samuel Sidi, A Thomas Look, Alan D'Andrea
Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells
Rod Balhorn, Saphon Hok, Sally DeNardo, Arutselvan Natarajan, Gary Mirick, Michele Corzett, Gerald DeNardo
Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells
Sanjeev Kumar, Christopher S Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P Steffes, Donald W Weaver, Robert Morris, John M Malone, Masood A Shammas, Madhu Prasad, Ramesh B Batchu
Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion
Satish B Cheepala, Weihong Yin, Zanobia Syed, Jennifer N Gill, Alaina McMillian, Heather E Kleiner, Mark Lynch, Rasiah Loganantharaj, Marjan Trutschl, Urska Cvek, John L Clifford
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
Dae Won Kim, Kyung-Ok Kim, Mike J Shin, Jung Hee Ha, Sung Wook Seo, Jay Yang, Francis Y Lee
Tissue expression of Squamous Cellular Carcinoma Antigen (SCCA) is inversely correlated to tumor size in HCC
Paolo Trerotoli, Emilia Fransvea, Umberto Angelotti, Giovanni Antonaci, Luigi Lupo, Antonio Mazzocca, Anita Mangia, Salvatore Antonaci, Gianluigi Giannelli
Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness
Ariadne Androulidaki, Erini Dermitzaki, Maria Venihaki, Effie Karagianni, Olga Rassouli, Erini Andreakou, Christos Stournaras, Andrew N Margioris, Christos Tsatsanis
CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
Fiona E McRonald, Mark R Morris, Dean Gentle, Laura Winchester, Dilair Baban, Jiannis Ragoussis, Noel W Clarke, Michael D Brown, Takeshi Kishida, Masahiro Yao, Farida Latif, Eamonn R Maher
The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells
Dong-yun Shi, Fei-zhou Xie, Chao Zhai, Jeremy S Stern, Yang Liu, Shan-lin Liu
Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
Carmen Aceves, Pablo García-Solís, Omar Arroyo-Helguera, Laura Vega-Riveroll, Guadalupe Delgado, Brenda Anguiano
Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
Shinji Mizuarai, Kazunori Yamanaka, Hiraku Itadani, Tsuyoshi Arai, Toshihide Nishibata, Hiroshi Hirai, Hidehito Kotani
Identification of novel Notch target genes in T cell leukaemia
Nicholas Chadwick, Leo Zeef, Virginia Portillo, Carl Fennessy, Fiona Warrander, Sarah Hoyle, Anne-Marie Buckle
Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups
Hammurabi Bartuma, Ioannis Panagopoulos, Anna Collin, Domenico Trombetta, Henryk A Domanski, Nils Mandahl, Fredrik Mertens
Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo
Philipp Nuhn, Beat M Künzli, René Hennig, Tomas Mitkus, Tadas Ramanauskas, Rainer Nobiling, Stefan C Meuer, Helmut Friess, Pascal O Berberat
Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis
Kristen Pollizzi, Izabela Malinowska-Kolodziej, Michael Stumm, Heidi Lane, David Kwiatkowski
Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation
Catherine Gill, Catherine Dowling, Amanda J O'Neill, R William G Watson
Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish
Bensheng Ju, Jan Spitsbergen, Christopher J Eden, Michael R Taylor, Wenbiao Chen
Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
Teresa WM Fan, Andrew N Lane, Richard M Higashi, Mohamed A Farag, Hong Gao, Michael Bousamra, Donald M Miller
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif
Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers
Chun Hei Antonio Cheung, Huang-Hui Chen, Ching-Chuan Kuo, Chi-Yen Chang, Mohane S Coumar, Hsing-Pang Hsieh, Jang-Yang Chang
Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines
Shinji Mizuarai, Aki Kawagishi, Hidehito Kotani
Oncolytic vaccinia therapy of squamous cell carcinoma
Zhenkun Yu, Sen Li, Peter Brader, Nanhai Chen, Yong A Yu, Qian Zhang, Aladar A Szalay, Yuman Fong, Richard J Wong
PRL-3 overexpression in epithelial cells is induced by surrounding stromal fibroblasts
David G Molleví, Alvaro Aytes, Mireia Berdiel, Laura Padullés, Maria Martínez-Iniesta, Xavier Sanjuan, Ramon Salazar, Alberto Villanueva
Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells
Shizuko Sei, Jodie K Mussio, Quan-en Yang, Kunio Nagashima, Ralph E Parchment, Matthew C Coffey, Robert H Shoemaker, Joseph E Tomaszewski
Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas
Elizabeth M Swisher, Rachel M Gonzalez, Toshiyasu Taniguchi, Rochelle L Garcia, Tom Walsh, Barbara A Goff, Piri Welcsh
Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact
Penny E Reid, Nicola J Brown, Ingunn Holen
Genomic imbalances in precancerous tissues signal oral cancer risk
Cathie Garnis, Raj Chari, Timon PH Buys, Lewei Zhang, Raymond T Ng, Miriam P Rosin, Wan L Lam
PIK3CA alterations in Middle Eastern ovarian cancers
Jehad Abubaker, Prashant Bavi, Wael Al-Haqawi, Zeenath Jehan, Adnan Munkarah, Shahab Uddin, Khawla S Al-Kuraya
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma
Stefania Gimelli, Silvana Beri, Harry A Drabkin, Claudio Gambini, Andrea Gregorio, Patrizia Fiorio, Orsetta Zuffardi, Robert M Gemmill, Roberto Giorda, Giorgio Gimelli
14-3-3σ gene silencing during melanoma progression and its role in cell cycle control and cellular senescence
Julia Schultz, Saleh M Ibrahim, Julio Vera, Manfred Kunz
Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype
Ad JC de Groof, Mariska M te Lindert, Michiel MT van Dommelen, Min Wu, Marieke Willemse, Amy L Smift, Mike Winer, Frank Oerlemans, Helma Pluk, Jack AM Fransen, Bé Wieringa
A class of DNA-binding peptides from wheat bud causes growth inhibition, G2 cell cycle arrest and apoptosis induction in HeLa cells
Loretta Mancinelli, Paula M De Angelis, Lucia Annulli, Valentina Padovini, Kjell Elgjo, Gian Luigi Gianfranceschi
Photodynamic therapy inhibits p-glycoprotein mediated multidrug resistance via JNK activation in human hepatocellular carcinoma using the photosensitizer pheophorbide a
Patrick Ming-Kuen Tang, Dong-Mei Zhang, Ngoc-Ha Bui Xuan, Stephen Kwok-Wing Tsui, Mary Miu-Yee Waye, Siu-Kai Kong, Wing-Ping Fong, Kwok-Pui Fung
Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs
Rajendra K Singh, Bal L Lokeshwar
Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility
Luisa Pecorari, Oriano Marin, Chiara Silvestri, Olivia Candini, Elena Rossi, Clara Guerzoni, Sara Cattelani, Samanta A Mariani, Francesca Corradini, Giovanna Ferrari-Amorotti, Laura Cortesi, Rita Bussolari, Giuseppe Raschellà, Massimo R Federico, Bruno Calabretta
Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus Latent Membrane Protein-1
Olivier Dellis, Atousa Arbabian, Jean-Philippe Brouland, Tünde Kovàcs, Martin Rowe, Christine Chomienne, Irène Joab, Béla Papp
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice
Rania Siam, Ryoko Harada, Chantal Cadieux, Robert Battat, Charles Vadnais, Alain Nepveu
Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo
Stephan Emmrich, Weiwei Wang, Katja John, Wenzhong Li, Brigitte M Pützer
Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells
Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto
Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients
Hidetaka Yamada, Kazuya Shinmura, Masanori Goto, Moriya Iwaizumi, Hiroyuki Konno, Hideki Kataoka, Masami Yamada, Takachika Ozawa, Toshihiro Tsuneyoshi, Fumihiko Tanioka, Haruhiko Sugimura
JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma
Qingshan Chang, Jianguo Chen, Kevin J Beezhold, Vince Castranova, Xianglin Shi, Fei Chen
NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells
Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Umashankar Das, Hari N Pati, Jonathan R Dimmock, Rajendra K Sharma
Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy
Khong Bee Kang, Congju Zhu, Sook Kwin Yong, Qiuhan Gao, Meng Cheong Wong
STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells
Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui, Robert A Kirken
Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
Melanie Mediavilla-Varela, Fabio J Pacheco, Frankis Almaguel, Jossymar Perez, Eva Sahakian, Tracy R Daniels, Lai Sum Leoh, Amelia Padilla, Nathan R Wall, Michael B Lilly, Marino De Leon, Carlos A Casiano
MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
Edurne San José-Enériz, José Román-Gómez, Antonio Jiménez-Velasco, Leire Garate, Vanesa Martin, Lucia Cordeu, Amaia Vilas-Zornoza, Paula Rodríguez-Otero, María José Calasanz, Felipe Prósper, Xabier Agirre
Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer
Na Wei, Stephanie S Liu, Thomas HY Leung, Kar F Tam, Xiao Y Liao, Annie NY Cheung, Karen KL Chan, Hextan YS Ngan
Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers
Jonathan M Dreyfuss, Mark D Johnson, Peter J Park
Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times
Gayathri T Selvarajah, Jolle Kirpensteijn, Monique E van Wolferen, Nagesha AS Rao, Hille Fieten, Jan A Mol
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
Xiaowei Sun, Rachid Essalmani, Nabil G Seidah, Annik Prat
Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
Shahab Uddin, Rong Bu, Maqbool Ahmed, Jehad Abubaker, Fouad Al-Dayel, Prashant Bavi, Khawla S Al-Kuraya
The rapamycin-regulated gene expression signature determines prognosis for breast cancer
Argun Akcakanat, Li Zhang, Spiridon Tsavachidis, Funda Meric-Bernstam
Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells
Wei Wei, Mei-Sze Chua, Susan Grepper, Samuel K So
Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2
Michael Koslowski, Özlem Türeci, Christoph Huber, Ugur Sahin
Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
Qin Yao, Xun Qu, Qifeng Yang, David A Good, Shuzhen Dai, Beihua Kong, Ming Q Wei
Discovery and identification of potential biomarkers of papillary thyroid carcinoma
Yuxia Fan, Linan Shi, Qiuliang Liu, Rui Dong, Qian Zhang, Shaobo Yang, Yingzhong Fan, Heying Yang, Peng Wu, Jiekai Yu, Shu Zheng, Fuquan Yang, Jiaxiang Wang
Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
Martin Michaelis, Denise Klassert, Susanne Barth, Tatyana Suhan, Rainer Breitling, Bernd Mayer, Nora Hinsch, Hans W Doerr, Jaroslav Cinatl, Jindrich Cinatl jr
Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action
Shan Wang, Qian Liu, Ying Zhang, Ke Liu, Pengfei Yu, Kun Liu, Jinling Luan, Huiying Duan, Zhaoqiao Lu, Fengfei Wang, Erxi Wu, Kazumi Yagasaki, Guoying Zhang
Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
Hongdo Do, Alexander Dobrovic
Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer
Nassima Redjimi, Françoise Gaudin, Cyril Touboul, Dominique Emilie, Marc Pallardy, Armelle Biola-Vidamment, Hervé Fernandez, Sophie Prévot, Karl Balabanian, Véronique Machelon
Retraction Note: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
Qin Yao, Xun Qu, Qifeng Yang, David A Good, Shuzhen Dai, Beihua Kong, Ming Q Wei
HIPK2 modulates p53 activity towards pro-apoptotic transcription
Rosa Puca, Lavinia Nardinocchi, Ada Sacchi, Gideon Rechavi, David Givol, Gabriella D'Orazi
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia
Sonja Röhrs, Wilhelm G Dirks, Claus Meyer, Rolf Marschalek, Michaela Scherr, Robert Slany, Andrew Wallace, Hans G Drexler, Hilmar Quentmeier
Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models
Ratna Kumari, Aanchal Sharma, Amrendra Kumar Ajay, Manoj Kumar Bhat
Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness
Nataša Obermajer, Bojan Doljak, Janko Kos
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
Ana M Cervera, Jean-Pierre Bayley, Peter Devilee, Kenneth J McCreath
Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
Haluk Yuzugullu, Khemais Benhaj, Nuri Ozturk, Serif Senturk, Emine Celik, Asli Toylu, Nilgun Tasdemir, Mustafa Yilmaz, Esra Erdal, Kamil Can Akcali, Nese Atabey, Mehmet Ozturk
Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
Alla V Ivanova, Sergey V Ivanov, Ljudmila Prudkin, Daisuke Nonaka, Zhandong Liu, Anne Tsao, Ignacio Wistuba, Jack Roth, Harvey I Pass
LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
HaiDan Liu, Hui Zheng, Zhi Duan, DuoSha Hu, Ming Li, SuFang Liu, ZiJian Li, XiYun Deng, ZhenLian Wang, Min Tang, Ying Shi, Wei Yi, Ya Cao
EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells
Prasanthi Karna, Starlette M Sharp, Clayton Yates, Satya Prakash, Ritu Aneja
Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response
Ramaswamy Bhuvaneswari, Yik Yuen Gan, Khee Chee Soo, Malini Olivo
Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival
Jin-e Yao, Min Yan, Zhong Guan, Chao-bin Pan, Liang-ping Xia, Chuan-xing Li, Li-hui Wang, Zi-jie Long, Yan Zhao, Ming-wei Li, Fei-meng Zheng, Jie Xu, Dong-jun Lin, Quentin Liu
No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue
Ludmila Prokunina-Olsson, Jennifer L Hall
A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity
Daniela Sorriento, Alfonso Campanile, Gaetano Santulli, Eleonora Leggiero, Lucio Pastore, Bruno Trimarco, Guido Iaccarino
PTEN inhibits BMI1 function independently of its phosphatase activity
Catherine Fan, Lizhi He, Anil Kapoor, Adrian P Rybak, Jason De Melo, Jean-Claude Cutz, Damu Tang
Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro
Jheri J Dupart, Jonathan C Trent, Ho-Young Lee, Kenneth R Hess, Andrew K Godwin, Takahiro Taguchi, Wei Zhang
A combination of indole-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy
Yoshitaka Nakamura, Shingo Yogosawa, Yasuyuki Izutani, Hirotsuna Watanabe, Eigo Otsuji, Tosiyuki Sakai
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Therese Bredholt, Elizabeth AO Dimba, Hanne R Hagland, Line Wergeland, Jørn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr, Bjørn T Gjertsen
MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
Ondrej Slaby, Marek Svoboda, Jaroslav Michalek, Rostislav Vyzula
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Peixin Dong, Zhujie Xu, Nan Jia, Dajin Li, Youji Feng
Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions
Caroline N Mills, Sandeep S Joshi, Richard M Niles
Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
Corina Kohler, Ramin Radpour, Zeinab Barekati, Reza Asadollahi, Johannes Bitzer, Edward Wight, Nicole Bürki, Claude Diesch, Wolfgang Holzgreve, Xiao Yan Zhong
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression
Aaron E Foster, Fatma V Okur, Ettore Biagi, An Lu, Gianpietro Dotti, Eric Yvon, Barbara Savoldo, George Carrum, Michael Andreeff, Margaret A Goodell, Helen E Heslop, Malcolm K Brenner
Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis
Alison K Bauer, Jennifer Fostel, Laura M Degraff, Elizabeth A Rondini, Christopher Walker, Sherry F Grissom, Julie Foley, Steven R Kleeberger
iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
Sara De Boo, Joanna Kopecka, Davide Brusa, Elena Gazzano, Lina Matera, Dario Ghigo, Amalia Bosia, Chiara Riganti
Antiproliferative effect of exemestane in lung cancer cells
Angelos Koutras, Efstathia Giannopoulou, Ismini Kritikou, Anna Antonacopoulou, TR Jeffry Evans, Athanasios G Papavassiliou, Haralabos Kalofonos
PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling
Lirong Peng, Xiaofang Xing, Weijun Li, Like Qu, Lin Meng, Shenyi Lian, Beihai Jiang, Jian Wu, Chengchao Shou
Dual effects of TGF-β on ERα-mediated estrogenic transcriptional activity in breast cancer
Yongsheng Ren, Liyu Wu, Andra R Frost, William Grizzle, Xu Cao, Mei Wan
Activation of hedgehog signaling is not a frequent event in ovarian cancers
Ling Yang, Jing He, Shuhong Huang, Xiaoli Zhang, Yuehong Bian, Nonggao He, Hongwei Zhang, Jingwu Xie
GLI1 genotypes do not predict basal cell carcinoma risk: a case control study
Andrea Watson, Paul Kent, Murad Alam, Amy S Paller, David M Umbach, Joon Won Yoon, Philip M Iannaccone, David O Walterhouse
Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo
Shuchen Gu, Natalia Papadopoulou, Eva-Maria Gehring, Omaima Nasir, Konstantinos Dimas, Shefalee K Bhavsar, Michael Föller, Konstantinos Alevizopoulos, Florian Lang, Christos Stournaras
An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang, Ayad M Al-Katib
Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3
Bianca R Dias, Elaine G Rodrigues, Leonardo Nimrichter, Ernesto S Nakayasu, Igor C Almeida, Luiz R Travassos
Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
Menghang Xia, Kun Bi, Ruili Huang, Ming-Hsuang Cho, Srilatha Sakamuru, Susanne C Miller, Hua Li, Yi Sun, John Printen, Christopher P Austin, James Inglese
Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
Ymera Pignochino, Giovanni Grignani, Giuliana Cavalloni, Manuela Motta, Marta Tapparo, Stefania Bruno, Alessia Bottos, Loretta Gammaitoni, Giorgia Migliardi, Giovanni Camussi, Marco Alberghini, Bruno Torchio, Stefano Ferrari, Federico Bussolino, Franca Fagioli, Piero Picci, Massimo Aglietta
CENPA overexpression promotes genome instability in pRb-depleted human cells
Angela Amato, Tiziana Schillaci, Laura Lentini, Aldo Di Leonardo
Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma
Pao-Ling Torng, Ching-Wei Lin, Michael WY Chan, Hui-Wen Yang, Su-Cheng Huang, Chin-Tarng Lin
Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Pedro Veliça, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride, Chris M Bunce
2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2
Hao Liu, Chen Chen Jiang, Christopher J Lavis, Amanda Croft, Li Dong, Hsin-Yi Tseng, Fan Yang, Kwang Hong Tay, Peter Hersey, Xu Dong Zhang
The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth
Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean-Jacques Helwig, Didier Jacqmin, Hervé Lang, Thierry Massfelder
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis
Mirco Menigatti, Elisa Cattaneo, Jacob Sabates-Bellver, Valery V Ilinsky, Philip Went, Federico Buffoli, Victor E Marquez, Josef Jiricny, Giancarlo Marra
Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines
Wu Huanwen, Liang Zhiyong, Shi Xiaohua, Ren Xinyu, Wang Kai, Liu Tonghua
CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation
Alex J Carlisle, Christopher A Lyttle, Rosalind Y Carlisle, John M Maris
microRNA evaluation of unknown primary lesions in the head and neck
Emma V Barker, Nilva K Cervigne, Patricia P Reis, Rashmi S Goswami, Wei Xu, Ilan Weinreb, Jonathan C Irish, Suzanne Kamel-Reid
Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
Suruchi Mittal, Deepa Subramanyam, Devaveena Dey, Rekha V Kumar, Annapoorni Rangarajan
Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells
Beatrice E Bachmeier, Cristina M Iancu, Peter H Killian, Emanuel Kronski, Valentina Mirisola, Giovanna Angelini, Marianne Jochum, Andreas G Nerlich, Ulrich Pfeffer
Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer
Nicole Chui Pressinotti, Helmut Klocker, Georg Schäfer, Van-Duc Luu, Markus Ruschhaupt, Ruprecht Kuner, Eberhard Steiner, Annemarie Poustka, Georg Bartsch, Holger Sültmann
Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
Boon Tin Chua, David Gallego-Ortega, Ana Ramirez de Molina, Axel Ullrich, Juan Carlos Lacal, Julian Downward
Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth
Jiyuan Ke, R Lakshman Chelvarajan, Vishal Sindhava, Darrell A Robertson, Lazaros Lekakis, C Darrell Jennings, Subbarao Bondada
Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
Igor Landais, Sanne Hiddingh, Matthew McCarroll, Chao Yang, Aiming Sun, Mitchell S Turker, James P Snyder, Maureen E Hoatlin