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Zeitschrift

Molecular Cancer

Molecular Cancer 1/2010

Ausgabe 1/2010

Inhaltsverzeichnis ( 320 Artikel )

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation

Robert Valentine, Christopher W Dawson, Chunfang Hu, Khilan M Shah, Thomas J Owen, Kathryn L Date, Sonia P Maia, Jianyong Shao, John R Arrand, Lawrence S Young, John D O'Neil

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

Christof Renner, Nadine Zemitzsch, Beate Fuchs, Kathrin D Geiger, Matthias Hermes, Jan Hengstler, Rolf Gebhardt, Jürgen Meixensberger, Frank Gaunitz

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer

Wun-Jae Kim, Eun-Jung Kim, Seon-Kyu Kim, Yong-June Kim, Yun-Sok Ha, Pildu Jeong, Min-Ju Kim, Seok-Joong Yun, Keon Myung Lee, Sung-Kwon Moon, Sang-Cheol Lee, Eun-Jong Cha, Suk-Chul Bae

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways

Yi-Lan Zhang, Jiang Li, Hao-Yuan Mo, Fang Qiu, Li-Min Zheng, Chao-Nan Qian, Yi-Xin Zeng

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Smoothened as a new therapeutic target for human osteosarcoma

Masataka Hirotsu, Takao Setoguchi, Hiromi Sasaki, Yukihiro Matsunoshita, Hui Gao, Hiroko Nagao, Osamu Kunigou, Setsuro Komiya

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death

Jing Wang, Ruihong Tang, Ming Lv, Jiyan Zhang, Beifen Shen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth

Xing Zhang, Li-hua Xu, Qiang Yu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

Regina A Oyesanya, Susie Greenbaum, David Dang, Zendra Lee, Abir Mukherjee, Jinhua Wu, Paul Dent, Xianjun Fang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells

Shumin Zhang, Haiyen E Zhau, Adeboye O Osunkoya, Shareen Iqbal, Xiaojian Yang, Songqing Fan, Zhengjia Chen, Ruoxiang Wang, Fray F Marshall, Leland WK Chung, Daqing Wu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo

Li Xiao, Liu Yan, Wen Zhongmei, Li Chang, Lu Huijun, Tian Mingyao, Jin Kuoshi, Sun Lili, Gao Pegn, Yang Encheng, Xu Xiaohong, Kan Shifu, Wang Zhuoyue, Wang Yuhang, Jin Ningyi

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells

Jennifer AA Gubbels, Mildred Felder, Sachi Horibata, Jennifer A Belisle, Arvinder Kapur, Helen Holden, Sarah Petrie, Martine Migneault, Claudine Rancourt, Joseph P Connor, Manish S Patankar

01.12.2010 | Research | Ausgabe 1/2010 Open Access

miR-21: an oncomir on strike in prostate cancer

Marco Folini, Paolo Gandellini, Nicole Longoni, Valentina Profumo, Maurizio Callari, Marzia Pennati, Maurizio Colecchia, Rosanna Supino, Silvia Veneroni, Roberto Salvioni, Riccardo Valdagni, Maria Grazia Daidone, Nadia Zaffaroni

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

Kusumawadee Utispan, Peti Thuwajit, Yoshimitsu Abiko, Komgrid Charngkaew, Anucha Paupairoj, Siri Chau-in, Chanitra Thuwajit

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)

Derek Murphy, Jeremy Parker, Minglong Zhou, Faisal M Fadlelmola, Christian Steidl, Aly Karsan, Randy D Gascoyne, Hong Chen, Diponkar Banerjee

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms

Ana M Jiménez-Lara, Ana Aranda, Hinrich Gronemeyer

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Regulation of the transcription factor NF-κB1 by microRNA-9 in human gastric adenocarcinoma

Hai-Ying Wan, Li-Min Guo, Tao Liu, Min Liu, Xin Li, Hua Tang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

Xiaojuan Sun, Lei Wei, Qian Chen, Richard M Terek

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

Jasmin R Agarwal, Frank Griesinger, Walter Stühmer, Luis A Pardo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization

Ansgar Brüning, Martina Rahmeh, Andrea Gingelmaier, Klaus Friese

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells

Lu Jiang, Xin Zeng, Zhi Wang, Ning Ji, Yu Zhou, Xianting Liu, Qianming Chen

01.12.2010 | Erratum | Ausgabe 1/2010 Open Access

Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers

Pedro Veliça, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride, Chris M Bunce

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Effects of nilotinib on regulatory T cells: the dose matters

Fei Fei, Yingzhe Yu, Anita Schmitt, Markus T Rojewski, Baoan Chen, Jochen Greiner, Marlies Götz, Donald Bunjes, Michael Schmitt

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

Shuzhen Chen, Lei Fu, Shruti M Raja, Ping Yue, Fadlo R Khuri, Shi-Yong Sun

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma

Nikolina Radulovich, Nhu-An Pham, Dan Strumpf, Lisa Leung, Wing Xie, Igor Jurisica, Ming-Sound Tsao

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells

Lian-He Yang, Hong-Tao Xu, Yang Han, Qing-Chang Li, Yang Liu, Yue Zhao, Zhi-Qiang Yang, Qian-Ze Dong, Yuan Miao, Shun-Dong Dai, En-Hua Wang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells

Mei Shi, Hong-Na Wang, Shu-Tao Xie, Yan Luo, Cai-Yun Sun, Xiu-Lan Chen, Yu-Zhong Zhang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Synergistic effect of gefitinib and rofecoxib in mesothelioma cells

Daniela Stoppoloni, Claudia Canino, Irene Cardillo, Alessandra Verdina, Alfonso Baldi, Ada Sacchi, Rossella Galati

01.12.2010 | Research | Ausgabe 1/2010 Open Access

An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo

Melissa C Cheung, Leigh Revers, Subodini Perampalam, Xin Wei, Reza Kiarash, David E Green, Aws Abdul-Wahid, Jean Gariépy

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage

Béatrix Bugler, Estelle Schmitt, Bernadette Aressy, Bernard Ducommun

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion

Siyi Hu, Nathalie Delorme, Zhenzhen Liu, Tao Liu, Cruz Velasco-Gonzalez, Jone Garai, Ashok Pullikuth, Shahriar Koochekpour

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Helicobacter pylori-induced activation of β-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

Thorsten Gnad, Maria Feoktistova, Martin Leverkus, Uwe Lendeckel, Michael Naumann

01.12.2010 | Research | Ausgabe 1/2010 Open Access

EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis

Ting-Yun Liu, Shang-Ju Wu, Mi-Hsin Huang, Fei-Yun Lo, Mong-Hsun Tsai, Ching-Hwa Tsai, Su-Ming Hsu, Chung-Wu Lin

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Ming Zhou, Yuhua Zhao, Yan Ding, Hao Liu, Zixing Liu, Oystein Fodstad, Adam I Riker, Sushama Kamarajugadda, Jianrong Lu, Laurie B Owen, Susan P Ledoux, Ming Tan

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

Junya Kobayashi, Akihiro Kato, Yosuke Ota, Reiko Ohba, Kenshi Komatsu

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression

Wilbur A Lam, Lizhi Cao, Vaibhavi Umesh, Albert J Keung, Shamik Sen, Sanjay Kumar

01.12.2010 | Research | Ausgabe 1/2010 Open Access

NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3

Byung-Hak Kim, Jun-Goo Jee, Chang-Hong Yin, Claudio Sandoval, Somasundaram Jayabose, Daisuke Kitamura, Erika A Bach, Gyeong-Hun Baeg

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak

Lisa Venticinque, Daniel Meruelo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression

James T Lynch, Ramkumar Rajendran, Georgia Xenaki, Ilhem Berrou, Constantinos Demonacos, Marija Krstic-Demonacos

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks

Kouichi Tabu, Taichi Kimura, Ken Sasai, Lei Wang, Norihisa Bizen, Hiroshi Nishihara, Tetsuya Taga, Shinya Tanaka

01.12.2010 | Research | Ausgabe 1/2010 Open Access

BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

Xiao-Wei Zhang, Ya-Ping Sheng, Qian Li, Wei Qin, You-Wei Lu, Yu-Fan Cheng, Bing-Ya Liu, Feng-Chun Zhang, Jin Li, Goberdhan P Dimri, Wei-Jian Guo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia

Sally L Rogers, Yun Zhao, Xiaoyan Jiang, Connie J Eaves, Dixie L Mager, Arefeh Rouhi

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

Christopher P Gully, Fanmao Zhang, Jian Chen, James A Yeung, Guermarie Velazquez-Torres, Edward Wang, Sai-Ching Jim Yeung, Mong-Hong Lee

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells

Ju-Fang Liu, Yi-Chin Fong, Chih-Shiang Chang, Chun-Yin Huang, Hsien-Te Chen, Wei-Hung Yang, Chin-Jung Hsu, Long-Bin Jeng, Chih-Yi Chen, Chih-Hsin Tang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A Genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers

Thomas Dunwell, Luke Hesson, Tibor A Rauch, Lihui Wang, Richard E Clark, Ashraf Dallol, Dean Gentle, Daniel Catchpoole, Eamonn R Maher, Gerd P Pfeifer, Farida Latif

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes

Muy-Teck Teh, Emilios Gemenetzidis, Tracy Chaplin, Bryan D Young, Michael P Philpott

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jean-Paul Brouillet, Alexandre Evrard

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells

Christopher S Bryant, Sanjeev Kumar, Sreedhar Chamala, Jay Shah, Jagannath Pal, Mahdi Haider, Shelly Seward, Aamer M Qazi, Robert Morris, Assaad Semaan, Masood A Shammas, Christopher Steffes, Ravindra B Potti, Madhu Prasad, Donald W Weaver, Ramesh B Batchu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas

Juan P Rodrigo, Dario García-Carracedo, María V González, Gonzalo Mancebo, Manuel F Fresno, Juana García-Pedrero

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo

Andelko Hrzenjak, Farid Moinfar, Marie-Luise Kremser, Bettina Strohmeier, Edgar Petru, Kurt Zatloukal, Helmut Denk

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Smita Misra, Shvetank Sharma, Anupriya Agarwal, Sheetal V Khedkar, Manish K Tripathi, Mukul K Mittal, Gautam Chaudhuri

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Identification of 5 novel genes methylated in breast and other epithelial cancers

Victoria K Hill, Luke B Hesson, Temuujin Dansranjavin, Ashraf Dallol, Ivan Bieche, Sophie Vacher, Stella Tommasi, Timothy Dobbins, Dean Gentle, David Euhus, Cheryl Lewis, Reinhard Dammann, Robyn L Ward, John Minna, Eammon R Maher, Gerd P Pfeifer, Farida Latif

01.12.2010 | Research | Ausgabe 1/2010 Open Access

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

Taha Elmetwali, Peter F Searle, Iain McNeish, Lawrence S Young, Daniel H Palmer

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1+/- mouse cerebellum

Mirella Tanori, Melissa Santone, Mariateresa Mancuso, Emanuela Pasquali, Simona Leonardi, Vincenzo Di Majo, Simonetta Rebessi, Anna Saran, Simonetta Pazzaglia

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice

Keren Bitton-Worms, Eli Pikarsky, Ami Aronheim

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells

Pinar Uysal-Onganer, Yoshiaki Kawano, Mercedes Caro, Marjorie M Walker, Soraya Diez, R Siobhan Darrington, Jonathan Waxman, Robert M Kypta

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study

Ioannis Psallidas, Sophia P Karabela, Charalampos Moschos, Taylor P Sherrill, Androniki Kollintza, Sophia Magkouta, Panagiota Theodoropoulou, Charis Roussos, Timothy S Blackwell, Ioannis Kalomenidis, Georgios T Stathopoulos

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo

Didier Roulin, Yannick Cerantola, Anne Dormond-Meuwly, Nicolas Demartines, Olivier Dormond

01.12.2010 | Research | Ausgabe 1/2010 Open Access

LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications

Susmita Ghosh, Amlan Ghosh, Guru P Maiti, Nupur Mukherjee, Sankhadeep Dutta, Anup Roy, Susanta Roychoudhury, Chinmay K Panda

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I. Field, John D Kelly, David E. Neal, Hiroki Yamaue, Bruce A. J. Ponder, Yusuke Nakamura, Ryuji Hamamoto

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Epithelial Protein Lost in Neoplasm α (Eplin-α) is transcriptionally regulated by G-actin and MAL/MRTF coactivators

Laura Leitner, Dmitry Shaposhnikov, Arnaud Descot, Reinhard Hoffmann, Guido Posern

01.12.2010 | Research | Ausgabe 1/2010 Open Access

RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones

Marco Della Peruta, Cinzia Giagulli, Carlo Laudanna, Aldo Scarpa, Claudio Sorio

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment

Monica Spinola, Felicia S. Falvella, Francesca Colombo, James P. Sullivan, David S. Shames, Luc Girard, Paola Spessotto, John D. Minna, Tommaso A. Dragani

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc Min and KRASV 12mutations

Mandayam O. Nandan, Amr M. Ghaleb, Beth B. McConnell, Nilesh V. Patel, Sylvie Robine, Vincent W. Yang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer

Chien-Hsing Lee, Hsing-Wen Hung, Pei-Hsin Hung, Yi-Shing Shieh

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2

Dirk Zboralski, Bettina Warscheid, Susanne Klein-Scory, M. Bassel Malas, Heiko Becker, Miriam Böckmann, Helmut E Meyer, Wolff Schmiegel, Patricia Simon-Assmann, Irmgard Schwarte-Waldhoff

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers

Alan J. Wright, Greg A. Fellows, John R. Griffiths, M. Wilson, B. Anthony Bell, Franklyn A. Howe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Mouse Rad1 deletion enhances susceptibility for skin tumor development

Lu Han, Zhishang Hu, Yuheng Liu, Xiangyuan Wang, Kevin M. Hopkins, Howard B. Lieberman, Haiying Hang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

Emelyne Dejeux, Jo Anders Rønneberg, Hiroko Solvang, Ida Bukholm, Stephanie Geisler, Turid Aas, Ivo G. Gut, Anne-Lise Børresen-Dale, Per Eystein Lønning, Vessela N. Kristensen, Jörg Tost

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy

Richard F. Kefford, Philip R. Clingan, Benjamin Brady, Andrea Ballmer, Adele Morganti, Peter Hersey

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Replication independent DNA double-strand break retention may prevent genomic instability

Narisorn Kongruttanachok, Chutipa Phuangphairoj, Araya Thongnak, Wanpen Ponyeam, Prakasit Rattanatanyong, Wichai Pornthanakasem, Apiwat Mutirangura

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma

Jian-Min Wu, Yan Xu, Nicholas J. Skill, Hongmiao Sheng, Zhenwen Zhao, Menggang Yu, Romil Saxena, Mary A. Maluccio

01.12.2010 | Research | Ausgabe 1/2010 Open Access

PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells

Tong Zhang, Xian-Hong Huang, Lan Dong, Deqing Hu, Changhui Ge, Yi-Qun Zhan, Wang-Xiang Xu, Miao Yu, Wei Li, Xiaohui Wang, Liujun Tang, Chang-Yan Li, Xiao-Ming Yang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway

Chenghai Li, Zhengfeng Yang, Chunyan Zhai, Wenwei Qiu, Dali Li, Zhengfang Yi, Lei Wang, Jie Tang, Min Qian, Jian Luo, Mingyao Liu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

Masato Tsuchiya, Joel S. Parker, Hiroshi Kono, Masanori Matsuda, Hideki Fujii, Ivan Rusyn

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

J. Rafael Sierra, Virna Cepero, Silvia Giordano

01.12.2010 | Research | Ausgabe 1/2010 Open Access

PKCα expression is a marker for breast cancer aggressiveness

Gry Kalstad Lønne, Louise Cornmark, Iris Omanovic Zahirovic, Göran Landberg, Karin Jirström, Christer Larsson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Chun Hei Antonio Cheung, Huang-Hui Chen, Li-Ting Cheng, Kevin W. Lyu, Jagat R. Kanwar, Jang-Yang Chang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

Luxia Tu, Zhen Liu, Xiufang He, Ying He, Huiling Yang, Qingping Jiang, Siming Xie, Guanghui Xiao, Xin Li, Kaitai Yao, Weiyi Fang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

Bin Peng, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan, Denghai Zhang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells

Susanne Schüler, Petra Fritsche, Sandra Diersch, Alexander Arlt, Roland M. Schmid, Dieter Saur, Günter Schneider

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma

Fenglian Ren, Hong Wu, Yunlong Lei, Haiyuan Zhang, Rui Liu, Yong Zhao, Xiancheng Chen, Dequan Zeng, Aiping Tong, Lijuan Chen, Yuquan Wei, Canhua Huang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Regulation of MCP-1 chemokine transcription by p53

Katrin Hacke, Bladimiro Rincon-Orozco, Gilles Buchwalter, Simone Y. Siehler, Bohdan Wasylyk, Lisa Wiesmüller, Frank Rösl

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2

Niamh H. Foley, Isabella M. Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan, Raymond L. Stallings

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Intracellular targets of RGDS peptide in melanoma cells

Maria Simona Aguzzi, Paola Fortugno, Claudia Giampietri, Gianluca Ragone, Maurizio C. Capogrossi, Antonio Facchiano

01.12.2010 | Research | Ausgabe 1/2010 Open Access

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

Christelle P. El Haibi, Praveen K. Sharma, Rajesh Singh, Paul R. Johnson, Jill Suttles, Shailesh Singh, James W. Lillard Jr

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNγ-inducible Cd74 isoform

Magdalena Pyrz, Bruce Wang, Matthias Wabl, Finn Skou Pedersen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL

Alena Vaculova, Vitaliy Kaminskyy, Elham Jalalvand, Olga Surova, Boris Zhivotovsky

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Mert Erkan, Nadine Weis, Zheng Pan, Christian Schwager, Tamar Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A. Giese, Wilhelm Ansorge, Jürgen Debus, Peter E. Huber, Helmut Friess, Amir Abdollahi, Jörg Kleeff

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

Mengqian Chen, Michael A. Feuerstein, Elina Levina, Prateek S. Baghel, Richard D. Carkner, Matthew J. Tanner, Michael Shtutman, Francis Vacherot, Stéphane Terry, Alexandre de la Taille, Ralph Buttyan

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice

Fan Feng, Yao-Chun Wang, Xing-Bin Hu, Xiao-Wei Liu, Gang Ji, Yun-Ru Chen, Lin Wang, Fei He, Guo-Rui Dou, Liang Liang, Hong-Wei Zhang, Hua Han

01.12.2010 | Research | Ausgabe 1/2010 Open Access

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase

Hong-Tai Ji, Li-Ting Chien, Yu-Hsin Lin, Hsiung-Fei Chien, Chin-Tin Chen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Myc interacts with Max and Miz1 to repress C/EBPδ promoter activity and gene expression

Junling Si, Xueyan Yu, Yingjie Zhang, James W. DeWille

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-β2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A

Fei Ye, Xiao-Chun Xu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma

Julia Freimuth, Nikolaus Gassler, Nives Moro, Rolf W. Günther, Christian Trautwein, Christian Liedtke, Gabriele A. Krombach

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

Kathryn G. Eby, Jennifer M. Rosenbluth, Deborah J. Mays, Clayton B. Marshall, Christopher E. Barton, Seema Sinha, Kimberly N. Johnson, Luojia Tang, Jennifer A. Pietenpol

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells

Bo Song, Yuan Wang, Matthew A. Titmus, Galina Botchkina, Andrea Formentini, Marko Kornmann, Jingfang Ju

01.12.2010 | Research | Ausgabe 1/2010 Open Access

NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma

Seong-Su Han, Hwakyung Yun, Dong-Ju Son, Van S. Tompkins, Liangping Peng, Seung-Tae Chung, Joong-Su Kim, Eun-Sung Park, Siegfried Janz

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Bi-Dar Wang, Christina Leah B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby, Norman H. Lee

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman, Wim Vanden Berghe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci

Marianne Berg, Trude H Ågesen, Espen Thiis-Evensen, Marianne A Merok, Manuel R Teixeira, Morten H Vatn, Arild Nesbakken, Rolf I Skotheim, Ragnhild A Lothe, [the INFAC-study group]

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells

Mansoor Ahmed, Gopal C Kundu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells

Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff, Frank Thévenod

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cyclin K and cyclin D1b are oncogenic in myeloma cells

Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir, Brigitte Sola

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors

Thomas W Sturgill, Paul B Stoddard, Steven M Cohn, Marty W Mayo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study

Amanda L Cleaver, Alex H Beesley, Martin J Firth, Nina C Sturges, Rebecca A O'Leary, Stephen P Hunger, David L Baker, Ursula R Kees

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients

Flavia RR Mangone, Fernando Walder, Simone Maistro, Fátima S Pasini, Carlos N Lehn, Marcos B Carvalho, M Mitzi Brentani, Igor Snitcovsky, Miriam HH Federico

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

Anders Olsson, Anders Björk, Johan Vallon-Christersson, John T Isaacs, Tomas Leanderson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β

Paul Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D Cramer, Jianfeng Xu, Ming Lei, Guangchao Sui

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

Jaehyouk Lee, Dong-Jun Jeong, Jinsun Kim, Soonduck Lee, Jin-Hwa Park, Boogi Chang, Sam-Il Jung, Lisha Yi, Youngsoo Han, Young Yang, Keun Il Kim, Jong-Seok Lim, Inchul Yang, Seob Jeon, Dong Han Bae, Chang-Jin Kim, Myeong-Sok Lee

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Characterization of bortezomib-adapted I-45 mesothelioma cells

Lidong Zhang, James E Littlejohn, Yu Cui, Xiaobo Cao, Chander Peddaboina, W Roy Smythe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer

Ali Naderi, Ji Liu, Luke Hughes-Davies

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao, Jingxuan Pan

01.12.2010 | Research | Ausgabe 1/2010 Open Access

NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations

Yi-Ping Fu, Hege Edvardsen, Alpana Kaushiva, Juan P Arhancet, Tiffany M Howe, Indu Kohaar, Patricia Porter-Gill, Anushi Shah, Hege Landmark-Høyvik, Sophie D Fosså, Stefan Ambs, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N Kristensen, Ludmila Prokunina-Olsson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence

Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno, Jose M Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Susana del Toro-Arreola, Ruth de Celis-Carrillo, Jose E Sahagun-Flores, Javier E Garcia de Alba-Garcia, Georgina Hernandez-Flores

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia

Etienne Moussay, Valérie Palissot, Laurent Vallar, Hélène A Poirel, Thomas Wenner, Victoria El Khoury, Nasséra Aouali, Kris Van Moer, Bernadette Leners, François Bernardin, Arnaud Muller, Pascale Cornillet-Lefebvre, Alain Delmer, Caroline Duhem, Fernand Ries, Eric van Dyck, Guy Berchem

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors

Sara Molatore, Eva Kiermaier, Christian B Jung, Misu Lee, Elke Pulz, Heinz Höfler, Michael J Atkinson, Natalia S Pellegata

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion

Kevin T Bauerle, Rebecca E Schweppe, Bryan R Haugen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

Jennifer A Belisle, Sachi Horibata, Gubbels AA Jennifer, Sarah Petrie, Arvinder Kapur, Sabine André, Hans-Joachim Gabius, Claudine Rancourt, Joseph Connor, James C Paulson, Manish S Patankar

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Characterization of the role of the tumor marker Nup88 in mitosis

Chieko Hashizume, Hiroshi Nakano, Kimihisa Yoshida, Richard W Wong

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements

Francesco Albano, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Paola Casieri, Antonella Russo Rossi, Laura Vicari, Vincenzo Liso, Mariano Rocchi, Giorgina Specchia

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Simona Corso, Elena Ghiso, Virna Cepero, J Rafael Sierra, Cristina Migliore, Andrea Bertotti, Livio Trusolino, Paolo M Comoglio, Silvia Giordano

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

Vidya Ganapathy, Rongrong Ge, Alison Grazioli, Wen Xie, Whitney Banach-Petrosky, Yibin Kang, Scott Lonning, John McPherson, Jonathan M Yingling, Swati Biswas, Gregory R Mundy, Michael Reiss

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

Manuela Ferracin, Barbara Zagatti, Lara Rizzotto, Francesco Cavazzini, Angelo Veronese, Maria Ciccone, Elena Saccenti, Laura Lupini, Andrea Grilli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling

Young-Rang Kim, Kyung-Jin Oh, Ra-Young Park, Nguyen Thi Xuan, Taek-Won Kang, Dong-Deuk Kwon, Chan Choi, Min Soo Kim, Kwang Il Nam, Kyu Youn Ahn, Chaeyong Jung

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors

Yoshifumi Baba, Curtis Huttenhower, Katsuhiko Nosho, Noriko Tanaka, Kaori Shima, Aditi Hazra, Eva S Schernhammer, David J Hunter, Edward L Giovannucci, Charles S Fuchs, Shuji Ogino

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation

Hsiao-Ling Cheng, Shu-Jem Su, Li-Wen Huang, Bau-Shan Hsieh, Yu-Chen Hu, Thu-Ching Hung, Kee-Lung Chang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

Andreas Palagyi, Kornelia Neveling, Ursula Plinninger, Andreas Ziesch, Bianca-Sabrina Targosz, Gerald U Denk, Stephanie Ochs, Antonia Rizzani, Daniel Meier, Wolfgang E Thasler, Helmut Hanenberg, Enrico N De Toni, Florian Bassermann, Claus Schäfer, Burkhard Göke, Detlev Schindler, Eike Gallmeier

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers

Jing Ping Tang, Cheng Peow Tan, Jie Li, Md Monowarul Siddique, Ke Guo, Siew Wee Chan, Jung Eun Park, Wan Ngee Tay, Zhi Yuan Huang, Wen Cai Li, Jian Chen, Qi Zeng

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tumor cell behaviour modulation by mesenchymal stromal cells

Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova, Cestmir Altaner

01.12.2010 | Research | Ausgabe 1/2010 Open Access

TGFBI expression is associated with a better response to chemotherapy in NSCLC

Marta Irigoyen, María J Pajares, Jackeline Agorreta, Mariano Ponz-Sarvisé, Elisabeth Salvo, María D Lozano, Ruben Pío, Ignacio Gil-Bazo, Ana Rouzaut

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil, Elzbieta Izbicka, Richard F Luduena, Jack A Tuszynski

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia, Dawei Xu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb, David Zagzag

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Microprocessor of microRNAs: regulation and potential for therapeutic intervention

Kevin J Beezhold, Vince Castranova, Fei Chen

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

Camilla Krakstad, Martha Chekenya

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Identification of non-coding RNAs embracing microRNA-143/145 cluster

Akio Iio, Yoshihito Nakagawa, Ichiro Hirata, Tomoki Naoe, Yukihiro Akao

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells

Marina Pisano, Gabriella Pagnan, Maria Antonietta Dettori, Sara Cossu, Irene Caffa, Ilaria Sassu, Laura Emionite, Davide Fabbri, Michele Cilli, Fabio Pastorino, Giuseppe Palmieri, Giovanna Delogu, Mirco Ponzoni, Carla Rozzo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors

Alexandre Chlenski, Lisa J Guerrero, Radhika Peddinti, Jared A Spitz, Payton T Leonhardt, Qiwei Yang, Yufeng Tian, Helen R Salwen, Susan L Cohn

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo

Yi-Fan Hsu, Daniel Ajona, Leticia Corrales, Jose M Lopez-Picazo, Alfonso Gurpide, Luis M Montuenga, Ruben Pio

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid

Molly K Altman, Vashisht Gopal, Wei Jia, Shuangxing Yu, Hassan Hall, Gordon B Mills, A Cary McGinnis, Michael G Bartlett, Guowei Jiang, Damian Madan, Glenn D Prestwich, Yong Xu, Michael A Davies, Mandi M Murph

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy

Sylvine Cottin, Karim Ghani, Pedro Otavio de Campos-Lima, Manuel Caruso

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability

Roberto Benelli, Stefano Monteghirfo, Roberta Venè, Francesca Tosetti, Nicoletta Ferrari

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival

Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Tessa C Rue, Melissa P Upton, John R Houck, Pawadee Lohavanichbutr, David R Doody, Neal D Futran, Lue Ping Zhao, Stephen M Schwartz, Chu Chen, Eduardo Méndez

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Glycogen synthase kinase 3 beta: can it be a target for oral cancer

Rajakishore Mishra

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

Yong-Yu Liu, Vineet Gupta, Gauri A Patwardhan, Kaustubh Bhinge, Yunfeng Zhao, Jianxiong Bao, Harihara Mehendale, Myles C Cabot, Yu-Teh Li, S Michal Jazwinski

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old

Dilek Colak, Muhammad A Chishti, Al-Bandary Al-Bakheet, Ahmed Al-Qahtani, Mohamed M Shoukri, Malcolm H Goyns, Pinar T Ozand, John Quackenbush, Ben H Park, Namik Kaya

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova, Borivoj Vojtesek

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: Regulation of MMP 9 by PDEF

Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham, Hari K Koul

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia

Ru Chen, Sheng Pan, Xiaobo Duan, Brad H Nelson, Rob A Sahota, Sarah de Rham, Richard A Kozarek, Martin McIntosh, Teresa A Brentnall

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

The ERα coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium

Jerzy Rokicki, Partha M Das, Jennifer M Giltnane, Olivia Wansbury, David L Rimm, Beatrice A Howard, Frank E Jones

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines

Stefan Nagel, Letizia Venturini, Victor E Marquez, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick AF MacLeod, Hans G Drexler

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer

Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen, Victor L Thijssen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing, Stefan Duensing

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes, Lu-Gang Yu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition

Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu, Lawrence S Young

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth

Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch, Fabrice Matifat

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways

Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck, Xuefen Le Bourhis

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger, Goberdhan P Dimri

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja, Krzysztof Reiss

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling

Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan, Laura S Schmidt

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tumor promoting effects of CD95 signaling in chemoresistant cells

Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva María Pastor-Arroyo, Pedro Gascón, Vanessa Almendro

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition

David S. Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R. Simoneau, Bang H. Hoang, Xiaolin Zi

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia

Robert J. Weeks, Ursula R. Kees, Sarah Song, Ian M. Morison

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1

Henry Zall, Arnim Weber, Robert Besch, Niko Zantl, Georg Häcker

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson Jr, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson III, Pui-Kai Li, Gregory B Lesinski

01.12.2010 | Research | Ausgabe 1/2010 Open Access

EGFR isoforms and gene regulation in human endometrial cancer cells

Lina Albitar, Gavin Pickett, Marilee Morgan, Jason A Wilken, Nita J Maihle, Kimberly K Leslie

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer

Saskia M Wilting, Robert AA van Boerdonk, Florianne E Henken, Chris JLM Meijer, Begoňa Diosdado, Gerrit A Meijer, Carlos le Sage, Reuven Agami, Peter JF Snijders, Renske DM Steenbergen

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip, Walter E Aulitzky

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation

Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata, Masao Tanaka

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

Ester Lara, Vincenzo Calvanese, Covadonga Huidobro, Agustin F Fernández, Ángela Moncada-Pazos, Álvaro J Obaya, Oscar Aguilera, José Manuel González-Sancho, Laura Sánchez, Aurora Astudillo, Alberto Muñoz, Carlos López-Otín, Manel Esteller, Mario F Fraga

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells

Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho, Paul Shore

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

The tumor suppressor gene KCTD11 REN is regulated by Sp1 and methylation and its expression is reduced in tumors

M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino, Edoardo Alesse

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers

Elisabet Ognedal Berge, Stian Knappskog, Stephanie Geisler, Vidar Staalesen, Marec Pacal, Anne-Lise Børresen-Dale, Pål Puntervoll, Johan Richard Lillehaug, Per Eystein Lønning

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood

Matthias Jost, John R Day, Ryan Slaughter, Theodore D Koreckij, Deanna Gonzales, Martin Kinnunen, Jack Groskopf, Harry G Rittenhouse, Robert L Vessella, Mark A Reynolds

01.12.2010 | Research | Ausgabe 1/2010 Open Access

p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker

Magdalena B Flak, Claire M Connell, Claude Chelala, Kyra Archibald, Michael A Salako, Katrina J Pirlo, Michelle Lockley, Sally P Wheatley, Frances R Balkwill, Iain A McNeish

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells

Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim, Parul Trivedi, Jaehyup Kim, Peiman Hematti, Shigeki Miyamoto

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma

Uta Berndt, Lars Philipsen, Sebastian Bartsch, Yuqin Hu, Christoph Röcken, Wiedenmann Bertram, Marcus Hämmerle, Thomas Rösch, Andreas Sturm

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells

Priyanka Sharma, Santosh Kumar, Gopal C Kundu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition

Yvonne L Chao, Christopher R Shepard, Alan Wells

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells

Bisrat G Debeb, Xiaomei Zhang, Savitri Krishnamurthy, Hui Gao, Evan Cohen, Li Li, Angel A Rodriguez, Melissa D Landis, Anthony Lucci, Naoto T Ueno, Fredika Robertson, Wei Xu, Lara Lacerda, Thomas A Buchholz, Massimo Cristofanilli, James M Reuben, Michael T Lewis, Wendy A Woodward

01.12.2010 | Research | Ausgabe 1/2010 Open Access

TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells

Irene Riz, Teresa S Hawley, Truong V Luu, Norman H Lee, Robert G Hawley

01.12.2010 | Research | Ausgabe 1/2010 Open Access

NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells

Ricardo Parrondo, Alicia de las Pozas, Teresita Reiner, Priyamvada Rai, Carlos Perez-Stable

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-κB-independent, proteasome-mediated mechanism

Konstantin Golovine, Peter Makhov, Robert G Uzzo, Alexander Kutikov, David J Kaplan, Eric Fox, Vladimir M Kolenko

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition

Adele Hannigan, Joanna B Wilson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

Paolo Fardin, Annalisa Barla, Sofia Mosci, Lorenzo Rosasco, Alessandro Verri, Rogier Versteeg, Huib N Caron, Jan J Molenaar, Ingrid Øra, Alessandra Eva, Maura Puppo, Luigi Varesio

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

Ying Liu, Yanfeng Chen, Amin Momin, Rebecca Shaner, Elaine Wang, Nathan J Bowen, Lilya V Matyunina, L DeEtte Walker, John F McDonald, M Cameron Sullards, Alfred H Merrill Jr

01.12.2010 | Research | Ausgabe 1/2010 Open Access

SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies

Elin Gustavsson, Sandra Sernbo, Elin Andersson, Donal J. Brennan, Michael Dictor, Mats Jerkeman, Carl A. K. Borrebaeck, Sara Ek

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

Xuchao Zhang, Shirley Zhang, Xuening Yang, Jinji Yang, Qing Zhou, Lucy Yin, Shejuan An, Jiaying Lin, Shiliang Chen, Zhi Xie, Mike Zhu, Xiaolin Zhang, Yi-long Wu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

Maria H Traka, Caroline A Spinks, Joanne F Doleman, Antonietta Melchini, Richard Y Ball, Robert D Mills, Richard F Mithen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene

Haiqing Ma, Desheng Weng, Yibing Chen, Wei Huang, Ke Pan, Hui Wang, Jiancong Sun, Qijing Wang, Zhiwei Zhou, Huiyun Wang, Jianchuan Xia

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia

Lionel Flamant, Annick Notte, Noelle Ninane, Martine Raes, Carine Michiels

01.12.2010 | Research | Ausgabe 1/2010 Open Access

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

Galina I Botchkina, Edison S Zuniga, Manisha Das, Yuan Wang, Haichao Wang, Shu Zhu, Anne G Savitt, Rebecca A Rowehl, Yan Leyfman, Jingfang Ju, Kenneth Shroyer, Iwao Ojima

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy

Ramón García-Escudero, Ana B Martínez-Cruz, Mirentxu Santos, Corina Lorz, Carmen Segrelles, Guillermo Garaulet, Cristina Saiz-Ladera, Clotilde Costa, Águeda Buitrago-Pérez, Marta Dueñas, Jesús M Paramio

01.12.2010 | Research | Ausgabe 1/2010 Open Access

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

Svetlana A Mikheeva, Andrei M Mikheev, Audrey Petit, Richard Beyer, Robert G Oxford, Leila Khorasani, John-Patrick Maxwell, Carlotta A Glackin, Hiroaki Wakimoto, Inés González-Herrero, Isidro Sánchez-García, John R Silber, Philip J Horner, Robert C Rostomily

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

Ashley L Craig, Jitka Holcakova, Lee E Finlan, Marta Nekulova, Roman Hrstka, Nuri Gueven, James DiRenzo, Graeme Smith, Ted R Hupp, Borivoj Vojtesek

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

María M Caffarel, Clara Andradas, Emilia Mira, Eduardo Pérez-Gómez, Camilla Cerutti, Gema Moreno-Bueno, Juana M Flores, Isabel García-Real, José Palacios, Santos Mañes, Manuel Guzmán, Cristina Sánchez

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

Giampiero Porcu, Cathal Wilson, Daniele Di Giandomenico, Antonella Ragnini-Wilson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Jipei Liao, Lei Yu, Yuping Mei, Maria Guarnera, Jun Shen, Ruiyun Li, Zhenqiu Liu, Feng Jiang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases

Suk-Bin Seo, Jung-Gu Hur, Mi-Ju Kim, Jae-Won Lee, Hak-Bong Kim, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Transcriptome analysis of human cancer reveals a functional role of Heme Oxygenase-1 in tumor cell adhesion

Stefanie Tauber, Alexander Jais, Markus Jeitler, Sandra Haider, Julia Husa, Josefine Lindroos, Martin Knöfler, Matthias Mayerhofer, Hubert Pehamberger, Oswald Wagner, Martin Bilban

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation

Svenja Meierjohann, Anita Hufnagel, Elisabeth Wende, Markus A Kleinschmidt, Katarina Wolf, Peter Friedl, Stefan Gaubatz, Manfred Schartl

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Personalized therapies in the cancer "omics" era

Alberto Ocaña, Atanasio Pandiella

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations

Prashant Bavi, Sarita E Prabhakaran, Jehad Abubaker, Zeeshan Qadri, Thara George, Nasser Al-Sanea, Alaa Abduljabbar, Luai H Ashari, Samar Alhomoud, Fouad Al-Dayel, Azhar R Hussain, Shahab Uddin, Khawla S Al-Kuraya

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

Amrendra K Ajay, Ankur K Upadhyay, Sandeep Singh, Maleppillil V Vijayakumar, Ratna Kumari, Vimal Pandey, Ramanamurthy Boppana, Manoj K Bhat

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Regulation of the Aurora-A gene following topoisomerase I inhibition: implication of the Myc transcription Factor

Sandy Courapied, Julia Cherier, Arnaud Vigneron, Marie-Bérangère Troadec, Sandrine Giraud, Isabelle Valo, Claude Prigent, Erick Gamelin, Olivier Coqueret, Benjamin Barré

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis

Pawan Kumar, Arti Yadav, Samip N Patel, Mozaffarul Islam, Quintin Pan, Sofia D Merajver, Theodoros N Teknos

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

Paola Matarrese, Barbara Ascione, Laura Ciarlo, Rosa Vona, Carlo Leonetti, Marco Scarsella, Anna M Mileo, Caterina Catricalà, Marco G Paggi, Walter Malorni

01.12.2010 | Research | Ausgabe 1/2010 Open Access

R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair

Mario Federico, Catherine E Symonds, Luigi Bagella, Flavio Rizzolio, Daniele Fanale, Antonio Russo, Antonio Giordano

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1

Kakali Dhar, Gopal Dhar, Monami Majumder, Inamul Haque, Smita Mehta, Peter J Van Veldhuizen, Sushanta K Banerjee, Snigdha Banerjee

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1

Yong Zhong Xu, Mitra Heravi, Thusanth Thuraisingam, Sergio Di Marco, Thierry Muanza, Danuta Radzioch

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network

Jianjun Zhang, Haiyan Guo, Guanxiang Qian, Shengfang Ge, Huifeng Ji, Xiaobo Hu, Wantao Chen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

Shailender S Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B Patel, Adhip PN Majumdar

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Loss, mutation and deregulation of L3MBTL4 in breast cancers

Lynda Addou-Klouche, José Adélaïde, Pascal Finetti, Nathalie Cervera, Anthony Ferrari, Ismahane Bekhouche, Fabrice Sircoulomb, Christos Sotiriou, Patrice Viens, Soraya Moulessehoul, François Bertucci, Daniel Birnbaum, Max Chaffanet

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MiTF links Erk1/2 kinase and p21CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells

Feng Liu, Amarinder Singh, Zhen Yang, Angela Garcia, Yu Kong, Frank L Meyskens Jr

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat

Meng Fang, Sylviane Dewaele, Yun-peng Zhao, Peter Stärkel, Valerie Vanhooren, Yue-ming Chen, Xin Ji, Ming Luo, Bao-mu Sun, Yves Horsmans, Anne Dell, Stuart M Haslam, Paola Grassi, Claude Libert, Chun-fang Gao, Cuiying Chitty Chen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

XIAP gene expression and function is regulated by autocrine and paracrine TGF-β signaling

Céline Van Themsche, Parvesh Chaudhry, Valérie Leblanc, Sophie Parent, Eric Asselin

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

Li Lin, Stephanie Deangelis, Elizabeth Foust, James Fuchs, Chenglong Li, Pui-Kai Li, Eric B Schwartz, Gregory B Lesinski, Don Benson, Jiagao Lü, Dale Hoyt, Jiayuh Lin

01.12.2010 | Research | Ausgabe 1/2010 Open Access

RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma

Shilpi Arora, Irma M Gonzales, R Tanner Hagelstrom, Christian Beaudry, Ashish Choudhary, Chao Sima, Raoul Tibes, Spyro Mousses, David O Azorsa

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma

Femke Heindryckx, Koen Mertens, Nicolas Charette, Bert Vandeghinste, Christophe Casteleyn, Christophe Van Steenkiste, Dominique Slaets, Louis Libbrecht, Steven Staelens, Peter Starkel, Anja Geerts, Isabelle Colle, Hans Van Vlierberghe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

Vineshkumar T Puliyappadamba, Vino T Cheriyan, Arun Kumar T Thulasidasan, Smitha V Bava, Balachandran S Vinod, Priya R Prabhu, Ranji Varghese, Arathy Bevin, Shalini Venugopal, Ruby John Anto

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival

Xiao-Yang Wang, Luiz OF Penalva, Hongyan Yuan, R Ilona Linnoila, Jiachun Lu, Hideyuki Okano, Robert I Glazer

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated

Soo-Yeon Park, Young Mee Kim, Hongryull Pyo

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells

Ruben Zamora, Magali Espinosa, Gisela Ceballos-Cancino, Blanca Segura, Vilma Maldonado, Jorge Melendez-Zajgla

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ

Zoi Diamantopoulou, Oya Bermek, Apostolos Polykratis, Yamina Hamma-Kourbali, Jean Delbé, José Courty, Panagiotis Katsoris

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression

Mehtap S Gündogdu, He Liu, Daniela Metzdorf, Dagmar Hildebrand, Michael Aigner, Klaus Aktories, Klaus Heeg, Katharina F Kubatzky

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Frances Wadelin, Joel Fulton, Paul A McEwan, Keith A Spriggs, Jonas Emsley, David M Heery

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion

Qingli Shen, Vito R Cicinnati, Xiaoyong Zhang, Speranta Iacob, Frank Weber, Georgios C Sotiropoulos, Arnold Radtke, Mengji Lu, Andreas Paul, Guido Gerken, Susanne Beckebaum

01.12.2010 | Research | Ausgabe 1/2010 Open Access

I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma

Ayad Al-Katib, Alan A Arnold, Amro Aboukameel, Angela Sosin, Peter Smith, Anwar N Mohamed, Frances W Beck, Ramzi M Mohammad

01.12.2010 | Research | Ausgabe 1/2010 Open Access

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma

Chun-Zhi Zhang, Jun-Xia Zhang, An-Ling Zhang, Zhen-Dong Shi, Lei Han, Zhi-Fan Jia, Wei-Dong Yang, Guang-Xiu Wang, Tao Jiang, Yong-Ping You, Pei-Yu Pu, Jin-Quan Cheng, Chun-Sheng Kang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation

Alessio Valletti, Anna Anselmo, Marina Mangiulli, Ilenia Boria, Flavio Mignone, Giuseppe Merla, Vincenzo D'Angelo, Apollonia Tullo, Elisabetta Sbisà, Anna Maria D'Erchia, Graziano Pesole

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis

Céline Sabatel, Anne M Cornet, Sébastien P Tabruyn, Ludovic Malvaux, Karolien Castermans, Joseph A Martial, Ingrid Struman

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

Ravindresh Chhabra, Richa Dubey, Neeru Saini

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Coordination of glioblastoma cell motility by PKCι

R Mitchell Baldwin, Gordon M Barrett, Doris AE Parolin, Jana K Gillies, Judith A Paget, Sylvie J Lavictoire, Douglas A Gray, Ian AJ Lorimer

01.12.2010 | Research | Ausgabe 1/2010 Open Access

An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients

François Ducray, Aurélien de Reyniès, Olivier Chinot, Ahmed Idbaih, Dominique Figarella-Branger, Carole Colin, Lucie Karayan-Tapon, Hervé Chneiweiss, Michel Wager, François Vallette, Yannick Marie, David Rickman, Emilie Thomas, Jean-Yves Delattre, Jérôme Honnorat, Marc Sanson, François Berger

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

Craig I Campbell, James J Petrik, Roger A Moorehead

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Convergence between Wnt-β-catenin and EGFR signaling in cancer

Tianhui Hu, Cunxi Li

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma

Jing-Yan Cao, Li Liu, Shu-Peng Chen, Xing Zhang, Yan-Jun Mi, Zhi-Gang Liu, Man-Zhi Li, Hua Zhang, Chao-Nan Qian, Jian-Yong Shao, Li-Wu Fu, Yun-Fei Xia, Mu-Sheng Zeng

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma

Patricia P Reis, Miranda Tomenson, Nilva K Cervigne, Jerry Machado, Igor Jurisica, Melania Pintilie, Mahadeo A Sukhai, Bayardo Perez-Ordonez, Reidar Grénman, Ralph W Gilbert, Patrick J Gullane, Jonathan C Irish, Suzanne Kamel-Reid

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

Susmita Mondal, Chandan Mandal, Rajender Sangwan, Sarmila Chandra, Chitra Mandal

01.12.2010 | Research | Ausgabe 1/2010 Open Access

t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer

Bhavatarini Vangamudi, Dun-Fa Peng, Qiuyin Cai, Wael El-Rifai, Wei Zheng, Abbes Belkhiri

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors

Thomas J Owen, John D O'Neil, Christopher W Dawson, Chunfang Hu, Xiaoyi Chen, Yunhong Yao, Victoria HJ Wood, Louise E Mitchell, Robert J White, Lawrence S Young, John R Arrand

01.12.2010 | Review | Ausgabe 1/2010 Open Access

A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12

David J Klinke II

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage

Chun-Hui Su, Ruiying Zhao, Guermarie Velazquez-Torres, Jian Chen, Christopher Gully, Sai-Ching J Yeung, Mong-Hong Lee

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

FATS is a transcriptional target of p53 and associated with antitumor activity

Xifeng Zhang, Qian Zhang, Jun Zhang, Li Qiu, Shuang-shuang Yan, Juling Feng, Yan Sun, Xingxu Huang, Karen H Lu, Zheng Li

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway

Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Fumie Shiraishi, Sachio Morimoto, Yutaka Watanabe, Masato Hirata, Sumio Hoka, Toshiyuki Sasaguri

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1

Edwin Chen, Xiaoyong Huang, Yanzhen Zheng, You-Jun Li, Alden Chesney, Yaacov Ben-David, Eric Yang, Margaret R Hough

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma

Xiaoyi Dun, Hua Jiang, Jianfeng Zou, Jun Shi, Lili Zhou, Rong Zhu, Jian Hou

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression

Svetlana Usanova, Andrea Piée-Staffa, Ulrike Sied, Jürgen Thomale, Astrid Schneider, Bernd Kaina, Beate Köberle

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8

Ahmed S Abdulamir, Rand R Hafidh, Fatimah Abu Bakar

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Multiple functions of CXCL12 in a syngeneic model of breast cancer

Sharon A Williams, Yuka Harata-Lee, Iain Comerford, Robin L Anderson, Mark J Smyth, Shaun R McColl

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Roles of Sema4D and Plexin-B1 in tumor progression

Ewe Seng Ch'ng, Atsushi Kumanogoh

01.12.2010 | Review | Ausgabe 1/2010 Open Access

MicroRNA roles in beta-catenin pathway

Kai Huang, Jun-Xia Zhang, Lei Han, Yong-Ping You, Tao Jiang, Pei-Yu Pu, Chun-Sheng Kang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway

Rafael Cubas, Sheng Zhang, Min Li, Changyi Chen, Qizhi Yao

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE

Stephanie M Pütz, Fotini Vogiatzi, Thorsten Stiewe, Albert Sickmann

01.12.2010 | Research | Ausgabe 1/2010 Open Access

P-cadherin counteracts myosin II-B function: implications in melanoma progression

Koen Jacobs, Mireille Van Gele, Ramses Forsyth, Lieve Brochez, Barbara Vanhoecke, Olivier De Wever, Marc Bracke

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

Nicolas Charette, Christine De Saeger, Valérie Lannoy, Yves Horsmans, Isabelle Leclercq, Peter Stärkel

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Stefan M Willems, Yvonne M Schrage, Inge H Briaire-de Bruijn, Karoly Szuhai, Pancras CW Hogendoorn, Judith VMG Bovée

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

Sanjeev K Baniwal, Omar Khalid, Yankel Gabet, Ruchir R Shah, Daniel J Purcell, Deepak Mav, Alice E Kohn-Gabet, Yunfan Shi, Gerhard A Coetzee, Baruch Frenkel

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Down-regulation of the Nucleotide Excision Repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

Maria Antonietta Sabatino, Mirko Marabese, Monica Ganzinelli, Elisa Caiola, Cristina Geroni, Massimo Broggini

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells

Brian W Robertson, Lauren Bonsal, Meenakshi A Chellaiah

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress

Alicia Arranz, Maria Venihaki, Berber Mol, Ariadne Androulidaki, Erini Dermitzaki, Olga Rassouli, Jorge Ripoll, Efstathios N Stathopoulos, Rosa P Gomariz, Andrew N Margioris, Christos Tsatsanis

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression

Ji-Young Jang, Yoon-Kyung Jeon, Yun Choi, Chul-Woo Kim

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor

Stephanie J Ellison-Zelski, Elaine T Alarid

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

Undraga Schagdarsurengin, Antje M Richter, Juliane Hornung, Cornelia Lange, Katrin Steinmann, Reinhard H Dammann

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer

Judy A King, Fang Tan, Flaubert Mbeunkui, Zachariah Chambers, Sarah Cantrell, Hairu Chen, Diego Alvarez, Lalita A Shevde, Solomon F Ofori-Acquah

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells

Lesley A Mathews, Elaine M Hurt, Xiaohu Zhang, William L Farrar

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

Zhao-Li Zhou, Zhi-Guo Luo, Bing Yu, Yi Jiang, Yi Chen, Jian-Ming Feng, Mei Dai, Lin-Jiang Tong, Zheng Li, Yuan-Chao Li, Jian Ding, Ze-Hong Miao

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer

Ming Shi, Dan Liu, Huijun Duan, Caili Han, Bo Wei, Lu Qian, Changguo Chen, Liang Guo, Meiru Hu, Ming Yu, Lun Song, Beifen Shen, Ning Guo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors

Ivy A Ho, Wai H Ng, Paula Y Lam

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

Sébastien Bergeron, Etienne Lemieux, Véronique Durand, Sébastien Cagnol, Julie C Carrier, Jacques G Lussier, Marie-Josée Boucher, Nathalie Rivard

01.12.2010 | Research | Ausgabe 1/2010 Open Access

An essential role for Ran GTPase in epithelial ovarian cancer cell survival

Véronique Barrès, Véronique Ouellet, Julie Lafontaine, Patricia N Tonin, Diane M Provencher, Anne-Marie Mes-Masson

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12

Antonella Rigo, Michele Gottardi, Alberto Zamò, Pierluigi Mauri, Massimiliano Bonifacio, Mauro Krampera, Ernesto Damiani, Giovanni Pizzolo, Fabrizio Vinante

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells

Yuanyuan Li, Yih-Ying Yuan, Syed M Meeran, Trygve O Tollefsbol

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line

Jennifer S Waby, Haridasan Chirakkal, ChenWei Yu, Gareth J Griffiths, Roderick SP Benson, Colin D Bingle, Bernard M Corfe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation

Danny CW Yu, Jennifer S Waby, Haridasan Chirakkal, Carolyn A Staton, Bernard M Corfe

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma

Idoia Garcia, Gemma Mayol, Eva Rodríguez, Mariona Suñol, Timothy R Gershon, José Ríos, Nai-Kong V Cheung, Mark W Kieran, Rani E George, Antonio R Perez-Atayde, Carla Casala, Patricia Galván, Carmen de Torres, Jaume Mora, Cinzia Lavarino

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line

Dario Caccia, Francesca Miccichè, Giuliana Cassinelli, Piera Mondellini, Patrizia Casalini, Italia Bongarzone

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Niina M Santio, Riitta L Vahakoski, Eeva-Marja Rainio, Jouko A Sandholm, Sanna S Virtanen, Michelle Prudhomme, Fabrice Anizon, Pascale Moreau, Päivi J Koskinen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness

Srinivas Vinod Saladi, Bridget Keenen, Himangi G Marathe, Huiling Qi, Khew-Voon Chin, Ivana L de la Serna

01.12.2010 | Research | Ausgabe 1/2010 Open Access

IGFBP-rP1, a potential molecule associated with colon cancer differentiation

Wenjing Ruan, Shuzhen Zhu, Haibing Wang, Fangying Xu, Hong Deng, Yu Ma, Maode Lai

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

Shirish Shukla, Gauri Shishodia, Sutapa Mahata, Suresh Hedau, Arvind Pandey, Suresh Bhambhani, Swaraj Batra, Seemi F Basir, Bhudev C Das, Alok C Bharti

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling

Meng-Ju Wu, Chia-Ing Jan, Yeou-Guang Tsay, Yau-Hua Yu, Chih-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Yu-Syuan Chen, Jeng-Fan Lo, Cheng-Chia Yu

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

Alex H Beesley, Janelle L Rampellini, Misty-Lee Palmer, Jasmin YS Heng, Amy L Samuels, Martin J Firth, Jette Ford, Ursula R Kees

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2

Mei Xu, Kimberly A Bower, Siying Wang, Jacqueline A Frank, Gang Chen, Min Ding, Shiow Wang, Xianglin Shi, Zunji Ke, Jia Luo

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ADP-ribose polymer - a novel and general biomarker of human cancers of head & neck, breast, and cervix

Rennie O Lakadong, Amal C Kataki, Rajeshwar N Sharan

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells

Hanako Suzuki, Mitsuho Onimaru, Yoshikazu Yonemitsu, Yoshihiko Maehara, Seiji Nakamura, Katsuo Sueishi

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis

Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Jau-Nan Lee, Ming-Feng Hou, Cheng-Yu Long, Hung-Sheng Chen, Eing-Mei Tsai

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

Shelley B Hooks, Phillip Callihan, Molly K Altman, Jillian H Hurst, Mourad W Ali, Mandi M Murph

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression

Matthew J Murray, Harpreet K Saini, Stijn van Dongen, Roger D Palmer, Balaji Muralidhar, Mark R Pett, Matias Piipari, Claire M Thornton, James C Nicholson, Anton J Enright, Nicholas Coleman

01.12.2010 | Research | Ausgabe 1/2010 Open Access

ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells

Aurélie Thollet, Julie A Vendrell, Léa Payen, Sandra E Ghayad, Sabrina Ben Larbi, Evelyne Grisard, Colin Collins, Marie Villedieu, Pascale A Cohen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3- mutated acute myeloid leukemia cells

Weina Chen, Elias Drakos, Ioannis Grammatikakis, Ellen J Schlette, Jiang Li, Vasiliki Leventaki, Efi Staikou-Drakopoulou, Efstratios Patsouris, Panayiotis Panayiotidis, L Jeffrey Medeiros, George Z Rassidakis

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

Sang Y Chun, Craig Johnson, Joseph G Washburn, Marcia R Cruz-Correa, Duyen T Dang, Long H Dang

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Aberrant WNT/β-catenin signaling in parathyroid carcinoma

Jessica Svedlund, Maria Aurén, Magnus Sundström, Henning Dralle, Göran Åkerström, Peyman Björklund, Gunnar Westin

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk

Lyndsay V Rhodes, James W Antoon, Shannon E Muir, Steven Elliott, Barbara S Beckman, Matthew E Burow

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

Wei Cao, Zhi-yuan Zhang, Qin Xu, Qiang Sun, Ming Yan, Jun Zhang, Ping Zhang, Ze-guang Han, Wan-tao Chen

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia

Julie Catusse, Marion Leick, Mareike Groch, David J Clark, Maike V Buchner, Katja Zirlik, Meike Burger

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

John R Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H Mach, William G Hawkins

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo

Jessamy C Tiffen, Charles G Bailey, Cynthia Ng, John EJ Rasko, Jeff Holst

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells

Laura D'Anello, Pasquale Sansone, Gianluca Storci, Valentina Mitrugno, Gabriele D'Uva, Pasquale Chieco, Massimiliano Bonafé

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

Marco de Bruyn, Anna A Rybczynska, Yunwei Wei, Michael Schwenkert, Georg H Fey, Rudi AJO Dierckx, Aren van Waarde, Wijnand Helfrich, Edwin Bremer

01.12.2010 | Research | Ausgabe 1/2010 Open Access

HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression

Hicham H Baydoun, Joanna Pancewicz, XueTao Bai, Christophe Nicot

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology

Ranjana Pal, Niloo Srivastava, Rupali Chopra, Sailesh Gochhait, Pawan Gupta, Neeraj Prakash, Gaurav Agarwal, Rameshwar NK Bamezai

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Human homolog of Drosophila H airy and e nhancer of s plit 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer

Jian-Ping Lu, Jiao Zhang, Kwonseop Kim, Thomas C Case, Robert J Matusik, Yan-hua Chen, Michael Wolfe, Jongdee Nopparat, Qun Lu

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation

Giovanni L Gravina, Claudio Festuccia, Francesco Marampon, Vladimir M Popov, Richard G Pestell, Bianca M Zani, Vincenzo Tombolini

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Serum microRNAs as non-invasive biomarkers for cancer

Jan C Brase, Daniela Wuttig, Ruprecht Kuner, Holger Sültmann

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase

Qi Ma, Kun Zhang, Sunny Guin, Yong-Qing Zhou, Ming-Hai Wang

01.12.2010 | Commentary | Ausgabe 1/2010 Open Access

Broccoli, PTEN deletion and prostate cancer: where is the link?

Giovanni Appendino, Alberto Bardelli

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells

Wei-Lun Huang, Hsuan-Heng Yeh, Chien-Chung Lin, Wu-Wei Lai, Jang-Yang Chang, Wen-Tsan Chang, Wu-Chou Su

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers

Maher S Saifo, Donald R Rempinski Jr, Youcef M Rustum, Rami G Azrak

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The antagonism between MCT-1 and p53 affects the tumorigenic outcomes

Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, ChikOn Choy, Tai-Du Lin, Linyi Chen, Hsin-Ling Hsu

01.12.2010 | Review | Ausgabe 1/2010 Open Access

Integrin-mediated function of Rab GTPases in cancer progression

Dhatchayini Subramani, Suresh K Alahari

01.12.2010 | Research | Ausgabe 1/2010 Open Access

The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma

Richard Keld, Baoqiang Guo, Paul Downey, Christian Gulmann, Yeng S Ang, Andrew D Sharrocks

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

Arti Shukla, Jedd M Hillegass, Maximilian B MacPherson, Stacie L Beuschel, Pamela M Vacek, Harvey I Pass, Michele Carbone, Joseph R Testa, Brooke T Mossman

01.12.2010 | Research | Ausgabe 1/2010 Open Access

c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL

Lei Fu, Yi-Dan Lin, Heath A Elrod, Ping Yue, Youtake Oh, Bo Li, Hui Tao, Georgia Z Chen, Dong M Shin, Fadlo R Khuri, Shi-Yong Sun

01.12.2010 | Research | Ausgabe 1/2010 Open Access

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Xin Yin, Jadwiga Truty, Roger Lawrence, Scott C Johns, R Sathish Srinivasan, Tracy M Handel, Mark M Fuster

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors

Diana M Cittelly, Partha M Das, Nicole S Spoelstra, Susan M Edgerton, Jennifer K Richer, Ann D Thor, Frank E Jones

01.12.2010 | Research | Ausgabe 1/2010 Open Access

Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers

LiLi Jiang, Michelle KY Siu, Oscar GW Wong, Kar Fai Tam, Eric W-F Lam, Hextan YS Ngan, Xiao-Feng Le, Esther SY Wong, Hoi Yan Chan, Annie NY Cheung

01.12.2010 | Research | Ausgabe 1/2010 Open Access

PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis

Kexiong Zhang, David J Waxman

01.12.2010 | Research | Ausgabe 1/2010 Open Access

VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A

Raúl Catena, Leyre Larzabal, Marta Larrayoz, Eva Molina, Jose Hermida, Jackeline Agorreta, Ramon Montes, Ruben Pio, Luis M Montuenga, Alfonso Calvo

01.12.2010 | Short communication | Ausgabe 1/2010 Open Access

Clinical significance of Polycomb gene expression in brain tumors

Francesco Crea, Elaine M Hurt, William L Farrar

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