Ausgabe 1/2010
Inhalt (320 Artikel)
Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
Robert Valentine, Christopher W Dawson, Chunfang Hu, Khilan M Shah, Thomas J Owen, Kathryn L Date, Sonia P Maia, Jianyong Shao, John R Arrand, Lawrence S Young, John D O'Neil
Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
Christof Renner, Nadine Zemitzsch, Beate Fuchs, Kathrin D Geiger, Matthias Hermes, Jan Hengstler, Rolf Gebhardt, Jürgen Meixensberger, Frank Gaunitz
Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer
Wun-Jae Kim, Eun-Jung Kim, Seon-Kyu Kim, Yong-June Kim, Yun-Sok Ha, Pildu Jeong, Min-Ju Kim, Seok-Joong Yun, Keon Myung Lee, Sung-Kwon Moon, Sang-Cheol Lee, Eun-Jong Cha, Suk-Chul Bae
Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways
Yi-Lan Zhang, Jiang Li, Hao-Yuan Mo, Fang Qiu, Li-Min Zheng, Chao-Nan Qian, Yi-Xin Zeng
Smoothened as a new therapeutic target for human osteosarcoma
Masataka Hirotsu, Takao Setoguchi, Hiromi Sasaki, Yukihiro Matsunoshita, Hui Gao, Hiroko Nagao, Osamu Kunigou, Setsuro Komiya
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death
Jing Wang, Ruihong Tang, Ming Lv, Jiyan Zhang, Beifen Shen
Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth
Xing Zhang, Li-hua Xu, Qiang Yu
Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid
Regina A Oyesanya, Susie Greenbaum, David Dang, Zendra Lee, Abir Mukherjee, Jinhua Wu, Paul Dent, Xianjun Fang
Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells
Shumin Zhang, Haiyen E Zhau, Adeboye O Osunkoya, Shareen Iqbal, Xiaojian Yang, Songqing Fan, Zhengjia Chen, Ruoxiang Wang, Fray F Marshall, Leland WK Chung, Daqing Wu
Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo
Li Xiao, Liu Yan, Wen Zhongmei, Li Chang, Lu Huijun, Tian Mingyao, Jin Kuoshi, Sun Lili, Gao Pegn, Yang Encheng, Xu Xiaohong, Kan Shifu, Wang Zhuoyue, Wang Yuhang, Jin Ningyi
MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
Jennifer AA Gubbels, Mildred Felder, Sachi Horibata, Jennifer A Belisle, Arvinder Kapur, Helen Holden, Sarah Petrie, Martine Migneault, Claudine Rancourt, Joseph P Connor, Manish S Patankar
miR-21: an oncomir on strike in prostate cancer
Marco Folini, Paolo Gandellini, Nicole Longoni, Valentina Profumo, Maurizio Callari, Marzia Pennati, Maurizio Colecchia, Rosanna Supino, Silvia Veneroni, Roberto Salvioni, Riccardo Valdagni, Maria Grazia Daidone, Nadia Zaffaroni
Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker
Kusumawadee Utispan, Peti Thuwajit, Yoshimitsu Abiko, Komgrid Charngkaew, Anucha Paupairoj, Siri Chau-in, Chanitra Thuwajit
Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)
Derek Murphy, Jeremy Parker, Minglong Zhou, Faisal M Fadlelmola, Christian Steidl, Aly Karsan, Randy D Gascoyne, Hong Chen, Diponkar Banerjee
Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms
Ana M Jiménez-Lara, Ana Aranda, Hinrich Gronemeyer
Regulation of the transcription factor NF-κB1 by microRNA-9 in human gastric adenocarcinoma
Hai-Ying Wan, Li-Min Guo, Tao Liu, Min Liu, Xin Li, Hua Tang
CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
Xiaojuan Sun, Lei Wei, Qian Chen, Richard M Terek
The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia
Jasmin R Agarwal, Frank Griesinger, Walter Stühmer, Luis A Pardo
The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization
Ansgar Brüning, Martina Rahmeh, Andrea Gingelmaier, Klaus Friese
Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells
Lu Jiang, Xin Zeng, Zhi Wang, Ning Ji, Yu Zhou, Xianting Liu, Qianming Chen
Erratum to: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Pedro Veliça, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride, Chris M Bunce
Effects of nilotinib on regulatory T cells: the dose matters
Fei Fei, Yingzhe Yu, Anita Schmitt, Markus T Rojewski, Baoan Chen, Jochen Greiner, Marlies Götz, Donald Bunjes, Michael Schmitt
Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis
Shuzhen Chen, Lei Fu, Shruti M Raja, Ping Yue, Fadlo R Khuri, Shi-Yong Sun
Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma
Nikolina Radulovich, Nhu-An Pham, Dan Strumpf, Lisa Leung, Wing Xie, Igor Jurisica, Ming-Sound Tsao
Axin downregulates TCF-4 transcription via β-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells
Lian-He Yang, Hong-Tao Xu, Yang Han, Qing-Chang Li, Yang Liu, Yue Zhao, Zhi-Qiang Yang, Qian-Ze Dong, Yuan Miao, Shun-Dong Dai, En-Hua Wang
Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells
Mei Shi, Hong-Na Wang, Shu-Tao Xie, Yan Luo, Cai-Yun Sun, Xiu-Lan Chen, Yu-Zhong Zhang
Synergistic effect of gefitinib and rofecoxib in mesothelioma cells
Daniela Stoppoloni, Claudia Canino, Irene Cardillo, Alessandra Verdina, Alfonso Baldi, Ada Sacchi, Rossella Galati
An evolved ribosome-inactivating protein targets and kills human melanoma cells in vitro and in vivo
Melissa C Cheung, Leigh Revers, Subodini Perampalam, Xin Wei, Reza Kiarash, David E Green, Aws Abdul-Wahid, Jean Gariépy
Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage
Béatrix Bugler, Estelle Schmitt, Bernadette Aressy, Bernard Ducommun
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion
Siyi Hu, Nathalie Delorme, Zhenzhen Liu, Tao Liu, Cruz Velasco-Gonzalez, Jone Garai, Ashok Pullikuth, Shahriar Koochekpour
Helicobacter pylori-induced activation of β-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled
Thorsten Gnad, Maria Feoktistova, Martin Leverkus, Uwe Lendeckel, Michael Naumann
EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis
Ting-Yun Liu, Shang-Ju Wu, Mi-Hsin Huang, Fei-Yun Lo, Mong-Hsun Tsai, Ching-Hwa Tsai, Su-Ming Hsu, Chung-Wu Lin
Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
Ming Zhou, Yuhua Zhao, Yan Ding, Hao Liu, Zixing Liu, Oystein Fodstad, Adam I Riker, Sushama Kamarajugadda, Jianrong Lu, Laurie B Owen, Susan P Ledoux, Ming Tan
Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation
Junya Kobayashi, Akihiro Kato, Yosuke Ota, Reiko Ohba, Kenshi Komatsu
Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression
Wilbur A Lam, Lizhi Cao, Vaibhavi Umesh, Albert J Keung, Shamik Sen, Sanjay Kumar
NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3
Byung-Hak Kim, Jun-Goo Jee, Chang-Hong Yin, Claudio Sandoval, Somasundaram Jayabose, Daisuke Kitamura, Erika A Bach, Gyeong-Hun Baeg
Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak
Lisa Venticinque, Daniel Meruelo
The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression
James T Lynch, Ramkumar Rajendran, Georgia Xenaki, Ilhem Berrou, Constantinos Demonacos, Marija Krstic-Demonacos
Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks
Kouichi Tabu, Taichi Kimura, Ken Sasai, Lei Wang, Norihisa Bizen, Hiroshi Nishihara, Tetsuya Taga, Shinya Tanaka
BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer
Xiao-Wei Zhang, Ya-Ping Sheng, Qian Li, Wei Qin, You-Wei Lu, Yu-Fan Cheng, Bing-Ya Liu, Feng-Chun Zhang, Jin Li, Goberdhan P Dimri, Wei-Jian Guo
Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia
Sally L Rogers, Yun Zhao, Xiaoyan Jiang, Connie J Eaves, Dixie L Mager, Arefeh Rouhi
Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer
Christopher P Gully, Fanmao Zhang, Jian Chen, James A Yeung, Guermarie Velazquez-Torres, Edward Wang, Sai-Ching Jim Yeung, Mong-Hong Lee
Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells
Ju-Fang Liu, Yi-Chin Fong, Chih-Shiang Chang, Chun-Yin Huang, Hsien-Te Chen, Wei-Hung Yang, Chin-Jung Hsu, Long-Bin Jeng, Chih-Yi Chen, Chih-Hsin Tang
A Genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers
Thomas Dunwell, Luke Hesson, Tibor A Rauch, Lihui Wang, Richard E Clark, Ashraf Dallol, Dean Gentle, Daniel Catchpoole, Eamonn R Maher, Gerd P Pfeifer, Farida Latif
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
Muy-Teck Teh, Emilios Gemenetzidis, Tracy Chaplin, Bryan D Young, Michael P Philpott
Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation
Caroline Raynal, Jean-Marc Pascussi, Géraldine Leguelinel, Cyril Breuker, Jovana Kantar, Benjamin Lallemant, Sylvain Poujol, Caroline Bonnans, Dominique Joubert, Frédéric Hollande, Serge Lumbroso, Jean-Paul Brouillet, Alexandre Evrard
Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells
Christopher S Bryant, Sanjeev Kumar, Sreedhar Chamala, Jay Shah, Jagannath Pal, Mahdi Haider, Shelly Seward, Aamer M Qazi, Robert Morris, Assaad Semaan, Masood A Shammas, Christopher Steffes, Ravindra B Potti, Madhu Prasad, Donald W Weaver, Ramesh B Batchu
Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas
Juan P Rodrigo, Dario García-Carracedo, María V González, Gonzalo Mancebo, Manuel F Fresno, Juana García-Pedrero
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
Andelko Hrzenjak, Farid Moinfar, Marie-Luise Kremser, Bettina Strohmeier, Edgar Petru, Kurt Zatloukal, Helmut Denk
Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells
Smita Misra, Shvetank Sharma, Anupriya Agarwal, Sheetal V Khedkar, Manish K Tripathi, Mukul K Mittal, Gautam Chaudhuri
Identification of 5 novel genes methylated in breast and other epithelial cancers
Victoria K Hill, Luke B Hesson, Temuujin Dansranjavin, Ashraf Dallol, Ivan Bieche, Sophie Vacher, Stella Tommasi, Timothy Dobbins, Dean Gentle, David Euhus, Cheryl Lewis, Reinhard Dammann, Robyn L Ward, John Minna, Eammon R Maher, Gerd P Pfeifer, Farida Latif
CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus
Taha Elmetwali, Peter F Searle, Iain McNeish, Lawrence S Young, Daniel H Palmer
Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1+/- mouse cerebellum
Mirella Tanori, Melissa Santone, Mariateresa Mancuso, Emanuela Pasquali, Simona Leonardi, Vincenzo Di Majo, Simonetta Rebessi, Anna Saran, Simonetta Pazzaglia
The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice
Keren Bitton-Worms, Eli Pikarsky, Ami Aronheim
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
Pinar Uysal-Onganer, Yoshiaki Kawano, Mercedes Caro, Marjorie M Walker, Soraya Diez, R Siobhan Darrington, Jonathan Waxman, Robert M Kypta
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study
Ioannis Psallidas, Sophia P Karabela, Charalampos Moschos, Taylor P Sherrill, Androniki Kollintza, Sophia Magkouta, Panagiota Theodoropoulou, Charis Roussos, Timothy S Blackwell, Ioannis Kalomenidis, Georgios T Stathopoulos
Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
Didier Roulin, Yannick Cerantola, Anne Dormond-Meuwly, Nicolas Demartines, Olivier Dormond
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications
Susmita Ghosh, Amlan Ghosh, Guru P Maiti, Nupur Mukherjee, Sankhadeep Dutta, Anup Roy, Susanta Roychoudhury, Chinmay K Panda
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway
Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I. Field, John D Kelly, David E. Neal, Hiroki Yamaue, Bruce A. J. Ponder, Yusuke Nakamura, Ryuji Hamamoto
Epithelial Protein Lost in Neoplasm α (Eplin-α) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
Laura Leitner, Dmitry Shaposhnikov, Arnaud Descot, Reinhard Hoffmann, Guido Posern
RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones
Marco Della Peruta, Cinzia Giagulli, Carlo Laudanna, Aldo Scarpa, Claudio Sorio
MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment
Monica Spinola, Felicia S. Falvella, Francesca Colombo, James P. Sullivan, David S. Shames, Luc Girard, Paola Spessotto, John D. Minna, Tommaso A. Dragani
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc Min and KRASV 12mutations
Mandayam O. Nandan, Amr M. Ghaleb, Beth B. McConnell, Nilesh V. Patel, Sylvie Robine, Vincent W. Yang
Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer
Chien-Hsing Lee, Hsing-Wen Hung, Pei-Hsin Hung, Yi-Shing Shieh
Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2
Dirk Zboralski, Bettina Warscheid, Susanne Klein-Scory, M. Bassel Malas, Heiko Becker, Miriam Böckmann, Helmut E Meyer, Wolff Schmiegel, Patricia Simon-Assmann, Irmgard Schwarte-Waldhoff
Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers
Alan J. Wright, Greg A. Fellows, John R. Griffiths, M. Wilson, B. Anthony Bell, Franklyn A. Howe
Mouse Rad1 deletion enhances susceptibility for skin tumor development
Lu Han, Zhishang Hu, Yuheng Liu, Xiangyuan Wang, Kevin M. Hopkins, Howard B. Lieberman, Haiying Hang
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
Emelyne Dejeux, Jo Anders Rønneberg, Hiroko Solvang, Ida Bukholm, Stephanie Geisler, Turid Aas, Ivo G. Gut, Anne-Lise Børresen-Dale, Per Eystein Lønning, Vessela N. Kristensen, Jörg Tost
A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy
Richard F. Kefford, Philip R. Clingan, Benjamin Brady, Andrea Ballmer, Adele Morganti, Peter Hersey
Replication independent DNA double-strand break retention may prevent genomic instability
Narisorn Kongruttanachok, Chutipa Phuangphairoj, Araya Thongnak, Wanpen Ponyeam, Prakasit Rattanatanyong, Wichai Pornthanakasem, Apiwat Mutirangura
Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma
Jian-Min Wu, Yan Xu, Nicholas J. Skill, Hongmiao Sheng, Zhenwen Zhao, Menggang Yu, Romil Saxena, Mary A. Maluccio
PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells
Tong Zhang, Xian-Hong Huang, Lan Dong, Deqing Hu, Changhui Ge, Yi-Qun Zhan, Wang-Xiang Xu, Miao Yu, Wei Li, Xiaohui Wang, Liujun Tang, Chang-Yan Li, Xiao-Ming Yang
Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway
Chenghai Li, Zhengfeng Yang, Chunyan Zhai, Wenwei Qiu, Dali Li, Zhengfang Yi, Lei Wang, Jie Tang, Min Qian, Jian Luo, Mingyao Liu
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma
Masato Tsuchiya, Joel S. Parker, Hiroshi Kono, Masanori Matsuda, Hideki Fujii, Ivan Rusyn
Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
J. Rafael Sierra, Virna Cepero, Silvia Giordano
PKCα expression is a marker for breast cancer aggressiveness
Gry Kalstad Lønne, Louise Cornmark, Iris Omanovic Zahirovic, Göran Landberg, Karin Jirström, Christer Larsson
Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells
Chun Hei Antonio Cheung, Huang-Hui Chen, Li-Ting Cheng, Kevin W. Lyu, Jagat R. Kanwar, Jang-Yang Chang
Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma
Luxia Tu, Zhen Liu, Xiufang He, Ying He, Huiling Yang, Qingping Jiang, Siming Xie, Guanghui Xiao, Xin Li, Kaitai Yao, Weiyi Fang
HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
Bin Peng, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan, Denghai Zhang
HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells
Susanne Schüler, Petra Fritsche, Sandra Diersch, Alexander Arlt, Roland M. Schmid, Dieter Saur, Günter Schneider
Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
Fenglian Ren, Hong Wu, Yunlong Lei, Haiyuan Zhang, Rui Liu, Yong Zhao, Xiancheng Chen, Dequan Zeng, Aiping Tong, Lijuan Chen, Yuquan Wei, Canhua Huang
Regulation of MCP-1 chemokine transcription by p53
Katrin Hacke, Bladimiro Rincon-Orozco, Gilles Buchwalter, Simone Y. Siehler, Bohdan Wasylyk, Lisa Wiesmüller, Frank Rösl
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
Niamh H. Foley, Isabella M. Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan, Raymond L. Stallings
Intracellular targets of RGDS peptide in melanoma cells
Maria Simona Aguzzi, Paola Fortugno, Claudia Giampietri, Gianluca Ragone, Maurizio C. Capogrossi, Antonio Facchiano
PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells
Christelle P. El Haibi, Praveen K. Sharma, Rajesh Singh, Paul R. Johnson, Jill Suttles, Shailesh Singh, James W. Lillard Jr
A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNγ-inducible Cd74 isoform
Magdalena Pyrz, Bruce Wang, Matthias Wabl, Finn Skou Pedersen
Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL
Alena Vaculova, Vitaliy Kaminskyy, Elham Jalalvand, Olga Surova, Boris Zhivotovsky
Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells
Mert Erkan, Nadine Weis, Zheng Pan, Christian Schwager, Tamar Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A. Giese, Wilhelm Ansorge, Jürgen Debus, Peter E. Huber, Helmut Friess, Amir Abdollahi, Jörg Kleeff
Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
Mengqian Chen, Michael A. Feuerstein, Elina Levina, Prateek S. Baghel, Richard D. Carkner, Matthew J. Tanner, Michael Shtutman, Francis Vacherot, Stéphane Terry, Alexandre de la Taille, Ralph Buttyan
The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice
Fan Feng, Yao-Chun Wang, Xing-Bin Hu, Xiao-Wei Liu, Gang Ji, Yun-Ru Chen, Lin Wang, Fei He, Guo-Rui Dou, Liang Liang, Hong-Wei Zhang, Hua Han
5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase
Hong-Tai Ji, Li-Ting Chien, Yu-Hsin Lin, Hsiung-Fei Chien, Chin-Tin Chen
Myc interacts with Max and Miz1 to repress C/EBPδ promoter activity and gene expression
Junling Si, Xueyan Yu, Yingjie Zhang, James W. DeWille
Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-β2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A
Fei Ye, Xiao-Chun Xu
Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma
Julia Freimuth, Nikolaus Gassler, Nives Moro, Rolf W. Günther, Christian Trautwein, Christian Liedtke, Gabriele A. Krombach
ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy
Kathryn G. Eby, Jennifer M. Rosenbluth, Deborah J. Mays, Clayton B. Marshall, Christopher E. Barton, Seema Sinha, Kimberly N. Johnson, Luojia Tang, Jennifer A. Pietenpol
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells
Bo Song, Yuan Wang, Matthew A. Titmus, Galina Botchkina, Andrea Formentini, Marko Kornmann, Jingfang Ju
NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma
Seong-Su Han, Hwakyung Yun, Dong-Ju Son, Van S. Tompkins, Liangping Peng, Seung-Tae Chung, Joong-Su Kim, Eun-Sung Park, Siegfried Janz
Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network
Bi-Dar Wang, Christina Leah B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby, Norman H. Lee
Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols
Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman, Wim Vanden Berghe
Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
Marianne Berg, Trude H Ågesen, Espen Thiis-Evensen, Marianne A Merok, Manuel R Teixeira, Morten H Vatn, Arild Nesbakken, Rolf I Skotheim, Ragnhild A Lothe
Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
Mansoor Ahmed, Gopal C Kundu
Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells
Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff, Frank Thévenod
Cyclin K and cyclin D1b are oncogenic in myeloma cells
Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir, Brigitte Sola
The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
Thomas W Sturgill, Paul B Stoddard, Steven M Cohn, Marty W Mayo
Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study
Amanda L Cleaver, Alex H Beesley, Martin J Firth, Nina C Sturges, Rebecca A O'Leary, Stephen P Hunger, David L Baker, Ursula R Kees
Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients
Flavia RR Mangone, Fernando Walder, Simone Maistro, Fátima S Pasini, Carlos N Lehn, Marcos B Carvalho, M Mitzi Brentani, Igor Snitcovsky, Miriam HH Federico
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors
Anders Olsson, Anders Björk, Johan Vallon-Christersson, John T Isaacs, Tomas Leanderson
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β
Paul Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D Cramer, Jianfeng Xu, Ming Lei, Guangchao Sui
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma
Jaehyouk Lee, Dong-Jun Jeong, Jinsun Kim, Soonduck Lee, Jin-Hwa Park, Boogi Chang, Sam-Il Jung, Lisha Yi, Youngsoo Han, Young Yang, Keun Il Kim, Jong-Seok Lim, Inchul Yang, Seob Jeon, Dong Han Bae, Chang-Jin Kim, Myeong-Sok Lee
Characterization of bortezomib-adapted I-45 mesothelioma cells
Lidong Zhang, James E Littlejohn, Yu Cui, Xiaobo Cao, Chander Peddaboina, W Roy Smythe
BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer
Ali Naderi, Ji Liu, Luke Hughes-Davies
Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl
Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao, Jingxuan Pan
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
Yi-Ping Fu, Hege Edvardsen, Alpana Kaushiva, Juan P Arhancet, Tiffany M Howe, Indu Kohaar, Patricia Porter-Gill, Anushi Shah, Hege Landmark-Høyvik, Sophie D Fosså, Stefan Ambs, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N Kristensen, Ludmila Prokunina-Olsson
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence
Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno, Jose M Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Susana del Toro-Arreola, Ruth de Celis-Carrillo, Jose E Sahagun-Flores, Javier E Garcia de Alba-Garcia, Georgina Hernandez-Flores
Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia
Etienne Moussay, Valérie Palissot, Laurent Vallar, Hélène A Poirel, Thomas Wenner, Victoria El Khoury, Nasséra Aouali, Kris Van Moer, Bernadette Leners, François Bernardin, Arnaud Muller, Pascale Cornillet-Lefebvre, Alain Delmer, Caroline Duhem, Fernand Ries, Eric van Dyck, Guy Berchem
Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
Sara Molatore, Eva Kiermaier, Christian B Jung, Misu Lee, Elke Pulz, Heinz Höfler, Michael J Atkinson, Natalia S Pellegata
Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion
Kevin T Bauerle, Rebecca E Schweppe, Bryan R Haugen
Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes
Jennifer A Belisle, Sachi Horibata, Gubbels AA Jennifer, Sarah Petrie, Arvinder Kapur, Sabine André, Hans-Joachim Gabius, Claudine Rancourt, Joseph Connor, James C Paulson, Manish S Patankar
Characterization of the role of the tumor marker Nup88 in mitosis
Chieko Hashizume, Hiroshi Nakano, Kimihisa Yoshida, Richard W Wong
Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements
Francesco Albano, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Paola Casieri, Antonella Russo Rossi, Laura Vicari, Vincenzo Liso, Mariano Rocchi, Giorgina Specchia
Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
Simona Corso, Elena Ghiso, Virna Cepero, J Rafael Sierra, Cristina Migliore, Andrea Bertotti, Livio Trusolino, Paolo M Comoglio, Silvia Giordano
Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis
Vidya Ganapathy, Rongrong Ge, Alison Grazioli, Wen Xie, Whitney Banach-Petrosky, Yibin Kang, Scott Lonning, John McPherson, Jonathan M Yingling, Swati Biswas, Gregory R Mundy, Michael Reiss
MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
Manuela Ferracin, Barbara Zagatti, Lara Rizzotto, Francesco Cavazzini, Angelo Veronese, Maria Ciccone, Elena Saccenti, Laura Lupini, Andrea Grilli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo
HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling
Young-Rang Kim, Kyung-Jin Oh, Ra-Young Park, Nguyen Thi Xuan, Taek-Won Kang, Dong-Deuk Kwon, Chan Choi, Min Soo Kim, Kwang Il Nam, Kyu Youn Ahn, Chaeyong Jung
Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
Yoshifumi Baba, Curtis Huttenhower, Katsuhiko Nosho, Noriko Tanaka, Kaori Shima, Aditi Hazra, Eva S Schernhammer, David J Hunter, Edward L Giovannucci, Charles S Fuchs, Shuji Ogino
Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation
Hsiao-Ling Cheng, Shu-Jem Su, Li-Wen Huang, Bau-Shan Hsieh, Yu-Chen Hu, Thu-Ching Hung, Kee-Lung Chang
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents
Andreas Palagyi, Kornelia Neveling, Ursula Plinninger, Andreas Ziesch, Bianca-Sabrina Targosz, Gerald U Denk, Stephanie Ochs, Antonia Rizzani, Daniel Meier, Wolfgang E Thasler, Helmut Hanenberg, Enrico N De Toni, Florian Bassermann, Claus Schäfer, Burkhard Göke, Detlev Schindler, Eike Gallmeier
VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers
Jing Ping Tang, Cheng Peow Tan, Jie Li, Md Monowarul Siddique, Ke Guo, Siew Wee Chan, Jung Eun Park, Wan Ngee Tay, Zhi Yuan Huang, Wen Cai Li, Jian Chen, Qi Zeng
Tumor cell behaviour modulation by mesenchymal stromal cells
Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova, Cestmir Altaner
TGFBI expression is associated with a better response to chemotherapy in NSCLC
Marta Irigoyen, María J Pajares, Jackeline Agorreta, Mariano Ponz-Sarvisé, Elisabeth Salvo, María D Lozano, Ruben Pío, Ignacio Gil-Bazo, Ana Rouzaut
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives
Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil, Elzbieta Izbicka, Richard F Luduena, Jack A Tuszynski
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia, Dawei Xu
Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres
Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb, David Zagzag
Microprocessor of microRNAs: regulation and potential for therapeutic intervention
Kevin J Beezhold, Vince Castranova, Fei Chen
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
Camilla Krakstad, Martha Chekenya
Identification of non-coding RNAs embracing microRNA-143/145 cluster
Akio Iio, Yoshihito Nakagawa, Ichiro Hirata, Tomoki Naoe, Yukihiro Akao
Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells
Marina Pisano, Gabriella Pagnan, Maria Antonietta Dettori, Sara Cossu, Irene Caffa, Ilaria Sassu, Laura Emionite, Davide Fabbri, Michele Cilli, Fabio Pastorino, Giuseppe Palmieri, Giovanna Delogu, Mirco Ponzoni, Carla Rozzo
Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors
Alexandre Chlenski, Lisa J Guerrero, Radhika Peddinti, Jared A Spitz, Payton T Leonhardt, Qiwei Yang, Yufeng Tian, Helen R Salwen, Susan L Cohn
Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo
Yi-Fan Hsu, Daniel Ajona, Leticia Corrales, Jose M Lopez-Picazo, Alfonso Gurpide, Luis M Montuenga, Ruben Pio
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
Molly K Altman, Vashisht Gopal, Wei Jia, Shuangxing Yu, Hassan Hall, Gordon B Mills, A Cary McGinnis, Michael G Bartlett, Guowei Jiang, Damian Madan, Glenn D Prestwich, Yong Xu, Michael A Davies, Mandi M Murph
Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy
Sylvine Cottin, Karim Ghani, Pedro Otavio de Campos-Lima, Manuel Caruso
The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability
Roberto Benelli, Stefano Monteghirfo, Roberta Venè, Francesca Tosetti, Nicoletta Ferrari
Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Tessa C Rue, Melissa P Upton, John R Houck, Pawadee Lohavanichbutr, David R Doody, Neal D Futran, Lue Ping Zhao, Stephen M Schwartz, Chu Chen, Eduardo Méndez
Glycogen synthase kinase 3 beta: can it be a target for oral cancer
Rajakishore Mishra
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling
Yong-Yu Liu, Vineet Gupta, Gauri A Patwardhan, Kaustubh Bhinge, Yunfeng Zhao, Jianxiong Bao, Harihara Mehendale, Myles C Cabot, Yu-Teh Li, S Michal Jazwinski
Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old
Dilek Colak, Muhammad A Chishti, Al-Bandary Al-Bakheet, Ahmed Al-Qahtani, Mohamed M Shoukri, Malcolm H Goyns, Pinar T Ozand, John Quackenbush, Ben H Park, Namik Kaya
The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin
Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova, Borivoj Vojtesek
RETRACTED ARTICLE: Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: Regulation of MMP 9 by PDEF
Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham, Hari K Koul
Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia
Ru Chen, Sheng Pan, Xiaobo Duan, Brad H Nelson, Rob A Sahota, Sarah de Rham, Richard A Kozarek, Martin McIntosh, Teresa A Brentnall
The ERα coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium
Jerzy Rokicki, Partha M Das, Jennifer M Giltnane, Olivia Wansbury, David L Rimm, Beatrice A Howard, Frank E Jones
Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
Stefan Nagel, Letizia Venturini, Victor E Marquez, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick AF MacLeod, Hans G Drexler
Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer
Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen, Victor L Thijssen
A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention
Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing, Stefan Duensing
Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis
Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes, Lu-Gang Yu
Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition
Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu, Lawrence S Young
Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth
Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch, Fabrice Matifat
Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways
Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck, Xuefen Le Bourhis
Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain
Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger, Goberdhan P Dimri
ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro
Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja, Krzysztof Reiss
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling
Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan, Laura S Schmidt
Tumor promoting effects of CD95 signaling in chemoresistant cells
Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva María Pastor-Arroyo, Pedro Gascón, Vanessa Almendro
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
David S. Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R. Simoneau, Bang H. Hoang, Xiaolin Zi
Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia
Robert J. Weeks, Ursula R. Kees, Sarah Song, Ian M. Morison
Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1
Henry Zall, Arnim Weber, Robert Besch, Niko Zantl, Georg Häcker
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson Jr, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson III, Pui-Kai Li, Gregory B Lesinski
EGFR isoforms and gene regulation in human endometrial cancer cells
Lina Albitar, Gavin Pickett, Marilee Morgan, Jason A Wilken, Nita J Maihle, Kimberly K Leslie
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
Saskia M Wilting, Robert AA van Boerdonk, Florianne E Henken, Chris JLM Meijer, Begoňa Diosdado, Gerrit A Meijer, Carlos le Sage, Reuven Agami, Peter JF Snijders, Renske DM Steenbergen
Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts
Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip, Walter E Aulitzky
MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata, Masao Tanaka
Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer
Ester Lara, Vincenzo Calvanese, Covadonga Huidobro, Agustin F Fernández, Ángela Moncada-Pazos, Álvaro J Obaya, Oscar Aguilera, José Manuel González-Sancho, Laura Sánchez, Aurora Astudillo, Alberto Muñoz, Carlos López-Otín, Manel Esteller, Mario F Fraga
The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells
Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho, Paul Shore
The tumor suppressor gene KCTD11 REN is regulated by Sp1 and methylation and its expression is reduced in tumors
M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino, Edoardo Alesse
Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers
Elisabet Ognedal Berge, Stian Knappskog, Stephanie Geisler, Vidar Staalesen, Marec Pacal, Anne-Lise Børresen-Dale, Pål Puntervoll, Johan Richard Lillehaug, Per Eystein Lønning
Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood
Matthias Jost, John R Day, Ryan Slaughter, Theodore D Koreckij, Deanna Gonzales, Martin Kinnunen, Jack Groskopf, Harry G Rittenhouse, Robert L Vessella, Mark A Reynolds
p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker
Magdalena B Flak, Claire M Connell, Claude Chelala, Kyra Archibald, Michael A Salako, Katrina J Pirlo, Michelle Lockley, Sally P Wheatley, Frances R Balkwill, Iain A McNeish
Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells
Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim, Parul Trivedi, Jaehyup Kim, Peiman Hematti, Shigeki Miyamoto
Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal adenocarcinoma
Uta Berndt, Lars Philipsen, Sebastian Bartsch, Yuqin Hu, Christoph Röcken, Wiedenmann Bertram, Marcus Hämmerle, Thomas Rösch, Andreas Sturm
Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells
Priyanka Sharma, Santosh Kumar, Gopal C Kundu
Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
Yvonne L Chao, Christopher R Shepard, Alan Wells
Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells
Bisrat G Debeb, Xiaomei Zhang, Savitri Krishnamurthy, Hui Gao, Evan Cohen, Li Li, Angel A Rodriguez, Melissa D Landis, Anthony Lucci, Naoto T Ueno, Fredika Robertson, Wei Xu, Lara Lacerda, Thomas A Buchholz, Massimo Cristofanilli, James M Reuben, Michael T Lewis, Wendy A Woodward
TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells
Irene Riz, Teresa S Hawley, Truong V Luu, Norman H Lee, Robert G Hawley
NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells
Ricardo Parrondo, Alicia de las Pozas, Teresita Reiner, Priyamvada Rai, Carlos Perez-Stable
Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-κB-independent, proteasome-mediated mechanism
Konstantin Golovine, Peter Makhov, Robert G Uzzo, Alexander Kutikov, David J Kaplan, Eric Fox, Vladimir M Kolenko
Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition
Adele Hannigan, Joanna B Wilson
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
Paolo Fardin, Annalisa Barla, Sofia Mosci, Lorenzo Rosasco, Alessandro Verri, Rogier Versteeg, Huib N Caron, Jan J Molenaar, Ingrid Øra, Alessandra Eva, Maura Puppo, Luigi Varesio
Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry
Ying Liu, Yanfeng Chen, Amin Momin, Rebecca Shaner, Elaine Wang, Nathan J Bowen, Lilya V Matyunina, L DeEtte Walker, John F McDonald, M Cameron Sullards, Alfred H Merrill Jr
SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
Elin Gustavsson, Sandra Sernbo, Elin Andersson, Donal J. Brennan, Michael Dictor, Mats Jerkeman, Carl A. K. Borrebaeck, Sara Ek
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
Xuchao Zhang, Shirley Zhang, Xuening Yang, Jinji Yang, Qing Zhou, Lucy Yin, Shejuan An, Jiaying Lin, Shiliang Chen, Zhi Xie, Mike Zhu, Xiaolin Zhang, Yi-long Wu
The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer
Maria H Traka, Caroline A Spinks, Joanne F Doleman, Antonietta Melchini, Richard Y Ball, Robert D Mills, Richard F Mithen
Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene
Haiqing Ma, Desheng Weng, Yibing Chen, Wei Huang, Ke Pan, Hui Wang, Jiancong Sun, Qijing Wang, Zhiwei Zhou, Huiyun Wang, Jianchuan Xia
Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
Lionel Flamant, Annick Notte, Noelle Ninane, Martine Raes, Carine Michiels
New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells
Galina I Botchkina, Edison S Zuniga, Manisha Das, Yuan Wang, Haichao Wang, Shu Zhu, Anne G Savitt, Rebecca A Rowehl, Yan Leyfman, Jingfang Ju, Kenneth Shroyer, Iwao Ojima
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy
Ramón García-Escudero, Ana B Martínez-Cruz, Mirentxu Santos, Corina Lorz, Carmen Segrelles, Guillermo Garaulet, Cristina Saiz-Ladera, Clotilde Costa, Águeda Buitrago-Pérez, Marta Dueñas, Jesús M Paramio
TWIST1 promotes invasion through mesenchymal change in human glioblastoma
Svetlana A Mikheeva, Andrei M Mikheev, Audrey Petit, Richard Beyer, Robert G Oxford, Leila Khorasani, John-Patrick Maxwell, Carlotta A Glackin, Hiroaki Wakimoto, Inés González-Herrero, Isidro Sánchez-García, John R Silber, Philip J Horner, Robert C Rostomily
ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
Ashley L Craig, Jitka Holcakova, Lee E Finlan, Marta Nekulova, Roman Hrstka, Nuri Gueven, James DiRenzo, Graeme Smith, Ted R Hupp, Borivoj Vojtesek
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
María M Caffarel, Clara Andradas, Emilia Mira, Eduardo Pérez-Gómez, Camilla Cerutti, Gema Moreno-Bueno, Juana M Flores, Isabel García-Real, José Palacios, Santos Mañes, Manuel Guzmán, Cristina Sánchez
A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics
Giampiero Porcu, Cathal Wilson, Daniele Di Giandomenico, Antonella Ragnini-Wilson
Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer
Jipei Liao, Lei Yu, Yuping Mei, Maria Guarnera, Jun Shen, Ruiyun Li, Zhenqiu Liu, Feng Jiang
TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
Suk-Bin Seo, Jung-Gu Hur, Mi-Ju Kim, Jae-Won Lee, Hak-Bong Kim, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Transcriptome analysis of human cancer reveals a functional role of Heme Oxygenase-1 in tumor cell adhesion
Stefanie Tauber, Alexander Jais, Markus Jeitler, Sandra Haider, Julia Husa, Josefine Lindroos, Martin Knöfler, Matthias Mayerhofer, Hubert Pehamberger, Oswald Wagner, Martin Bilban
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation
Svenja Meierjohann, Anita Hufnagel, Elisabeth Wende, Markus A Kleinschmidt, Katarina Wolf, Peter Friedl, Stefan Gaubatz, Manfred Schartl
Personalized therapies in the cancer "omics" era
Alberto Ocaña, Atanasio Pandiella
Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations
Prashant Bavi, Sarita E Prabhakaran, Jehad Abubaker, Zeeshan Qadri, Thara George, Nasser Al-Sanea, Alaa Abduljabbar, Luai H Ashari, Samar Alhomoud, Fouad Al-Dayel, Azhar R Hussain, Shahab Uddin, Khawla S Al-Kuraya
Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
Amrendra K Ajay, Ankur K Upadhyay, Sandeep Singh, Maleppillil V Vijayakumar, Ratna Kumari, Vimal Pandey, Ramanamurthy Boppana, Manoj K Bhat
Regulation of the Aurora-A gene following topoisomerase I inhibition: implication of the Myc transcription Factor
Sandy Courapied, Julia Cherier, Arnaud Vigneron, Marie-Bérangère Troadec, Sandrine Giraud, Isabelle Valo, Claude Prigent, Erick Gamelin, Olivier Coqueret, Benjamin Barré
Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
Pawan Kumar, Arti Yadav, Samip N Patel, Mozaffarul Islam, Quintin Pan, Sofia D Merajver, Theodoros N Teknos
Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study
Paola Matarrese, Barbara Ascione, Laura Ciarlo, Rosa Vona, Carlo Leonetti, Marco Scarsella, Anna M Mileo, Caterina Catricalà, Marco G Paggi, Walter Malorni
R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair
Mario Federico, Catherine E Symonds, Luigi Bagella, Flavio Rizzolio, Daniele Fanale, Antonio Russo, Antonio Giordano
Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1
Kakali Dhar, Gopal Dhar, Monami Majumder, Inamul Haque, Smita Mehta, Peter J Van Veldhuizen, Sushanta K Banerjee, Snigdha Banerjee
Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1
Yong Zhong Xu, Mitra Heravi, Thusanth Thuraisingam, Sergio Di Marco, Thierry Muanza, Danuta Radzioch
MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network
Jianjun Zhang, Haiyan Guo, Guanxiang Qian, Shengfang Ge, Huifeng Ji, Xiaobo Hu, Wantao Chen
The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres
Shailender S Kanwar, Yingjie Yu, Jyoti Nautiyal, Bhaumik B Patel, Adhip PN Majumdar
Loss, mutation and deregulation of L3MBTL4 in breast cancers
Lynda Addou-Klouche, José Adélaïde, Pascal Finetti, Nathalie Cervera, Anthony Ferrari, Ismahane Bekhouche, Fabrice Sircoulomb, Christos Sotiriou, Patrice Viens, Soraya Moulessehoul, François Bertucci, Daniel Birnbaum, Max Chaffanet
MiTF links Erk1/2 kinase and p21CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells
Feng Liu, Amarinder Singh, Zhen Yang, Angela Garcia, Yu Kong, Frank L Meyskens Jr
Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat
Meng Fang, Sylviane Dewaele, Yun-peng Zhao, Peter Stärkel, Valerie Vanhooren, Yue-ming Chen, Xin Ji, Ming Luo, Bao-mu Sun, Yves Horsmans, Anne Dell, Stuart M Haslam, Paola Grassi, Claude Libert, Chun-fang Gao, Cuiying Chitty Chen
XIAP gene expression and function is regulated by autocrine and paracrine TGF-β signaling
Céline Van Themsche, Parvesh Chaudhry, Valérie Leblanc, Sophie Parent, Eric Asselin
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
Li Lin, Stephanie Deangelis, Elizabeth Foust, James Fuchs, Chenglong Li, Pui-Kai Li, Eric B Schwartz, Gregory B Lesinski, Don Benson, Jiagao Lü, Dale Hoyt, Jiayuh Lin
RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma
Shilpi Arora, Irma M Gonzales, R Tanner Hagelstrom, Christian Beaudry, Ashish Choudhary, Chao Sima, Raoul Tibes, Spyro Mousses, David O Azorsa
Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
Femke Heindryckx, Koen Mertens, Nicolas Charette, Bert Vandeghinste, Christophe Casteleyn, Christophe Van Steenkiste, Dominique Slaets, Louis Libbrecht, Steven Staelens, Peter Starkel, Anja Geerts, Isabelle Colle, Hans Van Vlierberghe
Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
Vineshkumar T Puliyappadamba, Vino T Cheriyan, Arun Kumar T Thulasidasan, Smitha V Bava, Balachandran S Vinod, Priya R Prabhu, Ranji Varghese, Arathy Bevin, Shalini Venugopal, Ruby John Anto
Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival
Xiao-Yang Wang, Luiz OF Penalva, Hongyan Yuan, R Ilona Linnoila, Jiachun Lu, Hideyuki Okano, Robert I Glazer
Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated
Soo-Yeon Park, Young Mee Kim, Hongryull Pyo
Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
Ruben Zamora, Magali Espinosa, Gisela Ceballos-Cancino, Blanca Segura, Vilma Maldonado, Jorge Melendez-Zajgla
A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ
Zoi Diamantopoulou, Oya Bermek, Apostolos Polykratis, Yamina Hamma-Kourbali, Jean Delbé, José Courty, Panagiotis Katsoris
The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression
Mehtap S Gündogdu, He Liu, Daniela Metzdorf, Dagmar Hildebrand, Michael Aigner, Klaus Aktories, Klaus Heeg, Katharina F Kubatzky
Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
Frances Wadelin, Joel Fulton, Paul A McEwan, Keith A Spriggs, Jonas Emsley, David M Heery
Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
Qingli Shen, Vito R Cicinnati, Xiaoyong Zhang, Speranta Iacob, Frank Weber, Georgios C Sotiropoulos, Arnold Radtke, Mengji Lu, Andreas Paul, Guido Gerken, Susanne Beckebaum
I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma
Ayad Al-Katib, Alan A Arnold, Amro Aboukameel, Angela Sosin, Peter Smith, Anwar N Mohamed, Frances W Beck, Ramzi M Mohammad
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
Chun-Zhi Zhang, Jun-Xia Zhang, An-Ling Zhang, Zhen-Dong Shi, Lei Han, Zhi-Fan Jia, Wei-Dong Yang, Guang-Xiu Wang, Tao Jiang, Yong-Ping You, Pei-Yu Pu, Jin-Quan Cheng, Chun-Sheng Kang
Identification of tumor-associated cassette exons in human cancer through EST-based computational prediction and experimental validation
Alessio Valletti, Anna Anselmo, Marina Mangiulli, Ilenia Boria, Flavio Mignone, Giuseppe Merla, Vincenzo D'Angelo, Apollonia Tullo, Elisabetta Sbisà, Anna Maria D'Erchia, Graziano Pesole
Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis
Céline Sabatel, Anne M Cornet, Sébastien P Tabruyn, Ludovic Malvaux, Karolien Castermans, Joseph A Martial, Ingrid Struman
Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases
Ravindresh Chhabra, Richa Dubey, Neeru Saini
Coordination of glioblastoma cell motility by PKCι
R Mitchell Baldwin, Gordon M Barrett, Doris AE Parolin, Jana K Gillies, Judith A Paget, Sylvie J Lavictoire, Douglas A Gray, Ian AJ Lorimer
An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients
François Ducray, Aurélien de Reyniès, Olivier Chinot, Ahmed Idbaih, Dominique Figarella-Branger, Carole Colin, Lucie Karayan-Tapon, Hervé Chneiweiss, Michel Wager, François Vallette, Yannick Marie, David Rickman, Emilie Thomas, Jean-Yves Delattre, Jérôme Honnorat, Marc Sanson, François Berger
ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis
Craig I Campbell, James J Petrik, Roger A Moorehead
Convergence between Wnt-β-catenin and EGFR signaling in cancer
Tianhui Hu, Cunxi Li
Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma
Jing-Yan Cao, Li Liu, Shu-Peng Chen, Xing Zhang, Yan-Jun Mi, Zhi-Gang Liu, Man-Zhi Li, Hua Zhang, Chao-Nan Qian, Jian-Yong Shao, Li-Wu Fu, Yun-Fei Xia, Mu-Sheng Zeng
Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
Patricia P Reis, Miranda Tomenson, Nilva K Cervigne, Jerry Machado, Igor Jurisica, Melania Pintilie, Mahadeo A Sukhai, Bayardo Perez-Ordonez, Reidar Grénman, Ralph W Gilbert, Patrick J Gullane, Jonathan C Irish, Suzanne Kamel-Reid
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
Susmita Mondal, Chandan Mandal, Rajender Sangwan, Sarmila Chandra, Chitra Mandal
t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
Bhavatarini Vangamudi, Dun-Fa Peng, Qiuyin Cai, Wael El-Rifai, Wei Zheng, Abbes Belkhiri
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors
Thomas J Owen, John D O'Neil, Christopher W Dawson, Chunfang Hu, Xiaoyi Chen, Yunhong Yao, Victoria HJ Wood, Louise E Mitchell, Robert J White, Lawrence S Young, John R Arrand
A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12
David J Klinke II
Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage
Chun-Hui Su, Ruiying Zhao, Guermarie Velazquez-Torres, Jian Chen, Christopher Gully, Sai-Ching J Yeung, Mong-Hong Lee
FATS is a transcriptional target of p53 and associated with antitumor activity
Xifeng Zhang, Qian Zhang, Jun Zhang, Li Qiu, Shuang-shuang Yan, Juling Feng, Yan Sun, Xingxu Huang, Karen H Lu, Zheng Li
Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway
Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Fumie Shiraishi, Sachio Morimoto, Yutaka Watanabe, Masato Hirata, Sumio Hoka, Toshiyuki Sasaguri
Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1
Edwin Chen, Xiaoyong Huang, Yanzhen Zheng, You-Jun Li, Alden Chesney, Yaacov Ben-David, Eric Yang, Margaret R Hough
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma
Xiaoyi Dun, Hua Jiang, Jianfeng Zou, Jun Shi, Lili Zhou, Rong Zhu, Jian Hou
Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
Svetlana Usanova, Andrea Piée-Staffa, Ulrike Sied, Jürgen Thomale, Astrid Schneider, Bernd Kaina, Beate Köberle
Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8
Ahmed S Abdulamir, Rand R Hafidh, Fatimah Abu Bakar
Multiple functions of CXCL12 in a syngeneic model of breast cancer
Sharon A Williams, Yuka Harata-Lee, Iain Comerford, Robin L Anderson, Mark J Smyth, Shaun R McColl
Roles of Sema4D and Plexin-B1 in tumor progression
Ewe Seng Ch'ng, Atsushi Kumanogoh
MicroRNA roles in beta-catenin pathway
Kai Huang, Jun-Xia Zhang, Lei Han, Yong-Ping You, Tao Jiang, Pei-Yu Pu, Chun-Sheng Kang
Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
Rafael Cubas, Sheng Zhang, Min Li, Changyi Chen, Qizhi Yao
Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE
Stephanie M Pütz, Fotini Vogiatzi, Thorsten Stiewe, Albert Sickmann
P-cadherin counteracts myosin II-B function: implications in melanoma progression
Koen Jacobs, Mireille Van Gele, Ramses Forsyth, Lieve Brochez, Barbara Vanhoecke, Olivier De Wever, Marc Bracke
Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition
Nicolas Charette, Christine De Saeger, Valérie Lannoy, Yves Horsmans, Isabelle Leclercq, Peter Stärkel
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option
Stefan M Willems, Yvonne M Schrage, Inge H Briaire-de Bruijn, Karoly Szuhai, Pancras CW Hogendoorn, Judith VMG Bovée
Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
Sanjeev K Baniwal, Omar Khalid, Yankel Gabet, Ruchir R Shah, Daniel J Purcell, Deepak Mav, Alice E Kohn-Gabet, Yunfan Shi, Gerhard A Coetzee, Baruch Frenkel
Down-regulation of the Nucleotide Excision Repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells
Maria Antonietta Sabatino, Mirko Marabese, Monica Ganzinelli, Elisa Caiola, Cristina Geroni, Massimo Broggini
Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells
Brian W Robertson, Lauren Bonsal, Meenakshi A Chellaiah
The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress
Alicia Arranz, Maria Venihaki, Berber Mol, Ariadne Androulidaki, Erini Dermitzaki, Olga Rassouli, Jorge Ripoll, Efstathios N Stathopoulos, Rosa P Gomariz, Andrew N Margioris, Christos Tsatsanis
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression
Ji-Young Jang, Yoon-Kyung Jeon, Yun Choi, Chul-Woo Kim
Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor
Stephanie J Ellison-Zelski, Elaine T Alarid
Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences
Undraga Schagdarsurengin, Antje M Richter, Juliane Hornung, Cornelia Lange, Katrin Steinmann, Reinhard H Dammann
Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer
Judy A King, Fang Tan, Flaubert Mbeunkui, Zachariah Chambers, Sarah Cantrell, Hairu Chen, Diego Alvarez, Lalita A Shevde, Solomon F Ofori-Acquah
Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells
Lesley A Mathews, Elaine M Hurt, Xiaohu Zhang, William L Farrar
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
Zhao-Li Zhou, Zhi-Guo Luo, Bing Yu, Yi Jiang, Yi Chen, Jian-Ming Feng, Mei Dai, Lin-Jiang Tong, Zheng Li, Yuan-Chao Li, Jian Ding, Ze-Hong Miao
Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer
Ming Shi, Dan Liu, Huijun Duan, Caili Han, Bo Wei, Lu Qian, Changguo Chen, Liang Guo, Meiru Hu, Ming Yu, Lun Song, Beifen Shen, Ning Guo
FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors
Ivy A Ho, Wai H Ng, Paula Y Lam
The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis
Sébastien Bergeron, Etienne Lemieux, Véronique Durand, Sébastien Cagnol, Julie C Carrier, Jacques G Lussier, Marie-Josée Boucher, Nathalie Rivard
An essential role for Ran GTPase in epithelial ovarian cancer cell survival
Véronique Barrès, Véronique Ouellet, Julie Lafontaine, Patricia N Tonin, Diane M Provencher, Anne-Marie Mes-Masson
Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12
Antonella Rigo, Michele Gottardi, Alberto Zamò, Pierluigi Mauri, Massimiliano Bonifacio, Mauro Krampera, Ernesto Damiani, Giovanni Pizzolo, Fabrizio Vinante
Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells
Yuanyuan Li, Yih-Ying Yuan, Syed M Meeran, Trygve O Tollefsbol
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line
Jennifer S Waby, Haridasan Chirakkal, ChenWei Yu, Gareth J Griffiths, Roderick SP Benson, Colin D Bingle, Bernard M Corfe
Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation
Danny CW Yu, Jennifer S Waby, Haridasan Chirakkal, Carolyn A Staton, Bernard M Corfe
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma
Idoia Garcia, Gemma Mayol, Eva Rodríguez, Mariona Suñol, Timothy R Gershon, José Ríos, Nai-Kong V Cheung, Mark W Kieran, Rani E George, Antonio R Perez-Atayde, Carla Casala, Patricia Galván, Carmen de Torres, Jaume Mora, Cinzia Lavarino
Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line
Dario Caccia, Francesca Miccichè, Giuliana Cassinelli, Piera Mondellini, Patrizia Casalini, Italia Bongarzone
Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
Niina M Santio, Riitta L Vahakoski, Eeva-Marja Rainio, Jouko A Sandholm, Sanna S Virtanen, Michelle Prudhomme, Fabrice Anizon, Pascale Moreau, Päivi J Koskinen
Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness
Srinivas Vinod Saladi, Bridget Keenen, Himangi G Marathe, Huiling Qi, Khew-Voon Chin, Ivana L de la Serna
IGFBP-rP1, a potential molecule associated with colon cancer differentiation
Wenjing Ruan, Shuzhen Zhu, Haibing Wang, Fangying Xu, Hong Deng, Yu Ma, Maode Lai
Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection
Shirish Shukla, Gauri Shishodia, Sutapa Mahata, Suresh Hedau, Arvind Pandey, Suresh Bhambhani, Swaraj Batra, Seemi F Basir, Bhudev C Das, Alok C Bharti
Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling
Meng-Ju Wu, Chia-Ing Jan, Yeou-Guang Tsay, Yau-Hua Yu, Chih-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Yu-Syuan Chen, Jeng-Fan Lo, Cheng-Chia Yu
Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia
Alex H Beesley, Janelle L Rampellini, Misty-Lee Palmer, Jasmin YS Heng, Amy L Samuels, Martin J Firth, Jette Ford, Ursula R Kees
Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
Mei Xu, Kimberly A Bower, Siying Wang, Jacqueline A Frank, Gang Chen, Min Ding, Shiow Wang, Xianglin Shi, Zunji Ke, Jia Luo
ADP-ribose polymer - a novel and general biomarker of human cancers of head & neck, breast, and cervix
Rennie O Lakadong, Amal C Kataki, Rajeshwar N Sharan
Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells
Hanako Suzuki, Mitsuho Onimaru, Yoshikazu Yonemitsu, Yoshihiko Maehara, Seiji Nakamura, Katsuo Sueishi
Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis
Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Jau-Nan Lee, Ming-Feng Hou, Cheng-Yu Long, Hung-Sheng Chen, Eing-Mei Tsai
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells
Shelley B Hooks, Phillip Callihan, Molly K Altman, Jillian H Hurst, Mourad W Ali, Mandi M Murph
The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression
Matthew J Murray, Harpreet K Saini, Stijn van Dongen, Roger D Palmer, Balaji Muralidhar, Mark R Pett, Matias Piipari, Claire M Thornton, James C Nicholson, Anton J Enright, Nicholas Coleman
ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells
Aurélie Thollet, Julie A Vendrell, Léa Payen, Sandra E Ghayad, Sabrina Ben Larbi, Evelyne Grisard, Colin Collins, Marie Villedieu, Pascale A Cohen
mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3- mutated acute myeloid leukemia cells
Weina Chen, Elias Drakos, Ioannis Grammatikakis, Ellen J Schlette, Jiang Li, Vasiliki Leventaki, Efi Staikou-Drakopoulou, Efstratios Patsouris, Panayiotis Panayiotidis, L Jeffrey Medeiros, George Z Rassidakis
Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes
Sang Y Chun, Craig Johnson, Joseph G Washburn, Marcia R Cruz-Correa, Duyen T Dang, Long H Dang
Aberrant WNT/β-catenin signaling in parathyroid carcinoma
Jessica Svedlund, Maria Aurén, Magnus Sundström, Henning Dralle, Göran Åkerström, Peyman Björklund, Gunnar Westin
Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk
Lyndsay V Rhodes, James W Antoon, Shannon E Muir, Steven Elliott, Barbara S Beckman, Matthew E Burow
Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma
Wei Cao, Zhi-yuan Zhang, Qin Xu, Qiang Sun, Ming Yan, Jun Zhang, Ping Zhang, Ze-guang Han, Wan-tao Chen
Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia
Julie Catusse, Marion Leick, Mareike Groch, David J Clark, Maike V Buchner, Katja Zirlik, Meike Burger
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine
John R Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H Mach, William G Hawkins
Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo
Jessamy C Tiffen, Charles G Bailey, Cynthia Ng, John EJ Rasko, Jeff Holst
Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells
Laura D'Anello, Pasquale Sansone, Gianluca Storci, Valentina Mitrugno, Gabriele D'Uva, Pasquale Chieco, Massimiliano Bonafé
Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo
Marco de Bruyn, Anna A Rybczynska, Yunwei Wei, Michael Schwenkert, Georg H Fey, Rudi AJO Dierckx, Aren van Waarde, Wijnand Helfrich, Edwin Bremer
HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression
Hicham H Baydoun, Joanna Pancewicz, XueTao Bai, Christophe Nicot
Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology
Ranjana Pal, Niloo Srivastava, Rupali Chopra, Sailesh Gochhait, Pawan Gupta, Neeraj Prakash, Gaurav Agarwal, Rameshwar NK Bamezai
Human homolog of Drosophila H airy and e nhancer of s plit 1, Hes1, negatively regulates δ-catenin (CTNND2) expression in cooperation with E2F1 in prostate cancer
Jian-Ping Lu, Jiao Zhang, Kwonseop Kim, Thomas C Case, Robert J Matusik, Yan-hua Chen, Michael Wolfe, Jongdee Nopparat, Qun Lu
Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation
Giovanni L Gravina, Claudio Festuccia, Francesco Marampon, Vladimir M Popov, Richard G Pestell, Bianca M Zani, Vincenzo Tombolini
Serum microRNAs as non-invasive biomarkers for cancer
Jan C Brase, Daniela Wuttig, Ruprecht Kuner, Holger Sültmann
Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase
Qi Ma, Kun Zhang, Sunny Guin, Yong-Qing Zhou, Ming-Hai Wang
Broccoli, PTEN deletion and prostate cancer: where is the link?
Giovanni Appendino, Alberto Bardelli
Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells
Wei-Lun Huang, Hsuan-Heng Yeh, Chien-Chung Lin, Wu-Wei Lai, Jang-Yang Chang, Wen-Tsan Chang, Wu-Chou Su
Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers
Maher S Saifo, Donald R Rempinski Jr, Youcef M Rustum, Rami G Azrak
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes
Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, ChikOn Choy, Tai-Du Lin, Linyi Chen, Hsin-Ling Hsu
Integrin-mediated function of Rab GTPases in cancer progression
Dhatchayini Subramani, Suresh K Alahari
The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma
Richard Keld, Baoqiang Guo, Paul Downey, Christian Gulmann, Yeng S Ang, Andrew D Sharrocks
Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
Arti Shukla, Jedd M Hillegass, Maximilian B MacPherson, Stacie L Beuschel, Pamela M Vacek, Harvey I Pass, Michele Carbone, Joseph R Testa, Brooke T Mossman
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL
Lei Fu, Yi-Dan Lin, Heath A Elrod, Ping Yue, Youtake Oh, Bo Li, Hui Tao, Georgia Z Chen, Dong M Shin, Fadlo R Khuri, Shi-Yong Sun
A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis
Xin Yin, Jadwiga Truty, Roger Lawrence, Scott C Johns, R Sathish Srinivasan, Tracy M Handel, Mark M Fuster
Downregulation of miR-342 is associated with tamoxifen resistant breast tumors
Diana M Cittelly, Partha M Das, Nicole S Spoelstra, Susan M Edgerton, Jennifer K Richer, Ann D Thor, Frank E Jones
Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers
LiLi Jiang, Michelle KY Siu, Oscar GW Wong, Kar Fai Tam, Eric W-F Lam, Hextan YS Ngan, Xiao-Feng Le, Esther SY Wong, Hoi Yan Chan, Annie NY Cheung
PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis
Kexiong Zhang, David J Waxman
VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A
Raúl Catena, Leyre Larzabal, Marta Larrayoz, Eva Molina, Jose Hermida, Jackeline Agorreta, Ramon Montes, Ruben Pio, Luis M Montuenga, Alfonso Calvo
Clinical significance of Polycomb gene expression in brain tumors
Francesco Crea, Elaine M Hurt, William L Farrar