Ausgabe 1/2013
Inhalt (172 Artikel)
Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion
Neel Sengupta, Christopher Yau, Anuratha Sakthianandeswaren, Dmitri Mouradov, Peter Gibbs, Nirosha Suraweera, Jean-Baptiste Cazier, Guadalupe Polanco-Echeverry, Anil Ghosh, Mohamed Thaha, Shafi Ahmed, Roger Feakins, David Propper, Sina Dorudi, Oliver Sieber, Andrew Silver, Cecilia Lai
The Wilms’ tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells
Adina Brett, Sony Pandey, Gail Fraizer
Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells
Charlotte M Smith, Volker Haucke, Adam McCluskey, Phillip J Robinson, Megan Chircop
POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15)
Susana Lisboa, Nuno Cerveira, Susana Bizarro, Cecília Correia, Joana Vieira, Lurdes Torres, José M Mariz, Manuel R Teixeira
Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats
Dolores C García-Olmo, María G Picazo, Inmaculada Toboso, Ana I Asensio, Damián García-Olmo
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer
Yuanyuan Li, Syed M Meeran, Shweta N Patel, Huaping Chen, Tabitha M Hardy, Trygve O Tollefsbol
Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type
Steven Rust, Sandrine Guillard, Kris Sachsenmeier, Carl Hay, Max Davidson, Anders Karlsson, Roger Karlsson, Erin Brand, David Lowne, John Elvin, Matt Flynn, Gene Kurosawa, Robert Hollingsworth, Lutz Jermutus, Ralph Minter
Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity
Tibor Görögh, László Bèress, Elgar S Quabius, Petra Ambrosch, Markus Hoffmann
Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer
Rebekah L Zinn, Eric E Gardner, Irina Dobromilskaya, Sara Murphy, Luigi Marchionni, Christine L Hann, Charles M Rudin
Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration
Liangping Yuan, Hongying Zhang, Jingbo Liu, Joshua B Rubin, Yoon-Jae Cho, Hui Kuo Shu, Matthew Schniederjan, Tobey J MacDonald
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion
Vanessa M Freitas, Jônatas Bussador do Amaral, Thaiomara A Silva, Emerson S Santos, Flávia R Mangone, João de Jesus Pinheiro, Ruy G Jaeger, Maria A Nagai, Gláucia Maria Machado-Santelli
Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a
Chao Liang, Wei Chen, Xiao Zhi, Tao Ma, Xuefeng Xia, Hao Liu, Qi Zhang, Qida Hu, Yun Zhang, Xueli Bai, Tingbo Liang
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha
Chunhua Yang, Shujing Li, Miao Wang, Alan K Chang, Ying Liu, Feng Zhao, Liyun Xiao, Lin Han, Dao Wang, Shen Li, Huijian Wu
Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site
Kurtis Eisermann, Carly J Broderick, Anton Bazarov, Mustafa M Moazam, Gail C Fraizer
Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer
Robert S Hudson, Ming Yi, Natalia Volfovsky, Robyn L Prueitt, Dominic Esposito, Stefano Volinia, Chang-Gong Liu, Aaron J Schetter, Katrien Van Roosbroeck, Robert M Stephens, George A Calin, Carlo M Croce, Stefan Ambs
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
Laura Creevey, Jacqueline Ryan, Harry Harvey, Isabella M Bray, Maria Meehan, Adnan R Khan, Raymond L Stallings
1H-NMR based metabonomic profiling of human esophageal cancer tissue
Liang Wang, Jie Chen, Longqi Chen, Pengchi Deng, Qian bu, Pu Xiang, Manli Li, Wenjie Lu, Youzhi Xu, Hongjun Lin, Tianming Wu, Huijuan Wang, Jing Hu, Xiaoni Shao, Xiaobo Cen, Ying-Lan Zhao
Molecular features in arsenic-induced lung tumors
Roland Hubaux, Daiana D Becker-Santos, Katey SS Enfield, David Rowbotham, Stephen Lam, Wan L Lam, Victor D Martinez
Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
Mariana Toricelli, Fabiana HM Melo, Giovani B Peres, Débora CP Silva, Miriam G Jasiulionis
RETRACTED ARTICLE: Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells
David J Panka, Qingjun Liu, Andrew K Geissler, James W Mier
Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms
Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Hartmut Döhner, Konstanze Döhner, Marcus Matthias Schittenhelm
Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia
Takeo Nomura, Mutsushi Yamasaki, Kenichi Hirai, Toru Inoue, Ryuta Sato, Keiko Matsuura, Masatsugu Moriyama, Fuminori Sato, Hiromitsu Mimata
Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma
Yasufumi Katanasaka, Yasuo Kodera, Yuka Kitamura, Tatsuya Morimoto, Tomohide Tamura, Fumiaki Koizumi
Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells
Karthik M. Kodigepalli, Pavana Anur, Paul Spellman, Peter J. Sims, Meera Nanjundan
MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2
Mitsuhiro Matsuo, Chisato Nakada, Yoshiyuki Tsukamoto, Tsuyoshi Noguchi, Tomohisa Uchida, Naoki Hijiya, Keiko Matsuura, Masatsugu Moriyama
Molecular changes induced by the curcumin analogue D6 in human melanoma cells
Carla Rozzo, Manuela Fanciulli, Cristina Fraumene, Antonio Corrias, Tiziana Cubeddu, Ilaria Sassu, Sara Cossu, Valentina Nieddu, Grazia Galleri, Emanuela Azara, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri, Marina Pisano
MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells
Weiyun Wu, Jingfang Yang, Xiao Feng, Hao Wang, Shicai Ye, Pengchun Yang, Wenkai Tan, Guoli Wei, Yu Zhou
Gene expression profiling of chronic myeloid leukemia with variant t(9;22) reveals a different signature from cases with classic translocation
Francesco Albano, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Luciana Impera, Crescenzio Francesco Minervini, Angela Minervini, Antonella Russo Rossi, Giuseppina Tota, Paola Casieri, Giorgina Specchia
RETRACTED ARTICLE: Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer
Bethany Perez White, Mary Ellen Molloy, Huiping Zhao, Yiyun Zhang, Debra A. Tonetti
Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells
Catherine A. Taylor, Qifa Zheng, Zhongda Liu, John E. Thompson
Expression of HPV16 E5 down-modulates the TGFbeta signaling pathway
Deborah French, Francesca Belleudi, Maria Vittoria Mauro, Francesca Mazzetta, Salvatore Raffa, Vincenza Fabiano, Antonio Frega, Maria Rosaria Torrisi
Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
Xing Lu, Swetha Parvathaneni, Toshifumi Hara, Ashish Lal, Sudha Sharma
Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity
Melissa B Davis, Xinyu Liu, Shiyao Wang, Jaxk Reeves, Andrey Khramtsov, Dezheng Huo, Olufunmilayo I Olopade
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Michaela Lang, Melanie Borgmann, Georg Oberhuber, Rayko Evstatiev, Kristine Jimenez, Kyle W Dammann, Manuela Jambrich, Vineeta Khare, Christoph Campregher, Robin Ristl, Christoph Gasche
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak
Xiaobo Cao, Jeremy L Yap, M Karen Newell-Rogers, Chander Peddaboina, Weihua Jiang, Harry T Papaconstantinou, Dan Jupitor, Arun Rai, Kwan-Young Jung, Richard P Tubin, Wenbo Yu, Kenno Vanommeslaeghe, Paul T Wilder, Alexander D MacKerell JR, Steven Fletcher, Roy W Smythe
Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells
Alejandro García-Regalado, Miguel Vargas, Alejandro García-Carrancá, Elena Aréchaga-Ocampo, Claudia Haydée González-De la Rosa
The impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) in human breast cancer
Natalie Ludyga, Sonja Englert, Kerstin Pflieger, Sandra Rauser, Herbert Braselmann, Axel Walch, Gert Auer, Heinz Höfler, Michaela Aubele
IL-6 expression predicts treatment response and outcome in squamous cell carcinoma of the esophagus
Miao-Fen Chen, Ping-Tsung Chen, Ming Shian Lu, Paul Yang Lin, Wen-Cheng Chen, Kuan-Der Lee
Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden
Khalid Abubaker, Ardian Latifi, Rod Luwor, Simon Nazaretian, Hongjian Zhu, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
Vincenzo Pagliarulo, Patrizia Ancona, Mauro Niso, Nicola Antonio Colabufo, Marialessandra Contino, Luigi Cormio, Amalia Azzariti, Arcangelo Pagliarulo
The MicroRNA-148/152 Family: Multi-faceted Players
Yue Chen, Yong-Xi Song, Zhen-Ning Wang
Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells
Uri Rozovski, George A Calin, Tetsuro Setoyama, Lucilla D’Abundo, David M Harris, Ping Li, Zhiming Liu, Srdana Grgurevic, Alessandra Ferrajoli, Stefan Faderl, Jan A Burger, Susan O’Brien, William G Wierda, Michael J Keating, Zeev Estrov
Iodine and doxorubicin, a good combination for mammary cancer treatment: antineoplastic adjuvancy, chemoresistance inhibition, and cardioprotection
Yunuen Alfaro, Guadalupe Delgado, Alfonso Cárabez, Brenda Anguiano, Carmen Aceves
Raman imaging at biological interfaces: applications in breast cancer diagnosis
Jakub Surmacki, Jacek Musial, Radzislaw Kordek, Halina Abramczyk
Novel mechanism of regulation of fibrosis in kidney tumor with tuberous sclerosis
Sitai Liang, Gabriela Cuevas, Shaza Tizani, Tiffanie Salas, Huijuan Liu, Baojie Li, Samy L Habib
Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
Tao Ji, Carol Lin, Lauren S Krill, Ramez Eskander, Yi Guo, Xiaolin Zi, Bang H Hoang
MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair
Yen-Lin Chu, Xiling Wu, Yang Xu, Chengtao Her
BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
Abul Azad, Alan Storey
Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Katharina Henriette Rasp, Barbara Illing, Hartmut Döhner, Konstanze Döhner, Marcus Matthias Schittenhelm
Global profiling of prolactin-modulated transcripts in breast cancer in vivo
Takahiro Sato, Thai H Tran, Amy R Peck, Chengbao Liu, Adam Ertel, Justin Lin, Lynn M Neilson, Hallgeir Rui
6-Formylindolo (3,2-b)carbazole (FICZ) enhances retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells
Rodica P Bunaciu, Andrew Yen
Role of SIRT3 in the regulation of redox balance during oral carcinogenesis
I-Chieh Chen, Wei-Fan Chiang, Shyun-Yeu Liu, Pei-Fen Chen, Hung-Che Chiang
Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN
Pankaj Sharma, Ashley Evans Knowell, Swathi Chinaranagari, Shravan Komaragiri, Peri Nagappan, Divya Patel, Mathew C Havrda, Jaideep Chaudhary
Novel microRNA-based assay demonstrates 92% agreement with diagnosis based on clinicopathologic and management data in a cohort of patients with carcinoma of unknown primary
George Pentheroudakis, Nicholas Pavlidis, George Fountzilas, Dimitrios Krikelis, Anna Goussia, Aikaterini Stoyianni, Mats Sanden, Brianna St Cyr, Noga Yerushalmi, Hila Benjamin, Eti Meiri, Ayelet Chajut, Shai Rosenwald, Ranit Aharonov, Yael Spector
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy
Laura K Green, Sophie P Syddall, Kendall M Carlin, Glenn D Bell, Christopher P Guise, Alexandra M Mowday, Michael P Hay, Jeffrey B Smaill, Adam V Patterson, David F Ackerley
BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification
Ben-yuan Jiang, Xu-chao Zhang, Jian Su, Wei Meng, Xue-ning Yang, Jin-ji Yang, Qing Zhou, Zhi-yong Chen, Zhi-hong Chen, Zhi Xie, Shi-liang Chen, Yi-long Wu
Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers
Tsutomu Oshima, Shuji Sato, Junichi Kato, Yuki Ito, Takahiro Watanabe, Isamu Tsuji, Akira Hori, Tomofumi Kurokawa, Toshio Kokubo
Regulation of protumorigenic pathways by Insulin like growth factor binding protein2 and its association along with β-catenin in breast cancer lymph node metastasis
Priyanka Sehgal, Neeraj Kumar, Varuvar Rajesh Praveen Kumar, Shilpa Patil, Animesh Bhattacharya, Manavalan Vijaya Kumar, Geetashree Mukherjee, Paturu Kondaiah
Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma
Wen Zhou, Xiangling Feng, Caiping Ren, Xingjun Jiang, Weidong Liu, Wei Huang, Zhihong Liu, Zan Li, Liang Zeng, Lei Wang, Bin Zhu, Jia Shi, Jie Liu, Chang Zhang, Yanyu Liu, Kaitai Yao
EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
Agnieszka Martowicz, Johannes Rainer, Julien Lelong, Gilbert Spizzo, Guenther Gastl, Gerold Untergasser
Biochemical and biological characterization of exosomes containing prominin-1/CD133
Germana Rappa, Javier Mercapide, Fabio Anzanello, Robert M Pope, Aurelio Lorico
Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
Jianjun Lei, Jiguang Ma, Qingyong Ma, Xuqi Li, Han Liu, Qinhong Xu, Wanxing Duan, Qing Sun, Jun Xu, Zheng Wu, Erxi Wu
Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs
Dong Hyun Jo, Dain Son, Yirang Na, Manyoung Jang, Jae-Hoon Choi, Jin Hyoung Kim, Young Suk Yu, Seung Hyeok Seok, Jeong Hun Kim
Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
Mohd Askandar Iqbal, Farid Ahmad Siddiqui, Vibhor Gupta, Shilpi Chattopadhyay, Prakasam Gopinath, Bhupender Kumar, Siddharth Manvati, Noor Chaman, Rameshwar NK Bamezai
The evolution of malignant and reactive γδ + T cell clones in a relapse T-ALL case after allogeneic stem cell transplantation
Shaohua Chen, Xin Huang, Haitao Zheng, Suxia Geng, Xiuli Wu, Lijian Yang, Jianyu Weng, Xin Du, Yangqiu Li
Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Leroi V DeSouza, Ajay Matta, Zia Karim, Joydeep Mukherjee, X Simon Wang, Olga Krakovska, Gelareh Zadeh, Abhijit Guha, KW Michael Siu
Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5
Christelle P El-Haibi, Praveen Sharma, Rajesh Singh, Pranav Gupta, Dennis D Taub, Shailesh Singh, James W Lillard, Jr
Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase
Laetitia Moreno Y Banuls, Adriana Katz, Walter Miklos, Alessio Cimmino, Daniel M. Tal, Elena Ainbinder, Martin Zehl, Ernst Urban, Antonio Evidente, Brigitte Kopp, Walter Berger, Olivier Feron, Steven Karlish, Robert Kiss
A gene expression profile indicative of early stage HER2 targeted therapy response
Fiona O’Neill, Stephen F Madden, Martin Clynes, John Crown, Padraig Doolan, Sinéad T Aherne, Robert O’Connor
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
Parnetta Sutton, Jeffrey A Borgia, Philip Bonomi, Janet MD Plate
TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells
Daniel S Straus
Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma
Lei Jin, Erich M Sturgis, Yang Zhang, Zhigang Huang, Xicheng Song, Chao Li, Qingyi Wei, Guojun Li
miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer
Feng Wei, Yan Liu, Yanhai Guo, An Xiang, Guangyi Wang, Xiaochang Xue, Zifan Lu
TMEM16A alternative splicing coordination in breast cancer
Ifeoma Ubby, Erica Bussani, Antonio Colonna, Giuseppe Stacul, Martina Locatelli, Paolo Scudieri, Luis Galietta, Franco Pagani
Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase
Yuli Lin, Nana Peng, Jianping Li, Hongqin Zhuang, Zi-Chun Hua
Late developing mammary tumors and hyperplasia induced by a low-oncogenic variant of mouse mammary tumor virus (MMTV) express genes identical to those induced by canonical MMTV
Robert D Bruno, Sonia M Rosenfield, Gilbert H Smith
FGFR3 has tumor suppressor properties in cells with epithelial phenotype
Marie Lafitte, Isabelle Moranvillier, Stéphane Garcia, Evelyne Peuchant, Juan Iovanna, Benoit Rousseau, Pierre Dubus, Véronique Guyonnet-Dupérat, Geneviève Belleannée, Jeanne Ramos, Aurélie Bedel, Hubert de Verneuil, François Moreau-Gaudry, Sandrine Dabernat
The complexity of NF-κB signaling in inflammation and cancer
Bastian Hoesel, Johannes A Schmid
The regulation of toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells
Haiyan Guo, Ying Chen, Xiaobo Hu, Guanxiang Qian, Shengfang Ge, Jianjun Zhang
Cigarette smoke induces epithelial to mesenchymal transition and increases the metastatic ability of breast cancer cells
Francescopaolo Di Cello, V Lynn Flowers, Huili Li, Briana Vecchio-Pagán, Brent Gordon, Kirsten Harbom, James Shin, Robert Beaty, Wei Wang, Cory Brayton, Stephen B Baylin, Cynthia A Zahnow
Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma
Reju Korah, James M Healy, John W Kunstman, Annabelle L Fonseca, Amir H Ameri, Manju L Prasad, Tobias Carling
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts
Enas A El-Karim, Engda G Hagos, Amr M Ghaleb, Bing Yu, Vincent W Yang
Characterization and identification of PARM-1 as a new potential oncogene
Cyndia Charfi, Louis-Charles Levros Jr, Elsy Edouard, Eric Rassart
USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy
Iraia García-Santisteban, Godefridus J Peters, Elisa Giovannetti, Jose Antonio Rodríguez
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly, Vera Levina
The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells
Xin Yan, Hongwei Liang, Ting Deng, Kegan Zhu, Suyang Zhang, Nan Wang, Xueyuan Jiang, Xueliang Wang, Rui Liu, Ke Zen, Chen-Yu Zhang, Yi Ba, Xi Chen
PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
M Katie Conley-LaComb, Allen Saliganan, Pridvi Kandagatla, Yong Q Chen, Michael L Cher, Sreenivasa R Chinni
Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival
Serena Lucotti, Giuseppe Rainaldi, Monica Evangelista, Milena Rizzo
Cancer risk in immune-mediated inflammatory diseases (IMID)
Rudi Beyaert, Laurent Beaugerie, Gert Van Assche, Lieve Brochez, Jean-Christophe Renauld, Manuelle Viguier, Veronique Cocquyt, Guy Jerusalem, Jean-Pascal Machiels, Hans Prenen, Pierre Masson, Edouard Louis, Filip De Keyser
Glyceraldehyde-3-phosphate dehydrogenase gene over expression correlates with poor prognosis in non small cell lung cancer patients
Roberto Puzone, Graziana Savarino, Sandra Salvi, Maria Giovanna Dal Bello, Giulia Barletta, Carlo Genova, Erika Rijavec, Claudio Sini, Alessia Isabella Esposito, Giovanni Battista Ratto, Mauro Truini, Francesco Grossi, Ulrich Pfeffer
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
Annica Wilzén, Cecilia Krona, Baldur Sveinbjörnsson, Erik Kristiansson, Daniel Dalevi, Ingrid Øra, Katleen De Preter, Raymond L Stallings, John Maris, Rogier Versteeg, Staffan Nilsson, Per Kogner, Frida Abel
Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
Joanna Obacz, Silvia Pastorekova, Borek Vojtesek, Roman Hrstka
Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay
Simon Welner, Nicole Hartwig Trier, Morten Frisch, Henning Locht, Paul Robert Hansen, Gunnar Houen
The complexity of bladder cancer: long noncoding RNAs are on the stage
Quanan Zhang, Mo Su, Guangming Lu, Jiangdong Wang
Oncolytic viruses as therapeutic cancer vaccines
David L Bartlett, Zuqiang Liu, Magesh Sathaiah, Roshni Ravindranathan, Zongbi Guo, Yukai He, Zong Sheng Guo
Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines
Giampiero Porcu, Ainslie B Parsons, Daniele Di Giandomenico, Giuseppe Lucisano, Maria Giovanna Mosca, Charles Boone, Antonella Ragnini-Wilson
Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling
Xin Zheng, Xiaohong Gai, Feihu Ding, Zhongtang Lu, Kangsheng Tu, Yingmin Yao, Qingguang Liu
Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer
Kolaparthi Venkatasubbarao, Lindsay Peterson, Shujie Zhao, Ping Hill, Lin Cao, Qing Zhou, Steffan T Nawrocki, James W Freeman
Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds
Timur R Samatov, Alexander G Tonevitsky, Udo Schumacher
Cancer: tilting at windmills?
Prakash Kulkarni, Takumi Shiraishi, Rahul V Kulkarni
Expression profiling of ion channel genes predicts clinical outcome in breast cancer
Jae-Hong Ko, Eun A Ko, Wanjun Gu, Inja Lim, Hyoweon Bang, Tong Zhou
Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells
He Li, Juan Wang, Huiyu Xu, Rui Xing, Yuanming Pan, Wenmei Li, Jiantao Cui, Hongbing Zhang, Youyong Lu
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
Cinzia Tesauro, Blasco Morozzo della Rocca, Alessio Ottaviani, Andrea Coletta, Laura Zuccaro, Barbara Arnò, Ilda D'Annessa, Paola Fiorani, Alessandro Desideri
miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death
Zhiyu Chen, Veena Sangwan, Sulagna Banerjee, Tiffany Mackenzie, Vikas Dudeja, Xiaowu Li, Huaizhi Wang, Selwyn M Vickers, Ashok K Saluja
The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion
Jade Peres, Sharon Prince
Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells
Soumik Agarwal, Karishma S Amin, Shankar Jagadeesh, Gokul Baishay, Paruchuri G Rao, Nabin C Barua, Samir Bhattacharya, Partha P Banerjee
MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1
Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang
Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure
Kiriaki Panagopoulos, Sam Cross-Knorr, Christen Dillard, Dionysios Pantazatos, Michael Del Tatto, David Mills, Lisa Goldstein, Joseph Renzulli, Peter Quesenberry, Devasis Chatterjee
The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma
Daniel Weissinger, Katrin E Tagscherer, Stephan Macher-Göppinger, Axel Haferkamp, Nina Wagener, Wilfried Roth
Synthesis, characterization, and evaluation of a novel inhibitor of WNT/β-catenin signaling pathway
Zhao Yan, Zhongling Zhu, Jinghui Wang, Jian Sun, Yihui Chen, Guang Yang, Wenting Chen, Yuheng Deng
MiR-451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal carcinoma
Na Liu, Ning Jiang, Rui Guo, Wei Jiang, Qing-Mei He, Ya-Fei Xu, Ying-Qin Li, Ling-Long Tang, Yan-Ping Mao, Ying Sun, Jun Ma
Astrocyte elevated gene-1 is associated with metastasis in head and neck squamous cell carcinoma through p65 phosphorylation and upregulation of MMP1
Yi-Ping Wang, I-Ju Liu, Chiung-Pin Chiang, Han-Chung Wu
The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers
Iwona Ziółkowska-Suchanek, Maria Mosor, Małgorzata Wierzbicka, Małgorzata Rydzanicz, Marta Baranowska, Jerzy Nowak
MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma
Ning Wang, Meifen Zhu, Sai-Wah Tsao, Kwan Man, Zhangjin Zhang, Yibin Feng
CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis
Ai-Fang Huang, Min-Wei Chen, Shih-Ming Huang, Chu-Lien Kao, Hung-Cheng Lai, James Yi-Hsin Chan
¹H NMR-based metabolic profiling of human rectal cancer tissue
Huijuan Wang, Liang Wang, Hailong Zhang, Pengchi Deng, Jie Chen, Bin Zhou, Jing Hu, Jun Zou, Wenjie Lu, Pu Xiang, Tianming Wu, Xiaoni Shao, Yuan Li, Zongguang Zhou, Ying-Lan Zhao
The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells
Jingcao Huang, Shuiliang Wang, Hui Lyu, Bo Cai, XiaoHe Yang, Jianxiang Wang, Bolin Liu
Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model
Urska Kamensek, Gregor Sersa, Maja Cemazar
Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations
Angela A Fachel, Ana C Tahira, Santiago A Vilella-Arias, Vinicius Maracaja-Coutinho, Etel RP Gimba, Giselle M Vignal, Franz S Campos, Eduardo M Reis, Sergio Verjovski-Almeida
Ets-1 regulates intracellular glutathione levels: key target for resistant ovarian cancer
Meghan L Verschoor, Gurmit Singh
High mitochondria content is associated with prostate cancer disease progression
Katharina Grupp, Karolina Jedrzejewska, Maria Christina Tsourlakis, Christina Koop, Waldemar Wilczak, Meike Adam, Alexander Quaas, Guido Sauter, Ronald Simon, Jakob Robert Izbicki, Markus Graefen, Hartwig Huland, Thorsten Schlomm, Sarah Minner, Stefan Steurer
Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway
Leticia Oliveira-Ferrer, Jasmin Wellbrock, Udo Bartsch, Eva Maria Murga Penas, Jessica Hauschild, Marianne Klokow, Carsten Bokemeyer, Walter Fiedler, Gunter Schuch
Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
Giada Gelsomino, Paola A Corsetto, Ivana Campia, Gigliola Montorfano, Joanna Kopecka, Barbara Castella, Elena Gazzano, Dario Ghigo, Angela M Rizzo, Chiara Riganti
Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera
Miguel Gallardo, Santiago Barrio, Marisol Fernandez, Alberto Paradela, Alicia Arenas, Oscar Toldos, Rosa Ayala, Enriqueta Albizua, Ana Jimenez, Santiago Redondo, Rosa Maria Garcia-Martin, Florinda Gilsanz, Juan Pablo Albar, Joaquin Martinez-Lopez
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis
Hui Ren, Junghui Koo, Baoxiang Guan, Ping Yue, Xingming Deng, Mingwei Chen, Fadlo R Khuri, Shi-Yong Sun
Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1
Xuelei Cao, Li Zhang, Yongyu Shi, Yue Sun, Shen Dai, Chun Guo, Faliang Zhu, Qun wang, Jianing Wang, Xiaoyan Wang, Youhai H Chen, Lining Zhang
Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis
Jiao Zheng, Min Yang, Jianghua Shao, Yanju Miao, Jiahuai Han, Jie Du
LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway
Xuan Song, Jiabei Wang, Tongsen Zheng, Ruipeng Song, Yingjian Liang, Nishant Bhatta, Dalong Yin, Shangha Pan, Jiaren Liu, Hongchi Jiang, Lianxin Liu
RETRACTED ARTICLE: α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway
Sarita Saraswati, Shakti Kumar, Abdulqader A Alhaider
6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α
Qun Liu, Yong-Bo Peng, Ping Zhou, Lian-Wen Qi, Mu Zhang, Ning Gao, E-Hu Liu, Ping Li
PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathway
Jian-Ye Liu, Dong Qian, Li-Ru He, Yong-Hong Li, Yi-Ji Liao, Shi-Juan Mai, Xiao-Peng Tian, Yan-Hui Liu, Jia-Xing Zhang, Hsiang-Fu Kung, Yi-Xin Zeng, Fang-Jian Zhou, Dan Xie
TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer
Xiangbing Wu, Wei Cao, Xu Wang, Jianjun Zhang, Zhongjing Lv, Xing Qin, Yadi Wu, Wantao Chen
Tumor glycolysis as a target for cancer therapy: progress and prospects
Shanmugasundaram Ganapathy-Kanniappan, Jean-Francois H Geschwind
DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway
Liang Chen, Ming Li, Qian Li, Chao-jie Wang, Song-qiang Xie
Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir
Tim De Schutter, Graciela Andrei, Dimitri Topalis, Sophie Duraffour, Tania Mitera, Joost van den Oord, Patrick Matthys, Robert Snoeck
The roles of FOXM1 in pancreatic stem cells and carcinogenesis
Ming Quan, Peipei Wang, Jiujie Cui, Yong Gao, Keping Xie
Effects of miR-193a and sorafenib on hepatocellular carcinoma cells
Alessandro Salvi, Isabel Conde, Edoardo Abeni, Bruna Arici, Ilaria Grossi, Claudia Specchia, Nazario Portolani, Sergio Barlati, Giuseppina De Petro
Mapping PAM4 (clivatuzumab), a monoclonal antibody in clinical trials for early detection and therapy of pancreatic ductal adenocarcinoma, to MUC5AC mucin
David V Gold, Guy Newsome, Donglin Liu, David M Goldenberg
Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells
Sofia Winslow, Karin Leandersson, Christer Larsson
Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres
Monica Patanè, Paola Porrati, Elisa Bottega, Sara Morosini, Gabriele Cantini, Vita Girgenti, Ambra Rizzo, Marica Eoli, Bianca Pollo, Francesca L Sciacca, Serena Pellegatta, Gaetano Finocchiaro
Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer
Laisheng Li, Jinmei Luo, Bo Wang, Dong Wang, Xinhua Xie, Linjing Yuan, Jiaoli Guo, Shaoyan Xi, Jie Gao, Xiaoti Lin, Yanan Kong, Xiangdong Xu, Hailing Tang, Xiaoming Xie, Min Liu
In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness
Federica Brugnoli, Silvia Grassilli, Manuela Piazzi, Maria Palomba, Ervin Nika, Alberto Bavelloni, Silvano Capitani, Valeria Bertagnolo
Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines
Wenyu Liu, Gajan Jeganathan, Sohrab Amiri, Katherine M Morgan, Bríd M Ryan, Sharon R Pine
Id4 dependent acetylation restores mutant-p53 transcriptional activity
Ashley E Knowell, Divya Patel, Derrick J Morton, Pankaj Sharma, Shanora Glymph, Jaideep Chaudhary
miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression
Fang-Ting Duan, Feng Qian, Ke Fang, Kang-Yu Lin, Wen-Tao Wang, Yue-Qin Chen
Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells
Meiling Zhang, Jamie Truscott, Judith Davie
Activation of cellular immunity and marked inhibition of liver cancer in a mouse model following gene therapy and tumor expression of GM-SCF, IL-21, and Rae-1
Mingrong Cheng, Kangkang Zhi, Xiaoyan Gao, Bing He, Yingchun Li, Jiang Han, Zhiping Zhang, Yan Wu
A TrkB–STAT3–miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells
Wei Bao, Hui-Hui Wang, Fu-Ju Tian, Xiao-Ying He, Mei-Ting Qiu, Jing-Yun Wang, Hui-Juan Zhang, Li-Hua Wang, Xiao-Ping Wan
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior
Marina Poettler, Matthias Unseld, Kira Braemswig, Andrea Haitel, Christoph C Zielinski, Gerald W Prager
Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia - implications on constitutive activation of NFκB pathway
Lu Qian Wang, Yok Lam Kwong, Chi Shan Bonnie Kho, Kit Fai Wong, Kwan Yeung Wong, Manuela Ferracin, George A Calin, Chor Sang Chim
Group X secreted phospholipase A2 induces lipid droplet formation and prolongs breast cancer cell survival
Anja Pucer, Vesna Brglez, Christine Payré, Jože Pungerčar, Gérard Lambeau, Toni Petan
Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer
Louisa CE Windus, Tristan T Glover, Vicky M Avery
Targeted therapy against EGFR and VEGFR using ZD6474 enhances the therapeutic potential of UV-B phototherapy in breast cancer cells
Siddik Sarkar, Shashi Rajput, Amit Kumar Tripathi, Mahitosh Mandal
Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
Victor D Martinez, Emily A Vucic, Larissa A Pikor, Kelsie L Thu, Roland Hubaux, Wan L Lam
Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma
Fengming Gong, Xingchen Peng, Can Luo, Guobo Shen, Chengjian Zhao, Liqun Zou, Longhao Li, Yaxiong Sang, Yuwei Zhao, Xia Zhao
Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon
Pramudita Ramadhina Prasetyanti, Cheryl Doreen Zimberlin, Michael Bots, Louis Vermeulen, Felipe De Sousa E Melo, Jan Paul Medema
R-RAS2 overexpression in tumors of the human central nervous system
Sylvia Gutierrez-Erlandsson, Pedro Herrero-Vidal, Marcos Fernandez-Alfara, Susana Hernandez-Garcia, Sandra Gonzalo-Flores, Alberto Mudarra-Rubio, Manuel Fresno, Beatriz Cubelos
A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
King Chi Chan, Choi Man Ting, Pui Shan Chan, Ming Chu Lo, Kwok Wai Lo, Jayne E Curry, Tomoko Smyth, Anne Wing Mui Lee, Wai Tong Ng, George Sai Wah Tsao, Ricky Ngok Shun Wong, Maria Li Lung, Nai Ki Mak
Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin
Elaine Langenfeld, Malik Deen, Emmanuel Zachariah, John Langenfeld
miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression
Manuela Ferracin, Cristian Bassi, Massimo Pedriali, Sara Pagotto, Lucilla D’Abundo, Barbara Zagatti, Fabio Corrà, Gentian Musa, Elisa Callegari, Laura Lupini, Stefano Volpato, Patrizia Querzoli, Massimo Negrini
The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage
Orit Feldstein, Tal Nizri, Tirza Doniger, Jasmine Jacob, Gideon Rechavi, Doron Ginsberg
Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis
Mejdi Moumen, Aurélie Chiche, Charles Decraene, Valérie Petit, Alberto Gandarillas, Marie-Ange Deugnier, Marina A Glukhova, Marisa M Faraldo
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines
Hanneke Stegeman, Johannes HAM Kaanders, Marieke MG Verheijen, Wenny JM Peeters, Deric L Wheeler, Mari Iida, Reidar Grénman, Albert J van der Kogel, Paul N Span, Johan Bussink
Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma
Long Chen, Shuang Zhou, Jie Qin, Heng Hu, Huiying Ma, Binbin Liu, Xuan Wang, Jiaqi Ma, Shenglong Ye, Cuiping Zhong, Guomin Zhou, Chunmin Liang
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase
Lei Gong, Amber M Cumpian, Mauricio S Caetano, Cesar E Ochoa, Maria Miguelina De la Garza, Daniel J Lapid, Seyedeh Golsar Mirabolfathinejad, Burton F Dickey, Qinghua Zhou, Seyed Javad Moghaddam
Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors
Rainelli B Koumangoye, Gladys N Nangami, Pamela D Thompson, Vincent K Agboto, Josiah Ochieng, Amos M Sakwe
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas
Koji Shindo, Shinichi Aishima, Kenoki Ohuchida, Kenji Fujiwara, Minoru Fujino, Yusuke Mizuuchi, Masami Hattori, Kazuhiro Mizumoto, Masao Tanaka, Yoshinao Oda
Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms
Dhruv Kumar, Sharmila Shankar, Rakesh K Srivastava
DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival
Ying Tu, Chao Ji, Bo Yang, Zhi Yang, Hua Gu, Chun-Cheng Lu, Rong Wang, Zhong-Lan Su, Bin Chen, Wei-Ling Sun, Ji-Ping Xia, Zhi-Gang Bi, Li He
Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting vascular endothelial growth factor receptor 2–mediated angiogenesis
Sarita Saraswati, Pawan K Kanaujia, Shakti Kumar, Ranjeet Kumar, Abdulqader A Alhaider