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Zeitschrift

Molecular Cancer

Molecular Cancer 1/2014

Ausgabe 1/2014

Inhaltsverzeichnis ( 266 Artikel )

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin

Da-Liang Ou, Bin-Shyun Lee, Liang-In Lin, Jun-Yang Liou, Sheng-Chieh Liao, Chiun Hsu, Ann-Lii Cheng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer

Brian Gloss, Kim Moran-Jones, Vita Lin, Maria Gonzalez, James Scurry, Neville F Hacker, Robert L Sutherland, Susan J Clark, Goli Samimi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells

Yi-Chen Yen, Shine-Gwo Shiah, Hsiao-Chien Chu, Yuan-Ming Hsu, Jenn-Ren Hsiao, Jang-Yang Chang, Wen-Chun Hung, Chun-Ta Liao, Ann-Joy Cheng, Ya-Ching Lu, Ya-Wen Chen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli

Xia Zhan, Juan Wang, Yuan Liu, Yuanqiu Peng, Wenfu Tan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma

Jian Kong, Fandong Kong, Jun Gao, Qiangbo Zhang, Shuying Dong, Fang Gu, Shan Ke, Bing Pan, Qiang Shen, Huichuan Sun, Lemin Zheng, Wenbing Sun

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance

Richard Ottman, Camha Nguyen, Robert Lorch, Ratna Chakrabarti

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies

Marine Pesson, Béatrice Eymin, Pierre De La Grange, Brigitte Simon, Laurent Corcos

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation

Selina M Riplinger, Guido H Wabnitz, Henning Kirchgessner, Beate Jahraus, Felix Lasitschka, Bianca Schulte, Gabri van der Pluijm, Geertje van der Horst, Günter J Hämmerling, Inaam Nakchbandi, Yvonne Samstag

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1

Inga Hinrichsen, Benjamin Philipp Ernst, Franziska Nuber, Sandra Passmann, Dieter Schäfer, Verena Steinke, Nicolaus Friedrichs, Guido Plotz, Stefan Zeuzem, Angela Brieger

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration

Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Annika Herrmann, Ernst Wagner, Andreas Roidl

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma

Yao Zhang, Li Bao, Jin Lu, Kai-Yan Liu, Jin-Lan Li, Ya-Zhen Qin, Huan Chen, Ling-Di Li, Yuan Kong, Hong-Xia Shi, Yue-Yun Lai, Yan-Rong Liu, Bin Jiang, Shan-Shan Chen, Xiao-Jun Huang, Guo-Rui Ruan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

Katrin K Fleischmann, Philipp Pagel, Irene Schmid, Adelbert A Roscher

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin

Yanli Jin, Ke Ding, Honglin Li, Mengzhu Xue, Xiaoke Shi, Chengyan Wang, Jingxuan Pan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

ADAM17 mediates OSCC development in an orthotopic murine model

Fernando Moreira Simabuco, Rebeca Kawahara, Sami Yokoo, Daniela C Granato, Lucas Miguel, Michelle Agostini, Annelize ZB Aragão, Romênia R Domingues, Isadora L Flores, Carolina CS Macedo, Ricardo Della Coletta, Edgard Graner, Adriana Franco Paes Leme

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia

Carme Camps, Harpreet K Saini, David R Mole, Hani Choudhry, Martin Reczko, José Afonso Guerra-Assunção, Ya-Min Tian, Francesca M Buffa, Adrian L Harris, Artemis G Hatzigeorgiou, Anton J Enright, Jiannis Ragoussis

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth

Leila Haery, Julián G Lugo-Picó, Ryan A Henry, Andrew J Andrews, Thomas D Gilmore

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer

Daniel SW Tan, Benjamin Haaland, Jia Min Gan, Su Chin Tham, Indrajit Sinha, Eng Huat Tan, Kiat Hon Lim, Angela Takano, Sai Sakktee Krisna, Minn Minn Myint Thu, Hoe Peng Liew, Axel Ullrich, Wan-Teck Lim, Boon Tin Chua

01.12.2014 | Research | Ausgabe 1/2014 Open Access

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

Qiang Ding, Yumi Miyazaki, Koichiro Tsukasa, Shyuichiro Matsubara, Makoto Yoshimitsu, Sonshin Takao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway

Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes, Makhluf J Haddadin, Marwan El-Sabban, Hala Gali-Muhtasib

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Irem Gurbuz, Jacqueline Ferralli, Tim Roloff, Ruth Chiquet-Ehrismann, Maria B Asparuhova

01.12.2014 | Research | Ausgabe 1/2014 Open Access

IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9

Qiaojia Huang, Fenghua Lan, Xiaoting Wang, Yinghao Yu, Xuenong Ouyang, Feng Zheng, Junyong Han, Youdong Lin, Yanchuan Xie, Feilai Xie, Wei Liu, Xiaoli Yang, Han Wang, Lihong Dong, Lie Wang, Jianming Tan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis

Diego Cardani, Claudia Sardi, Barbara La Ferla, Giuseppe D’Orazio, Michele Sommariva, Fabrizio Marcucci, Daniela Olivero, Elda Tagliabue, Hermann Koepsell, Francesco Nicotra, Andrea Balsari, Cristiano Rumio

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Bo Liu, Qing Yang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

Wen Zhu, Gulnaz Begum, Kelli Pointer, Paul A Clark, Sung-Sen Yang, Shih-Hua Lin, Kristopher T Kahle, John S Kuo, Dandan Sun

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

Lays M Sobral, Lucas O Sousa, Ricardo D Coletta, Hamilton Cabral, Lewis J Greene, Eloiza H Tajara, J Silvio Gutkind, Carlos Curti, Andréia M Leopoldino

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128

Yogita K Adlakha, Neeru Saini

01.12.2014 | Research | Ausgabe 1/2014 Open Access

β-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro

Roger A Vaughan, Nicholas P Gannon, Randi Garcia-Smith, Yamhilette Licon-Munoz, Miguel A Barberena, Marco Bisoffi, Kristina A Trujillo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin

Gagan Deep, Anil K Jain, Anand Ramteke, Harold Ting, Kavitha C Vijendra, Subhash C Gangar, Chapla Agarwal, Rajesh Agarwal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

CD8+T cell–specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors

Jiemiao Hu, Shiguo Zhu, Xueqing Xia, Liangfang Zhang, Eugenie S Kleinerman, Shulin Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3

Na Zhao, Ruizhi Wang, Liangji Zhou, Ying Zhu, Jiao Gong, Shi-Mei Zhuang

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment

Yan-Yang Wang, Hong Zhe, Ren Zhao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction

Jun Ma, Jun Liu, Zhiming Wang, Xixi Gu, Yue Fan, Wen Zhang, Lili Xu, Jianjun Zhang, Dingfang Cai

01.12.2014 | Research | Ausgabe 1/2014 Open Access

High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

Elke Joeckel, Tobias Haber, Dirk Prawitt, Kerstin Junker, Christian Hampel, Joachim W Thüroff, Frederik C Roos, Walburgis Brenner

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy

Lisha Wang, Sean R Williamson, Mingsheng Wang, Darrell D Davidson, Shaobo Zhang, Lee Ann Baldridge, Xiang Du, Liang Cheng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MEK targeting in N-RAS mutated metastatic melanoma

Jaykumar Thumar, David Shahbazian, Saadia A Aziz, Lucia B Jilaveanu, Harriet M Kluger

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

Yang Yang, Xueting Cai, Jie Yang, Xiaoyan Sun, Chunping Hu, Zhanpeng Yan, Xiaojun Xu, Wuguang Lu, Xiaoning Wang, Peng Cao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small RNAs in the peripheral blood discriminate metastasized from non-metastasized seminoma

Christian G Ruf, Daniela Dinger, Matthias Port, Hans-Ulrich Schmelz, Walter Wagner, Cord Matthies, Bertram Müller-Myhsok, Viktor Meineke, Michael Abend

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells

Liqun Chen, Lilly Y W Bourguignon

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer

Ping Li, Ru Yang, Wei-Qiang Gao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer

Benoît Romain, Muriel Hachet-Haas, Serge Rohr, Cécile Brigand, Jean-Luc Galzi, Marie-Pierre Gaub, Erwan Pencreach, Dominique Guenot

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk, Tapas K Kundu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

Kunrong Cheng, Guofeng Xie, Sandeep Khurana, Jonathon Heath, Cinthia B Drachenberg, Jennifer Timmons, Nirish Shah, Jean-Pierre Raufman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease

Barbara Nuvoli, Sabrina Germoni, Carlotta Morosetti, Raffaela Santoro, Giancarlo Cortese, Serena Masi, Iole Cordone, Rossella Galati

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression

Lide Alaña, Marta Sesé, Verónica Cánovas, Yolanda Punyal, Yolanda Fernández, Ibane Abasolo, Inés de Torres, Cristina Ruiz, Lluís Espinosa, Anna Bigas, Santiago Ramón y Cajal, Pedro L Fernández, Florenci Serras, Montserrat Corominas, Timothy M Thomson, Rosanna Paciucci

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

Valentina Rapozzi, Sonia Zorzet, Marina Zacchigna, Emilia Della Pietra, Susanna Cogoi, Luigi E Xodo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TGFβR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness

Xiaoming Lyu, Weiyi Fang, Longmei Cai, Hang Zheng, Yanfen Ye, Lan Zhang, Jinbang li, Hong Peng, William C S Cho, Ena Wang, Francesco M Marincola, Kaitai Yao, Hongbing Cai, Jiliang Li, Xin Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Ilango Balakrishnan, Brian Cristiano, Andrew M Donson, Adrian M Dubuc, Michael D Taylor, Nicholas K Foreman, Philip Reigan, Rajeev Vibhakar

01.12.2014 | Research | Ausgabe 1/2014 Open Access

F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation

Su Dong, Jing Zhao, Jianxin Wei, Rachel K Bowser, Andrew Khoo, Zhonghui Liu, James D Luketich, Arjun Pennathur, Haichun Ma, Yutong Zhao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A novel autoantibody test for the detection of pre-neoplastic lung lesions

Frazer J Lowe, Weike Shen, Jinchi Zu, Junfu Li, Hao Wang, Xufei Zhang, Li Zhong

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ

Hyun Min Jung, Brittany L Phillips, Edward KL Chan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis

Lupeng Li, Lixiang Wang, Ping Song, Xue Geng, Xiuming Liang, Minran Zhou, Yangyang Wang, Chunyan Chen, Jihui Jia, Jiping Zeng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

IRF-1 regulates alternative mRNA splicing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in breast epithelial cells generating an immunoreceptor tyrosine-based inhibition motif (ITIM) containing isoform

Kenneth J Dery, Maciej Kujawski, David Grunert, Xiwei Wu, Tung Ngyuen, Celeste Cheung, John H Yim, John E Shively

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma

Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi’an Zhang, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, WeiYi Fang, Songtao Qi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium

Stefanie Aust, Katharina Auer, Anna Bachmayr-Heyda, Carsten Denkert, Jalid Sehouli, Ioana Braicu, Sven Mahner, Sandrina Lambrechts, Ignace Vergote, Christoph Grimm, Reinhard Horvat, Dan Cacsire Castillo-Tong, Robert Zeillinger, Dietmar Pils

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition

Ming Sun, Xiang-Hua Liu, Ke-Ming Wang, Feng-qi Nie, Rong Kong, Jin-song Yang, Rui Xia, Tong-Peng Xu, Fei-Yan Jin, Zhi-Jun Liu, Jin-fei Chen, Er-Bao Zhang, Wei De, Zhao-Xia Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)

Kamini Singh, Arishya Sharma, Maria C Mir, Judith A Drazba, Warren D Heston, Cristina Magi-Galluzzi, Donna Hansel, Brian P Rubin, Eric A Klein, Alexandru Almasan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by rapamycin in vitro and further improved by hyaluronan in vivo

Mingzhe Weng, Wei Gong, Mingzhe Ma, Bingfeng Chu, Yiyu Qin, Mingdi Zhang, Xueqing Lun, Grant McFadden, Peter Forsyth, Yong Yang, Zhiwei Quan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy

Li-Sheng Chang, Chih-Hsiang Leng, Yi-Chen Yeh, Chiao-Chieh Wu, Hsin-Wei Chen, Hai-Mei Huang, Shih-Jen Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

Nagarathinam Selvaraj, Justin A Budka, Mary W Ferris, Travis J Jerde, Peter C Hollenhorst

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer

Jennifer A Morrison, Laura A Pike, Sharon B Sams, Vibha Sharma, Qiong Zhou, Jill J Severson, Aik-Choon Tan, William M Wood, Bryan R Haugen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

Kai-Liang Zhang, Xuan Zhou, Lei Han, Lu-Yue Chen, Ling-Chao Chen, Zhen-Dong Shi, Ming Yang, Yu Ren, Jing-Xuan Yang, Thomas S Frank, Chuan-Bao Zhang, Jun-Xia Zhang, Pei-Yu Pu, Jian-Ning Zhang, Tao Jiang, Eric J Wagner, Min Li, Chun-Sheng Kang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma

Amanda Lassen, Mohammad Atefi, Lidia Robert, Deborah JL Wong, Michael Cerniglia, Begonya Comin-Anduix, Antoni Ribas

01.12.2014 | Research | Ausgabe 1/2014 Open Access

E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation

Zijia Ren, Wenyao Kang, Lihua Wang, Baoliang Sun, Jiajia Ma, Chaogu Zheng, Jie Sun, Zhigang Tian, Xiaoyi Yang, Weihua Xiao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling

Lingyi Fu, Ke Shi, Jingshu Wang, Wangbing Chen, Dingbo Shi, Yun Tian, Wei Guo, Wendan Yu, Xiangsheng Xiao, Tiebang Kang, Shusen Wang, Wenlin Huang, Wuguo Deng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer

Xiang-hua Liu, Ming Sun, Feng-qi Nie, Ying-bin Ge, Er-bao Zhang, Dan-dan Yin, Rong Kong, Rui Xia, Kai-hua Lu, Jin-hai Li, Wei De, Ke-ming Wang, Zhao-xia Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1

Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu, Jian Huang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells

Bin Wang, Zhenhong Ni, Xufang Dai, Liyan Qin, Xinzhe Li, Liang Xu, Jiqin Lian, Fengtian He

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia

Catalina A Palma, Dima Al Sheikha, Teck Khai Lim, Adam Bryant, Thi Thanh Vu, Vivek Jayaswal, David D F Ma

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death

Kim L Brunekreeft, Corinna Strohm, Marloes J Gooden, Anna A Rybczynska, Hans W Nijman, Götz U Grigoleit, Wijnand Helfrich, Edwin Bremer, Daniela Siegmund, Harald Wajant, Marco de Bruyn

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1

Dengbo Ji, Zhiguo Chen, Ming Li, Tiancheng Zhan, Yunfeng Yao, Zhiqian Zhang, Jianzhong Xi, Li Yan, Jin Gu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Long-term reduction of T-cell intracellular antigens leads to increased beta-actin expression

Isabel Carrascoso, Carmen Sánchez-Jiménez, José M Izquierdo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

Kelie M Reece, Emily D Richardson, Kristina M Cook, Tessa J Campbell, Stephen T Pisle, Alesia J Holly, David J Venzon, David J Liewehr, Cindy H Chau, Douglas K Price, William D Figg

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Function of RasGRP3 in the formation and progression of human breast cancer

Zsuzsanna Nagy, Ilona Kovács, Miklós Török, Dezső Tóth, György Vereb, Krisztina Buzás, István Juhász, Peter M Blumberg, Tamás Bíró, Gabriella Czifra

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway

Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu, Bingya Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A 3′UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1

Neval Akdeli, Kathrin Riemann, Jana Westphal, Jochen Hess, Winfried Siffert, Hagen S Bachmann

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis

Shuji Kitahara, Yasuhiro Suzuki, Masae Morishima, Asuka Yoshii, Sachiko Kikuta, Kazuhiko Shimizu, Shunichi Morikawa, Yasufumi Sato, Taichi Ezaki

01.12.2014 | Research | Ausgabe 1/2014 Open Access

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

Elin J Ekström, Caroline Bergenfelz, Verena von Bülow, Filiz Serifler, Eric Carlemalm, Göran Jönsson, Tommy Andersson, Karin Leandersson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma

Hala Girgis, Olena Masui, Nicole MA White, Andreas Scorilas, Fabio Rotondo, Annetta Seivwright, Manal Gabril, Emily R Filter, Andrew HA Girgis, Georg A Bjarnason, Michael AS Jewett, Andrew Evans, Sahar Al-Haddad, KW Michael Siu, George M Yousef

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Targeting of erbB3 receptor to overcome resistance in cancer treatment

Jian Ma, Hui Lyu, Jingcao Huang, Bolin Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication

Yoshinori Hoshino, Tetsu Hayashida, Akira Hirata, Hidena Takahashi, Naokazu Chiba, Mitsuyo Ohmura, Masatoshi Wakui, Hiromitsu Jinno, Hirotoshi Hasegawa, Shyamala Maheswaran, Makoto Suematsu, Yuko Kitagawa

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy

Yan Wang, Ziliang Wang, Zihao Qi, Sheng Yin, Na Zhang, Yang Liu, Mingming Liu, Jiao Meng, Rongyu Zang, Zhen Zhang, Gong Yang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor

Xi Wang, Chuyong Lin, Xiaohui Zhao, Aibin Liu, Jinrong Zhu, Xinghua Li, Libing Song

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model

Tale Barøy, Stine H Kresse, Magne Skårn, Marianne Stabell, Russell Castro, Silje Lauvrak, Antonio Llombart-Bosch, Ola Myklebost, Leonardo A Meza-Zepeda

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1

Nathaniel Weygant, Dongfeng Qu, William L Berry, Randal May, Parthasarathy Chandrakesan, Daniel B Owen, Sripathi M Sureban, Naushad Ali, Ralf Janknecht, Courtney W Houchen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small nucleolar RNA signatures of lung tumor-initiating cells

Kaiissar Mannoor, Jun Shen, Jipei Liao, Zhenqiu Liu, Feng Jiang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease

Victoria E Shaw, Brian Lane, Claire Jenkinson, Trevor Cox, William Greenhalf, Christopher M Halloran, Joseph Tang, Robert Sutton, John P Neoptolemos, Eithne Costello

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

Ingvild Haaland, Jill A Opsahl, Frode S Berven, Håkon Reikvam, Hanne K Fredly, Ragnhild Haugse, Bernd Thiede, Emmet McCormack, Sonia Lain, Øystein Bruserud, Bjørn Tore Gjertsen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

Kangsheng Tu, Wei Yang, Chao Li, Xin Zheng, Zhongtang Lu, Cheng Guo, Yingmin Yao, Qingguang Liu

01.12.2014 | Review | Ausgabe 1/2014 Open Access

P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy

Ding-Guo Zhang, Jun-Nian Zheng, Dong-Sheng Pei

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells

Benjamin Hirschi, Eike Gallmeier, Andreas Ziesch, Maximilian Marschall, Frank T Kolligs

01.12.2014 | Research | Ausgabe 1/2014 Open Access

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase

Mathieu Amand, Charlotte Erpicum, Khalid Bajou, Fabio Cerignoli, Silvia Blacher, Maud Martin, Franck Dequiedt, Pierre Drion, Pratibha Singh, Tinatin Zurashvili, Maud Vandereyken, Lucia Musumeci, Tomas Mustelin, Michel Moutschen, Christine Gilles, Agnes Noel, Souad Rahmouni

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells

Kelong Ma, Xiaorong Pan, Pingsheng Fan, Yinghua He, Jun Gu, Wei Wang, Tengyue Zhang, Zonghai Li, Xiaoying Luo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

GAS5 long non-coding RNA in malignant pleural mesothelioma

Arun Renganathan, Jelena Kresoja-Rakic, Nohemy Echeverry, Gabriela Ziltener, Bart Vrugt, Isabelle Opitz, Rolf A Stahel, Emanuela Felley-Bosco

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53

Ralf Wiedemuth, Barbara Klink, Katrin Töpfer, Evelin Schröck, Gabriele Schackert, Masaaki Tatsuka, Achim Temme

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway

Xin Xu, Jian Wu, Shiqi Li, Zhenghui Hu, Xianglai Xu, Yi Zhu, Zhen Liang, Xiao Wang, Yiwei Lin, Yeqing Mao, Hong Chen, Jindan Luo, Ben Liu, Xiangyi Zheng, Liping Xie

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A novel approach to identify driver genes involved in androgen-independent prostate cancer

Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows, Grant D Trobridge

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer

Jingshuang Yu, Furong Xie, Xin Bao, Wantao Chen, Qin Xu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV

Yantao Duan, Lei Hu, Bing Liu, Beiqin Yu, Jianfang Li, Min Yan, Yingyan Yu, Chen Li, Liping Su, Zhenggang Zhu, Ming Xiang, Bingya Liu, Qiumeng Yang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP

Weiying Zhang, Zhanping Lu, Guangyao Kong, Yuen Gao, Tao Wang, Qi Wang, Na Cai, Honghui Wang, Fabao Liu, Lihong Ye, Xiaodong Zhang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth

Na Liu, Qing-Mei He, Jie-Wei Chen, Ying-Qin Li, Ya-Fei Xu, Xian-Yue Ren, Ying Sun, Hai-Qiang Mai, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Jun Ma

01.12.2014 | Review | Ausgabe 1/2014 Open Access

MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress

Mildred Felder, Arvinder Kapur, Jesus Gonzalez-Bosquet, Sachi Horibata, Joseph Heintz, Ralph Albrecht, Lucas Fass, Justanjyot Kaur, Kevin Hu, Hadi Shojaei, Rebecca J Whelan, Manish S Patankar

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

Jing-Jing Zhang, Yi Zhu, Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang, Zheng Li, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du, Yi Miao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

Tongsen Zheng, Dalong Yin, Zhaoyang Lu, Jiabei Wang, Yuejin Li, Xi Chen, Yingjian Liang, Xuan Song, Shuyi Qi, Boshi Sun, Changming Xie, Xianzhi Meng, Shangha Pan, Jiaren Liu, Hongchi Jiang, Lianxin Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

Yosuke Togashi, Hiroki Sakamoto, Hidetoshi Hayashi, Masato Terashima, Marco A de Velasco, Yoshihiko Fujita, Yasuo Kodera, Kazuko Sakai, Shuta Tomida, Masayuki Kitano, Akihiko Ito, Masatoshi Kudo, Kazuto Nishio

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer

Elizabeth Salvo, Saray Garasa, Javier Dotor, Xabier Morales, Rafael Peláez, Peter Altevogt, Ana Rouzaut

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1

Leah Morenos, Zac Chatterton, Jane L Ng, Minhee S Halemba, Mandy Parkinson-Bates, Francoise Mechinaud, Ngaire Elwood, Richard Saffery, Nicholas C Wong

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

Yu Imamura, Paul Lochhead, Mai Yamauchi, Aya Kuchiba, Zhi Rong Qian, Xiaoyun Liao, Reiko Nishihara, Seungyoun Jung, Kana Wu, Katsuhiko Nosho, Yaoyu E Wang, Shouyong Peng, Adam J Bass, Kevin M Haigis, Jeffrey A Meyerhardt, Andrew T Chan, Charles S Fuchs, Shuji Ogino

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells

Heming Li, Ling Xu, Ce Li, Lei Zhao, Yanju Ma, Huachuan Zheng, Zhi Li, Ye Zhang, Ruoyu Wang, Yunpeng Liu, Xiujuan Qu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Evaluation of microRNA-10b prognostic significance in a prospective cohort of breast cancer patients

Paola Parrella, Raffaela Barbano, Barbara Pasculli, Andrea Fontana, Massimiliano Copetti, Vanna Maria Valori, Maria Luana Poeta, Giuseppe Perrone, Daniela Righi, Marina Castelvetere, Michelina Coco, Teresa Balsamo, Maria Morritti, Fabio Pellegrini, Andrea Onetti-Muda, Evaristo Maiello, Roberto Murgo, Vito Michele Fazio

01.12.2014 | Research | Ausgabe 1/2014 Open Access

USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity

Bangxing Hong, Haiyan Li, Yong Lu, Mingjun Zhang, Yuhuan Zheng, Jianfei Qian, Qing Yi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

Ying Sun, Yunshan Wang, Cong Fan, Peng Gao, Xiuwen Wang, Guangwei Wei, Junmin Wei

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Trastuzumab emtansine is active on HER-2 overexpressing NSCLC cell lines and overcomes gefitinib resistance

Daniele Cretella, Francesca Saccani, Federico Quaini, Caterina Frati, Costanza Lagrasta, Mara Bonelli, Cristina Caffarra, Andrea Cavazzoni, Claudia Fumarola, Maricla Galetti, Silvia La Monica, Luca Ampollini, Marcello Tiseo, Andrea Ardizzoni, Pier Giorgio Petronini, Roberta R Alfieri

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1

Kelly J Gauger, Lotfi M Bassa, Elizabeth M Henchey, Josephine Wyman, Jennifer Ser-Dolansky, Akihiko Shimono, Sallie S Schneider

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

Ping Li, Weixi Tian, Xiaofeng Ma

01.12.2014 | Research | Ausgabe 1/2014 Open Access

mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells

Sarah Smalley, Anthony J Chalmers, Simon J Morley

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth

SWei Sunny Hann, Qing Tang, Fang Zheng, Shunyu Zhao, Jianping Chen, ZhiYu Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

Lijing Zhang, Yujuan Dong, Nana Zhu, Ho Tsoi, Zengren Zhao, Chung Wah Wu, Kunning Wang, Shu Zheng, Simon SM Ng, Francis KL Chan, Joseph JY Sung, Jun Yu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells

Konrad Steinestel, Silke Brüderlein, Jochen K Lennerz, Julie Steinestel, Klaus Kraft, Christian Pröpper, Viktor Meineke, Peter Möller

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes

Nathalie Martin, Clara Salazar-Cardozo, Chantal Vercamer, Louise Ott, Guillemette Marot, Predrag Slijepcevic, Corinne Abbadie, Olivier Pluquet

01.12.2014 | Research | Ausgabe 1/2014 Open Access

DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells

Samia B Bachmann, Sandra C Frommel, Rosalba Camicia, Hans C Winkler, Raffaella Santoro, Paul O Hassa

01.12.2014 | Research | Ausgabe 1/2014 Open Access

RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy

Naoomi Tominaga, Keitaro Hagiwara, Nobuyoshi Kosaka, Kimi Honma, Hitoshi Nakagama, Takahiro Ochiya

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells

Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim, Byoung Heon Kang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A mechanically-induced colon cancer cell population shows increased metastatic potential

Xin Tang, Theresa B Kuhlenschmidt, Qian Li, Shahjahan Ali, Stephane Lezmi, Hong Chen, Melissa Pires-Alves, William W Laegreid, Taher A Saif, Mark S Kuhlenschmidt

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab

Jeonghee Cho, Adam J Bass, Michael S Lawrence, Kristian Cibulskis, Ahye Cho, Shi-Nai Lee, Mai Yamauchi, Nikhil Wagle, Panisa Pochanard, Nayoung Kim, Angela K J Park, Jonghwa Won, Hyung-Suk Hur, Heidi Greulich, Shuji Ogino, Carrie Sougnez, Douglas Voet, Josep Tabernero, Jose Jimenez, Jose Baselga, Stacey B Gabriel, Eric S Lander, Gad Getz, Michael J Eck, Woong-Yang Park, Matthew Meyerson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

Wei Huang, Min Ye, Lian-ru Zhang, Qun-dan Wu, Min Zhang, Jian-hua Xu, Wei Zheng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A

Eva Juengel, Snigdha Nowaz, Jasmina Makarevi, Iyad Natsheh, Isabella Werner, Karen Nelson, Michael Reiter, Igor Tsaur, Jens Mani, Sebastian Harder, Georg Bartsch, Axel Haferkamp, Roman A Blaheta

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival

Changhua Zhuo, Zhiyuan Li, Ye Xu, Yuwei Wang, Qingguo Li, Junjie Peng, Hongtu Zheng, Peng Wu, Bin Li, Sanjun Cai

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Bortezomib treatment causes long-term testicular dysfunction in young male mice

Mi Hou, Emma Eriksson, Konstantin Svechnikov, Kirsi Jahnukainen, Olle Söder, Andreas Meinhardt, Lars Sävendahl

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling

Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker, Rainer Schneider

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

Imanol Arozarena, Ibai Goicoechea, Oihane Erice, Jennnifer Ferguson, Geoffrey P Margison, Claudia Wellbrock

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

Christopher Bryant, Kirsten Scriven, Andrew J Massey

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2

Joshua C Doloff, Chong-Sheng Chen, David J Waxman

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer

Ming-zhe Ma, Chun-xiao Li, Yan Zhang, Ming-zhe Weng, Ming-di Zhang, Yi-yu Qin, Wei Gong, Zhi-wei Quan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer

Katerina D Fagan-Solis, Denise K Reaves, M Cristina Rangel, Michel R Popoff, Bradley G Stiles, Jodie M Fleming

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling

Cheng-Yi Chen, I-Hsiao Chung, Ming-Ming Tsai, Yi-Hsin Tseng, Hsiang-Cheng Chi, Chung-Ying Tsai, Yang-Hsiang Lin, You-Ching Wang, Chie-Pein Chen, Tzu-I Wu, Chau-Ting Yeh, Dar-In Tai, Kwang-Huei Lin

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Anterior gradient protein 2 promotes survival, migration and invasion of papillary thyroid carcinoma cells

Gennaro Di Maro, Paolo Salerno, Kristian Unger, Francesca Maria Orlandella, Mario Monaco, Gennaro Chiappetta, Gerry Thomas, Malgorzata Oczko-Wojciechowska, Mariorosario Masullo, Barbara Jarzab, Massimo Santoro, Giuliana Salvatore

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Aldolase positively regulates of the canonical Wnt signaling pathway

Michal Caspi, Gili Perry, Nir Skalka, Shilhav Meisel, Anastasia Firsow, Maayan Amit, Rina Rosin-Arbesfeld

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents

Magdalena Klanova, Lucie Lorkova, Ondrej Vit, Bokang Maswabi, Jan Molinsky, Jana Pospisilova, Petra Vockova, Cory Mavis, Lucie Lateckova, Vojtech Kulvait, Dana Vejmelkova, Radek Jaksa, Francisco Hernandez, Marek Trneny, Martin Vokurka, Jiri Petrak, Pavel Klener Jr

01.12.2014 | Research | Ausgabe 1/2014 Open Access

HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin

Song Yi Ko, Honami Naora

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25

Jing Li, Qiang Tan, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Guoliang Bao, Hanwei Kong, Chao Ge, Fanglin Zhang, Tao Yu, Jinjun Li, Xianghuo He, Ming Yao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

Jillian L Pope, Rizwan Ahmad, Ajaz A Bhat, Mary K Washington, Amar B Singh, Punita Dhawan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells

Simona Taverna, Valeria Amodeo, Laura Saieva, Antonio Russo, Marco Giallombardo, Giacomo De Leo, Riccardo Alessandro

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma

Kai-Chun Li, Kuo-Tai Hua, Yi-Shen Lin, Chia-Yi Su, Jenq-Yuh Ko, Michael Hsiao, Min-Liang Kuo, Ching-Ting Tan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma

Abdul K Siraj, Rong Bu, Sarita Prabhakaran, Prashant Bavi, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Khadija Alobaisi, Fouad Al-Dayel, Hadeel AlManea, Nasser Al-Sanea, Shahab Uddin, Khawla S Al-Kuraya

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family

Lei Wang, Fangchun Jin, An Qin, Yongqiang Hao, Yufeng Dong, Shengfang Ge, Kerong Dai

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling

Christof Bernemann, Carolin Hülsewig, Christian Ruckert, Sarah Schäfer, Lena Blümel, Georg Hempel, Martin Götte, Burkhard Greve, Peter J Barth, Ludwig Kiesel, Cornelia Liedtke

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias

Deepti Malik, Deepak Kaul, Nalini Chauhan, Ram Kumar Marwaha

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts

Jeffery S Russell, J Martin Brown

01.12.2014 | Research | Ausgabe 1/2014 Open Access

KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer

YingYing Qian, Shoujie Chai, Zuyu Liang, Yongfang Wang, You Zhou, Xia Xu, Chenchen Zhang, Min Zhang, Jingxing Si, Feiteng Huang, Zhangdan Huang, Wei Hong, Kai Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia

Stephan Emmrich, Alexandra Streltsov, Franziska Schmidt, Veera Raghavan Thangapandi, Dirk Reinhardt, Jan-Henning Klusmann

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas

Chong-kui Sun, Xiao-bo Luo, Ya-ping Gou, Ling Hu, Kun Wang, Chao Li, Zhen-ting Xiang, Ping Zhang, Xiang-li Kong, Chao-liang Zhang, Qin Yang, Jing Li, Li-ying Xiao, Yan Li, Qian-ming Chen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner

Sajitha Nair, Namrata Bora-Singhal, Deepak Perumal, Srikumar Chellappan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Effective inhibition of melanoma tumorigenesis and growth via a new complex vaccine based on NY-ESO-1-alum-polysaccharide-HH2

Meng Li, Huashan Shi, Yandong Mu, Zichao Luo, Hailong Zhang, Yang Wan, Dongmei Zhang, Lian Lu, Ke Men, Yaomei Tian, Xiaozhe Wu, Xiaoyan Liu, Ying Pan, Yingzi Fan, Chaoheng Yu, Bailing Zhou, Rong Xiang, Xiancheng Chen, Li Yang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex

Qiao Zhang, Zhe Yang, Zhuqing Jia, Cuiling Liu, Chen Guo, Huafei Lu, Ping Chen, Kangtao Ma, Weiping Wang, Chunyan Zhou

01.12.2014 | Research | Ausgabe 1/2014 Open Access

HMGN2, a new anti-tumor effector molecule of CD8+ T cells

Lin Su, Ankang Hu, Yang Luo, Wenjie Zhou, Ping Zhang, Yun Feng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis

Chartia Ching-Mei Cheung, Grace Tin-Yun Chung, Samantha Wei-Man Lun, Ka-Fai To, Kwong-Wai Choy, Kin-Mang Lau, Sharie Pui-Kei Siu, Xin-Yuan Guan, Roger Kai-Cheong Ngan, Timothy Tak-Chun Yip, Pierre Busson, Sai-Wah Tsao, Kwok-Wai Lo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma

Yoshinori Imura, Hirohiko Yasui, Hidetatsu Outani, Toru Wakamatsu, Kenichiro Hamada, Takaaki Nakai, Shutaro Yamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

Wantong Yao, Shunrong Ji, Yi Qin, Jingxuan Yang, Jin Xu, Bo Zhang, Wenyan Xu, Jiang Liu, Si Shi, Liang Liu, Chen Liu, Jiang Long, Quanxing Ni, Min Li, Xianjun Yu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma

Pei-jian Yue, Lei He, Shu-wei Qiu, Yi Li, Yi-ji Liao, Xiang-pen Li, Dan Xie, Ying Peng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice

Michael Rosemann, Iria Gonzalez-Vasconcellos, Tanja Domke, Virginija Kuosaite, Ralf Schneider, Markus Kremer, Jack Favor, Michaela Nathrath, Michael J Atkinson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

Kuo-Tai Hua, Ming-Yang Wang, Min-Wei Chen, Lin-Hung Wei, Chi-Kuan Chen, Ching-Huai Ko, Yung-Ming Jeng, Pi-Lin Sung, Yi-Hua Jan, Michael Hsiao, Min-Liang Kuo, Men-Luh Yen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells

Liliana P Cantini, Lourdes M Andino, Christopher C Attaway, Betsy Butler, Anca Dumitriu, Aaron Blackshaw, Andrew Jakymiw

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue

Jessica L Christenson, Susan E Kane

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma

Kevin Tak-Pan Ng, Aimin Xu, Qiao Cheng, Dong Yong Guo, Zophia Xue-Hui Lim, Chris Kin-Wai Sun, Jeffrey Hon-Sing Fung, Ronnie Tung-Ping Poon, Sheung Tat Fan, Chung Mau Lo, Kwan Man

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma

Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo, Antoni Ribas

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells

Jipeng Li, Yiping Wang, Yulan Song, Zhongming Fu, Wanjun Yu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Transducin β-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in Nasopharyngeal Carcinoma via activation of NF-κB pathway

Shu-Peng Chen, Qi Yang, Chan-Juan Wang, Long-Juan Zhang, Yi Fang, Fang-Yong Lei, Shu Wu, Li-Bing Song, Xiang Guo, Ling Guo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

Chirine El-Baba, Vijayalakshmi Mahadevan, Fabian B Fahlbusch, Suma Mohan S, Tilman T Rau, Hala Gali-Muhtasib, Regine Schneider-Stock

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The blood-borne miRNA signature of lung cancer patients is independent of histology but influenced by metastases

Petra Leidinger, Christina Backes, Michael Blatt, Andreas Keller, Hanno Huwer, Philipp Lepper, Robert Bals, Eckart Meese

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy

Wei Shao, Jinping Gu, Caihua Huang, Dan Liu, Huiying Huang, Zicheng Huang, Zhen Lin, Wensheng Yang, Kun Liu, Donghai Lin, Tianhai Ji

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs

Joel D Pearson, Jingxi Zhang, Zuoqiao Wu, Kayla D Thew, Katelynn J Rowe, Julinor TC Bacani, Robert J Ingham

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

Zhenlong Yu, Wei Guo, Xiaochi Ma, Baojing Zhang, Peipei Dong, Lin Huang, Xiuli Wang, Chao Wang, Xiaokui Huo, Wendan Yu, Canhui Yi, Yao Xiao, Wenjing Yang, Yu Qin, Yuhui Yuan, Songshu Meng, Quentin Liu, Wuguo Deng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation

Nicole Salazar, Daniel Muñoz, Georgios Kallifatidis, Rajendra K Singh, Mercè Jordà, Bal L Lokeshwar

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions

Hassiba Chaib-Mezrag, Delphine Lemaçon, Hélène Fontaine, Marcia Bellon, Xue Tao Bai, Marjorie Drac, Arnaud Coquelle, Christophe Nicot

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7

Boxing Su, Wei Zhao, Bentao Shi, Zhongyuan Zhang, Xi Yu, Feng Xie, Zhongqiang Guo, Xiaoyu Zhang, Jin Liu, Qi Shen, Jinghua Wang, Xuesong Li, Zhiqian Zhang, Liqun Zhou

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer

Danfang Zhang, Baocun Sun, Xiulan Zhao, Yuemei Ma, Ru Ji, Qiang Gu, Xueyi Dong, Jing Li, Fang Liu, Xiaohua Jia, Xue Leng, Chong Zhang, Ran Sun, Jiadong Chi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases

Seung Ho Choi, Heekyoung Yang, Seung Ho Lee, Joo-Hyun Ki, Do-Hyun Nam, Hae Yong Yoo

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

MicroRNA-21 inhibits p57Kip2 expression in prostate cancer

Sweta Mishra, Chun-Lin Lin, Tim H-M Huang, Hakim Bouamar, Lu-Zhe Sun

01.12.2014 | Research | Ausgabe 1/2014 Open Access

microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer

Jack W Rostas III, Hawley C Pruitt, Brandon J Metge, Aparna Mitra, Sarah K Bailey, Sejong Bae, Karan P Singh, Daniel J Devine, Donna L Dyess, William O Richards, J Allan Tucker, Lalita A Shevde, Rajeev S Samant

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Small nucleolar RNA 113–1 suppresses tumorigenesis in hepatocellular carcinoma

Gang Xu, Fang Yang, Cui-Ling Ding, Lan-Juan Zhao, Hao Ren, Ping Zhao, Wen Wang, Zhong-Tian Qi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Induction of integrin α2 in a highly bone metastatic human prostate cancer cell line: roles of RANKL and AR under three-dimensional suspension culture

Shabnam Ziaee, Leland WK Chung

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway

Julia Roediger, Wiebke Hessenkemper, Sophie Bartsch, Marina Manvelyan, Soeren S Huettner, Thomas Liehr, Mohsen Esmaeili, Susan Foller, Iver Petersen, Marc-Oliver Grimm, Aria Baniahmad

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma

Naoshad Mohammad, Parmanand Malvi, Avtar Singh Meena, Shivendra Vikram Singh, Balkrishna Chaube, Garikapati Vannuruswamy, Mahesh J Kulkarni, Manoj Kumar Bhat

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosis

Sahana Holla, Devram Sampat Ghorpade, Vikas Singh, Kushagra Bansal, Kithiganahalli Narayanaswamy Balaji

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation

Carl Sandén, Linnea Järvstråt, Andreas Lennartsson, Per Ludvik Brattås, Björn Nilsson, Urban Gullberg

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system

Nanae Harashima, Takafumi Minami, Hirotsugu Uemura, Mamoru Harada

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription

Jaime G Fernández, Diego A Rodríguez, Manuel Valenzuela, Claudia Calderon, Ulises Urzúa, David Munroe, Carlos Rosas, David Lemus, Natalia Díaz, Mathew C Wright, Lisette Leyton, Julio C Tapia, Andrew FG Quest

01.12.2014 | Research | Ausgabe 1/2014 Open Access

ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells

Felicia Leccia, Luigi Del Vecchio, Elisabetta Mariotti, Rosa Di Noto, Anne-Pierre Morel, Alain Puisieux, Francesco Salvatore, Stéphane Ansieau

01.12.2014 | Research | Ausgabe 1/2014 Open Access

OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway

Ya-Ching Lu, Joseph T Chang, Chun-Ta Liao, Chung-Jan Kang, Shiang-Fu Huang, I-How Chen, Chi-Che Huang, Yu-Chen Huang, Wen-Ho Chen, Chi-Ying Tsai, Hung-Ming Wang, Tzu-Chen Yen, Guo-Rung You, Chang-Hsu Chiang, Ann-Joy Cheng

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects

Huan Shi, Meili Sun, Lin Liu, Zhehai Wang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer

Xin Yan, Xi Chen, Hongwei Liang, Ting Deng, Weixu Chen, Suyang Zhang, Minghui Liu, Xiujuan Gao, Yanqing Liu, Chihao Zhao, Xueliang Wang, Nan Wang, Jialu Li, Rui Liu, Ke Zen, Chen-Yu Zhang, Baorui Liu, Yi Ba

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer

Ruochuan Sun, Jifeng Wu, Yuanyuan Chen, Mingdian Lu, Shangxin Zhang, Daru Lu, Yongxiang Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

Xinlai Cheng, Palvo Holenya, Suzan Can, Hamed Alborzinia, Riccardo Rubbiani, Ingo Ott, Stefan Wölfl

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Hepatitis B virus X protein specially regulates the sialyl lewis a synthesis among glycosylation events for metastasis

Tae-Wook Chung, Seok-Jo Kim, Hee-Jung Choi, Kwon-Ho Song, Un-Ho Jin, Dae-Yeul Yu, Je-Kyung Seong, Jong-Guk Kim, Keuk-Jun Kim, Jeong-Heon Ko, Ki-Tae Ha, Young-Choon Lee, Cheorl-Ho Kim

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer

Lorena Alonso-Alconada, Laura Muinelo-Romay, Kadri Madissoo, Antonio Diaz-Lopez, Camilla Krakstad, Jone Trovik, Elisabeth Wik, Dharani Hapangama, Lieve Coenegrachts, Amparo Cano, Antonio Gil-Moreno, Luis Chiva, Juan Cueva, Maria Vieito, Eugenia Ortega, Javier Mariscal, Eva Colas, Josep Castellvi, Maite Cusido, Xavier Dolcet, Hans W Nijman, Tjalling Bosse, John A Green, Andrea Romano, Jaume Reventos, Rafael Lopez-Lopez, Helga B Salvesen, Frederic Amant, Xavier Matias-Guiu, Gema Moreno-Bueno, Miguel Abal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma

Stefan Salcher, Judith Hagenbuchner, Kathrin Geiger, Maximilian A Seiter, Johannes Rainer, Reinhard Kofler, Martin Hermann, Ursula Kiechl-Kohlendorfer, Michael J Ausserlechner, Petra Obexer

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Agonist activation of estrogen receptor beta (ERβ) sensitizes malignant pleural mesothelioma cells to cisplatin cytotoxicity

Giulia Pinton, Arcangela G Manente, Antonio Daga, Michele Cilli, Maurizio Rinaldi, Stefan Nilsson, Laura Moro

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Claudin-low breast cancers: clinical, pathological, molecular and prognostic characterization

Renaud Sabatier, Pascal Finetti, Arnaud Guille, José Adelaide, Max Chaffanet, Patrice Viens, Daniel Birnbaum, François Bertucci

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

Donatella Del Bufalo, Marianna Desideri, Teresa De Luca, Marta Di Martile, Chiara Gabellini, Valentina Monica, Simone Busso, Adriana Eramo, Ruggero De Maria, Michele Milella, Daniela Trisciuoglio

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation

Ming-Xuan Feng, Ming-Ze Ma, Ying Fu, Jun Li, Tao Wang, Feng Xue, Jian-Jun Zhang, Wen-Xin Qin, Jian-Ren Gu, Zhi-Gang Zhang, Qiang Xia

01.12.2014 | Research | Ausgabe 1/2014 Open Access

EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer

Xiaofeng Lin, Shuangshuang Zhong, Xiaofeng Ye, Yueling Liao, Feng Yao, Xiaohua Yang, Beibei Sun, Jie Zhang, Qi Li, Yong Gao, Yifan Wang, Jingyi Liu, Baohui Han, Y Eugene Chin, Binhua P Zhou, Jiong Deng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway

Hui Deng, Lei Lv, Yang Li, Cheng Zhang, Fang Meng, Youguang Pu, Jun Xiao, Liting Qian, Weidong Zhao, Qi Liu, Daming Zhang, Yingwei Wang, Hongyu Zhang, Yinghua He, Jingde Zhu

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

Birgit Schittek, Tobias Sinnberg

01.12.2014 | Research | Ausgabe 1/2014 Open Access

microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity

Elizabeth C Martin, Lyndsay V Rhodes, Steven Elliott, Adrienne E Krebs, Kenneth P Nephew, Erik K Flemington, Bridgette M Collins-Burow, Matthew E Burow

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway

Chun-Han Hou, Feng-Ling Lin, Sheng-Mon Hou, Ju-Fang Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations

Francesca Mateo, Óscar Meca-Cortés, Toni Celià-Terrassa, Yolanda Fernández, Ibane Abasolo, Lourdes Sánchez-Cid, Raquel Bermudo, Amaia Sagasta, Leonardo Rodríguez-Carunchio, Mònica Pons, Verónica Cánovas, Mercedes Marín-Aguilera, Lourdes Mengual, Antonio Alcaraz, Simó Schwartz Jr., Begoña Mellado, Kristina Y Aguilera, Rolf Brekken, Pedro L Fernández, Rosanna Paciucci, Timothy M Thomson

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

Chiara Arrigoni, Paola De Luca, Mara Gilardi, Sara Previdi, Massimo Broggini, Matteo Moretti

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Targeting DNA-PKcs and telomerase in brain tumour cells

Resham Lal Gurung, Hui Kheng Lim, Shriram Venkatesan, Phoebe Su Wen Lee, M Prakash Hande

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer

Wenshuai Pang, Xin Tian, Fan Bai, Ruiyu Han, Juan Wang, Haitao Shen, Xianghong Zhang, Yueping Liu, Xia Yan, Feng Jiang, Lingxiao Xing

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

Ayesha N Shajahan-Haq, Katherine L Cook, Jessica L Schwartz-Roberts, Ahreej E Eltayeb, Diane M Demas, Anni M Warri, Caroline O B Facey, Leena A Hilakivi-Clarke, Robert Clarke

01.12.2014 | Research | Ausgabe 1/2014 Open Access

OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets

Stephen F Madden, Colin Clarke, Britta Stordal, Mark S Carey, Russell Broaddus, William M Gallagher, John Crown, Gordon B Mills, Bryan T Hennessy

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells

Huiyu Zhuang, Mingzi Tan, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao, Liancheng Zhu, Bei Lin

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer

Min-Xia Liu, Ke-Cheng Zhou, Yi Cao

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment

Carlo Cenciarelli, Hany ES Marei, Manuela Zonfrillo, Pasquale Pierimarchi, Emanuela Paldino, Patrizia Casalbore, Armando Felsani, Angelo Luigi Vescovi, Giulio Maira, Annunziato Mangiola

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model

Tobias Brodbeck, Nina Nehmann, Anja Bethge, Gero Wedemann, Udo Schumacher

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis

Aiqin Sun, Guanzhen Yu, Xiaoyan Dou, Xiaowei Yan, Wannian Yang, Qiong Lin

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1

Smrithi Rajendiran, Anil V Parwani, Richard J Hare, Subhamoy Dasgupta, Rhonda K Roby, Jamboor K Vishwanatha

01.12.2014 | Research | Ausgabe 1/2014 Open Access

CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR

Yunshan Wang, Pengju Zhang, Ziming Liu, Qin Wang, Mingxin Wen, Yuli Wang, Hongtu Yuan, Jian-Hua Mao, Guangwei Wei

01.12.2014 | Research | Ausgabe 1/2014 Open Access

MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma

Xiao Hong Peng, Hao Ran Huang, Juan Lu, Xiong Liu, Fei Peng Zhao, Bao Zhang, Shao Xiong Lin, Lu Wang, Huai Hong Chen, Xia Xu, Fan Wang, Xiang Ping Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface

Mohcine Benbijja, Amine Mellouk, Pierre Bobé

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway

Yanqiong Zhang, Xiaodong Guo, Lu Xiong, Lingxiang Yu, Zhiwei Li, Qiuyan Guo, Zhiyan Li, Boan Li, Na Lin

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

I-Chieh Chen, Wei-Fan Chiang, Hsin-Hsiu Huang, Pei-Fen Chen, Ying-Ying Shen, Hung-Che Chiang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

Ramesh Singh, Radhika Pochampally, Kounosuke Watabe, Zhaohui Lu, Yin-Yuan Mo

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PhiC31/PiggyBac modified stromal stem cells: effect of interferon γ and/or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on murine melanoma

Vahid Bahrambeigi, Nafiseh Ahmadi, Stefan Moisyadi, Johann Urschitz, Rasoul Salehi, Shaghayegh Haghjooy Javanmard

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma

Ali Khammanivong, Raj Gopalakrishnan, Erin B Dickerson

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy

Mari Iida, Toni M Brand, Megan M Starr, Evan J Huppert, Neha Luthar, Harsh Bahrar, John P Coan, Hannah E Pearson, Ravi Salgia, Deric L Wheeler

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Dynamics of double strand breaks and chromosomal translocations

Olga V Iarovaia, Mikhail Rubtsov, Elena Ioudinkova, Tatiana Tsfasman, Sergey V Razin, Yegor S Vassetzky

01.12.2014 | Research | Ausgabe 1/2014 Open Access

P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer

Venkatasubbaiah A Venkatesha, Asavari Joshi, Magesh Venkataraman, Vinay Sonawane, Dimple Bhatia, Prashant Tannu, Julie Bose, Sarika Choudhari, Ankita Srivastava, Prashant Kumar Pandey, Vaibhavi J Lad, Ramachandra Sangana, Tausif Ahmed, Anagha Damre, Vijaykumar Deore, Bichismita Sahu, Sanjay Kumar, Somesh Sharma, Veena R Agarwal

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Downregulation of miR-610 promotes proliferation and tumorigenicity and activates Wnt/β-catenin signaling in human hepatocellular carcinoma

Xian-Cheng Zeng, Fo-Qiu Liu, Rong Yan, Hui-Min Yi, Tong Zhang, Guo-Ying Wang, Yang Li, Nan Jiang

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention

Brendan Ffrench, Claudia Gasch, John J O’Leary, Michael F Gallagher

01.12.2014 | Short communication | Ausgabe 1/2014 Open Access

Ranolazine inhibits NaV1.5-mediated breast cancer cell invasiveness and lung colonization

Virginie Driffort, Ludovic Gillet, Emeline Bon, Séverine Marionneau-Lambot, Thibauld Oullier, Virginie Joulin, Christine Collin, Jean-Christophe Pagès, Marie-Lise Jourdan, Stéphan Chevalier, Philippe Bougnoux, Jean-Yves Le Guennec, Pierre Besson, Sébastien Roger

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells

Regina Ebert, Jutta Meissner-Weigl, Sabine Zeck, Jorma Määttä, Seppo Auriola, Sofia Coimbra de Sousa, Birgit Mentrup, Stephanie Graser, Tilman D Rachner, Lorenz C Hofbauer, Franz Jakob

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer

Ting Li, Hanqing Guo, Ying Song, Xiaodi Zhao, Yongquan Shi, Yuanyuan Lu, Sijun Hu, Yongzhan Nie, Daiming Fan, Kaichun Wu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma

Zhong Guan, Jialiang Zhang, Jing Wang, Hefei Wang, Feimeng Zheng, Jieren Peng, Yaodong Xu, Min Yan, Bing Liu, Bai Cui, Ying Huang, Quentin Liu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer

Yi Zhou, Jiangxue Wu, Xiang Fu, Wuying Du, Ling Zhou, Xiangqi Meng, Hongyan Yu, Jiaxin Lin, Wen Ye, Jiani Liu, Hui Peng, Ran-yi Liu, Changchuan Pan, Wenlin Huang

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Function and mechanism of tumor suppressor gene LRRC4/NGL-2

Peiyao Li, Gang Xu, Guiyuan Li, Minghua Wu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia

Han Zhang, Lin Zhu, Huacheng He, Shanshan Zhu, Wei Zhang, Xiao Liu, Xiaoxi Zhao, Chao Gao, Mei Mei, Shilai Bao, Huyong Zheng

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Heng Li, Gan Yu, Runlin Shi, Bin Lang, Xianguo Chen, Ding Xia, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye, Wei Xiao, Hua Xu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Identification and validation of PROM1 and CRTC2 mutations in lung cancer patients

Yanqi He, Yalun Li, Zhixin Qiu, Bin Zhou, Shaoqin Shi, Kui Zhang, Yangkun Luo, Qian Huang, Weimin Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival

Juan M Funes, Stephen Henderson, Rachel Kaufman, James M Flanagan, Mathew Robson, Barbara Pedley, Salvador Moncada, Chris Boshoff

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Shikha Gaur, Linling Chen, Vincent Ann, Wei-Chen Lin, Yafan Wang, Vincent HS Chang, Nan Yong Hsu, Her-Shuyong Shia, Yun Yen

01.12.2014 | Research | Ausgabe 1/2014 Open Access

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells

Eun-Ah Cho, Eui-Jun Kim, Sahng-June Kwak, Yong-Sung Juhnn

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma

Zhou Luan, Ying He, Mohamed Alattar, Zhishui Chen, Fan He

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

April L Risinger, Stephen M Riffle, Manu Lopus, Mary A Jordan, Leslie Wilson, Susan L Mooberry

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

Min Yang, Jingwei Liu, Jianghua Shao, Yanwen Qin, Qunsheng Ji, Xiaolin Zhang, Jie Du

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity

Li Tang, Rui Duan, Yan-jun Zhong, Raymond A Firestone, Ya-ping Hong, Ji-guo Li, Yan-chao Xin, Han-lin Wu, Yan Li

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer

Rebeca Sanz-Pamplona, Antoni Berenguer, David Cordero, David G Molleví, Marta Crous-Bou, Xavier Sole, Laia Paré-Brunet, Elisabet Guino, Ramón Salazar, Cristina Santos, Javier de Oca, Xavier Sanjuan, Francisco Rodriguez-Moranta, Victor Moreno

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer

Cuilan Li, Vincent WS Liu, Pui Man Chiu, Kwok-Ming Yao, Hextan YS Ngan, David W Chan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer

Gunjal Garg, Suwanna Vangveravong, Chenbo Zeng, Lynne Collins, Mary Hornick, Yassar Hashim, David Piwnica-Worms, Matthew A Powell, David G Mutch, Robert H Mach, William G Hawkins, Dirk Spitzer

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer

Donglin Liu, Thomas M Cardillo, Yang Wang, Edmund A Rossi, David M Goldenberg, Chien-Hsing Chang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways

Reidun Aesoy, Katarina Gradin, Kathrine S Aasrud, Erling A Hoivik, Jorge L Ruas, Lorenz Poellinger, Marit Bakke

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Tag SNPs in complement receptor-1 contribute to the susceptibility to non-small cell lung cancer

Xinfeng Yu, Juan Rao, Jia Lin, Zhi Zhang, Lei Cao, Xuemei Zhang

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Gold (I) N-heterocyclic carbene complex inhibits mouse melanoma growth by p53 upregulation

Abhishek Nandy, Sumit Kumar Dey, Sujata Das, Rudra Narayan Munda, Joydev Dinda, Krishna Das Saha

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor

Huan Zhou, Minying Xu, Ya Gao, Zhigang Deng, Hanwei Cao, Wenqing Zhang, Qiao Wang, Bing Zhang, Gang Song, Yanyan Zhan, Tianhui Hu

01.12.2014 | Research | Ausgabe 1/2014 Open Access

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

Claire Corcoran, Sweta Rani, Susan Breslin, Martina Gogarty, Irene M Ghobrial, John Crown, Lorraine O’Driscoll

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PSMD9 expression predicts radiotherapy response in breast cancer

Fiona E Langlands, David Dodwell, Andrew M Hanby, Kieran Horgan, Rebecca A Millican-Slater, Valerie Speirs, Eldo T Verghese, Laura Smith, Thomas A Hughes

01.12.2014 | Research | Ausgabe 1/2014 Open Access

microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway

Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, Mohamed Kamel Hassan, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka, Noriaki Sakuragi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

Zuzana Pernicová, Eva Slabáková, Radek Fedr, Šárka Šimečková, Josef Jaroš, Tereza Suchánková, Jan Bouchal, Gvantsa Kharaishvili, Milan Král, Alois Kozubík, Karel Souček

01.12.2014 | Research | Ausgabe 1/2014 Open Access

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy

Martina S J McDermott, Brigid C Browne, Neil T Conlon, Neil A O’Brien, Dennis J Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown, Norma O’Donovan

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Copy-neutral loss of heterozygosity and chromosome gains and losses are frequent in gastrointestinal stromal tumors

Nelson Lourenço, Zofia Hélias-Rodzewicz, Jean-Baptiste Bachet, Sabrina Brahimi-Adouane, Fabrice Jardin, Jeanne Tran van Nhieu, Frédérique Peschaud, Emmanuel Martin, Alain Beauchet, Frédéric Chibon, Jean-François Emile

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum to: microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway

Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Masaya Miyazaki, Makiko Kitagawa, Mohamed Kamel Hassan, Peixin Dong, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka, Noriaki Sakuragi

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum to: Reduced expression of AMPK-ß1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer

Cuilan Li, Vincent WS Liu, Pui Man Chiu, Kwok-Ming Yao, Hextan YS Ngan, David W Chan

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum To: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy

Heng Li, Gan Yu, Runlin Shi, Bin Lang, Xianguo Chen, Ding Xia, Haibing Xiao, Xiaolin Guo, Wei Guan, Zhangqun Ye, Wei Xiao, Hua Xu

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum to: Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer

Louisa CE Windus, Tristan T Glover, Vicky M Avery

01.12.2014 | Erratum | Ausgabe 1/2014 Open Access

Erratum to: Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma

Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi’an Zhang, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, WeiYi Fang, Songtao Qi

01.12.2014 | Research | Ausgabe 1/2014 Open Access

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

Banzhou Pan, Dongqin Chen, Jiayuan Huang, Rui Wang, Bing Feng, Haizhu Song, Longbang Chen

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