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Zeitschrift

Molecular Cancer

Molecular Cancer 1/2015

Ausgabe 1/2015

Inhaltsverzeichnis ( 214 Artikel )

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia

John Adams Fischer, Stefano Rossetti, Arani Datta, Kevin Hasegawa Eng, Alessandro Beghini, Nicoletta Sacchi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu, Amilcar Flores-Morales

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling

Evan M Cherry, Dong W Lee, Ji-Ung Jung, Raquel Sitcheran

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

Fei Wang, Jin-Lian Yang, Ke-ke Yu, Mei Xu, You-zhi Xu, Li Chen, Yan-min Lu, Hao-shu Fang, Xin-yi Wang, Zhong-qian Hu, Fei-fei Li, Lixin Kan, Jia Luo, Si-Ying Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer

Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W Nasser, Ramesh K Ganju

01.12.2015 | Research | Ausgabe 1/2015 Open Access

SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway

Yi-Jun Shu, Hao Weng, Yuan-Yuan Ye, Yun-Ping Hu, Run-Fa Bao, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Xiang-Song Wu, Mao-Lan Li, Lin Jiang, Wei Lu, Bao-San Han, Zhi-Gang Jie, Ying-Bin Liu

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis

Michaela Nelson, Ming Yang, Adam A Dowle, Jerry R Thomas, William J Brackenbury

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death

Elin Hallan Naderi, Seham Skah, Hege Ugland, Ola Myklebost, Dagny Lise Sandnes, Maria Lyngaas Torgersen, Dag Josefsen, Ellen Ruud, Soheil Naderi, Heidi Kiil Blomhoff

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells

Hooi Ching Lim, Hinke AB Multhaupt, John R Couchman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals

Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li, Chawnshang Chang

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

Jenny Zinke, Fabian T Schneider, Patrick N Harter, Sonja Thom, Nicole Ziegler, Rune Toftgård, Karl H Plate, Stefan Liebner

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Oncogenic KRAS promotes malignant brain tumors in zebrafish

Bensheng Ju, Wenbiao Chen, Brent A Orr, Jan M Spitsbergen, Sujuan Jia, Christopher J Eden, Hannah E Henson, Michael R Taylor

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor

Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, Evangelia Papadimitriou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

Rajakishore Mishra, Siddavaram Nagini, Ajay Rana

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A molecular signature for the prediction of recurrence in colorectal cancer

Lisha Wang, Xiaohan Shen, Zhimin Wang, Xiuying Xiao, Ping Wei, Qifeng Wang, Fei Ren, Yiqin Wang, Zebing Liu, Weiqi Sheng, Wei Huang, Xiaoyan Zhou, Xiang Du

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity

Seoung-Ae Lee, Hong Kim, You-Sub Won, Seung-Hyeok Seok, YiRang Na, Han-Bo Shin, Kyung-Soo Inn, Bum-Joon Kim

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of rare germline copy number variations over-represented in five human cancer types

Richard W Park, Tae-Min Kim, Simon Kasif, Peter J Park

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients

Qing Ouyang, Xueyang Gong, Hualiang Xiao, Ji Zhou, Minhui Xu, Yun Dai, Lunshan Xu, Hua Feng, Hongjuan Cui, Liang Yi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah JL Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G Graeber, Antoni Ribas

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

Shan Shao, Xiaoai Zhao, Xiaojin Zhang, Minna Luo, Xiaoxiao Zuo, Shangke Huang, Ying Wang, Shanzhi Gu, Xinhan Zhao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

ID helix-loop-helix proteins as determinants of cell survival in B-cell chronic lymphocytic leukemia cells in vitro

Sarah Weiler, Jolaolu A Ademokun, John D Norton

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Prognostic relevance of acquired uniparental disomy in serous ovarian cancer

Musaffe Tuna, Zhenlin Ju, Marcel Smid, Christopher I Amos, Gordon B Mills

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

Wei Li, Zhiwu Jiang, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng, Jianyu Weng, Xin Du, Pentao Liu, Yangqiu Li, Hudan Liu, Yao Yao, Peng Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

RhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression

Xi Chen, Shuo Chen, Yin-Ling Xiu, Kai-Xuan Sun, Zhi-Hong Zong, Yang Zhao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism

Erica Maria Pimenta, Betsy J Barnes

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage

Anne Olazabal-Herrero, Iraia García-Santisteban, Jose Antonio Rodríguez

01.12.2015 | Review | Ausgabe 1/2015 Open Access

MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer

Anna Maria Rusek, Mohammed Abba, Andrzej Eljaszewicz, Marcin Moniuszko, Jacek Niklinski, Heike Allgayer

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis

Elena Tutunea-Fatan, Mousumi Majumder, Xiping Xin, Peeyush K Lala

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

Yao-Yin Chang, Wen-Hung Kuo, Jui-Hui Hung, Chien-Yueh Lee, Yung-Hua Lee, Ya-Chu Chang, Wen-Chun Lin, Cheng-Ying Shen, Chiun-Sheng Huang, Fon-Jou Hsieh, Liang-Chuan Lai, Mong-Hsun Tsai, King-Jen Chang, Eric Y Chuang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

RETRACTED ARTICLE: miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer

Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li, Guoqiang Zhao

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients

Katharina Ilm, Wolfgang Kemmner, Marc Osterland, Susen Burock, Gudrun Koch, Pia Herrmann, Peter M Schlag, Ulrike Stein

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

Ursula Kern, Vladimir Wischnewski, Martin L Biniossek, Oliver Schilling, Thomas Reinheckel

01.12.2015 | Short Communication | Ausgabe 1/2015 Open Access

Drug sensitivity in cancer cell lines is not tissue-specific

Samira Jaeger, Miquel Duran-Frigola, Patrick Aloy

01.12.2015 | Research | Ausgabe 1/2015 Open Access

OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy

Ichiyo Shibahara, Ryuta Saito, Rong Zhang, Masashi Chonan, Takuhiro Shoji, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Masahiko Kanehira, Toshiaki Kikuchi, Takanori So, Takashi Watanabe, Hiroaki Takahashi, Erina Iwabuchi, Yuetsu Tanaka, Yukiko Shibahara, Hironobu Sasano, Naoto Ishii, Teiji Tominaga

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death

Sumana Bhattacharjya, Kumar Singha Roy, Abira Ganguly, Shreya Sarkar, Chinmay K Panda, Dibyendu Bhattacharyya, Nitai P Bhattacharyya, Susanta Roychoudhury

01.12.2015 | Review | Ausgabe 1/2015 Open Access

The role of the insulin-like growth factor-1 system in breast cancer

Panagiotis F Christopoulos, Pavlos Msaouel, Michael Koutsilieris

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma

Dag Andre Nymoen, Arild Holth, Thea E Hetland Falkenthal, Claes G Tropé, Ben Davidson

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer

Martin P Barr, Steven G Gray, Kathy Gately, Emily Hams, Padraic G Fallon, Anthony Mitchell Davies, Derek J Richard, Graham P Pidgeon, Kenneth J O’Byrne

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo

Abhijit Parolia, Francesco Crea, Hui Xue, Yuwei Wang, Fan Mo, Varune Rohan Ramnarine, Hui Hsuan Liu, Dong Lin, Nur Ridzwan Nur Saidy, Pier-Luc Clermont, Hongwei Cheng, Colin Collins, Yuzhuo Wang, Cheryl D Helgason

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2

Dan Li, Hong Mei, Jiarui Pu, Xuan Xiang, Xiang Zhao, Hongxia Qu, Kai Huang, Liduan Zheng, Qiangsong Tong

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Apoptosis, autophagy, necroptosis, and cancer metastasis

Zhenyi Su, Zuozhang Yang, Yongqing Xu, Yongbin Chen, Qiang Yu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver

Alisha M Mendonsa, Michael N VanSaun, Alessandro Ustione, David W Piston, Barbara M Fingleton, David Lee Gorden

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Single live cell TGF-β signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-β-Smad3 activity

Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression

Yongguo Shi, Juan Li, Yangchen Liu, Jie Ding, Yingrui Fan, Yun Tian, Li Wang, Yifan Lian, Keming Wang, Yongqian Shu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma

Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Junhong Zhao, Qiaoyi Liang, Li Zhang, Yi Pan, Weiqin Yang, Jesse CS Pang, Alfred SL Cheng, Jun Yu, Ka Fai To

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK+ T-cell lymphoma

Deeksha Vishwamitra, Choladda V Curry, Serhan Alkan, Yao-Hua Song, Gary E Gallick, Ahmed O Kaseb, Ping Shi, Hesham M Amin

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines

Simone Gusenbauer, Emanuele Zanucco, Pjotr Knyazev, Axel Ullrich

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway

Pingyu Zhang, Xianbin Yang, Xiaoyan Ma, Davis R Ingram, Alexander J Lazar, Keila E Torres, Raphael E Pollock

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

Yi Zhang, Hai-xuan Chen, Shu-yan Zhou, Shao-xiang Wang, Kai Zheng, Dan-dan Xu, Yu-ting Liu, Xiao-yan Wang, Xiao Wang, Hai-zhao Yan, Li Zhang, Qiu-ying Liu, Wan-qun Chen, Yi-fei Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization

Carina Fischer, Katharina Leithner, Christoph Wohlkoenig, Franz Quehenberger, Alexandra Bertsch, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

Ondřej Kodet, Lukáš Lacina, Eliška Krejčí, Barbora Dvořánková, Miloš Grim, Jiří Štork, Daniela Kodetová, Čestmír Vlček, Jana Šáchová, Michal Kolář, Hynek Strnad, Karel Smetana

01.12.2015 | Research | Ausgabe 1/2015 Open Access

microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma

Zheng Zhang, Yang Zhang, Xiu-Xuan Sun, Xi Ma, Zhi-Nan Chen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells

Rainelli B Koumangoye, Thomas Andl, Kenneth J Taubenslag, Steven T Zilberman, Chase J Taylor, Holli A Loomans, Claudia D Andl

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6

Bairong Xia, Shanshan Yang, Tianbo Liu, Ge Lou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3

Hongwei Liang, Xin Yan, Yi Pan, Yongsheng Wang, Nan Wang, Limin Li, Yuan Liu, Xi Chen, Chen-Yu Zhang, Hongwei Gu, Ke Zen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Huanxin Liu, Jie Huang, Juan Peng, Xiaoxia Wu, Yan Zhang, Weiliang Zhu, Linlang Guo

01.12.2015 | Research | Ausgabe 1/2015 Open Access

In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAF V600E in melanoma

Xingyi Guo, Yaomin Xu, Zhongming Zhao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon

Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Charlotte Gröschel, Samawansha Tennakoon, Anastasia Meshcheryakova, Wenhan Chang, Edward M Brown, Diana Mechtcheriakova, Enikö Kállay

01.12.2015 | Research | Ausgabe 1/2015 Open Access

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas

Koen MO Galenkamp, Paulina Carriba, Jorge Urresti, Laura Planells-Ferrer, Elena Coccia, Joaquín Lopez-Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, Miguel F Segura, Joan X Comella

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation

Xiang Zhou, Ruohua Chen, Zhenhai Yu, Rui Li, Jiajin Li, Xiaoping Zhao, Shaoli Song, Jianjun Liu, Gang Huang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesis

Bing Han, Haolei Cai, Ying Chen, Bing Hu, Hongyu Luo, Yulian Wu, Jiangping Wu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival

Tao Liu, Hailong Zhang, Jing Xiong, Sha Yi, Lubing Gu, Muxiang Zhou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway

Meilin Shi, Menghan Cao, Jun Song, Qinghua Liu, Hailong Li, Fei Meng, Zhenqiang Pan, Jin Bai, Junnian Zheng

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells

Suhail Ahmed Kabeer Rasheed, Cui Rong Teo, Emmanuel Jean Beillard, P Mathijs Voorhoeve, Wei Zhou, Sujoy Ghosh, Patrick J Casey

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma

Liron Zehavi, Hagit Schayek, Jasmine Jacob-Hirsch, Yechezkel Sidi, Raya Leibowitz-Amit, Dror Avni

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma

Elizabeth F Wiseman, Xi Chen, Namshik Han, Aaron Webber, Zongling Ji, Andrew D Sharrocks, Yeng S Ang

01.12.2015 | Reviewer acknowledgement | Ausgabe 1/2015 Open Access

Thanking our 2014 peer reviewers

Christophe Nicot, Alan Storey

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer

Simone Punt, Jeanine J Houwing-Duistermaat, Iris A Schulkens, Victor L Thijssen, Elisabeth M Osse, Cornelis D de Kroon, Arjan W Griffioen, Gert Jan Fleuren, Arko Gorter, Ekaterina S Jordanova

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells

Armine Matevossian, Marilyn D Resh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer

Dan He, Jun Wang, Chunfang Zhang, Bin Shan, Xiyun Deng, Bin Li, Yanwu Zhou, Wei Chen, Jidong Hong, Yang Gao, Zhuchu Chen, Chaojun Duan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma

Khadija Rebbani, Agnès Marchio, Sayeh Ezzikouri, Rajaa Afifi, Mostafa Kandil, Olfa Bahri, Henda Triki, Abdellah Essaid El Feydi, Anne Dejean, Soumaya Benjelloun, Pascal Pineau

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Biological characteristics of a new human glioma cell line transformed into A2B5+ stem cells

Yanyan Li, Hangzhou Wang, Ting Sun, Jinming Chen, Lingchuan Guo, Haitao Shen, Ziwei Du, Youxin Zhou

01.12.2015 | Review | Ausgabe 1/2015 Open Access

p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis

Sahar S Bhat, Deepak Anand, Firdous A Khanday

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer

Shiro Koizume, Shin Ito, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Mitsuko Furuya, Roppei Yamada, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano, Yohei Miyagi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas

Mahaboob K Sulaiman, Zhengtao Chu, Victor M Blanco, Subrahmanya D Vallabhapurapu, Robert S Franco, Xiaoyang Qi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1

Magali Rebucci, Audrey Sermeus, Elodie Leonard, Edouard Delaive, Marc Dieu, Maude Fransolet, Thierry Arnould, Carine Michiels

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26+ cancer stem cells in colorectal carcinoma

Ariel KM Chow, Nathan SM Cheng, Colin SC Lam, Lui Ng, Sunny KM Wong, Timothy MH Wan, Johnny HW Man, Alvin HK Cheung, Thomas CC Yau, Jensen TC Poon, Wai-Lun Law, Roberta WC Pang

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22)

Hong Yao, Jinlan Pan, Chunxiao Wu, Hongjie Shen, Jundan Xie, Qinrong Wang, Lijun Wen, Qian Wang, Liang Ma, Lili Wu, Nana Ping, Yun Zhao, Aining Sun, Suning Chen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16

Rong Kong, Er-bao Zhang, Dan-dan Yin, Liang-hui You, Tong-peng Xu, Wen-ming Chen, Rui Xia, Li Wan, Ming Sun, Zhao-xia Wang, Wei De, Zhi-hong Zhang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer

Chang-Han Chen, Alice YW Chang, Shau-Hsuan Li, Hsin-Ting Tsai, Li-Yen Shiu, Li-Jen Su, Wen-Lung Wang, Tai-Jen Chiu, Sheng-Dean Luo, Tai-Lin Huang, Chih-Yen Chien

01.12.2015 | Research | Ausgabe 1/2015 Open Access

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH

Guopei Zheng, Cong Peng, Xiaoting Jia, Yixue Gu, Zhijie Zhang, Yingen Deng, Chengkun Wang, Nan Li, Jiang Yin, Xiaorong Liu, Minying Lu, Hailin Tang, Zhimin He

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progression

Anthony J Apostoli, Jennifer M Roche, Mark M Schneider, Sandip K SenGupta, Michael A Di Lena, Rachel E Rubino, Nichole T Peterson, Christopher JB Nicol

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma

Tao Ji, Yi Guo, Kapjun Kim, Peter McQueen, Samia Ghaffar, Alexander Christ, Carol Lin, Ramez Eskander, Xiaolin Zi, Bang H Hoang

01.12.2015 | Review | Ausgabe 1/2015 Open Access

The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

Lifang Zhang, Jianhong Wu, Ming Tat Ling, Liang Zhao, Kong-Nan Zhao

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Zhiqun Shang, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu, Amilcar Flores-Morales

01.12.2015 | Letter to the Editor | Ausgabe 1/2015 Open Access

Characterization of 46 patient-specific BCR-ABL1 fusions and detection of SNPs upstream and downstream the breakpoints in chronic myeloid leukemia using next generation sequencing

Jana Linhartova, Lenka Hovorkova, Simona Soverini, Adela Benesova, Monika Jaruskova, Hana Klamova, Jan Zuna, Katerina Machova Polakova

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression

Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida, Takeshi Yamazaki

01.12.2015 | Research | Ausgabe 1/2015 Open Access

KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation

Xinpei Ci, Changsheng Xing, Baotong Zhang, Zhiqian Zhang, Jenny Jianping Ni, Wei Zhou, Jin-Tang Dong

01.12.2015 | Research | Ausgabe 1/2015 Open Access

FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance

David Westover, Xiang Ling, Hong Lam, Jacob Welch, Chunyang Jin, Celine Gongora, Maguy Del Rio, Mansukh Wani, Fengzhi Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

Chencheng Xie, Huarui Lu, Alice Nomura, Eric Allan Hanse, Colleen Lynn Forster, Josh Berken Parker, Michael Andrew Linden, Chris Karasch, Timothy Curtis Hallstrom

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis, Jörg Kleeff, Peter Winter, Christoph W Michalski

01.12.2015 | Research | Ausgabe 1/2015 Open Access

High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma

Xinxiang Li, Lei Liang, Liyong Huang, Xiaoji Ma, Dawei Li, Sanjun Cai

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3

Lijuan Sun, Bodu Liu, Zhaoyu Lin, Yandan Yao, Yanyang Chen, Yang Li, Jianing Chen, Dongsheng Yu, Zhangui Tang, Bosheng Wang, Shuguang Zeng, Song Fan, Youyuan Wang, Yilin Li, Erwei Song, Jinsong Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The homeoprotein DLX4 controls inducible nitric oxide synthase-mediated angiogenesis in ovarian cancer

Bon Trinh, Song Yi Ko, Dhwani Haria, Nicolas Barengo, Honami Naora

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-21 and miR-145 cooperation in regulation of colon cancer stem cells

Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana, Sindhu G. Rajendra, Edi Levi, Adhip PN Majumdar

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu, Wafik S El-Deiry

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

Wei Wen, Jun Wu, Lucy Liu, Yan Tian, Ralf Buettner, Meng-Yin Hsieh, David Horne, Thanh H Dellinger, Ernest S Han, Richard Jove, John H Yim

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

Changchang Liu, Elise P DeRoo, Catherine Stecyk, Margaret Wolsey, Mateusz Szuchnicki, Engda G Hagos

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast cancer cells through upregulating mir-200a/b expression via association with p73

Zhenduo Lu, Dechuang Jiao, Jianghua Qiao, Sen Yang, Min Yan, Shude Cui, Zhenzhen Liu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

Hui-Hui Cao, Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Hui Guo, Ting Li, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Hua Yu, Zhi-Ling Yu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes

Jung Eun Koo, Seung Won Shin, Soong Ho Um, Joo Young Lee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

Diogo Gomes Garcia, Hugo Caire de Castro-Faria-Neto, Camila Ignácio da Silva, Kauê Francisco Correa de Souza e Souza, Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Lidia Maria da Fonte de Amorim, Aline Soares Freire, Ricardo Erthal Santelli, Luan Pereira Diniz, Flávia Carvalho Alcantara Gomes, Mauro Velho de Castro Faria, Patrícia Burth

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Aurora kinase A in gastrointestinal cancers: time to target

Ahmed Katsha, Abbes Belkhiri, Laura Goff, Wael El-Rifai

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients

Carola H. Schrader, Markus Kolb, Karim Zaoui, Christa Flechtenmacher, Niels Grabe, Klaus-Josef Weber, Thomas Hielscher, Peter K. Plinkert, Jochen Hess

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

Judith Heubach, Juliana Monsior, René Deenen, Günter Niegisch, Tibor Szarvas, Christian Niedworok, Wolfgang Arthur Schulz, Michèle Janine Hoffmann

01.12.2015 | Research | Ausgabe 1/2015 Open Access

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Bianca T. Hofmann, Laura Schlüter, Philip Lange, Baris Mercanoglu, Florian Ewald, Aljonna Fölster, Aeint-Steffen Picksak, Sönke Harder, Alexander T. El Gammal, Katharina Grupp, Cenap Güngör, Astrid Drenckhan, Hartmut Schlüter, Christoph Wagener, Jakob R. Izbicki, Manfred Jücker, Maximilian Bockhorn, Gerrit Wolters-Eisfeld

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

Yu-Suo Tong, Xiao-Wei Wang, Xi-Lei Zhou, Zi-Hao Liu, Tong-Xin Yang, Wei-Hong Shi, Hai-Wei Xie, Jin Lv, Qing-Quan Wu, Xiu-Feng Cao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors

Teerapong Yata, Eugene L. Q. Lee, Keittisak Suwan, Nelofer Syed, Paladd Asavarut, Amin Hajitou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma

Hui Wang, Jian-Qing Pan, Lun Luo, Xin-jie Ning, Zhuo-Peng Ye, Zhe Yu, Wen-Sheng Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner

Keqin Tang, Yinlong Cai, Sangeeta Joshi, Elizabeth Tovar, Stephanie C. Tucker, Krishna Rao Maddipati, John D. Crissman, William T. Repaskey, Kenneth V. Honn

01.12.2015 | Research | Ausgabe 1/2015 Open Access

HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells

Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Maria Alfonsina Desiderio

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer

Hye-Young Min, Hye Jeong Yun, Ji-Sun Lee, Hyo-Jong Lee, Jaebeom Cho, Hyun-Ji Jang, Shin-Hyung Park, Diane Liu, Seung-Hyun Oh, J. Jack Lee, Ignacio I. Wistuba, Ho-Young Lee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden

Christian Prinz, Elena Vasyutina, Gregor Lohmann, Alexandra Schrader, Steffen Romanski, Christoph Hirschhäuser, Petra Mayer, Corazon Frias, Carmen D. Herling, Michael Hallek, Hans-Günther Schmalz, Aram Prokop, Dimitrios Mougiakakos, Marco Herling

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

Sarah T. Boyle, Jessica W. Faulkner, Shaun R. McColl, Marina Kochetkova

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis

Gauri Shishodia, Shirish Shukla, Yogesh Srivastava, Shashank Masaldan, Sumita Mehta, Suresh Bhambhani, Shashi Sharma, Ravi Mehrotra, Bhudev Chandra Das, Alok Chandra Bharti

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Osteoprotegerin in breast cancer: beyond bone remodeling

Michael Weichhaus, Stephanie Tsang Mui Chung, Linda Connelly

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms

Ruchi Pandey, Reuben Kapur

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

De-Kuan Chang, Raymond J. Moniz, Zhongyao Xu, Jiusong Sun, Sabina Signoretti, Quan Zhu, Wayne A. Marasco

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment

Zhe Lu, Do Hyung Kim, Junming Fan, Qun Lu, Kathryn Verbanac, Lei Ding, Randall Renegar, Yan-Hua Chen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

Mrinal Joel, Awais A. Mughal, Zanina Grieg, Wayne Murrell, Sheryl Palmero, Birthe Mikkelsen, Hege B. Fjerdingstad, Cecilie J. Sandberg, Jinan Behnan, Joel C. Glover, Iver A. Langmoen, Biljana Stangeland

01.12.2015 | Research | Ausgabe 1/2015 Open Access

GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells

Styliani Karanika, Theodoros Karantanos, Shinji Kurosaka, Jianxiang Wang, Takahiro Hirayama, Guang Yang, Sanghee Park, Alexei A. Golstov, Ryuta Tanimoto, Likun Li, Timothy C. Thompson

01.12.2015 | Research | Ausgabe 1/2015 Open Access

NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

Suhrid Banskota, Sushil C. Regmi, Jung-Ae Kim

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression

Mi Hee Park, Ji Eun Hong, Eun Sook Park, Hee Sung Yoon, Doo Won Seo, Byung Kook Hyun, Sang-Bae Han, Young Won Ham, Bang Yeon Hwang, Jin Tae Hong

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer

Tianzhen Wang, Guangyu Wang, Dapeng Hao, Xi Liu, Dong Wang, Ning Ning, Xiaobo Li

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer

Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson, Lloyd T. Lam

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Significance of filamin A in mTORC2 function in glioblastoma

Naphat Chantaravisoot, Piriya Wongkongkathep, Joseph A. Loo, Paul S. Mischel, Fuyuhiko Tamanoi

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma

Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo, Antoni Ribas

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid

Rong-Zong Liu, Elizabeth Garcia, Darryl D. Glubrecht, Ho Yin Poon, John R. Mackey, Roseline Godbout

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells

Francesca De Amicis, Saveria Aquila, Catia Morelli, Carmela Guido, Marta Santoro, Ida Perrotta, Loredana Mauro, Francesca Giordano, Alessandra Nigro, Sebastiano Andò, Maria L. Panno

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells

Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, Khawla S. Al-Kuraya

01.12.2015 | Research | Ausgabe 1/2015 Open Access

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

Nitesh Sharma, Vera Magistroni, Rocco Piazza, Stefania Citterio, Caterina Mezzatesta, Praveen Khandelwal, Alessandra Pirola, Carlo Gambacorti-Passerini

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley, Wei-Qun Ding

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma

Sylvain Ferrandon, Céline Malleval, Badia El Hamdani, Priscillia Battiston-Montagne, Radu Bolbos, Jean-Baptiste Langlois, Patrick Manas, Sergei M Gryaznov, Gersende Alphonse, Jérôme Honnorat, Claire Rodriguez-Lafrasse, Delphine Poncet

01.12.2015 | Research | Ausgabe 1/2015 Open Access

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants

Eumorphia G. Konstantakou, Gerassimos E. Voutsinas, Athanassios D. Velentzas, Aggeliki-Stefania Basogianni, Efthimios Paronis, Evangelos Balafas, Nikolaos Kostomitsopoulos, Konstantinos N. Syrigos, Ema Anastasiadou, Dimitrios J. Stravopodis

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

Ling Ling, Si Kee Tan, Ting Hwee Goh, Edwin Cheung, Victor Nurcombe, Andre J. van Wijnen, Simon M. Cool

01.12.2015 | Review | Ausgabe 1/2015 Open Access

RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression

Karine A. Cohen-Solal, Rajeev K. Boregowda, Ahmed Lasfar

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival

Mariya Farooqui, Laura R. Bohrer, Nicholas J. Brady, Pavlina Chuntova, Sarah E. Kemp, C. Taylor Wardwell, Andrew C. Nelson, Kathryn L. Schwertfeger

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling

Carole M. Tactacan, Yu Wei Phua, Ling Liu, Luxi Zhang, Emily S. Humphrey, Mark Cowley, Mark Pinese, Andrew V. Biankin, Roger J. Daly

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma

Ni Chen, Meiping Ren, Rong Li, Xin Deng, Yongjie Li, Kai Yan, Lamei Xiao, Yan Yang, Liqun Wang, Mao Luo, William P. Fay, Jianbo Wu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma

Michael R. Miller, Deqin Ma, James Schappet, Patrick Breheny, Sarah L. Mott, Nadine Bannick, Eric Askeland, James Brown, Michael D. Henry

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

Stratifin accelerates progression of lung adenocarcinoma at an early stage

Aya Shiba-Ishii, Yunjung Kim, Toshihiro Shiozawa, Shinji Iyama, Kaishi Satomi, Junko Kano, Shingo Sakashita, Yukio Morishita, Masayuki Noguchi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27

Heidi Högel, Petra Miikkulainen, Lucia Bino, Panu M. Jaakkola

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis, Jörg Kleeff, Peter Winter, Christoph W Michalski

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Genetic instability in the tumor microenvironment: a new look at an old neighbor

Antonio Palumbo Jr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti

01.12.2015 | Research | Ausgabe 1/2015 Open Access

AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation

Maria Victoria Maliandi, Ana Mato-Berciano, Luciano Sobrevals, Gaël Roué, Anabel José, Cristina Fillat

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth, Ralph Minter

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

María Contador-Troca, Alberto Alvarez-Barrientos, Jaime M. Merino, Antonio Morales-Hernández, María I. Rodríguez, Javier Rey-Barroso, Eva Barrasa, María I. Cerezo-Guisado, Inmaculada Catalina-Fernández, Javier Sáenz-Santamaría, Francisco J. Oliver, Pedro M. Fernandez-Salguero

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

Abdullah Alsuliman, Dilek Colak, Olfat Al-Harazi, Hanaa Fitwi, Asma Tulbah, Taher Al-Tweigeri, Monther Al-Alwan, Hazem Ghebeh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma

Mayumi Higashi, Venkatadri Kolla, Radhika Iyer, Koumudi Naraparaju, Tiangang Zhuang, Sriharsha Kolla, Garrett M. Brodeur

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Identification of a blood-borne miRNA signature of synovial sarcoma

Alba Fricke, Prisca V. Ullrich, Jürgen Heinz, Dietmar Pfeifer, Jutta Scholber, Georg W. Herget, Oliver Hauschild, Peter Bronsert, G. Björn Stark, Holger Bannasch, Steffen U. Eisenhardt, David Braig

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer

Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs

TB Rounge, K Furu, RI Skotheim, TB Haugen, T Grotmol, E Enerly

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway

Xuewei Xia, Yong Li, Wenbo Wang, Fang Tang, Jie Tan, Liyuan Sun, Qinghua Li, Li Sun, Bo Tang, Songqing He

01.12.2015 | Research | Ausgabe 1/2015 Open Access

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

Alice Conigliaro, Viviana Costa, Alessia Lo Dico, Laura Saieva, Simona Buccheri, Francesco Dieli, Mauro Manno, Samuele Raccosta, Carmine Mancone, Marco Tripodi, Giacomo De Leo, Riccardo Alessandro

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression

Marilyne Kpetemey, Subhamoy Dasgupta, Smrithi Rajendiran, Susobhan Das, Lee D. Gibbs, Praveenkumar Shetty, Zygmunt Gryczynski, Jamboor K. Vishwanatha

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF

Evelyn Fessler, Tijana Borovski, Jan Paul Medema

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair

Xiaolong He, Pei Zhang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity

Seung Joon Lee, Alisa Litan, Zhiqin Li, Bruce Graves, Stephan Lindsey, Sonali P. Barwe, Sigrid A. Langhans

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Awais A. Mughal, Zanina Grieg, Håvard Skjellegrind, Artem Fayzullin, Mustapha Lamkhannat, Mrinal Joel, M. Shakil Ahmed, Wayne Murrell, Einar O. Vik-Mo, Iver A. Langmoen, Biljana Stangeland

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

Mariana Toricelli, Fabiana H. M. Melo, Giovani B. Peres, Débora C. P. Silva, Miriam G. Jasiulionis

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A

Moitri Basu, Rahul Bhattacharya, Upasana Ray, Satinath Mukhopadhyay, Uttara Chatterjee, Sib Sankar Roy

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells

Jialin He, Kai Zhao, Lu Zheng, Zhizhen Xu, Wei Gong, Shan Chen, Xiaodong Shen, Gang Huang, Min Gao, Yijun Zeng, Yan Zhang, Fengtian He

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival

Satbir Thakur, Arash Nabbi, Alexander Klimowicz, Karl Riabowol

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2

Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu, Pei Ma, Yong-qian Shu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Carbon ion beam combined with cisplatin effectively disrupts triple negative breast cancer stem-like cells in vitro

Sei Sai, Guillaume Vares, Eun Ho Kim, Kumiko Karasawa, Bing Wang, Mitsuru Nenoi, Yoshiya Horimoto, Mitsuhiro Hayashi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells

Jonatan Darr, Agnes Klochendler, Sara Isaac, Tami Geiger, Amir Eden

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activation of peroxisome proliferator-activated receptor gamma is crucial for antitumoral effects of 6-iodolactone

Mario Nava-Villalba, Rosa E. Nuñez-Anita, Alexander Bontempo, Carmen Aceves

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Helen B. Pearson, Edwina McGlinn, Toby J. Phesse, Holger Schlüter, Anuratha Srikumar, Nathan J. Gödde, Christina B. Woelwer, Andrew Ryan, Wayne A. Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Aldolase B inhibits metastasis through Ten–Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma

Qi-fei Tao, Sheng-xian Yuan, Fu Yang, Sen Yang, Yuan Yang, Ji-hang Yuan, Zhen-guang Wang, Qing-guo Xu, Kong-ying Lin, Jie Cai, Jian Yu, Wei-long Huang, Xiao-lei Teng, Chuan-chuan Zhou, Fang Wang, Shu-han Sun, Wei-ping Zhou

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer

Guanglong Dong, Xianli He, Yibing Chen, Haiyan Cao, Jiaojiao Wang, Xiaonan Liu, Shukui Wang, Shaogui Wan, Jinliang Xing

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4

Hamza Hanieh

01.12.2015 | Research | Ausgabe 1/2015 Open Access

BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells

Jeong Seon Kim, Jonathan M. Kurie, Young-Ho Ahn

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

Tien-Jen Lin, Hsin-Ting Lin, Wei-Ting Chang, Pradeep Mitapalli. S, Pei-Wen Hsiao, Shu-Yi Yin, Ning-Sun Yang

01.12.2015 | Short communication | Ausgabe 1/2015 Open Access

Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma

Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan, Chor Sang Chim

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Rebecca Kohnken, Karthik M. Kodigepalli, Li Wu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation

Bin Song, Qi Bian, Yi-Jie Zhang, Cheng-Hao Shao, Gang Li, An-An Liu, Wei Jing, Rui Liu, Ying-Qi Zhou, Gang Jin, Xian-Gui Hu

01.12.2015 | Review | Ausgabe 1/2015 Open Access

P-cadherin and the journey to cancer metastasis

André Filipe Vieira, Joana Paredes

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

Ming-Chen Yang, Hao-Chen Wang, Ya-Chin Hou, Hui-Ling Tung, Tai-Jan Chiu, Yan-Shen Shan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells

Shien Hu, Lan Liu, Eugene B. Chang, Jian-Ying Wang, Jean-Pierre Raufman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma

Maarouf A. Saad, Selena Z. Kuo, Elham Rahimy, Angela E. Zou, Avinaash Korrapati, Mehran Rahimy, Elizabeth Kim, Hao Zheng, Michael Andrew Yu, Jessica Wang-Rodriguez, Weg M. Ongkeko

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer

Jessica Bauer, Ozkan Ozden, Naomi Akagi, Timothy Carroll, Daniel R. Principe, Jonas J. Staudacher, Martina E. Spehlmann, Lars Eckmann, Paul J. Grippo, Barbara Jung

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis

Martin Hufbauer, James Cooke, Gijsbertus T. J. van der Horst, Herbert Pfister, Alan Storey, Baki Akgül

01.12.2015 | Review | Ausgabe 1/2015 Open Access

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

Eli Raveh, Imad J. Matouk, Michal Gilon, Abraham Hochberg

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies

Sayer Al-harbi, Gaurav S. Choudhary, Jey Sabith Ebron, Brian T. Hill, Nagarajavel Vivekanathan, Angela H. Ting, Tomas Radivoyevitch, Mitchell R. Smith, Girish C. Shukla, Alex Almasan

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression

Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li, Hongyang Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression

Panagiotis Maragozidis, Eirini Papanastasi, Diana Scutelnic, Athina Totomi, Ioanna Kokkori, Sotirios G. Zarogiannis, Theodora Kerenidi, Konstantinos I. Gourgoulianis, Nikolaos A. A. Balatsos

01.12.2015 | Review | Ausgabe 1/2015 Open Access

DDX3, a potential target for cancer treatment

Guus Martinus Bol, Min Xie, Venu Raman

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide

Jonathan L. Tso, Shuai Yang, Jimmy C. Menjivar, Kazunari Yamada, Yibei Zhang, Irene Hong, Yvonne Bui, Alexandra Stream, William H. McBride, Linda M. Liau, Stanley F. Nelson, Timothy F. Cloughesy, William H. Yong, Albert Lai, Cho-Lea Tso

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α

Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan, Si-Ying Wang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer

Yuchen Wu, Li Yang, Jiang Zhao, Cong Li, Jia Nie, Fangqi Liu, Changhua Zhuo, Yaxin Zheng, Bin Li, Zhimin Wang, Ye Xu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer

Andrew J. Wilson, Jeanette Saskowski, Whitney Barham, Dineo Khabele, Fiona Yull

01.12.2015 | Research | Ausgabe 1/2015 Open Access

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu, Wenlong Yu, Guangzhi Jin, Dongyun Xu, Ying Chen, Tian Xia, Allan Yu, Wenzheng Fang, Xiaoli Zhang, Zhaosheng Li, Keping Xie

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer

David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned, Carmen J. Marsit

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer

Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W. Nasser, Ramesh K. Ganju

01.12.2015 | Research | Ausgabe 1/2015 Open Access

miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

Marijn T. M. van Jaarsveld, Patricia F. van Kuijk, Antonius W. M. Boersma, Jozien Helleman, Wilfred F. van IJcken, Ron H. J. Mathijssen, Joris Pothof, Els M. J. J. Berns, Jaap Verweij, Erik A. C. Wiemer

01.12.2015 | Letter to the Editor | Ausgabe 1/2015 Open Access

Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis

Paulo Vidal Campregher, Welbert de Oliveira Pereira, Bianca Lisboa, Renato Puga, Ricardo Helman, Mariana Miyagi, Evelyn Helena Ascendino da Mata, Tarcila Santos Datoguia, Elvira Deolinda Rodrigues Pereira Velloso, Nydia Strachman Bacal, Jeffrey S. Ross, Siraj Ali, Vincent Miller, Fernando Ferreira Costa, Nelson Hamerschlak, Fabio Pires de Souza Santos

01.12.2015 | Review | Ausgabe 1/2015 Open Access

The twisted survivin connection to angiogenesis

C. Sanhueza, S. Wehinger, J. Castillo Bennett, M. Valenzuela, G. I. Owen, A. F. G. Quest

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert, Frank Gieseler, Hendrik Ungefroren

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Minnelide effectively eliminates CD133+ side population in pancreatic cancer

Alice Nomura, Olivia McGinn, Vikas Dudeja, Veena Sangwan, Ashok K. Saluja, Sulagna Banerjee

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells

Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich, Mariusz Z. Ratajczak

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer

Vivian Yvonne Shin, Enders K. O. Ng, Vivian W. Chan, Ava Kwong, Kent-Man Chu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

Andrea Giannuzzo, Stine Falsig Pedersen, Ivana Novak

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon, Jochen Hess

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

S. Kreuz, K. B. Holmes, R. M. Tooze, P. F. Lefevre

01.12.2015 | Research | Ausgabe 1/2015 Open Access

A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators

Jamie Freeman, David Smith, Branko Latinkic, Ken Ewan, Lee Samuel, Massimo Zollo, Natascia Marino, Lorraine Tyas, Nick Jones, Trevor C. Dale

01.12.2015 | Review | Ausgabe 1/2015 Open Access

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

Rosalba Camicia, Hans C. Winkler, Paul O. Hassa

01.12.2015 | Research | Ausgabe 1/2015 Open Access

MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy

Xinfeng Yu, Aiping Luo, Yicong Liu, Shuqing Wang, Ye Li, Wenna Shi, Zhihua Liu, Xianjun Qu

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL

Rhiannon French, Olivia Hayward, Samuel Jones, William Yang, Richard Clarkson

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model

Estanislao Nistal-Villan, Maria Bunuales, Joanna Poutou, Manuela Gonzalez-Aparicio, Carlos Bravo-Perez, Jose I. Quetglas, Beatriz Carte, Gloria Gonzalez-Aseguinolaza, Jesus Prieto, Esther Larrea, Ruben Hernandez-Alcoceba

01.12.2015 | Letter to the Editor | Ausgabe 1/2015 Open Access

t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders

Alberto L’Abbate, Doron Tolomeo, Francesca De Astis, Angelo Lonoce, Crocifissa Lo Cunsolo, Dominique Mühlematter, Jacqueline Schoumans, Peter Vandenberghe, Achilles Van Hoof, Orazio Palumbo, Massimo Carella, Tommaso Mazza, Clelia Tiziana Storlazzi

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

Bo Kong, Tao Cheng, Chengjia Qian, Weiwei Wu, Katja Steiger, Jing Cao, Anna Melissa Schlitter, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff, Christoph W. Michalski

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

Shan-Shan Sun, Xuan Zhou, Yuan-Yuan Huang, Ling-Ping Kong, Mei Mei, Wen-Yu Guo, Ming-Hui Zhao, Yu Ren, Qiang Shen, Lun Zhang

01.12.2015 | Research | Ausgabe 1/2015 Open Access

BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia

Norma I. Rodríguez-Malavé, Thilini R. Fernando, Parth C. Patel, Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Jaime Anguiano, Michael J. Davoren, Michael O. Alberti, Kimanh T. Pioli, Salemiz Sandoval, Gay M. Crooks, Dinesh S. Rao

01.12.2015 | Research | Ausgabe 1/2015 Open Access

The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors

Anup S Pathania, Zahoor A Wani, Santosh K Guru, Suresh Kumar, Shashi Bhushan, Hasan Korkaya, Darren F Seals, Ajay Kumar, Dilip M Mondhe, Zabeer Ahmed, Bal K Chandan, Fayaz Malik

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