Ausgabe 1/2015
Inhalt (214 Artikel)
miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia
John Adams Fischer, Stefano Rossetti, Arani Datta, Kevin Hasegawa Eng, Alessandro Beghini, Nicoletta Sacchi
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu, Amilcar Flores-Morales
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling
Evan M Cherry, Dong W Lee, Ji-Ung Jung, Raquel Sitcheran
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma
Fei Wang, Jin-Lian Yang, Ke-ke Yu, Mei Xu, You-zhi Xu, Li Chen, Yan-min Lu, Hao-shu Fang, Xin-yi Wang, Zhong-qian Hu, Fei-fei Li, Lixin Kan, Jia Luo, Si-Ying Wang
miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W Nasser, Ramesh K Ganju
SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway
Yi-Jun Shu, Hao Weng, Yuan-Yuan Ye, Yun-Ping Hu, Run-Fa Bao, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Xiang-Song Wu, Mao-Lan Li, Lin Jiang, Wei Lu, Bao-San Han, Zhi-Gang Jie, Ying-Bin Liu
The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis
Michaela Nelson, Ming Yang, Adam A Dowle, Jerry R Thomas, William J Brackenbury
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death
Elin Hallan Naderi, Seham Skah, Hege Ugland, Ola Myklebost, Dagny Lise Sandnes, Maria Lyngaas Torgersen, Dag Josefsen, Ellen Ruud, Soheil Naderi, Heidi Kiil Blomhoff
Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells
Hooi Ching Lim, Hinke AB Multhaupt, John R Couchman
Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals
Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li, Chawnshang Chang
β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma
Jenny Zinke, Fabian T Schneider, Patrick N Harter, Sonja Thom, Nicole Ziegler, Rune Toftgård, Karl H Plate, Stefan Liebner
Oncogenic KRAS promotes malignant brain tumors in zebrafish
Bensheng Ju, Wenbiao Chen, Brent A Orr, Jan M Spitsbergen, Sujuan Jia, Christopher J Eden, Hannah E Henson, Michael R Taylor
Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor
Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara, Evangelia Papadimitriou
Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression
Rajakishore Mishra, Siddavaram Nagini, Ajay Rana
A molecular signature for the prediction of recurrence in colorectal cancer
Lisha Wang, Xiaohan Shen, Zhimin Wang, Xiuying Xiao, Ping Wei, Qifeng Wang, Fei Ren, Yiqin Wang, Zebing Liu, Weiqi Sheng, Wei Huang, Xiaoyan Zhou, Xiang Du
Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity
Seoung-Ae Lee, Hong Kim, You-Sub Won, Seung-Hyeok Seok, YiRang Na, Han-Bo Shin, Kyung-Soo Inn, Bum-Joon Kim
Identification of rare germline copy number variations over-represented in five human cancer types
Richard W Park, Tae-Min Kim, Simon Kasif, Peter J Park
Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients
Qing Ouyang, Xueyang Gong, Hualiang Xiao, Ji Zhou, Minhui Xu, Yun Dai, Lunshan Xu, Hua Feng, Hongjuan Cui, Liang Yi
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma
Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah JL Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G Graeber, Antoni Ribas
Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
Shan Shao, Xiaoai Zhao, Xiaojin Zhang, Minna Luo, Xiaoxiao Zuo, Shangke Huang, Ying Wang, Shanzhi Gu, Xinhan Zhao
ID helix-loop-helix proteins as determinants of cell survival in B-cell chronic lymphocytic leukemia cells in vitro
Sarah Weiler, Jolaolu A Ademokun, John D Norton
Prognostic relevance of acquired uniparental disomy in serous ovarian cancer
Musaffe Tuna, Zhenlin Ju, Marcel Smid, Christopher I Amos, Gordon B Mills
Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes
Wei Li, Zhiwu Jiang, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng, Jianyu Weng, Xin Du, Pentao Liu, Yangqiu Li, Hudan Liu, Yao Yao, Peng Li
RhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression
Xi Chen, Shuo Chen, Yin-Ling Xiu, Kai-Xuan Sun, Zhi-Hong Zong, Yang Zhao
A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism
Erica Maria Pimenta, Betsy J Barnes
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage
Anne Olazabal-Herrero, Iraia García-Santisteban, Jose Antonio Rodríguez
MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer
Anna Maria Rusek, Mohammed Abba, Andrzej Eljaszewicz, Marcin Moniuszko, Jacek Niklinski, Heike Allgayer
The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis
Elena Tutunea-Fatan, Mousumi Majumder, Xiping Xin, Peeyush K Lala
Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing
Yao-Yin Chang, Wen-Hung Kuo, Jui-Hui Hung, Chien-Yueh Lee, Yung-Hua Lee, Ya-Chu Chang, Wen-Chun Lin, Cheng-Ying Shen, Chiun-Sheng Huang, Fon-Jou Hsieh, Liang-Chuan Lai, Mong-Hsun Tsai, King-Jen Chang, Eric Y Chuang
RETRACTED ARTICLE: miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer
Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li, Guoqiang Zhao
High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients
Katharina Ilm, Wolfgang Kemmner, Marc Osterland, Susen Burock, Gudrun Koch, Pia Herrmann, Peter M Schlag, Ulrike Stein
Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells
Ursula Kern, Vladimir Wischnewski, Martin L Biniossek, Oliver Schilling, Thomas Reinheckel
Drug sensitivity in cancer cell lines is not tissue-specific
Samira Jaeger, Miquel Duran-Frigola, Patrick Aloy
OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy
Ichiyo Shibahara, Ryuta Saito, Rong Zhang, Masashi Chonan, Takuhiro Shoji, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Masahiko Kanehira, Toshiaki Kikuchi, Takanori So, Takashi Watanabe, Hiroaki Takahashi, Erina Iwabuchi, Yuetsu Tanaka, Yukiko Shibahara, Hironobu Sasano, Naoto Ishii, Teiji Tominaga
Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death
Sumana Bhattacharjya, Kumar Singha Roy, Abira Ganguly, Shreya Sarkar, Chinmay K Panda, Dibyendu Bhattacharyya, Nitai P Bhattacharyya, Susanta Roychoudhury
The role of the insulin-like growth factor-1 system in breast cancer
Panagiotis F Christopoulos, Pavlos Msaouel, Michael Koutsilieris
CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma
Dag Andre Nymoen, Arild Holth, Thea E Hetland Falkenthal, Claes G Tropé, Ben Davidson
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
Martin P Barr, Steven G Gray, Kathy Gately, Emily Hams, Padraic G Fallon, Anthony Mitchell Davies, Derek J Richard, Graham P Pidgeon, Kenneth J O’Byrne
The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo
Abhijit Parolia, Francesco Crea, Hui Xue, Yuwei Wang, Fan Mo, Varune Rohan Ramnarine, Hui Hsuan Liu, Dong Lin, Nur Ridzwan Nur Saidy, Pier-Luc Clermont, Hongwei Cheng, Colin Collins, Yuzhuo Wang, Cheryl D Helgason
Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2
Dan Li, Hong Mei, Jiarui Pu, Xuan Xiang, Xiang Zhao, Hongxia Qu, Kai Huang, Liduan Zheng, Qiangsong Tong
Apoptosis, autophagy, necroptosis, and cancer metastasis
Zhenyi Su, Zuozhang Yang, Yongqing Xu, Yongbin Chen, Qiang Yu
Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver
Alisha M Mendonsa, Michael N VanSaun, Alessandro Ustione, David W Piston, Barbara M Fingleton, David Lee Gorden
Single live cell TGF-β signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-β-Smad3 activity
Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson, Hong-Jian Zhu
The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression
Yongguo Shi, Juan Li, Yangchen Liu, Jie Ding, Yingrui Fan, Yun Tian, Li Wang, Yifan Lian, Keming Wang, Yongqian Shu
Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma
Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Junhong Zhao, Qiaoyi Liang, Li Zhang, Yi Pan, Weiqin Yang, Jesse CS Pang, Alfred SL Cheng, Jun Yu, Ka Fai To
The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK+ T-cell lymphoma
Deeksha Vishwamitra, Choladda V Curry, Serhan Alkan, Yao-Hua Song, Gary E Gallick, Ahmed O Kaseb, Ping Shi, Hesham M Amin
Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines
Simone Gusenbauer, Emanuele Zanucco, Pjotr Knyazev, Axel Ullrich
Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway
Pingyu Zhang, Xianbin Yang, Xiaoyan Ma, Davis R Ingram, Alexander J Lazar, Keila E Torres, Raphael E Pollock
Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway
Yi Zhang, Hai-xuan Chen, Shu-yan Zhou, Shao-xiang Wang, Kai Zheng, Dan-dan Xu, Yu-ting Liu, Xiao-yan Wang, Xiao Wang, Hai-zhao Yan, Li Zhang, Qiu-ying Liu, Wan-qun Chen, Yi-fei Wang
Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization
Carina Fischer, Katharina Leithner, Christoph Wohlkoenig, Franz Quehenberger, Alexandra Bertsch, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak
Melanoma cells influence the differentiation pattern of human epidermal keratinocytes
Ondřej Kodet, Lukáš Lacina, Eliška Krejčí, Barbora Dvořánková, Miloš Grim, Jiří Štork, Daniela Kodetová, Čestmír Vlček, Jana Šáchová, Michal Kolář, Hynek Strnad, Karel Smetana
microRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma
Zheng Zhang, Yang Zhang, Xiu-Xuan Sun, Xi Ma, Zhi-Nan Chen
SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells
Rainelli B Koumangoye, Thomas Andl, Kenneth J Taubenslag, Steven T Zilberman, Chase J Taylor, Holli A Loomans, Claudia D Andl
miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6
Bairong Xia, Shanshan Yang, Tianbo Liu, Ge Lou
MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
Hongwei Liang, Xin Yan, Yi Pan, Yongsheng Wang, Nan Wang, Limin Li, Yuan Liu, Xi Chen, Chen-Yu Zhang, Hongwei Gu, Ke Zen
Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway
Huanxin Liu, Jie Huang, Juan Peng, Xiaoxia Wu, Yan Zhang, Weiliang Zhu, Linlang Guo
In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAF V600E in melanoma
Xingyi Guo, Yaomin Xu, Zhongming Zhao
The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon
Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Charlotte Gröschel, Samawansha Tennakoon, Anastasia Meshcheryakova, Wenhan Chang, Edward M Brown, Diana Mechtcheriakova, Enikö Kállay
TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas
Koen MO Galenkamp, Paulina Carriba, Jorge Urresti, Laura Planells-Ferrer, Elena Coccia, Joaquín Lopez-Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, Miguel F Segura, Joan X Comella
Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation
Xiang Zhou, Ruohua Chen, Zhenhai Yu, Rui Li, Jiajin Li, Xiaoping Zhao, Shaoli Song, Jianjun Liu, Gang Huang
The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesis
Bing Han, Haolei Cai, Ying Chen, Bing Hu, Hongyu Luo, Yulian Wu, Jiangping Wu
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival
Tao Liu, Hailong Zhang, Jing Xiong, Sha Yi, Lubing Gu, Muxiang Zhou
PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway
Meilin Shi, Menghan Cao, Jun Song, Qinghua Liu, Hailong Li, Fei Meng, Zhenqiang Pan, Jin Bai, Junnian Zheng
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells
Suhail Ahmed Kabeer Rasheed, Cui Rong Teo, Emmanuel Jean Beillard, P Mathijs Voorhoeve, Wei Zhou, Sujoy Ghosh, Patrick J Casey
MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma
Liron Zehavi, Hagit Schayek, Jasmine Jacob-Hirsch, Yechezkel Sidi, Raya Leibowitz-Amit, Dror Avni
Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma
Elizabeth F Wiseman, Xi Chen, Namshik Han, Aaron Webber, Zongling Ji, Andrew D Sharrocks, Yeng S Ang
Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer
Simone Punt, Jeanine J Houwing-Duistermaat, Iris A Schulkens, Victor L Thijssen, Elisabeth M Osse, Cornelis D de Kroon, Arjan W Griffioen, Gert Jan Fleuren, Arko Gorter, Ekaterina S Jordanova
Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells
Armine Matevossian, Marilyn D Resh
Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer
Dan He, Jun Wang, Chunfang Zhang, Bin Shan, Xiyun Deng, Bin Li, Yanwu Zhou, Wei Chen, Jidong Hong, Yang Gao, Zhuchu Chen, Chaojun Duan
TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma
Khadija Rebbani, Agnès Marchio, Sayeh Ezzikouri, Rajaa Afifi, Mostafa Kandil, Olfa Bahri, Henda Triki, Abdellah Essaid El Feydi, Anne Dejean, Soumaya Benjelloun, Pascal Pineau
Biological characteristics of a new human glioma cell line transformed into A2B5+ stem cells
Yanyan Li, Hangzhou Wang, Ting Sun, Jinming Chen, Lingchuan Guo, Haitao Shen, Ziwei Du, Youxin Zhou
p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis
Sahar S Bhat, Deepak Anand, Firdous A Khanday
Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer
Shiro Koizume, Shin Ito, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Mitsuko Furuya, Roppei Yamada, Etsuko Miyagi, Fumiki Hirahara, Yasuo Takano, Yohei Miyagi
SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas
Mahaboob K Sulaiman, Zhengtao Chu, Victor M Blanco, Subrahmanya D Vallabhapurapu, Robert S Franco, Xiaoyang Qi
miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1
Magali Rebucci, Audrey Sermeus, Elodie Leonard, Edouard Delaive, Marc Dieu, Maude Fransolet, Thierry Arnould, Carine Michiels
Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26+ cancer stem cells in colorectal carcinoma
Ariel KM Chow, Nathan SM Cheng, Colin SC Lam, Lui Ng, Sunny KM Wong, Timothy MH Wan, Johnny HW Man, Alvin HK Cheung, Thomas CC Yau, Jensen TC Poon, Wai-Lun Law, Roberta WC Pang
Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22)
Hong Yao, Jinlan Pan, Chunxiao Wu, Hongjie Shen, Jundan Xie, Qinrong Wang, Lijun Wen, Qian Wang, Liang Ma, Lili Wu, Nana Ping, Yun Zhao, Aining Sun, Suning Chen
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16
Rong Kong, Er-bao Zhang, Dan-dan Yin, Liang-hui You, Tong-peng Xu, Wen-ming Chen, Rui Xia, Li Wan, Ming Sun, Zhao-xia Wang, Wei De, Zhi-hong Zhang
Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer
Chang-Han Chen, Alice YW Chang, Shau-Hsuan Li, Hsin-Ting Tsai, Li-Yen Shiu, Li-Jen Su, Wen-Lung Wang, Tai-Jen Chiu, Sheng-Dean Luo, Tai-Lin Huang, Chih-Yen Chien
ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH
Guopei Zheng, Cong Peng, Xiaoting Jia, Yixue Gu, Zhijie Zhang, Yingen Deng, Chengkun Wang, Nan Li, Jiang Yin, Xiaorong Liu, Minying Lu, Hailin Tang, Zhimin He
Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progression
Anthony J Apostoli, Jennifer M Roche, Mark M Schneider, Sandip K SenGupta, Michael A Di Lena, Rachel E Rubino, Nichole T Peterson, Christopher JB Nicol
Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma
Tao Ji, Yi Guo, Kapjun Kim, Peter McQueen, Samia Ghaffar, Alexander Christ, Carol Lin, Ramez Eskander, Xiaolin Zi, Bang H Hoang
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses
Lifang Zhang, Jianhong Wu, Ming Tat Ling, Liang Zhao, Kong-Nan Zhao
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Zhiqun Shang, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu, Amilcar Flores-Morales
Characterization of 46 patient-specific BCR-ABL1 fusions and detection of SNPs upstream and downstream the breakpoints in chronic myeloid leukemia using next generation sequencing
Jana Linhartova, Lenka Hovorkova, Simona Soverini, Adela Benesova, Monika Jaruskova, Hana Klamova, Jan Zuna, Katerina Machova Polakova
Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression
Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida, Takeshi Yamazaki
KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation
Xinpei Ci, Changsheng Xing, Baotong Zhang, Zhiqian Zhang, Jenny Jianping Ni, Wei Zhou, Jin-Tang Dong
FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance
David Westover, Xiang Ling, Hong Lam, Jacob Welch, Chunyang Jin, Celine Gongora, Maguy Del Rio, Mansukh Wani, Fengzhi Li
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas
Chencheng Xie, Huarui Lu, Alice Nomura, Eric Allan Hanse, Colleen Lynn Forster, Josh Berken Parker, Michael Andrew Linden, Chris Karasch, Timothy Curtis Hallstrom
Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis, Jörg Kleeff, Peter Winter, Christoph W Michalski
High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma
Xinxiang Li, Lei Liang, Liyong Huang, Xiaoji Ma, Dawei Li, Sanjun Cai
MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3
Lijuan Sun, Bodu Liu, Zhaoyu Lin, Yandan Yao, Yanyang Chen, Yang Li, Jianing Chen, Dongsheng Yu, Zhangui Tang, Bosheng Wang, Shuguang Zeng, Song Fan, Youyuan Wang, Yilin Li, Erwei Song, Jinsong Li
The homeoprotein DLX4 controls inducible nitric oxide synthase-mediated angiogenesis in ovarian cancer
Bon Trinh, Song Yi Ko, Dhwani Haria, Nicolas Barengo, Honami Naora
miR-21 and miR-145 cooperation in regulation of colon cancer stem cells
Yingjie Yu, Pratima Nangia-Makker, Lulu Farhana, Sindhu G. Rajendra, Edi Levi, Adhip PN Majumdar
Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu, Wafik S El-Deiry
Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer
Wei Wen, Jun Wu, Lucy Liu, Yan Tian, Ralf Buettner, Meng-Yin Hsieh, David Horne, Thanh H Dellinger, Ernest S Han, Richard Jove, John H Yim
Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation
Changchang Liu, Elise P DeRoo, Catherine Stecyk, Margaret Wolsey, Mateusz Szuchnicki, Engda G Hagos
Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast cancer cells through upregulating mir-200a/b expression via association with p73
Zhenduo Lu, Dechuang Jiao, Jianghua Qiao, Sen Yang, Min Yan, Shude Cui, Zhenzhen Liu
Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion
Hui-Hui Cao, Chi-Yan Cheng, Tao Su, Xiu-Qiong Fu, Hui Guo, Ting Li, Anfernee Kai-Wing Tse, Hiu-Yee Kwan, Hua Yu, Zhi-Ling Yu
X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes
Jung Eun Koo, Seung Won Shin, Soong Ho Um, Joo Young Lee
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol
Diogo Gomes Garcia, Hugo Caire de Castro-Faria-Neto, Camila Ignácio da Silva, Kauê Francisco Correa de Souza e Souza, Cassiano Felippe Gonçalves-de-Albuquerque, Adriana Ribeiro Silva, Lidia Maria da Fonte de Amorim, Aline Soares Freire, Ricardo Erthal Santelli, Luan Pereira Diniz, Flávia Carvalho Alcantara Gomes, Mauro Velho de Castro Faria, Patrícia Burth
Aurora kinase A in gastrointestinal cancers: time to target
Ahmed Katsha, Abbes Belkhiri, Laura Goff, Wael El-Rifai
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients
Carola H. Schrader, Markus Kolb, Karim Zaoui, Christa Flechtenmacher, Niels Grabe, Klaus-Josef Weber, Thomas Hielscher, Peter K. Plinkert, Jochen Hess
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells
Judith Heubach, Juliana Monsior, René Deenen, Günter Niegisch, Tibor Szarvas, Christian Niedworok, Wolfgang Arthur Schulz, Michèle Janine Hoffmann
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
Bianca T. Hofmann, Laura Schlüter, Philip Lange, Baris Mercanoglu, Florian Ewald, Aljonna Fölster, Aeint-Steffen Picksak, Sönke Harder, Alexander T. El Gammal, Katharina Grupp, Cenap Güngör, Astrid Drenckhan, Hartmut Schlüter, Christoph Wagener, Jakob R. Izbicki, Manfred Jücker, Maximilian Bockhorn, Gerrit Wolters-Eisfeld
Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma
Yu-Suo Tong, Xiao-Wei Wang, Xi-Lei Zhou, Zi-Hao Liu, Tong-Xin Yang, Wei-Hong Shi, Hai-Wei Xie, Jin Lv, Qing-Quan Wu, Xiu-Feng Cao
Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors
Teerapong Yata, Eugene L. Q. Lee, Keittisak Suwan, Nelofer Syed, Paladd Asavarut, Amin Hajitou
NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
Hui Wang, Jian-Qing Pan, Lun Luo, Xin-jie Ning, Zhuo-Peng Ye, Zhe Yu, Wen-Sheng Li
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner
Keqin Tang, Yinlong Cai, Sangeeta Joshi, Elizabeth Tovar, Stephanie C. Tucker, Krishna Rao Maddipati, John D. Crissman, William T. Repaskey, Kenneth V. Honn
RETRACTED ARTICLE: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells
Paola Bendinelli, Paola Maroni, Emanuela Matteucci, Maria Alfonsina Desiderio
Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer
Hye-Young Min, Hye Jeong Yun, Ji-Sun Lee, Hyo-Jong Lee, Jaebeom Cho, Hyun-Ji Jang, Shin-Hyung Park, Diane Liu, Seung-Hyun Oh, J. Jack Lee, Ignacio I. Wistuba, Ho-Young Lee
Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden
Christian Prinz, Elena Vasyutina, Gregor Lohmann, Alexandra Schrader, Steffen Romanski, Christoph Hirschhäuser, Petra Mayer, Corazon Frias, Carmen D. Herling, Michael Hallek, Hans-Günther Schmalz, Aram Prokop, Dimitrios Mougiakakos, Marco Herling
The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages
Sarah T. Boyle, Jessica W. Faulkner, Shaun R. McColl, Marina Kochetkova
Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis
Gauri Shishodia, Shirish Shukla, Yogesh Srivastava, Shashank Masaldan, Sumita Mehta, Suresh Bhambhani, Shashi Sharma, Ravi Mehrotra, Bhudev Chandra Das, Alok Chandra Bharti
Osteoprotegerin in breast cancer: beyond bone remodeling
Michael Weichhaus, Stephanie Tsang Mui Chung, Linda Connelly
Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms
Ruchi Pandey, Reuben Kapur
Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo
De-Kuan Chang, Raymond J. Moniz, Zhongyao Xu, Jiusong Sun, Sabina Signoretti, Quan Zhu, Wayne A. Marasco
A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Zhe Lu, Do Hyung Kim, Junming Fan, Qun Lu, Kathryn Verbanac, Lei Ding, Randall Renegar, Yan-Hua Chen
Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo
Mrinal Joel, Awais A. Mughal, Zanina Grieg, Wayne Murrell, Sheryl Palmero, Birthe Mikkelsen, Hege B. Fjerdingstad, Cecilie J. Sandberg, Jinan Behnan, Joel C. Glover, Iver A. Langmoen, Biljana Stangeland
GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells
Styliani Karanika, Theodoros Karantanos, Shinji Kurosaka, Jianxiang Wang, Takahiro Hirayama, Guang Yang, Sanghee Park, Alexei A. Golstov, Ryuta Tanimoto, Likun Li, Timothy C. Thompson
NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7
Suhrid Banskota, Sushil C. Regmi, Jung-Ae Kim
Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression
Mi Hee Park, Ji Eun Hong, Eun Sook Park, Hee Sung Yoon, Doo Won Seo, Byung Kook Hyun, Sang-Bae Han, Young Won Ham, Bang Yeon Hwang, Jin Tae Hong
Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
Tianzhen Wang, Guangyu Wang, Dapeng Hao, Xi Liu, Dong Wang, Ning Ning, Xiaobo Li
Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer
Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson, Lloyd T. Lam
Significance of filamin A in mTORC2 function in glioblastoma
Naphat Chantaravisoot, Piriya Wongkongkathep, Joseph A. Loo, Paul S. Mischel, Fuyuhiko Tamanoi
Erratum to: Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma
Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo, Antoni Ribas
CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid
Rong-Zong Liu, Elizabeth Garcia, Darryl D. Glubrecht, Ho Yin Poon, John R. Mackey, Roseline Godbout
Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells
Francesca De Amicis, Saveria Aquila, Catia Morelli, Carmela Guido, Marta Santoro, Ida Perrotta, Loredana Mauro, Francesca Giordano, Alessandra Nigro, Sebastiano Andò, Maria L. Panno
Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells
Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, Nasser Al-Sanea, Fouad Al-Dayel, Mohammed Al-Assiri, Shaham Beg, Khawla S. Al-Kuraya
BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene
Nitesh Sharma, Vera Magistroni, Rocco Piazza, Stefania Citterio, Caterina Mezzatesta, Praveen Khandelwal, Alessandra Pirola, Carlo Gambacorti-Passerini
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)
Bethany N. Hannafon, Karla J. Carpenter, William L. Berry, Ralf Janknecht, William C. Dooley, Wei-Qun Ding
Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma
Sylvain Ferrandon, Céline Malleval, Badia El Hamdani, Priscillia Battiston-Montagne, Radu Bolbos, Jean-Baptiste Langlois, Patrick Manas, Sergei M Gryaznov, Gersende Alphonse, Jérôme Honnorat, Claire Rodriguez-Lafrasse, Delphine Poncet
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants
Eumorphia G. Konstantakou, Gerassimos E. Voutsinas, Athanassios D. Velentzas, Aggeliki-Stefania Basogianni, Efthimios Paronis, Evangelos Balafas, Nikolaos Kostomitsopoulos, Konstantinos N. Syrigos, Ema Anastasiadou, Dimitrios J. Stravopodis
Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy
Ling Ling, Si Kee Tan, Ting Hwee Goh, Edwin Cheung, Victor Nurcombe, Andre J. van Wijnen, Simon M. Cool
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression
Karine A. Cohen-Solal, Rajeev K. Boregowda, Ahmed Lasfar
Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival
Mariya Farooqui, Laura R. Bohrer, Nicholas J. Brady, Pavlina Chuntova, Sarah E. Kemp, C. Taylor Wardwell, Andrew C. Nelson, Kathryn L. Schwertfeger
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
Carole M. Tactacan, Yu Wei Phua, Ling Liu, Luxi Zhang, Emily S. Humphrey, Mark Cowley, Mark Pinese, Andrew V. Biankin, Roger J. Daly
Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma
Ni Chen, Meiping Ren, Rong Li, Xin Deng, Yongjie Li, Kai Yan, Lamei Xiao, Yan Yang, Liqun Wang, Mao Luo, William P. Fay, Jianbo Wu
Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma
Michael R. Miller, Deqin Ma, James Schappet, Patrick Breheny, Sarah L. Mott, Nadine Bannick, Eric Askeland, James Brown, Michael D. Henry
Stratifin accelerates progression of lung adenocarcinoma at an early stage
Aya Shiba-Ishii, Yunjung Kim, Toshihiro Shiozawa, Shinji Iyama, Kaishi Satomi, Junko Kano, Shingo Sakashita, Yukio Morishita, Masayuki Noguchi
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
Heidi Högel, Petra Miikkulainen, Lucia Bino, Panu M. Jaakkola
Erratum to: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
Sören Müller, Susanne Raulefs, Philipp Bruns, Fabian Afonso-Grunz, Anne Plötner, Rolf Thermann, Carsten Jäger, Anna Melissa Schlitter, Bo Kong, Ivonne Regel, W Kurt Roth, Björn Rotter, Klaus Hoffmeier, Günter Kahl, Ina Koch, Fabian J Theis, Jörg Kleeff, Peter Winter, Christoph W Michalski
Genetic instability in the tumor microenvironment: a new look at an old neighbor
Antonio Palumbo Jr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti
AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation
Maria Victoria Maliandi, Ana Mato-Berciano, Luciano Sobrevals, Gaël Roué, Anabel José, Cristina Fillat
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling
Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth, Ralph Minter
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
María Contador-Troca, Alberto Alvarez-Barrientos, Jaime M. Merino, Antonio Morales-Hernández, María I. Rodríguez, Javier Rey-Barroso, Eva Barrasa, María I. Cerezo-Guisado, Inmaculada Catalina-Fernández, Javier Sáenz-Santamaría, Francisco J. Oliver, Pedro M. Fernandez-Salguero
Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells
Abdullah Alsuliman, Dilek Colak, Olfat Al-Harazi, Hanaa Fitwi, Asma Tulbah, Taher Al-Tweigeri, Monther Al-Alwan, Hazem Ghebeh
Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma
Mayumi Higashi, Venkatadri Kolla, Radhika Iyer, Koumudi Naraparaju, Tiangang Zhuang, Sriharsha Kolla, Garrett M. Brodeur
Identification of a blood-borne miRNA signature of synovial sarcoma
Alba Fricke, Prisca V. Ullrich, Jürgen Heinz, Dietmar Pfeifer, Jutta Scholber, Georg W. Herget, Oliver Hauschild, Peter Bronsert, G. Björn Stark, Holger Bannasch, Steffen U. Eisenhardt, David Braig
A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer
Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed
Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
TB Rounge, K Furu, RI Skotheim, TB Haugen, T Grotmol, E Enerly
MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway
Xuewei Xia, Yong Li, Wenbo Wang, Fang Tang, Jie Tan, Liyuan Sun, Qinghua Li, Li Sun, Bo Tang, Songqing He
CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Alice Conigliaro, Viviana Costa, Alessia Lo Dico, Laura Saieva, Simona Buccheri, Francesco Dieli, Mauro Manno, Samuele Raccosta, Carmine Mancone, Marco Tripodi, Giacomo De Leo, Riccardo Alessandro
MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression
Marilyne Kpetemey, Subhamoy Dasgupta, Smrithi Rajendiran, Susobhan Das, Lee D. Gibbs, Praveenkumar Shetty, Zygmunt Gryczynski, Jamboor K. Vishwanatha
Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF
Evelyn Fessler, Tijana Borovski, Jan Paul Medema
Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair
Xiaolong He, Pei Zhang
Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity
Seung Joon Lee, Alisa Litan, Zhiqin Li, Bruce Graves, Stephan Lindsey, Sonali P. Barwe, Sigrid A. Langhans
Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells
Awais A. Mughal, Zanina Grieg, Håvard Skjellegrind, Artem Fayzullin, Mustapha Lamkhannat, Mrinal Joel, M. Shakil Ahmed, Wayne Murrell, Einar O. Vik-Mo, Iver A. Langmoen, Biljana Stangeland
Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
Mariana Toricelli, Fabiana H. M. Melo, Giovani B. Peres, Débora C. P. Silva, Miriam G. Jasiulionis
Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A
Moitri Basu, Rahul Bhattacharya, Upasana Ray, Satinath Mukhopadhyay, Uttara Chatterjee, Sib Sankar Roy
Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells
Jialin He, Kai Zhao, Lu Zheng, Zhizhen Xu, Wei Gong, Shan Chen, Xiaodong Shen, Gang Huang, Min Gao, Yijun Zeng, Yan Zhang, Fengtian He
Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival
Satbir Thakur, Arash Nabbi, Alexander Klimowicz, Karl Riabowol
Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2
Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu, Pei Ma, Yong-qian Shu
Carbon ion beam combined with cisplatin effectively disrupts triple negative breast cancer stem-like cells in vitro
Sei Sai, Guillaume Vares, Eun Ho Kim, Kumiko Karasawa, Bing Wang, Mitsuru Nenoi, Yoshiya Horimoto, Mitsuhiro Hayashi
Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells
Jonatan Darr, Agnes Klochendler, Sara Isaac, Tami Geiger, Amir Eden
Activation of peroxisome proliferator-activated receptor gamma is crucial for antitumoral effects of 6-iodolactone
Mario Nava-Villalba, Rosa E. Nuñez-Anita, Alexander Bontempo, Carmen Aceves
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis
Helen B. Pearson, Edwina McGlinn, Toby J. Phesse, Holger Schlüter, Anuratha Srikumar, Nathan J. Gödde, Christina B. Woelwer, Andrew Ryan, Wayne A. Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert
Aldolase B inhibits metastasis through Ten–Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma
Qi-fei Tao, Sheng-xian Yuan, Fu Yang, Sen Yang, Yuan Yang, Ji-hang Yuan, Zhen-guang Wang, Qing-guo Xu, Kong-ying Lin, Jie Cai, Jian Yu, Wei-long Huang, Xiao-lei Teng, Chuan-chuan Zhou, Fang Wang, Shu-han Sun, Wei-ping Zhou
Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer
Guanglong Dong, Xianli He, Yibing Chen, Haiyan Cao, Jiaojiao Wang, Xiaonan Liu, Shukui Wang, Shaogui Wan, Jinliang Xing
Aryl hydrocarbon receptor-microRNA-212/132 axis in human breast cancer suppresses metastasis by targeting SOX4
Hamza Hanieh
BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells
Jeong Seon Kim, Jonathan M. Kurie, Young-Ho Ahn
Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components
Tien-Jen Lin, Hsin-Ting Lin, Wei-Ting Chang, Pradeep Mitapalli. S, Pei-Wen Hsiao, Shu-Yi Yin, Ning-Sun Yang
Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma
Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan, Chor Sang Chim
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications
Rebecca Kohnken, Karthik M. Kodigepalli, Li Wu
Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation
Bin Song, Qi Bian, Yi-Jie Zhang, Cheng-Hao Shao, Gang Li, An-An Liu, Wei Jing, Rui Liu, Ying-Qi Zhou, Gang Jin, Xian-Gui Hu
P-cadherin and the journey to cancer metastasis
André Filipe Vieira, Joana Paredes
Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine
Ming-Chen Yang, Hao-Chen Wang, Ya-Chin Hou, Hui-Ling Tung, Tai-Jan Chiu, Yan-Shen Shan
Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells
Shien Hu, Lan Liu, Eugene B. Chang, Jian-Ying Wang, Jean-Pierre Raufman
Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma
Maarouf A. Saad, Selena Z. Kuo, Elham Rahimy, Angela E. Zou, Avinaash Korrapati, Mehran Rahimy, Elizabeth Kim, Hao Zheng, Michael Andrew Yu, Jessica Wang-Rodriguez, Weg M. Ongkeko
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Jessica Bauer, Ozkan Ozden, Naomi Akagi, Timothy Carroll, Daniel R. Principe, Jonas J. Staudacher, Martina E. Spehlmann, Lars Eckmann, Paul J. Grippo, Barbara Jung
Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis
Martin Hufbauer, James Cooke, Gijsbertus T. J. van der Horst, Herbert Pfister, Alan Storey, Baki Akgül
The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory
Eli Raveh, Imad J. Matouk, Michal Gilon, Abraham Hochberg
miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies
Sayer Al-harbi, Gaurav S. Choudhary, Jey Sabith Ebron, Brian T. Hill, Nagarajavel Vivekanathan, Angela H. Ting, Tomas Radivoyevitch, Mitchell R. Smith, Girish C. Shukla, Alex Almasan
A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression
Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li, Hongyang Wang
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression
Panagiotis Maragozidis, Eirini Papanastasi, Diana Scutelnic, Athina Totomi, Ioanna Kokkori, Sotirios G. Zarogiannis, Theodora Kerenidi, Konstantinos I. Gourgoulianis, Nikolaos A. A. Balatsos
DDX3, a potential target for cancer treatment
Guus Martinus Bol, Min Xie, Venu Raman
Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide
Jonathan L. Tso, Shuai Yang, Jimmy C. Menjivar, Kazunari Yamada, Yibei Zhang, Irene Hong, Yvonne Bui, Alexandra Stream, William H. McBride, Linda M. Liau, Stanley F. Nelson, Timothy F. Cloughesy, William H. Yong, Albert Lai, Cho-Lea Tso
RETRACTED ARTICLE: MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α
Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan, Si-Ying Wang
Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer
Yuchen Wu, Li Yang, Jiang Zhao, Cong Li, Jia Nie, Fangqi Liu, Changhua Zhuo, Yaxin Zheng, Bin Li, Zhimin Wang, Ye Xu
Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer
Andrew J. Wilson, Jeanette Saskowski, Whitney Barham, Dineo Khabele, Fiona Yull
PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma
Guanzhen Yu, Wenlong Yu, Guangzhi Jin, Dongyun Xu, Ying Chen, Tian Xia, Allan Yu, Wenzheng Fang, Xiaoli Zhang, Zhaosheng Li, Keping Xie
MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer
David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned, Carmen J. Marsit
Erratum to: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W. Nasser, Ramesh K. Ganju
miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
Marijn T. M. van Jaarsveld, Patricia F. van Kuijk, Antonius W. M. Boersma, Jozien Helleman, Wilfred F. van IJcken, Ron H. J. Mathijssen, Joris Pothof, Els M. J. J. Berns, Jaap Verweij, Erik A. C. Wiemer
Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis
Paulo Vidal Campregher, Welbert de Oliveira Pereira, Bianca Lisboa, Renato Puga, Ricardo Helman, Mariana Miyagi, Evelyn Helena Ascendino da Mata, Tarcila Santos Datoguia, Elvira Deolinda Rodrigues Pereira Velloso, Nydia Strachman Bacal, Jeffrey S. Ross, Siraj Ali, Vincent Miller, Fernando Ferreira Costa, Nelson Hamerschlak, Fabio Pires de Souza Santos
The twisted survivin connection to angiogenesis
C. Sanhueza, S. Wehinger, J. Castillo Bennett, M. Valenzuela, G. I. Owen, A. F. G. Quest
Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action
Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert, Frank Gieseler, Hendrik Ungefroren
Minnelide effectively eliminates CD133+ side population in pancreatic cancer
Alice Nomura, Olivia McGinn, Vikas Dudeja, Veena Sangwan, Ashok K. Saluja, Sulagna Banerjee
Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells
Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich, Mariusz Z. Ratajczak
A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer
Vivian Yvonne Shin, Enders K. O. Ng, Vivian W. Chan, Ava Kwong, Kent-Man Chu
The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells
Andrea Giannuzzo, Stine Falsig Pedersen, Ivana Novak
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma
Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon, Jochen Hess
Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas
S. Kreuz, K. B. Holmes, R. M. Tooze, P. F. Lefevre
A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators
Jamie Freeman, David Smith, Branko Latinkic, Ken Ewan, Lee Samuel, Massimo Zollo, Natascia Marino, Lorraine Tyas, Nick Jones, Trevor C. Dale
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Rosalba Camicia, Hans C. Winkler, Paul O. Hassa
MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy
Xinfeng Yu, Aiping Luo, Yicong Liu, Shuqing Wang, Ye Li, Wenna Shi, Zhihua Liu, Xianjun Qu
Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL
Rhiannon French, Olivia Hayward, Samuel Jones, William Yang, Richard Clarkson
Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model
Estanislao Nistal-Villan, Maria Bunuales, Joanna Poutou, Manuela Gonzalez-Aparicio, Carlos Bravo-Perez, Jose I. Quetglas, Beatriz Carte, Gloria Gonzalez-Aseguinolaza, Jesus Prieto, Esther Larrea, Ruben Hernandez-Alcoceba
t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders
Alberto L’Abbate, Doron Tolomeo, Francesca De Astis, Angelo Lonoce, Crocifissa Lo Cunsolo, Dominique Mühlematter, Jacqueline Schoumans, Peter Vandenberghe, Achilles Van Hoof, Orazio Palumbo, Massimo Carella, Tommaso Mazza, Clelia Tiziana Storlazzi
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma
Bo Kong, Tao Cheng, Chengjia Qian, Weiwei Wu, Katja Steiger, Jing Cao, Anna Melissa Schlitter, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff, Christoph W. Michalski
Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma
Shan-Shan Sun, Xuan Zhou, Yuan-Yuan Huang, Ling-Ping Kong, Mei Mei, Wen-Yu Guo, Ming-Hui Zhao, Yu Ren, Qiang Shen, Lun Zhang
BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia
Norma I. Rodríguez-Malavé, Thilini R. Fernando, Parth C. Patel, Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Jaime Anguiano, Michael J. Davoren, Michael O. Alberti, Kimanh T. Pioli, Salemiz Sandoval, Gay M. Crooks, Dinesh S. Rao
The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors
Anup S Pathania, Zahoor A Wani, Santosh K Guru, Suresh Kumar, Shashi Bhushan, Hasan Korkaya, Darren F Seals, Ajay Kumar, Dilip M Mondhe, Zabeer Ahmed, Bal K Chandan, Fayaz Malik